DE60323468D1 - Vögelzell-linien und deren verwendung zur herstellung interessanter biologischer substanzen - Google Patents
Vögelzell-linien und deren verwendung zur herstellung interessanter biologischer substanzenInfo
- Publication number
- DE60323468D1 DE60323468D1 DE60323468T DE60323468T DE60323468D1 DE 60323468 D1 DE60323468 D1 DE 60323468D1 DE 60323468 T DE60323468 T DE 60323468T DE 60323468 T DE60323468 T DE 60323468T DE 60323468 D1 DE60323468 D1 DE 60323468D1
- Authority
- DE
- Germany
- Prior art keywords
- cell lines
- serum
- growth factors
- medium
- feeder layer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000126 substance Substances 0.000 title 1
- 239000003102 growth factor Substances 0.000 abstract 4
- 210000002966 serum Anatomy 0.000 abstract 4
- 241000271566 Aves Species 0.000 abstract 3
- 239000002609 medium Substances 0.000 abstract 3
- 239000007640 basal medium Substances 0.000 abstract 2
- 230000001464 adherent effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000000750 progressive effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
- C12N2500/92—Medium free of human- or animal-derived components
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
- C12N2500/95—Protein-free medium and culture conditions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Chemical & Material Sciences (AREA)
- Gynecology & Obstetrics (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Reproductive Health (AREA)
- Developmental Biology & Embryology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Feeding And Watering For Cattle Raising And Animal Husbandry (AREA)
- Farming Of Fish And Shellfish (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0202945A FR2836924B1 (fr) | 2002-03-08 | 2002-03-08 | Lignees de cellules aviaires utiles pour la production de substances d'interet |
| PCT/FR2003/000735 WO2003076601A1 (fr) | 2002-03-08 | 2003-03-07 | Lignées de cellules aviaires utiles pour la production de substances d'intérêt |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60323468D1 true DE60323468D1 (de) | 2008-10-23 |
Family
ID=27763651
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60323468T Expired - Lifetime DE60323468D1 (de) | 2002-03-08 | 2003-03-07 | Vögelzell-linien und deren verwendung zur herstellung interessanter biologischer substanzen |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US20040058441A1 (enExample) |
| EP (2) | EP1992687B1 (enExample) |
| JP (2) | JP5025888B2 (enExample) |
| CN (2) | CN101676388B (enExample) |
| AT (1) | ATE408004T1 (enExample) |
| AU (1) | AU2003227820B2 (enExample) |
| CA (1) | CA2478125C (enExample) |
| DE (1) | DE60323468D1 (enExample) |
| DK (1) | DK1483369T3 (enExample) |
| ES (1) | ES2312775T3 (enExample) |
| FR (1) | FR2836924B1 (enExample) |
| PT (1) | PT1483369E (enExample) |
| SI (1) | SI1483369T1 (enExample) |
| WO (1) | WO2003076601A1 (enExample) |
Families Citing this family (120)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7445924B2 (en) * | 2000-11-23 | 2008-11-04 | Bavarian Nordic A/S | Modified Vaccinia Ankara virus variant and cultivation method |
| US7145057B2 (en) | 2002-02-01 | 2006-12-05 | Origen Therapeutics, Inc. | Chimeric bird from embryonic stem cells |
| US20060191026A1 (en) | 2005-02-18 | 2006-08-24 | Origen Therapeutics, Inc. | Tissue specific expression of antibodies in chickens |
| FR2836924B1 (fr) | 2002-03-08 | 2005-01-14 | Vivalis | Lignees de cellules aviaires utiles pour la production de substances d'interet |
