CY1105839T1 - 4-(4-μεθυλπιπepαζιν-1-υλμεθυλ)-ν-[4-μεθυλ-3-(4-πυριδιν-3-υλ)πυριμιδιν-2-υλ-αμινο)φαινυλ]-βενζαμιδη για τη θepαπεια αng ii - μεσολαβουμενων ασθενειων - Google Patents

4-(4-μεθυλπιπepαζιν-1-υλμεθυλ)-ν-[4-μεθυλ-3-(4-πυριδιν-3-υλ)πυριμιδιν-2-υλ-αμινο)φαινυλ]-βενζαμιδη για τη θepαπεια αng ii - μεσολαβουμενων ασθενειων

Info

Publication number
CY1105839T1
CY1105839T1 CY20061101774T CY061101774T CY1105839T1 CY 1105839 T1 CY1105839 T1 CY 1105839T1 CY 20061101774 T CY20061101774 T CY 20061101774T CY 061101774 T CY061101774 T CY 061101774T CY 1105839 T1 CY1105839 T1 CY 1105839T1
Authority
CY
Cyprus
Prior art keywords
methyl
pyrimidin
benzamide
ylmethyl
pyridin
Prior art date
Application number
CY20061101774T
Other languages
Greek (el)
English (en)
Inventor
Richard Ernest Gilbert
Darren James Kelly
David Louis Feldman
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0206216A external-priority patent/GB0206216D0/en
Priority claimed from GB0206217A external-priority patent/GB0206217D0/en
Priority claimed from GB0217505A external-priority patent/GB0217505D0/en
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CY1105839T1 publication Critical patent/CY1105839T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/549—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame having two or more nitrogen atoms in the same ring, e.g. hydrochlorothiazide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CY20061101774T 2002-03-15 2006-12-11 4-(4-μεθυλπιπepαζιν-1-υλμεθυλ)-ν-[4-μεθυλ-3-(4-πυριδιν-3-υλ)πυριμιδιν-2-υλ-αμινο)φαινυλ]-βενζαμιδη για τη θepαπεια αng ii - μεσολαβουμενων ασθενειων CY1105839T1 (el)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0206216A GB0206216D0 (en) 2002-03-15 2002-03-15 Organic compounds
GB0206217A GB0206217D0 (en) 2002-03-15 2002-03-15 Organic compounds
GB0217505A GB0217505D0 (en) 2002-07-29 2002-07-29 Organic compounds
PCT/EP2003/002709 WO2003077892A2 (en) 2002-03-15 2003-03-14 4-(4-methylpiperazin-1-ylmethyl)-n-[4-methyl-3(4-pyridin-3-yl)pyrimidin-2-yl-amino)phenyl]-benzamide for treating ang ii-mediated diseases

Publications (1)

Publication Number Publication Date
CY1105839T1 true CY1105839T1 (el) 2011-04-06

Family

ID=28045959

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20061101774T CY1105839T1 (el) 2002-03-15 2006-12-11 4-(4-μεθυλπιπepαζιν-1-υλμεθυλ)-ν-[4-μεθυλ-3-(4-πυριδιν-3-υλ)πυριμιδιν-2-υλ-αμινο)φαινυλ]-βενζαμιδη για τη θepαπεια αng ii - μεσολαβουμενων ασθενειων

Country Status (11)

