DE68918248T2 - TGF beta 1/beta2: ein chimärer transformierender Wachstumsfaktor. - Google Patents

TGF beta 1/beta2: ein chimärer transformierender Wachstumsfaktor.

Info

Publication number
DE68918248T2
DE68918248T2 DE68918248T DE68918248T DE68918248T2 DE 68918248 T2 DE68918248 T2 DE 68918248T2 DE 68918248 T DE68918248 T DE 68918248T DE 68918248 T DE68918248 T DE 68918248T DE 68918248 T2 DE68918248 T2 DE 68918248T2
Authority
DE
Germany
Prior art keywords
growth factor
transforming growth
beta2
tgf beta
chimeric transforming
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68918248T
Other languages
English (en)
Other versions
DE68918248D1 (de
Inventor
Anthony F Purchio
Linda Madisen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oncogen LP
Original Assignee
Oncogen LP
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncogen LP filed Critical Oncogen LP
Publication of DE68918248D1 publication Critical patent/DE68918248D1/de
Application granted granted Critical
Publication of DE68918248T2 publication Critical patent/DE68918248T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
DE68918248T 1988-12-15 1989-12-13 TGF beta 1/beta2: ein chimärer transformierender Wachstumsfaktor. Expired - Fee Related DE68918248T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US28497288A 1988-12-15 1988-12-15

Publications (2)

Publication Number Publication Date
DE68918248D1 DE68918248D1 (de) 1994-10-20
DE68918248T2 true DE68918248T2 (de) 1995-05-04

Family

ID=23092228

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68918248T Expired - Fee Related DE68918248T2 (de) 1988-12-15 1989-12-13 TGF beta 1/beta2: ein chimärer transformierender Wachstumsfaktor.

Country Status (18)

Country Link
US (1) US5244793A (de)
EP (1) EP0374044B1 (de)
JP (1) JPH0335794A (de)
KR (1) KR900009983A (de)
CN (1) CN1045994A (de)
AT (1) ATE111520T1 (de)
AU (1) AU634733B2 (de)
CA (1) CA2005120A1 (de)
DE (1) DE68918248T2 (de)
DK (1) DK633389A (de)
ES (1) ES2063834T3 (de)
FI (1) FI97299C (de)
HU (1) HUT52550A (de)
IE (1) IE66571B1 (de)
IL (1) IL92669A (de)
NO (1) NO300464B1 (de)
PT (1) PT92603B (de)
ZA (1) ZA899517B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5304541A (en) * 1988-12-15 1994-04-19 Bristol-Myers Squibb Company Methods using novel chimeric transforming growth factor-β1/β2
CA2003886A1 (en) * 1988-12-16 1990-06-16 Anthony F. Purchio Cloning and expression of simian transforming growth factor-beta 1
US5169764A (en) * 1990-08-08 1992-12-08 Regeneron Pharmaceuticals, Inc. Multitrophic and multifunctional chimeric neurotrophic factors, and nucleic acids and plasmids encoding the chimeras
US5206023A (en) * 1991-01-31 1993-04-27 Robert F. Shaw Method and compositions for the treatment and repair of defects or lesions in cartilage
GB9106678D0 (en) * 1991-03-28 1991-05-15 Ferguson Mark W J Wound healing
US5270300A (en) * 1991-09-06 1993-12-14 Robert Francis Shaw Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone
US6515009B1 (en) 1991-09-27 2003-02-04 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5811447A (en) 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
AU2738392A (en) * 1991-11-11 1993-05-13 Ciba-Geigy Ag Novel hybrid transforming growth factors
IT1259042B (it) * 1992-01-27 1996-03-11 Mini Ricerca Scient Tecnolog Preparazione di vettori di espressione per la sintesi del polipeptide chiamato fattore osteogenetico op-1 in cellule eucariotiche di spodoptera frugiperda via infezione con baculovirus ricombinante
US6395494B1 (en) 1993-05-13 2002-05-28 Neorx Corporation Method to determine TGF-β
US5420243A (en) * 1993-01-26 1995-05-30 Celtrix Pharmaceuticals, Inc. Biologically active TGF-β2 peptides
US5981568A (en) 1993-01-28 1999-11-09 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6663881B2 (en) 1993-01-28 2003-12-16 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6491938B2 (en) 1993-05-13 2002-12-10 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
ATE406909T1 (de) * 1993-05-13 2008-09-15 Poniard Pharmaceuticals Inc Prävention und behandlung von pathologien, die mit einer abnormalen proliferationglatter muskelzellen verbunden sind
US6117911A (en) 1997-04-11 2000-09-12 Neorx Corporation Compounds and therapies for the prevention of vascular and non-vascular pathologies
WO2003077852A2 (en) * 2002-03-12 2003-09-25 Tissuegene, Inc. CARTILAGE REGENERATION USING CHONDROCYTE AND TGF-β

Also Published As

Publication number Publication date
AU4683489A (en) 1990-06-21
IE66571B1 (en) 1996-01-24
FI97299C (fi) 1996-11-25
PT92603A (pt) 1990-06-29
CN1045994A (zh) 1990-10-10
DK633389A (da) 1990-06-16
JPH0335794A (ja) 1991-02-15
AU634733B2 (en) 1993-03-04
DE68918248D1 (de) 1994-10-20
ES2063834T3 (es) 1995-01-16
ATE111520T1 (de) 1994-09-15
CA2005120A1 (en) 1990-06-15
IL92669A (en) 1997-02-18
EP0374044A2 (de) 1990-06-20
HUT52550A (en) 1990-07-28
EP0374044A3 (de) 1991-07-31
KR900009983A (ko) 1990-07-06
NO300464B1 (no) 1997-06-02
IE893984L (en) 1990-06-15
ZA899517B (en) 1990-09-26
NO895028L (no) 1990-06-18
IL92669A0 (en) 1990-08-31
FI895935A0 (fi) 1989-12-12
DK633389D0 (da) 1989-12-14
FI97299B (fi) 1996-08-15
HU896613D0 (en) 1990-02-28
PT92603B (pt) 1995-09-12
NO895028D0 (no) 1989-12-14
US5244793A (en) 1993-09-14
EP0374044B1 (de) 1994-09-14

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee