DE68907934D1 - Verfahren zur herstellung von 4-demethoxydaunomycinon, das aglycon von 4-demethoxydaunorubicin. - Google Patents

Verfahren zur herstellung von 4-demethoxydaunomycinon, das aglycon von 4-demethoxydaunorubicin.

Info

Publication number
DE68907934D1
DE68907934D1 DE8989301282T DE68907934T DE68907934D1 DE 68907934 D1 DE68907934 D1 DE 68907934D1 DE 8989301282 T DE8989301282 T DE 8989301282T DE 68907934 T DE68907934 T DE 68907934T DE 68907934 D1 DE68907934 D1 DE 68907934D1
Authority
DE
Germany
Prior art keywords
daunomycinone
group
amino
demethoxydaunomycinon
demethoxydaunorubicin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8989301282T
Other languages
English (en)
Other versions
DE68907934T2 (de
Inventor
Bernardinis Silvia De
Walter Cabri
Tiziano Martinengo
Franco Francalanci
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmitalia Carlo Erba SRL
Carlo Erba SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmitalia Carlo Erba SRL, Carlo Erba SpA filed Critical Farmitalia Carlo Erba SRL
Application granted granted Critical
Publication of DE68907934D1 publication Critical patent/DE68907934D1/de
Publication of DE68907934T2 publication Critical patent/DE68907934T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C50/00—Quinones
    • C07C50/38—Quinones containing —CHO or non—quinoid keto groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C46/00—Preparation of quinones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE89301282T 1988-02-12 1989-02-10 Verfahren zur Herstellung von 4-Demethoxydaunomycinon, das Aglycon von 4-Demethoxydaunorubicin. Expired - Fee Related DE68907934T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888803301A GB8803301D0 (en) 1988-02-12 1988-02-12 Process for preparation of 4-demethoxy-daunomycinone aglycone of 4-demethoxy-daunorubicin

Publications (2)

Publication Number Publication Date
DE68907934D1 true DE68907934D1 (de) 1993-09-09
DE68907934T2 DE68907934T2 (de) 1994-04-28

Family

ID=10631620

Family Applications (1)

Application Number Title Priority Date Filing Date
DE89301282T Expired - Fee Related DE68907934T2 (de) 1988-02-12 1989-02-10 Verfahren zur Herstellung von 4-Demethoxydaunomycinon, das Aglycon von 4-Demethoxydaunorubicin.

Country Status (26)

Country Link
US (1) US5015745A (de)
EP (1) EP0328399B1 (de)
JP (1) JP2784202B2 (de)
KR (1) KR970000484B1 (de)
CN (1) CN1020592C (de)
AT (1) ATE92457T1 (de)
AU (1) AU605960B2 (de)
CA (1) CA1339634C (de)
CS (1) CS273198B2 (de)
DE (1) DE68907934T2 (de)
DK (1) DK170248B1 (de)
ES (1) ES2059718T3 (de)
FI (1) FI92186C (de)
GB (1) GB8803301D0 (de)
HU (1) HU200979B (de)
IE (1) IE62954B1 (de)
IL (1) IL89198A (de)
MY (1) MY104941A (de)
NO (1) NO169483C (de)
NZ (1) NZ227873A (de)
PH (1) PH27328A (de)
PT (1) PT89663B (de)
RU (1) RU1819256C (de)
UA (1) UA19151A (de)
YU (1) YU47206B (de)
ZA (1) ZA891018B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ224252A (en) * 1987-04-21 1991-09-25 Erba Carlo Spa An anthracycline glycoside and its preparation
GB8808475D0 (en) * 1988-04-11 1988-05-11 Erba Carlo Spa Process for preparing 4-demethoxydauno-mycinone
IT1275953B1 (it) * 1995-03-22 1997-10-24 Sicor Spa Procedimento per la preparazione di antibiotici della classe delle antracicline
AUPQ319799A0 (en) * 1999-10-01 1999-10-28 Institute Of Drug Technology Australia Limited Chemical methods
US7053191B2 (en) 2003-05-21 2006-05-30 Solux Corporation Method of preparing 4-R-substituted 4-demethoxydaunorubicin
KR20070058491A (ko) * 2004-08-23 2007-06-08 시코르, 인크. 이다루비신 아글리콘의 합성
DE06848583T1 (de) 2005-12-13 2011-03-17 Solux Corporation, San Diego Verfahren zur herstellung von 4-demethyldaunorubicin
US8802830B2 (en) 2005-12-20 2014-08-12 Solux Corporation Synthesis of epirubicin from 13-dihydrodaunorubicine
US8357785B2 (en) 2008-01-08 2013-01-22 Solux Corporation Method of aralkylation of 4′-hydroxyl group of anthracylins
US8846882B2 (en) * 2011-04-29 2014-09-30 Synbias Pharma Ag Method of producing 4-demethoxydaunorubicin