| UA85543C2 (ru) * | 2002-09-05 | 2009-02-10 | Бавариан Нордик А/С | Способ культивирования первичных клеток и амплификации вирусов в условиях безсывороточной среды, композиция и ее применение, и способ лечения или вакцинации животных |
| CA2510229A1 (en) * | 2002-12-13 | 2004-07-08 | Aventis Pasteur, Inc. | Production of alvac on avian embryonic stem cells |
| EP1500699A1 (en) * | 2003-07-22 | 2005-01-26 | Vivalis | Production of vaccinia virus with adherent or non adherent avian cell lines |
| JP4787156B2 (ja) * | 2003-07-22 | 2011-10-05 | ビバリス | 付着または非付着の鳥類細胞系を用いた、ポックスウィルスの作製法 |
| US20070275010A1 (en) * | 2003-09-18 | 2007-11-29 | Mark Feinberg | Mva Vaccines |
| EP2848692B1 (en) | 2004-05-21 | 2017-08-16 | Novartis Vaccines and Diagnostics, Inc. | Alphavirus vectors for influenza virus vaccines |
| EP2578229B1 (en) | 2004-09-09 | 2013-07-10 | Novartis Vaccines and Diagnostics GmbH | Decreasing potential iatrogenic risks associated with vaccine antigens |
| EP1807116B1 (en) | 2004-11-03 | 2015-05-06 | Novartis Vaccines and Diagnostics, Inc. | Influenza vaccination |
| FR2878860A1 (fr) * | 2004-12-08 | 2006-06-09 | Vivalis Sa | Lignees de cellules souches humaines derivees de cellules es et utilisations pour la production de vaccins et de proteines recombinantes |
| AU2011253998B2 (en) * | 2005-04-11 | 2014-04-24 | Valneva | Process of manufacturing viral vaccines in suspension avian embryonic derived stem cell lines |
| FR2884255B1 (fr) * | 2005-04-11 | 2010-11-05 | Vivalis | Utilisation de lignees de cellules souches aviaires ebx pour la production de vaccin contre la grippe |
| CN101365480B (zh) | 2005-11-01 | 2014-11-05 | 诺华疫苗和诊断有限两合公司 | 经由β-丙内酯处理的残留细胞DNA水平降低的细胞衍生病毒疫苗 |
| EA014028B1 (ru) | 2005-11-04 | 2010-08-30 | Новартис Вэксинс Энд Диагностикс Срл | Эмульсии, содержащие свободное поверхностно-активное вещество в водной фазе в качестве адъюванта сплит вакцин против гриппа |
| WO2007052058A1 (en) | 2005-11-04 | 2007-05-10 | Novartis Vaccines And Diagnostics Srl | Influenza vaccines including combinations of particulate adjuvants and immunopotentiators |
| HUE051122T2 (hu) | 2005-11-04 | 2021-03-01 | Seqirus Uk Ltd | Sejttenyészetben növesztett influenzavírusból elõállított nemvirion anti-géneket tartalmazó adjuvált vakcinák |
| NZ592713A (en) | 2005-11-04 | 2012-12-21 | Novartis Vaccines & Diagnostic | Adjuvanted influenza vaccines including a cytokine-inducing agents other than an agonist of Toll-Like Receptor 9 |
| AU2006310163B2 (en) | 2005-11-04 | 2011-09-15 | Seqirus UK Limited | Influenza vaccine with reduced amount of oil-in-water emulsion as adjuvant |
| HUE049580T2 (hu) | 2006-01-27 | 2020-09-28 | Seqirus Uk Ltd | Hemagglutinint és mátrixfehérjéket tartalmazó, influenza elleni oltóanyagok |
| FR2898909A1 (fr) | 2006-03-24 | 2007-09-28 | Agronomique Inst Nat Rech | Combinaison de marqueurs de cellules aviaires |
| CN101448523A (zh) | 2006-03-24 | 2009-06-03 | 诺华疫苗和诊断有限两合公司 | 无需冷藏储存流感疫苗 |
| GB0614460D0 (en) | 2006-07-20 | 2006-08-30 | Novartis Ag | Vaccines |
| EP2500417A1 (en) | 2006-08-09 | 2012-09-19 | Vivalis | Method of production of transgenic avian using embryonic stem cells |
| EP4585610A3 (en) | 2006-09-11 | 2025-09-24 | Seqirus UK Limited | Making influenza virus vaccines without using eggs |
| PL2121011T3 (pl) | 2006-12-06 | 2014-10-31 | Novartis Ag | Szczepionki zawierające antygeny czterech szczepów wirusa grypy |
| CN100443588C (zh) * | 2006-12-11 | 2008-12-17 | 中国农业科学院北京畜牧兽医研究所 | 静宁鸡胚成纤维细胞系及其培养方法 |
| EP1985305A1 (en) * | 2007-04-24 | 2008-10-29 | Vivalis | Duck embryonic derived stem cell lines for the production of viral vaccines |
