DE60335922D1 - Verfahren zur Unterscheidung von Metaplasien von neoplastischen oder präneoplastischen Läsionen - Google Patents

Verfahren zur Unterscheidung von Metaplasien von neoplastischen oder präneoplastischen Läsionen

Info

Publication number
DE60335922D1
DE60335922D1 DE60335922T DE60335922T DE60335922D1 DE 60335922 D1 DE60335922 D1 DE 60335922D1 DE 60335922 T DE60335922 T DE 60335922T DE 60335922 T DE60335922 T DE 60335922T DE 60335922 D1 DE60335922 D1 DE 60335922D1
Authority
DE
Germany
Prior art keywords
neoplastic
hpv
metaplasia
distinguishing
lesions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60335922T
Other languages
English (en)
Inventor
Peter Martin
Knebel Doeberitz Magnus Von
Ruediger Ridder
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche MTM Laboratories AG
Original Assignee
Roche MTM Laboratories AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche MTM Laboratories AG filed Critical Roche MTM Laboratories AG
Application granted granted Critical
Publication of DE60335922D1 publication Critical patent/DE60335922D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/708—Specific hybridization probes for papilloma
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57411—Specifically defined cancers of cervix
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/01—DNA viruses
    • G01N2333/025—Papovaviridae, e.g. papillomavirus, polyomavirus, SV40, BK virus, JC virus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Geophysics And Detection Of Objects (AREA)
  • Separation Of Suspended Particles By Flocculating Agents (AREA)
  • Paper (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE60335922T 2002-04-09 2003-04-08 Verfahren zur Unterscheidung von Metaplasien von neoplastischen oder präneoplastischen Läsionen Expired - Lifetime DE60335922D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP20020007954 EP1369694A1 (de) 2002-04-09 2002-04-09 Verfahren zur Unterscheidung zwischen Metaplasien und neoplastischen oder präneoplastischen Läsionen

Publications (1)

Publication Number Publication Date
DE60335922D1 true DE60335922D1 (de) 2011-03-10

Family

ID=29433069

Family Applications (2)

Application Number Title Priority Date Filing Date
DE2003618415 Expired - Lifetime DE60318415T2 (de) 2002-04-09 2003-04-08 Verfahren zur unterscheidung von metaplasien von neoplastischen oder präneoplastischen läsionen
DE60335922T Expired - Lifetime DE60335922D1 (de) 2002-04-09 2003-04-08 Verfahren zur Unterscheidung von Metaplasien von neoplastischen oder präneoplastischen Läsionen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE2003618415 Expired - Lifetime DE60318415T2 (de) 2002-04-09 2003-04-08 Verfahren zur unterscheidung von metaplasien von neoplastischen oder präneoplastischen läsionen

Country Status (10)

Country Link
US (6) US7422859B2 (de)
EP (3) EP1369694A1 (de)
JP (2) JP4290118B2 (de)
CN (1) CN1643378A (de)
AT (2) ATE382863T1 (de)
AU (1) AU2003274105A1 (de)
DE (2) DE60318415T2 (de)
ES (2) ES2297209T3 (de)
MX (1) MXPA04009584A (de)
WO (1) WO2004005927A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1369694A1 (de) 2002-04-09 2003-12-10 MTM Laboratories AG Verfahren zur Unterscheidung zwischen Metaplasien und neoplastischen oder präneoplastischen Läsionen
ES2215957T3 (es) 2002-08-01 2004-10-16 Mtm Laboratories Ag Metodo para diagnostico basado en una solucion.
EP1422526A1 (de) * 2002-10-28 2004-05-26 MTM Laboratories AG Verfahren zur verbesserten Diagnose von Dysplasien
US7972776B2 (en) * 2005-11-15 2011-07-05 Oncohealth Corporation Protein chips for HPV detection
US7732166B2 (en) 2005-11-15 2010-06-08 Oncohealth Corporation Detection method for human pappilomavirus (HPV) and its application in cervical cancer
US8968995B2 (en) * 2008-11-12 2015-03-03 Oncohealth Corp. Detection, screening, and diagnosis of HPV-associated cancers
US8278056B2 (en) * 2008-06-13 2012-10-02 Oncohealth Corp. Detection of early stages and late stages HPV infection
US7838215B2 (en) * 2007-09-25 2010-11-23 Canvir, Inc. Advanced cervical cell screening methods
EP2262911B1 (de) * 2008-04-17 2016-10-12 QIAGEN Gaithersburg, Inc. Zusammensetzungen, verfahren und kits mit synthetischen sonden zum nachweis der anwesenheit einer target-nukleinsäure
WO2010025928A1 (en) * 2008-09-04 2010-03-11 Mtm Laboratories Ag Method for prediction of the progression risk of tumors
EP2427763A4 (de) 2009-05-07 2013-08-21 Oncohealth Corp Identifikation eines hohen cin2-grades zur erkennung von früh- und spätstadien sowie zum screening und zur diagnose des menschlichen papillomavirus (hpv) und mit diesem assoziierter krebserkrankungen
CN102822672B (zh) 2010-01-08 2015-12-09 安科健康公司 用于诊断和筛选与hpv有关的癌症的高通量细胞基hpv免疫测定
JP2014528066A (ja) * 2011-09-09 2014-10-23 アムジエン・インコーポレーテツド 癌治療での、ＥＧＦｒに結合する薬剤を確立することにおける、ヒトパピローマウイルスステータスの使用
CN103076453B (zh) * 2012-12-24 2015-04-15 何以丰 P16免疫细胞化学试剂盒及其制备用多肽序列
CA2946534A1 (en) * 2014-04-28 2015-11-05 Arizona Board Of Regents On Behalf Of Arizona State University Novel methods, bioassays, and biomarkers for hpv-related conditions
WO2016207414A1 (en) * 2015-06-25 2016-12-29 Universitaet Des Saarlandes Improved diagnostic method for hpv-induced cancer and precancerous lesion screening and diagnosis
EP3921441A1 (de) * 2019-02-08 2021-12-15 Charité - Universitätsmedizin Berlin Verfahren zur bestimmung des schweregrades von durch das humane papillomavirus (hpv) induzierter dysplasie