Country Link
US (1) US20050124624A1 (enExample)
EP (1) EP1487424B1 (enExample)
JP (1) JP2005527523A (enExample)
AT (1) ATE339197T1 (enExample)
AU (1) AU2003233946A1 (enExample)
CY (1) CY1105839T1 (enExample)
DE (1) DE60308337T2 (enExample)
DK (1) DK1487424T3 (enExample)
ES (1) ES2274234T3 (enExample)
PT (1) PT1487424E (enExample)
WO (1) WO2003077892A2 (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060154936A1 (en) * 2002-10-25 2006-07-13 Lasky Joseph A Use of n-'5-'4-(4-methylpiperaziomethyl)-benzoylamido!-2-methylphenyl!-4-(3-pyridyl)2-pyridine-amine for the treatment of pulmonary hypertension
US7750160B2 (en) 2003-11-13 2010-07-06 Ambit Biosciences Corporation Isoxazolyl urea derivatives as kinase modulators
WO2005070406A1 (en) * 2004-01-22 2005-08-04 Novartis Ag Combination of organic compounds
GB0401761D0 (en) * 2004-01-27 2004-03-03 Novartis Ag Organic compounds
MY144177A (en) * 2004-02-04 2011-08-15 Novartis Ag Salt forms of 4-(4-methylpiperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl)pyrimidin-2-ylamino)phenyl]-benzamide.
MY148074A (en) * 2005-05-10 2013-02-28 Novartis Ag Pharmaceutical compositions comprising imatinib and a release retardant
EP1741432A1 (de) * 2005-07-07 2007-01-10 Universitätsklinikum Freiburg Tyrosinkinase-Inhibitor Imatinib zur Behandlung von Bluthochdruck
DE102005042544A1 (de) * 2005-09-07 2007-03-08 Ernst-Moritz-Arndt-Universität Beeinflussung des kardialen Fc-Rezeptors zur Behandlung der dilatativen Kardiomyopathie
WO2007084949A2 (en) * 2006-01-18 2007-07-26 The Uab Research Foundation Modulators of cardiac cell hypertrophy and hyperplasia
KR20080104149A (ko) * 2006-03-13 2008-12-01 엔싸이시브 파마슈티칼즈 인코퍼레이티드 확장기 심장 부전의 치료를 위한 방법 및 조성물
WO2007106467A2 (en) * 2006-03-13 2007-09-20 Encysive Pharmaceuticals, Inc. Polymorphs of n-(4-chloro-3-methyl-5-isoxazolyl)2-[2-methyl-4,5-(methylenedioxy) phenylacetyl]thiophene-3-sulfonamide, sodium salt
MX2009002336A (es) * 2006-09-01 2009-03-20 Teva Pharma Composiciones de imatinib.
TW201006823A (en) * 2008-07-14 2010-02-16 Novartis Ag Use of pyrimidylaminobenzamide derivatives for the treatment of fibrosis
KR20210142154A (ko) 2019-03-21 2021-11-24 옹쎄오 암 치료를 위한 키나제 억제제와 조합된 dbait 분자
US20220229072A1 (en) 2019-06-04 2022-07-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of cd9 as a biomarker and as a biotarget in glomerulonephritis or glomerulosclerosis
JP2023500906A (ja) 2019-11-08 2023-01-11 インサーム（インスティテュ ナシオナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシェ メディカル） キナーゼ阻害剤に対する獲得抵抗性を有するがんの処置方法
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
WO2025024488A2 (en) * 2023-07-27 2025-01-30 Mineralys Therapeutics, Inc. Methods of treating hypertension with a combination of lorundrostat and two or more anti-hypertensive medications

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5521184A (en) * 1992-04-03 1996-05-28 Ciba-Geigy Corporation Pyrimidine derivatives and processes for the preparation thereof
US20010051631A1 (en) * 1994-07-15 2001-12-13 Muneo Takatani Tricyclic compounds, their production and use
ATE209047T1 (de) * 1995-06-07 2001-12-15 Searle & Co Epoxysteroide aldosteronantagonist und angiotensin ii rezeptor antagonist kombinationstherapie zur behandlung von congestivem herzversagen
CO4940418A1 (es) * 1997-07-18 2000-07-24 Novartis Ag Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso

Also Published As

Publication number Publication date
WO2003077892A2 (en) 2003-09-25
ES2274234T3 (es) 2007-05-16
WO2003077892A3 (en) 2003-12-24
PT1487424E (pt) 2007-01-31
DE60308337D1 (de) 2006-10-26
ATE339197T1 (de) 2006-10-15
DE60308337T2 (de) 2007-09-20
AU2003233946A8 (en) 2003-09-29
US20050124624A1 (en) 2005-06-09
EP1487424A2 (en) 2004-12-22
DK1487424T3 (da) 2007-01-08
AU2003233946A1 (en) 2003-09-29
JP2005527523A (ja) 2005-09-15
EP1487424B1 (en) 2006-09-13

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