| EP1995309A1 (en) * | 2007-05-21 | 2008-11-26 | Vivalis | Recombinant protein production in avian EBx® cells |
| CN101784283A (zh) | 2007-06-27 | 2010-07-21 | 诺华有限公司 | 低添加流感疫苗 |
| CN101688182A (zh) * | 2007-07-03 | 2010-03-31 | 特兰斯吉恩股份有限公司 | 永生化禽细胞系 |
| US20090028831A1 (en) * | 2007-07-23 | 2009-01-29 | University Of Kentucky Research Foundation | Stem cell regulator, compositions and methods of use |
| GB0810305D0 (en) | 2008-06-05 | 2008-07-09 | Novartis Ag | Influenza vaccination |
| US8685654B2 (en) | 2007-12-24 | 2014-04-01 | Novartis Ag | Assays for adsorbed influenza vaccines |
| US8506966B2 (en) | 2008-02-22 | 2013-08-13 | Novartis Ag | Adjuvanted influenza vaccines for pediatric use |
| KR101445433B1 (ko) * | 2008-02-25 | 2014-09-26 | 백스터 인터내셔널 인코포레이티드 | 연속 세포주 제조 방법 |
| EA201071086A1 (ru) | 2008-03-18 | 2011-04-29 | Новартис Аг | Усовершенствованный способ получения вакцинных антигенов вируса гриппа |
| WO2009132195A1 (en) * | 2008-04-23 | 2009-10-29 | Michigan State University | Immortal avian cell line and methods of use |
| EP2379598B1 (en) | 2009-01-19 | 2015-03-11 | Innate Pharma | Anti-kir3d antibodies |
| EP2396031A1 (en) | 2009-02-10 | 2011-12-21 | Novartis AG | Influenza vaccines with increased amounts of h3 antigen |
| US20120093859A1 (en) | 2009-02-10 | 2012-04-19 | Novartis Ag | Influenza vaccine regimens for pandemic-associated strains |
| EP3173097A3 (en) | 2009-02-10 | 2017-07-12 | Seqirus UK Limited | Influenza vaccines with reduced amounts of squalene |
| CN102548577A (zh) | 2009-04-27 | 2012-07-04 | 诺华有限公司 | 用于抵抗流感的佐剂疫苗 |
| SI3178490T1 (sl) | 2009-07-15 | 2022-08-31 | Glaxosmithkline Biologicals S.A. | Sestavki proteina F RSV-ja in postopki za pripravo le-teh |
| US20120237536A1 (en) | 2009-09-10 | 2012-09-20 | Novartis | Combination vaccines against respiratory tract diseases |
| GB0918830D0 (en) | 2009-10-27 | 2009-12-09 | Glaxosmithkline Biolog Niederl | Process |
| GB0919117D0 (en) | 2009-10-30 | 2009-12-16 | Glaxosmithkline Biolog Sa | Process |
| CA2725435C (en) | 2009-12-15 | 2023-01-03 | University Of Saskatchewan | Vaccines for inclusion body hepatitis |
| US20120309056A1 (en) | 2010-02-04 | 2012-12-06 | Leon Arnaud | Fed-batch process using concentrated cell culture medium for the efficient production of biologics in eb66 cells |
| FR2956409A1 (fr) | 2010-02-15 | 2011-08-19 | Univ Claude Bernard Lyon | Procedes pour optimiser la production virale par l'inactivation ou l'inhibition du gene hipk2 et cellules modifiees pour la production virale |
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| FR2967072B1 (fr) | 2010-11-05 | 2013-03-29 | Univ Dundee | Procede pour ameliorer la production de virus et semences vaccinales influenza |
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| HRP20190791T1 (hr) | 2011-01-26 | 2019-06-28 | Glaxosmithkline Biologicals Sa | Režim imuniziranja protiv rsv |
| SI3275892T1 (sl) | 2011-05-13 | 2020-06-30 | Glaxosmithkline Biologicals S.A. | Prefuzijski RSV F antigeni |
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| GB201218195D0 (en) | 2012-10-10 | 2012-11-21 | Istituto Zooprofilattico Sperimentale Delle Venezie | Composition |
| BR112015011389A2 (pt) | 2012-11-20 | 2017-08-22 | Glaxosmithkline Biologicals Sa | Complexo f do vírus sincicial respiratório, métodos para produzir um complexo f do vírus sincicial respiratório e para indução de uma resposta imunológica a um f de rsv em um indivíduo, e, composição imunogênica |
| US20140255447A1 (en) * | 2013-03-05 | 2014-09-11 | Biomune Company | Production of avian embryo cells |
