ES2063834T3 - Tgf-beta 1/beta 2: un nuevo factor del crecimiento-beta transformante quimerico. - Google Patents

Tgf-beta 1/beta 2: un nuevo factor del crecimiento-beta transformante quimerico.

Info

Publication number
ES2063834T3
ES2063834T3 ES89403463T ES89403463T ES2063834T3 ES 2063834 T3 ES2063834 T3 ES 2063834T3 ES 89403463 T ES89403463 T ES 89403463T ES 89403463 T ES89403463 T ES 89403463T ES 2063834 T3 ES2063834 T3 ES 2063834T3
Authority
ES
Spain
Prior art keywords
beta
growth factor
tgf
new growth
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89403463T
Other languages
English (en)
Inventor
Anthony F Purchio
Linda Madisen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oncogen LP
Original Assignee
Oncogen LP
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncogen LP filed Critical Oncogen LP
Application granted granted Critical
Publication of ES2063834T3 publication Critical patent/ES2063834T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Abstract

LA PRESENTE INVENCION PRESENTA UN FACTOR-(BETA) 1/(BETA) 2) DE CRECIMIENTO DE LA TRANSFORMACION QUIMERICA QUE COMPRENDE LA SECUENCIA AMINO ACIDA DE UN AMINO ACIDO NUMERO 279 A UN RESIDUO DE AMINO ACIDO DE NUMERO 390 COMO ES DESCRITO EN FIG.1.
ES89403463T 1988-12-15 1989-12-13 Tgf-beta 1/beta 2: un nuevo factor del crecimiento-beta transformante quimerico. Expired - Lifetime ES2063834T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US28497288A 1988-12-15 1988-12-15

Publications (1)

Publication Number Publication Date
ES2063834T3 true ES2063834T3 (es) 1995-01-16

Family

ID=23092228

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89403463T Expired - Lifetime ES2063834T3 (es) 1988-12-15 1989-12-13 Tgf-beta 1/beta 2: un nuevo factor del crecimiento-beta transformante quimerico.

Country Status (18)

Country Link
US (1) US5244793A (es)
EP (1) EP0374044B1 (es)
JP (1) JPH0335794A (es)
KR (1) KR900009983A (es)
CN (1) CN1045994A (es)
AT (1) ATE111520T1 (es)
AU (1) AU634733B2 (es)
CA (1) CA2005120A1 (es)
DE (1) DE68918248T2 (es)
DK (1) DK633389A (es)
ES (1) ES2063834T3 (es)
FI (1) FI97299C (es)
HU (1) HUT52550A (es)
IE (1) IE66571B1 (es)
IL (1) IL92669A (es)
NO (1) NO300464B1 (es)
PT (1) PT92603B (es)
ZA (1) ZA899517B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5304541A (en) * 1988-12-15 1994-04-19 Bristol-Myers Squibb Company Methods using novel chimeric transforming growth factor-β1/β2
CA2003886A1 (en) * 1988-12-16 1990-06-16 Anthony F. Purchio Cloning and expression of simian transforming growth factor-beta 1
US5169764A (en) * 1990-08-08 1992-12-08 Regeneron Pharmaceuticals, Inc. Multitrophic and multifunctional chimeric neurotrophic factors, and nucleic acids and plasmids encoding the chimeras
US5206023A (en) * 1991-01-31 1993-04-27 Robert F. Shaw Method and compositions for the treatment and repair of defects or lesions in cartilage
GB9106678D0 (en) * 1991-03-28 1991-05-15 Ferguson Mark W J Wound healing
US5270300A (en) * 1991-09-06 1993-12-14 Robert Francis Shaw Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone
US6515009B1 (en) 1991-09-27 2003-02-04 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5811447A (en) 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
AU2738392A (en) * 1991-11-11 1993-05-13 Ciba-Geigy Ag Novel hybrid transforming growth factors
IT1259042B (it) * 1992-01-27 1996-03-11 Mini Ricerca Scient Tecnolog Preparazione di vettori di espressione per la sintesi del polipeptide chiamato fattore osteogenetico op-1 in cellule eucariotiche di spodoptera frugiperda via infezione con baculovirus ricombinante
US6395494B1 (en) 1993-05-13 2002-05-28 Neorx Corporation Method to determine TGF-β
US5420243A (en) * 1993-01-26 1995-05-30 Celtrix Pharmaceuticals, Inc. Biologically active TGF-β2 peptides
US5981568A (en) 1993-01-28 1999-11-09 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6663881B2 (en) 1993-01-28 2003-12-16 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6491938B2 (en) 1993-05-13 2002-12-10 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
ATE406909T1 (de) * 1993-05-13 2008-09-15 Poniard Pharmaceuticals Inc Prävention und behandlung von pathologien, die mit einer abnormalen proliferationglatter muskelzellen verbunden sind
US6117911A (en) 1997-04-11 2000-09-12 Neorx Corporation Compounds and therapies for the prevention of vascular and non-vascular pathologies
WO2003077852A2 (en) * 2002-03-12 2003-09-25 Tissuegene, Inc. CARTILAGE REGENERATION USING CHONDROCYTE AND TGF-β

Also Published As

Publication number Publication date
AU4683489A (en) 1990-06-21
IE66571B1 (en) 1996-01-24
FI97299C (fi) 1996-11-25
PT92603A (pt) 1990-06-29
CN1045994A (zh) 1990-10-10
DK633389A (da) 1990-06-16
JPH0335794A (ja) 1991-02-15
AU634733B2 (en) 1993-03-04
DE68918248D1 (de) 1994-10-20
ATE111520T1 (de) 1994-09-15
CA2005120A1 (en) 1990-06-15
IL92669A (en) 1997-02-18
EP0374044A2 (en) 1990-06-20
HUT52550A (en) 1990-07-28
EP0374044A3 (en) 1991-07-31
KR900009983A (ko) 1990-07-06
NO300464B1 (no) 1997-06-02
IE893984L (en) 1990-06-15
DE68918248T2 (de) 1995-05-04
ZA899517B (en) 1990-09-26
NO895028L (no) 1990-06-18
IL92669A0 (en) 1990-08-31
FI895935A0 (fi) 1989-12-12
DK633389D0 (da) 1989-12-14
FI97299B (fi) 1996-08-15
HU896613D0 (en) 1990-02-28
PT92603B (pt) 1995-09-12
NO895028D0 (no) 1989-12-14
US5244793A (en) 1993-09-14
EP0374044B1 (en) 1994-09-14

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