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3862225A (en) * 1961-08-18 1975-01-21 Pfizer D-ring substituted tetracyclines
US4020270A (en) * 1974-05-02 1977-04-26 Societa' Farmaceutici Italia S.P.A. L-lyxohex-1-enopyranose derivative
GB1467383A (en) * 1974-06-12 1977-03-16 Farmaceutici Italia Daunomycin analogues
GB1500421A (en) * 1975-01-22 1978-02-08 Farmaceutici Italia Optically active anthracyclinones
GB1509875A (en) * 1976-06-14 1978-05-04 Farmaceutici Italia Optically active anthracyclinones and anthracycline glycosides
GB1527050A (en) * 1976-06-19 1978-10-04 Farmaceutici Italia Optically active anthracyclinones
GB8317037D0 (en) * 1983-06-23 1983-07-27 Erba Farmitalia 6-deoxyanthracyclines
US4495103A (en) * 1982-07-30 1985-01-22 Sumitomo Chemical Company, Ltd. Preparation of optically active 4-demethoxydaunomycinone
JPS61501388A (ja) * 1983-10-19 1986-07-10 ザ　ユニヴア−シテイ　オブ　メルボルン 有機化合物類
NZ224252A (en) * 1987-04-21 1991-09-25 Erba Carlo Spa An anthracycline glycoside and its preparation
GB8808475D0 (en) * 1988-04-11 1988-05-11 Erba Carlo Spa Process for preparing 4-demethoxydauno-mycinone
GB8824947D0 (en) * 1988-10-25 1988-11-30 Erba Carlo Spa New 4-substituted anthracyclinones & process for preparing them

Also Published As

Publication number Publication date
CA1339634C (en) 1998-01-20
DK63889D0 (da) 1989-02-10
UA19151A (uk) 1997-12-25
DE68907934T2 (de) 1994-04-28
DK170248B1 (da) 1995-07-17
IE62954B1 (en) 1995-02-20
FI890612A (fi) 1989-08-13
JP2784202B2 (ja) 1998-08-06
RU1819256C (en) 1993-05-30
YU31089A (en) 1990-08-31
FI890612A0 (fi) 1989-02-09
EP0328399A2 (de) 1989-08-16
NO890566L (no) 1989-08-11
IL89198A (en) 1994-10-07
HU200979B (en) 1990-09-28
NO169483B (no) 1992-03-23
MY104941A (en) 1994-07-30
NO169483C (no) 1992-07-01
AU2974589A (en) 1989-08-17
ZA891018B (en) 1989-10-25
HUT49319A (en) 1989-09-28
DK63889A (da) 1989-08-13
ATE92457T1 (de) 1993-08-15
AU605960B2 (en) 1991-01-24
GB8803301D0 (en) 1988-03-09
JPH021423A (ja) 1990-01-05
ES2059718T3 (es) 1994-11-16
IL89198A0 (en) 1989-09-10
CS273198B2 (en) 1991-03-12
IE890383L (en) 1989-08-12
FI92186C (fi) 1994-10-10
NZ227873A (en) 1990-09-26
NO890566D0 (no) 1989-02-09
KR890012931A (ko) 1989-09-20
PT89663B (pt) 1994-02-28
PH27328A (en) 1993-06-08
US5015745A (en) 1991-05-14
KR970000484B1 (ko) 1997-01-13
EP0328399B1 (de) 1993-08-04
FI92186B (fi) 1994-06-30
PT89663A (pt) 1989-10-04
CN1037152A (zh) 1989-11-15
CN1020592C (zh) 1993-05-12
CS80789A2 (en) 1990-06-13
EP0328399A3 (en) 1990-03-07
YU47206B (sh) 1995-01-31

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: PHARMACIA & UPJOHN S.P.A., MAILAND/MILANO, IT

8339 Ceased/non-payment of the annual fee