DE60308337T2 - 4-(4-Methylpiperazin-1-ylmethyl)-N-(4-methyl-3-(4-pyrimidin-3-yl)pyrimidin-2-ylamino)phenylbenzamid zur Behandlung von Ang II vermitteltern Erkrankungen - Google Patents
4-(4-Methylpiperazin-1-ylmethyl)-N-(4-methyl-3-(4-pyrimidin-3-yl)pyrimidin-2-ylamino)phenylbenzamid zur Behandlung von Ang II vermitteltern Erkrankungen Download PDFInfo
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- DE60308337T2 DE60308337T2 DE60308337T DE60308337T DE60308337T2 DE 60308337 T2 DE60308337 T2 DE 60308337T2 DE 60308337 T DE60308337 T DE 60308337T DE 60308337 T DE60308337 T DE 60308337T DE 60308337 T2 DE60308337 T2 DE 60308337T2
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- Prior art keywords
- angiotensin
- hypertrophy
- hypertension
- treatment
- methyl
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- 230000001404 mediated effect Effects 0.000 title claims description 37
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- HRWCVUIFMSZDJS-SZMVWBNQSA-N spirapril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CC2(C1)SCCS2)C(O)=O)CC1=CC=CC=C1 HRWCVUIFMSZDJS-SZMVWBNQSA-N 0.000 description 1
- 108700035424 spirapril Proteins 0.000 description 1
- 238000013222 sprague-dawley male rat Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 238000005556 structure-activity relationship Methods 0.000 description 1
- 239000007940 sugar coated tablet Substances 0.000 description 1
- 238000009495 sugar coating Methods 0.000 description 1
- 150000003460 sulfonic acids Chemical class 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 208000037905 systemic hypertension Diseases 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 229960000651 tasosartan Drugs 0.000 description 1
- ADXGNEYLLLSOAR-UHFFFAOYSA-N tasosartan Chemical compound C12=NC(C)=NC(C)=C2CCC(=O)N1CC(C=C1)=CC=C1C1=CC=CC=C1C=1N=NNN=1 ADXGNEYLLLSOAR-UHFFFAOYSA-N 0.000 description 1
- 229960005187 telmisartan Drugs 0.000 description 1
- 229960004084 temocapril Drugs 0.000 description 1
- FIQOFIRCTOWDOW-BJLQDIEVSA-N temocapril Chemical compound C([C@@H](C(=O)OCC)N[C@@H]1C(N(CC(O)=O)C[C@H](SC1)C=1SC=CC=1)=O)CC1=CC=CC=C1 FIQOFIRCTOWDOW-BJLQDIEVSA-N 0.000 description 1
- 229950000584 tezosentan Drugs 0.000 description 1
- 239000003451 thiazide diuretic agent Substances 0.000 description 1
- 229950003137 tiapamil Drugs 0.000 description 1
- 229960004605 timolol Drugs 0.000 description 1
- 229960002051 trandolapril Drugs 0.000 description 1
- 229940099456 transforming growth factor beta 1 Drugs 0.000 description 1
- 230000014616 translation Effects 0.000 description 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 description 1
- 230000001228 trophic effect Effects 0.000 description 1
- 230000003966 vascular damage Effects 0.000 description 1
- 230000004218 vascular function Effects 0.000 description 1
- 210000005166 vasculature Anatomy 0.000 description 1
- 230000002227 vasoactive effect Effects 0.000 description 1
- 230000003639 vasoconstrictive effect Effects 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/549—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame having two or more nitrogen atoms in the same ring, e.g. hydrochlorothiazide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0206217 | 2002-03-15 | ||
| GB0206216A GB0206216D0 (en) | 2002-03-15 | 2002-03-15 | Organic compounds |
| GB0206217A GB0206217D0 (en) | 2002-03-15 | 2002-03-15 | Organic compounds |
| GB0206216 | 2002-03-15 | ||
| GB0217505A GB0217505D0 (en) | 2002-07-29 | 2002-07-29 | Organic compounds |
| GB0217505 | 2002-07-29 | ||
| PCT/EP2003/002709 WO2003077892A2 (en) | 2002-03-15 | 2003-03-14 | 4-(4-methylpiperazin-1-ylmethyl)-n-[4-methyl-3(4-pyridin-3-yl)pyrimidin-2-yl-amino)phenyl]-benzamide for treating ang ii-mediated diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60308337D1 DE60308337D1 (de) | 2006-10-26 |
| DE60308337T2 true DE60308337T2 (de) | 2007-09-20 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60308337T Expired - Lifetime DE60308337T2 (de) | 2002-03-15 | 2003-03-14 | 4-(4-Methylpiperazin-1-ylmethyl)-N-(4-methyl-3-(4-pyrimidin-3-yl)pyrimidin-2-ylamino)phenylbenzamid zur Behandlung von Ang II vermitteltern Erkrankungen |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20050124624A1 (enExample) |
| EP (1) | EP1487424B1 (enExample) |
| JP (1) | JP2005527523A (enExample) |
| AT (1) | ATE339197T1 (enExample) |
| AU (1) | AU2003233946A1 (enExample) |
| CY (1) | CY1105839T1 (enExample) |
| DE (1) | DE60308337T2 (enExample) |
| DK (1) | DK1487424T3 (enExample) |
| ES (1) | ES2274234T3 (enExample) |
| PT (1) | PT1487424E (enExample) |
