ATE382863T1 - Verfahren zur unterscheidung von metaplasien von neoplastischen oder präneoplastischen läsionen - Google Patents

Verfahren zur unterscheidung von metaplasien von neoplastischen oder präneoplastischen läsionen

Info

Publication number
ATE382863T1
ATE382863T1 AT03758090T AT03758090T ATE382863T1 AT E382863 T1 ATE382863 T1 AT E382863T1 AT 03758090 T AT03758090 T AT 03758090T AT 03758090 T AT03758090 T AT 03758090T AT E382863 T1 ATE382863 T1 AT E382863T1
Authority
AT
Austria
Prior art keywords
neoplastic
hpv
metaplasia
differentiating
lesions
Prior art date
Application number
AT03758090T
Other languages
English (en)
Inventor
Peter Martin
Knebel Doeberitz Magnus Von
Original Assignee
Mtm Lab Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mtm Lab Ag filed Critical Mtm Lab Ag
Application granted granted Critical
Publication of ATE382863T1 publication Critical patent/ATE382863T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/708—Specific hybridization probes for papilloma
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57411—Specifically defined cancers of cervix
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/01—DNA viruses
    • G01N2333/025—Papovaviridae, e.g. papillomavirus, polyomavirus, SV40, BK virus, JC virus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Virology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Geophysics And Detection Of Objects (AREA)
  • Separation Of Suspended Particles By Flocculating Agents (AREA)
  • Paper (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT03758090T 2002-04-09 2003-04-08 Verfahren zur unterscheidung von metaplasien von neoplastischen oder präneoplastischen läsionen ATE382863T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP20020007954 EP1369694A1 (de) 2002-04-09 2002-04-09 Verfahren zur Unterscheidung zwischen Metaplasien und neoplastischen oder präneoplastischen Läsionen

Publications (1)

Publication Number Publication Date
ATE382863T1 true ATE382863T1 (de) 2008-01-15

Family

ID=29433069

Family Applications (2)

Application Number Title Priority Date Filing Date
AT03758090T ATE382863T1 (de) 2002-04-09 2003-04-08 Verfahren zur unterscheidung von metaplasien von neoplastischen oder präneoplastischen läsionen
AT07106444T ATE497169T1 (de) 2002-04-09 2003-04-08 Verfahren zur unterscheidung von metaplasien von neoplastischen oder präneoplastischen läsionen

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT07106444T ATE497169T1 (de) 2002-04-09 2003-04-08 Verfahren zur unterscheidung von metaplasien von neoplastischen oder präneoplastischen läsionen

Country Status (10)

Country Link
US (6) US7422859B2 (de)
EP (3) EP1369694A1 (de)
JP (2) JP4290118B2 (de)
CN (1) CN1643378A (de)
AT (2) ATE382863T1 (de)
AU (1) AU2003274105A1 (de)
DE (2) DE60318415T2 (de)
ES (2) ES2360342T3 (de)
MX (1) MXPA04009584A (de)
WO (1) WO2004005927A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1369694A1 (de) 2002-04-09 2003-12-10 MTM Laboratories AG Verfahren zur Unterscheidung zwischen Metaplasien und neoplastischen oder präneoplastischen Läsionen
ES2215957T3 (es) 2002-08-01 2004-10-16 Mtm Laboratories Ag Metodo para diagnostico basado en una solucion.
EP1422526A1 (de) * 2002-10-28 2004-05-26 MTM Laboratories AG Verfahren zur verbesserten Diagnose von Dysplasien
US7972776B2 (en) * 2005-11-15 2011-07-05 Oncohealth Corporation Protein chips for HPV detection
US7732166B2 (en) 2005-11-15 2010-06-08 Oncohealth Corporation Detection method for human pappilomavirus (HPV) and its application in cervical cancer
US8968995B2 (en) * 2008-11-12 2015-03-03 Oncohealth Corp. Detection, screening, and diagnosis of HPV-associated cancers
US8859218B2 (en) * 2008-06-13 2014-10-14 Oncohealth Corp. In situ detection of early stages and late stages HPV infection
US7838215B2 (en) 2007-09-25 2010-11-23 Canvir, Inc. Advanced cervical cell screening methods
CA2726396C (en) * 2008-04-17 2019-03-19 Qiagen Gaithersburg, Inc. Compositions, methods, and kits using synthetic probes for determining the presence of a target nucleic acid
CA3117744C (en) * 2008-09-04 2022-07-19 Ventana Medical Systems, Inc. Method for prediction of the progression risk of tumors
CN102449479B (zh) 2009-05-07 2015-11-25 安科健康公司 鉴别高度或≥cin2用于人乳头瘤病毒(hpv)与hpv相关癌症的早期及晚期检测、筛检和诊断
JP5819851B2 (ja) 2010-01-08 2015-11-24 オンコヘルス コーポレーション Ｈｐｖ関連の癌の治療及びスクリーニングのための細胞に基づいた高処理能力ｈｐｖ免疫アッセイ
MX351251B (es) * 2011-09-09 2017-10-06 Amgen Inc Uso del estado del virus del papiloma humano en establecer el uso de un agente que enlaza el receptor del factor de crecimiento anti-epidermal en el tratamiento de cáncer.
CN103076453B (zh) * 2012-12-24 2015-04-15 何以丰 P16免疫细胞化学试剂盒及其制备用多肽序列
US20170045515A1 (en) * 2014-04-28 2017-02-16 Arizona Board Of Regents On Behalf Of Arizona State University Novel methods, bioassays, and biomarkers for hpv-related conditions
EP3314019A1 (de) * 2015-06-25 2018-05-02 Universität des Saarlandes Verbessertes diagnoseverfahren für hpv-induzierten krebs sowie präkanzeröse läsionsabschirmung und diagnose
WO2020161285A1 (en) * 2019-02-08 2020-08-13 Charité - Universitätsmedizin Berlin A method for determining the severity or grade of human papillomavirus (hpv)-induced dysplasia

