DE60307289D1 - Spirosubstituierte piperidine als selektive antagonisten des melanin konzentrierenden hormon rezeptors für die behandlung von fettleibigkeit - Google Patents

Spirosubstituierte piperidine als selektive antagonisten des melanin konzentrierenden hormon rezeptors für die behandlung von fettleibigkeit

Info

Publication number
DE60307289D1
DE60307289D1 DE60307289T DE60307289T DE60307289D1 DE 60307289 D1 DE60307289 D1 DE 60307289D1 DE 60307289 T DE60307289 T DE 60307289T DE 60307289 T DE60307289 T DE 60307289T DE 60307289 D1 DE60307289 D1 DE 60307289D1
Authority
DE
Germany
Prior art keywords
spirosubstituted
piperidines
treatment
hormone receptor
concentrating hormone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60307289T
Other languages
English (en)
Other versions
DE60307289T2 (de
Inventor
A Burnett
Wen-Lian Wu
K Sasikumar
S Domalski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of DE60307289D1 publication Critical patent/DE60307289D1/de
Publication of DE60307289T2 publication Critical patent/DE60307289T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE60307289T 2002-06-27 2003-06-26 Spirosubstituierte piperidine als selektive antagonisten des melanin konzentrierenden hormon rezeptors für die behandlung von fettleibigkeit Expired - Lifetime DE60307289T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US39181302P 2002-06-27 2002-06-27
US391813P 2002-06-27
PCT/US2003/020088 WO2004002987A1 (en) 2002-06-27 2003-06-26 Spirosubstituted piperidines as selective melanin concentrating hormone receptor antagonists for the treatment of obesity

Publications (2)

Publication Number Publication Date
DE60307289D1 true DE60307289D1 (de) 2006-09-14
DE60307289T2 DE60307289T2 (de) 2007-10-18

Family

ID=30000757

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60307289T Expired - Lifetime DE60307289T2 (de) 2002-06-27 2003-06-26 Spirosubstituierte piperidine als selektive antagonisten des melanin konzentrierenden hormon rezeptors für die behandlung von fettleibigkeit

Country Status (15)

Country Link
US (1) US7109207B2 (de)
EP (1) EP1532147B1 (de)
JP (1) JP4522853B2 (de)
CN (1) CN100374440C (de)
AR (1) AR040344A1 (de)
AT (1) ATE334983T1 (de)
AU (1) AU2003258957A1 (de)
CA (1) CA2490531C (de)
DE (1) DE60307289T2 (de)
ES (1) ES2266861T3 (de)
HK (1) HK1071567A1 (de)
MX (1) MXPA05000185A (de)
PE (1) PE20040749A1 (de)
TW (1) TW200401777A (de)
WO (1) WO2004002987A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7084156B2 (en) 2001-11-27 2006-08-01 Merck & Co., Inc. 2-Aminoquinoline compounds
JPWO2004069798A1 (ja) 2003-02-10 2006-05-25 萬有製薬株式会社 ピペリジン誘導体を有効成分とするメラニン凝集ホルモン受容体拮抗剤
DE602004013427T2 (de) * 2003-02-28 2009-06-04 Schering Corp. Biaryltetrahydroisochinolin-piperidine als selektive mch-rezeptor-antagonisten zur behandlung von adipositas und verwandten erkrankungen
US7354925B2 (en) 2004-03-29 2008-04-08 Pfizer Inc. Alpha aryl or heteroaryl methyl beta piperidino propanamide compounds as ORL1-receptor antagonists
TW200630337A (en) * 2004-10-14 2006-09-01 Euro Celtique Sa Piperidinyl compounds and the use thereof
WO2006104136A1 (ja) * 2005-03-29 2006-10-05 Banyu Pharmaceutical Co., Ltd. 非アルコール性脂肪性肝疾患の治療剤、及び非アルコール性脂肪性肝疾患の治療又は予防のための薬剤の候補化合物のスクリーニング方法
US8247442B2 (en) * 2006-03-29 2012-08-21 Purdue Pharma L.P. Benzenesulfonamide compounds and their use
WO2007118854A1 (en) * 2006-04-13 2007-10-25 Euro-Celtique S.A. Benzenesulfonamide compounds and the use thereof
TW200815353A (en) * 2006-04-13 2008-04-01 Euro Celtique Sa Benzenesulfonamide compounds and their use
CA2664358A1 (en) * 2006-09-28 2008-04-03 Banyu Pharmaceutical Co., Ltd. Diarylketimine derivative
US8399486B2 (en) * 2007-04-09 2013-03-19 Purdue Pharma L.P. Benzenesulfonyl compounds and the use thereof
US8765736B2 (en) * 2007-09-28 2014-07-01 Purdue Pharma L.P. Benzenesulfonamide compounds and the use thereof
WO2011146069A1 (en) 2010-05-21 2011-11-24 Hewlett-Packard Development Company, L.P. Fluid ejection device including recirculation system
US9963739B2 (en) 2010-05-21 2018-05-08 Hewlett-Packard Development Company, L.P. Polymerase chain reaction systems
WO2016078770A1 (en) * 2014-11-21 2016-05-26 Laboratorios Del Dr. Esteve, S.A. Spiro-isoquinoline-1,4'-piperidine compounds having multimodal activity against pain
CN107312056B (zh) * 2017-08-24 2019-10-25 广西师范学院 2-(3’-羟基-17’-孕甾烷基)-5-氟苯并咪唑的合成方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5908830A (en) * 1996-10-31 1999-06-01 Merck & Co., Inc. Combination therapy for the treatment of diabetes and obesity
TWI279402B (en) * 1999-08-20 2007-04-21 Banyu Pharma Co Ltd Spiro compounds having NPY antagonistic activities and agents containing the same
JP2003507424A (ja) * 1999-08-26 2003-02-25 ブリストル−マイヤーズ スクイブ カンパニー Ｎｐｙアンタゴニスト：スピロイソキノリノン誘導体
AU4928101A (en) * 2000-03-23 2001-10-03 Merck & Co Inc Spiropiperidine derivatives as melanocortin receptor agonists
CA2384041A1 (en) * 2000-07-05 2002-01-24 Synaptic Pharmaceuticals Corporation Selective melanin concentrating hormone-1 (mch1) receptor antagonists and uses thereof