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4281061A (en) * 1979-07-27 1981-07-28 Syva Company Double antibody for enhanced sensitivity in immunoassay
US6316208B1 (en) * 1994-01-07 2001-11-13 Memorial Sloan-Kettering Cancer Center Methods for determining isolated p27 protein levels and uses thereof
US6033847A (en) * 1995-02-06 2000-03-07 St. Jude Children's Research Hospital InK4c-p18 and InK4d-p19, inhibitors of cyclin-dependent kinases CDK4 and CDK6, and uses thereof
US6407062B1 (en) 1995-09-27 2002-06-18 St. Jude Children's Research Hospital ARF-P19, a novel regulator of the mammalian cell cycle
US5723313A (en) 1995-09-27 1998-03-03 St. Jude Children's Research Hospital ARF-p19, a novel regulator of the mammalian cell cycle
US5858683A (en) * 1996-08-30 1999-01-12 Matritech, Inc. Methods and compositions for the detection of cervical cancer
US6303323B1 (en) 1997-10-21 2001-10-16 Cancer Research Campaign Technology Limited Detection of dysplastic or neoplastic cells using anti-MCM5 antibodies
AU751754B2 (en) 1997-10-21 2002-08-29 Cancer Research Technology Limited Determination of cellular growth abnormality
DE19829473C2 (de) * 1998-07-01 2000-08-10 Magnus Von Knebel Doeberitz Ch Verfahren zur frühen Diagnose von Carcinomen
DE19957689A1 (de) 1999-11-30 2001-06-13 Deutsches Krebsforsch Proteaseresistenter Tumorsuppressor p14(ARF)
GB0018140D0 (en) * 2000-07-24 2000-09-13 Medical Res Council Screening for abnormalities
DE10063179A1 (de) * 2000-12-18 2002-06-20 Bayer Ag Verfahren zur spezifischen Detektion von Tumorzellen und ihren Vorstufen in Gebärmutterhalsabstrichen durch simultane Messung von mindestens zwei verschiedenen molekularen Markern
BR0306723A (pt) * 2002-01-07 2004-12-21 Norchip As Métodos in vitro para selecionar sujeitos humanos para avaliar seu risco de desenvolver carcinoma cervical, e para selecionar sujeitos humanos quanto à presença de hpv integrado ou um genoma de hpv epissÈmico modificado, método in vitro para identificar sujeitos humanos apresentado alterações anormais de células no cervix, e, kit para uso na detecção de transcrições de mrna dos genes l1 e e6 do hpv
EP1369694A1 (de) 2002-04-09 2003-12-10 MTM Laboratories AG Verfahren zur Unterscheidung zwischen Metaplasien und neoplastischen oder präneoplastischen Läsionen
EP1387173A1 (de) 2002-07-29 2004-02-04 MTM Laboratories AG Verfahren zur verbesserten Diagnose von Zervixläsionen basierend auf dem Nachweis von INK4a Genprodukten
US20050272038A1 (en) 2002-07-29 2005-12-08 Ruediger Ridder Compositions and methods for diagnosis and therapy of cancers
ES2215957T3 (es) 2002-08-01 2004-10-16 Mtm Laboratories Ag Metodo para diagnostico basado en una solucion.
EP1422526A1 (de) 2002-10-28 2004-05-26 MTM Laboratories AG Verfahren zur verbesserten Diagnose von Dysplasien
US7361460B2 (en) 2003-04-11 2008-04-22 Digene Corporation Approach to molecular diagnosis of human papillomavirus-related diseases
WO2010025928A1 (en) 2008-09-04 2010-03-11 Mtm Laboratories Ag Method for prediction of the progression risk of tumors

Also Published As

Publication number Publication date
MXPA04009584A (es) 2005-01-11
US20090104609A1 (en) 2009-04-23
DE60318415T2 (de) 2009-01-08
JP4809408B2 (ja) 2011-11-09
EP1821102A1 (de) 2007-08-22
US20120052510A1 (en) 2012-03-01
US20050255468A1 (en) 2005-11-17
EP1493032A1 (de) 2005-01-05
AU2003274105A1 (en) 2004-01-23
US10822660B2 (en) 2020-11-03
ATE382863T1 (de) 2008-01-15
US8043819B2 (en) 2011-10-25
US7422859B2 (en) 2008-09-09
CN1643378A (zh) 2005-07-20
US11155878B2 (en) 2021-10-26
EP1493032B1 (de) 2008-01-02
EP1369694A1 (de) 2003-12-10
JP2005523039A (ja) 2005-08-04
US8815520B2 (en) 2014-08-26
ES2297209T3 (es) 2008-05-01
WO2004005927A1 (en) 2004-01-15
JP2009000127A (ja) 2009-01-08
JP4290118B2 (ja) 2009-07-01
US20190177804A1 (en) 2019-06-13
US10246751B2 (en) 2019-04-02
US20140308660A1 (en) 2014-10-16
US20170268068A1 (en) 2017-09-21
ES2360342T3 (es) 2011-06-03
DE60318415D1 (de) 2008-02-14
EP1821102B1 (de) 2011-01-26
ATE497169T1 (de) 2011-02-15

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