| WO (1) | WO2003077892A2 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060154936A1 (en) * | 2002-10-25 | 2006-07-13 | Lasky Joseph A | Use of n-'5-'4-(4-methylpiperaziomethyl)-benzoylamido!-2-methylphenyl!-4-(3-pyridyl)2-pyridine-amine for the treatment of pulmonary hypertension |
| US7750160B2 (en) | 2003-11-13 | 2010-07-06 | Ambit Biosciences Corporation | Isoxazolyl urea derivatives as kinase modulators |
| WO2005070406A1 (en) * | 2004-01-22 | 2005-08-04 | Novartis Ag | Combination of organic compounds |
| GB0401761D0 (en) * | 2004-01-27 | 2004-03-03 | Novartis Ag | Organic compounds |
| MY144177A (en) * | 2004-02-04 | 2011-08-15 | Novartis Ag | Salt forms of 4-(4-methylpiperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl)pyrimidin-2-ylamino)phenyl]-benzamide. |
| MY148074A (en) * | 2005-05-10 | 2013-02-28 | Novartis Ag | Pharmaceutical compositions comprising imatinib and a release retardant |
| EP1741432A1 (de) * | 2005-07-07 | 2007-01-10 | Universitätsklinikum Freiburg | Tyrosinkinase-Inhibitor Imatinib zur Behandlung von Bluthochdruck |
| DE102005042544A1 (de) * | 2005-09-07 | 2007-03-08 | Ernst-Moritz-Arndt-Universität | Beeinflussung des kardialen Fc-Rezeptors zur Behandlung der dilatativen Kardiomyopathie |
| WO2007084949A2 (en) * | 2006-01-18 | 2007-07-26 | The Uab Research Foundation | Modulators of cardiac cell hypertrophy and hyperplasia |
| KR20080104149A (ko) * | 2006-03-13 | 2008-12-01 | 엔싸이시브 파마슈티칼즈 인코퍼레이티드 | 확장기 심장 부전의 치료를 위한 방법 및 조성물 |
| WO2007106467A2 (en) * | 2006-03-13 | 2007-09-20 | Encysive Pharmaceuticals, Inc. | Polymorphs of n-(4-chloro-3-methyl-5-isoxazolyl)2-[2-methyl-4,5-(methylenedioxy) phenylacetyl]thiophene-3-sulfonamide, sodium salt |
| MX2009002336A (es) * | 2006-09-01 | 2009-03-20 | Teva Pharma | Composiciones de imatinib. |
| TW201006823A (en) * | 2008-07-14 | 2010-02-16 | Novartis Ag | Use of pyrimidylaminobenzamide derivatives for the treatment of fibrosis |
| KR20210142154A (ko) | 2019-03-21 | 2021-11-24 | 옹쎄오 | 암 치료를 위한 키나제 억제제와 조합된 dbait 분자 |
| US20220229072A1 (en) | 2019-06-04 | 2022-07-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of cd9 as a biomarker and as a biotarget in glomerulonephritis or glomerulosclerosis |
| JP2023500906A (ja) | 2019-11-08 | 2023-01-11 | インサーム（インスティテュ ナシオナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシェ メディカル） | キナーゼ阻害剤に対する獲得抵抗性を有するがんの処置方法 |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| WO2025024488A2 (en) * | 2023-07-27 | 2025-01-30 | Mineralys Therapeutics, Inc. | Methods of treating hypertension with a combination of lorundrostat and two or more anti-hypertensive medications |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5521184A (en) * | 1992-04-03 | 1996-05-28 | Ciba-Geigy Corporation | Pyrimidine derivatives and processes for the preparation thereof |
| US20010051631A1 (en) * | 1994-07-15 | 2001-12-13 | Muneo Takatani | Tricyclic compounds, their production and use |
| ATE209047T1 (de) * | 1995-06-07 | 2001-12-15 | Searle & Co | Epoxysteroide aldosteronantagonist und angiotensin ii rezeptor antagonist kombinationstherapie zur behandlung von congestivem herzversagen |
| CO4940418A1 (es) * | 1997-07-18 | 2000-07-24 | Novartis Ag | Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso |
-
2003
- 2003-03-14 ES ES03727265T patent/ES2274234T3/es not_active Expired - Lifetime
- 2003-03-14 PT PT03727265T patent/PT1487424E/pt unknown
- 2003-03-14 AT AT03727265T patent/ATE339197T1/de active
- 2003-03-14 DE DE60308337T patent/DE60308337T2/de not_active Expired - Lifetime
- 2003-03-14 AU AU2003233946A patent/AU2003233946A1/en not_active Abandoned
- 2003-03-14 EP EP03727265A patent/EP1487424B1/en not_active Expired - Lifetime
- 2003-03-14 WO PCT/EP2003/002709 patent/WO2003077892A2/en not_active Ceased
- 2003-03-14 JP JP2003575945A patent/JP2005527523A/ja active Pending
- 2003-03-14 US US10/507,642 patent/US20050124624A1/en not_active Abandoned
- 2003-03-14 DK DK03727265T patent/DK1487424T3/da active
-
2006
- 2006-12-11 CY CY20061101774T patent/CY1105839T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003077892A2 (en) | 2003-09-25 |
| ES2274234T3 (es) | 2007-05-16 |
| WO2003077892A3 (en) | 2003-12-24 |
| PT1487424E (pt) | 2007-01-31 |
| DE60308337D1 (de) | 2006-10-26 |
| ATE339197T1 (de) | 2006-10-15 |
| AU2003233946A8 (en) | 2003-09-29 |
| US20050124624A1 (en) | 2005-06-09 |
| EP1487424A2 (en) | 2004-12-22 |
| DK1487424T3 (da) | 2007-01-08 |
| AU2003233946A1 (en) | 2003-09-29 |
| JP2005527523A (ja) | 2005-09-15 |
| CY1105839T1 (el) | 2011-04-06 |
| EP1487424B1 (en) | 2006-09-13 |
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| 8364 | No opposition during term of opposition | ||
| 8328 | Change in the person/name/address of the agent |
Representative=s name: BOEHMERT & BOEHMERT, 80336 MUENCHEN |