| FR3008992A1 (fr) * | 2013-07-25 | 2015-01-30 | Agronomique Inst Nat Rech | Procede de selection d'une lignee cellulaire permissive pour la replication de virus aviaires |
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| WO2023144665A1 (en) | 2022-01-28 | 2023-08-03 | Glaxosmithkline Biologicals Sa | Modified human cytomegalovirus proteins |
| CN114480286B (zh) * | 2022-02-16 | 2024-05-31 | 上海健士拜生物科技有限公司 | 无血清悬浮型lmh细胞系及其制备方法和应用 |
| CN116656628A (zh) * | 2023-07-31 | 2023-08-29 | 深圳市卫光生物制品股份有限公司 | 一种痘病毒载体疫苗的制备方法 |
| EP4567102A1 (en) | 2023-12-05 | 2025-06-11 | Suprême | Methods for isolating embryonic stem cells from avian embryonic cells |
| CN118956737A (zh) * | 2024-07-17 | 2024-11-15 | 广州沃亘生物科技有限公司 | 一种长期维持df-1细胞活力的培养基及其用途 |
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-
2002
- 2002-03-08 FR FR0202945A patent/FR2836924B1/fr not_active Expired - Lifetime
-
2003
- 2003-03-07 CN CN2009101796309A patent/CN101676388B/zh not_active Expired - Lifetime
- 2003-03-07 JP JP2003574808A patent/JP5025888B2/ja not_active Expired - Fee Related
- 2003-03-07 ES ES03725273T patent/ES2312775T3/es not_active Expired - Lifetime
- 2003-03-07 DK DK03725273T patent/DK1483369T3/da active
- 2003-03-07 CA CA2478125A patent/CA2478125C/fr not_active Expired - Fee Related
- 2003-03-07 WO PCT/FR2003/000735 patent/WO2003076601A1/fr not_active Ceased
- 2003-03-07 EP EP08163979.1A patent/EP1992687B1/fr not_active Expired - Lifetime
- 2003-03-07 AU AU2003227820A patent/AU2003227820B2/en not_active Expired
- 2003-03-07 CN CNB038101203A patent/CN100562567C/zh not_active Expired - Fee Related
- 2003-03-07 PT PT03725273T patent/PT1483369E/pt unknown
- 2003-03-07 AT AT03725273T patent/ATE408004T1/de active
- 2003-03-07 DE DE60323468T patent/DE60323468D1/de not_active Expired - Lifetime
- 2003-03-07 SI SI200331354T patent/SI1483369T1/sl unknown
- 2003-03-07 EP EP03725273A patent/EP1483369B1/fr not_active Expired - Lifetime
- 2003-07-24 US US10/625,847 patent/US20040058441A1/en not_active Abandoned
-
2009
- 2009-01-08 US US12/350,781 patent/US20090239297A1/en not_active Abandoned
-
2010
- 2010-03-03 US US12/717,096 patent/US9382513B2/en not_active Expired - Fee Related
-
2011
- 2011-08-09 US US13/206,056 patent/US20110294209A1/en not_active Abandoned
-
2012
- 2012-02-09 JP JP2012026135A patent/JP5784521B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003227820B2 (en) | 2008-04-03 |
| EP1992687A3 (fr) | 2009-03-25 |
| CN101676388A (zh) | 2010-03-24 |
| CA2478125C (fr) | 2013-05-07 |
| CN101676388B (zh) | 2013-09-04 |
| HK1142094A1 (en) | 2010-11-26 |
| US20110294209A1 (en) | 2011-12-01 |
| EP1483369B1 (fr) | 2008-09-10 |
| WO2003076601A8 (fr) | 2005-05-12 |
| EP1992687A2 (fr) | 2008-11-19 |
| SI1483369T1 (sl) | 2008-12-31 |
| ATE408004T1 (de) | 2008-09-15 |
| PT1483369E (pt) | 2008-12-17 |
| DK1483369T3 (da) | 2008-12-01 |
| US20120070893A9 (en) | 2012-03-22 |
| EP1483369A1 (fr) | 2004-12-08 |
| CN1649999A (zh) | 2005-08-03 |
| FR2836924B1 (fr) | 2005-01-14 |
| JP2005525803A (ja) | 2005-09-02 |
| US20090239297A1 (en) | 2009-09-24 |
| JP5784521B2 (ja) | 2015-09-24 |
| FR2836924A1 (fr) | 2003-09-12 |
| US20100221825A1 (en) | 2010-09-02 |
| JP2012110344A (ja) | 2012-06-14 |
| CA2478125A1 (fr) | 2003-09-18 |
| CN100562567C (zh) | 2009-11-25 |
| WO2003076601A1 (fr) | 2003-09-18 |
| AU2003227820A1 (en) | 2003-09-22 |
| ES2312775T3 (es) | 2009-03-01 |
| EP1992687B1 (fr) | 2019-06-26 |
| US20040058441A1 (en) | 2004-03-25 |
| US9382513B2 (en) | 2016-07-05 |
| JP5025888B2 (ja) | 2012-09-12 |
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