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4281061A (en) 1979-07-27 1981-07-28 Syva Company Double antibody for enhanced sensitivity in immunoassay
US6316208B1 (en) 1994-01-07 2001-11-13 Memorial Sloan-Kettering Cancer Center Methods for determining isolated p27 protein levels and uses thereof
US6033847A (en) 1995-02-06 2000-03-07 St. Jude Children's Research Hospital InK4c-p18 and InK4d-p19, inhibitors of cyclin-dependent kinases CDK4 and CDK6, and uses thereof
US6407062B1 (en) 1995-09-27 2002-06-18 St. Jude Children's Research Hospital ARF-P19, a novel regulator of the mammalian cell cycle
US5723313A (en) 1995-09-27 1998-03-03 St. Jude Children's Research Hospital ARF-p19, a novel regulator of the mammalian cell cycle
US5858683A (en) 1996-08-30 1999-01-12 Matritech, Inc. Methods and compositions for the detection of cervical cancer
US6303323B1 (en) 1997-10-21 2001-10-16 Cancer Research Campaign Technology Limited Detection of dysplastic or neoplastic cells using anti-MCM5 antibodies
ATE290213T1 (de) 1997-10-21 2005-03-15 Cancer Rec Tech Ltd Nachweis von zellwachstumabnormalität
DE19829473C2 (de) * 1998-07-01 2000-08-10 Magnus Von Knebel Doeberitz Ch Verfahren zur frühen Diagnose von Carcinomen
DE19957689A1 (de) 1999-11-30 2001-06-13 Deutsches Krebsforsch Proteaseresistenter Tumorsuppressor p14(ARF)
GB0018140D0 (en) * 2000-07-24 2000-09-13 Medical Res Council Screening for abnormalities
DE10063179A1 (de) 2000-12-18 2002-06-20 Bayer Ag Verfahren zur spezifischen Detektion von Tumorzellen und ihren Vorstufen in Gebärmutterhalsabstrichen durch simultane Messung von mindestens zwei verschiedenen molekularen Markern
EP2272988A3 (de) * 2002-01-07 2011-06-15 Norchip A/S Detektionsverfahren für papillomavirus mRNA
EP1369694A1 (de) 2002-04-09 2003-12-10 MTM Laboratories AG Verfahren zur Unterscheidung zwischen Metaplasien und neoplastischen oder präneoplastischen Läsionen
EP1387173A1 (de) 2002-07-29 2004-02-04 MTM Laboratories AG Verfahren zur verbesserten Diagnose von Zervixläsionen basierend auf dem Nachweis von INK4a Genprodukten
US20050272038A1 (en) 2002-07-29 2005-12-08 Ruediger Ridder Compositions and methods for diagnosis and therapy of cancers
ES2215957T3 (es) 2002-08-01 2004-10-16 Mtm Laboratories Ag Metodo para diagnostico basado en una solucion.
EP1422526A1 (de) 2002-10-28 2004-05-26 MTM Laboratories AG Verfahren zur verbesserten Diagnose von Dysplasien
US7361460B2 (en) 2003-04-11 2008-04-22 Digene Corporation Approach to molecular diagnosis of human papillomavirus-related diseases
CA3117744C (en) 2008-09-04 2022-07-19 Ventana Medical Systems, Inc. Method for prediction of the progression risk of tumors

Also Published As

Publication number Publication date
JP4809408B2 (ja) 2011-11-09
US20190177804A1 (en) 2019-06-13
US10246751B2 (en) 2019-04-02
US20120052510A1 (en) 2012-03-01
EP1493032B1 (de) 2008-01-02
JP2005523039A (ja) 2005-08-04
CN1643378A (zh) 2005-07-20
ES2360342T3 (es) 2011-06-03
US7422859B2 (en) 2008-09-09
EP1493032A1 (de) 2005-01-05
DE60335922D1 (de) 2011-03-10
MXPA04009584A (es) 2005-01-11
WO2004005927A1 (en) 2004-01-15
JP2009000127A (ja) 2009-01-08
US20090104609A1 (en) 2009-04-23
EP1821102B1 (de) 2011-01-26
ES2297209T3 (es) 2008-05-01
AU2003274105A1 (en) 2004-01-23
EP1369694A1 (de) 2003-12-10
EP1821102A1 (de) 2007-08-22
US20140308660A1 (en) 2014-10-16
US20170268068A1 (en) 2017-09-21
US11155878B2 (en) 2021-10-26
DE60318415T2 (de) 2009-01-08
DE60318415D1 (de) 2008-02-14
US8043819B2 (en) 2011-10-25
US8815520B2 (en) 2014-08-26
ATE497169T1 (de) 2011-02-15
JP4290118B2 (ja) 2009-07-01
US20050255468A1 (en) 2005-11-17
US10822660B2 (en) 2020-11-03

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