Also Published As

Publication number Publication date
CN1665812A (zh) 2005-09-07
PE20040749A1 (es) 2004-10-23
JP4522853B2 (ja) 2010-08-11
EP1532147A1 (de) 2005-05-25
CA2490531C (en) 2011-03-22
DE60307289T2 (de) 2007-10-18
JP2005535641A (ja) 2005-11-24
AU2003258957A1 (en) 2004-01-19
HK1071567A1 (en) 2005-07-22
WO2004002987A1 (en) 2004-01-08
ATE334983T1 (de) 2006-08-15
ES2266861T3 (es) 2007-03-01
EP1532147B1 (de) 2006-08-02
AR040344A1 (es) 2005-03-30
MXPA05000185A (es) 2005-04-08
US20040024002A1 (en) 2004-02-05
CN100374440C (zh) 2008-03-12
TW200401777A (en) 2004-02-01
US7109207B2 (en) 2006-09-19
CA2490531A1 (en) 2004-01-08

Similar Documents

Publication Publication Date Title
DE60307289D1 (de) Spirosubstituierte piperidine als selektive antagonisten des melanin konzentrierenden hormon rezeptors für die behandlung von fettleibigkeit
DE60010722D1 (de) Dibenzopyrane als glucocorticoid-rezeptor-antagonisten für die behandlung von zuckerkrankheit
ATE420083T1 (de) Harnstoff-derivate als vanilloid-rezeptor- antagonisten für die schmerzbehandlung
MX2007004306A (es) Compuestos biciclicos como antagonistas del receptor de la hormona concentradora de melanina selectivos para el tratamiento de la obesidad y trastornos relacionados.
DE60236218D1 (de) CCR5 Antagonisten verwendbar für die Behandlung von Aids
ATE374182T1 (de) Selektive agonisten des ep4 rezeptors für die behandlung von osteoporose
DE60212146D1 (de) Piperidin derivate als ccr5 rezeptor antagonisten zur behandlung von hiv
ATE346082T1 (de) Glucocorticoidrezeptorliganden zur behandlung von stoffwechselstörungen
DE602005015562D1 (de) Verwendung eines nmda-rezeptor-antagonisten für die behandlung von durch cochleäre exzitotoxizität hervorgerufenem tinnitus
ATE177095T1 (de) Substituierte piperidine für die behandlung von allergischen krankheiten
DE60234116D1 (de) Piperidin mch antagonisten und ihre verwendung in der behandlung von obesität und störungen des zentralnervensystems
DE60105144D1 (de) Pyrrolidin und piperidin derivate für die behandlung von neurodegenerativen erkrankungen
DE602007006019D1 (de) Für die behandlung von durch den gpr38-rezeptor vermittelten krankheiten geeignete piperazinylderivate
AU2003287880A8 (en) Cyclic quinoline compounds for use in mch receptor related disorders
DE60032905D1 (de) Selektive iglur5 rezeptorantagonisten zur behandlung der migräne
DE60300021D1 (de) (S)-4-Amino-5-Chloro-2-Methoxy-N-[1-[1-(2-Tetrahydrofuryl-Carbonyl)-4-Piperidinylmethyl]-4-Piperidinyl]benzamid zur Behandlung von Magen-Darmbewegungskrankheiten
DE50011178D1 (de) Substituierte 1,5-dihydropyrrol-2-on-derivate wirksam als nmda-rezeptor-antagonisten für die behandlung von schmerzzuständen
ATE393766T1 (de) Biaryltetrahydroisochinolin-piperidine als selektive mch-rezeptor-antagonisten zur behandlung von adipositas und verwandten erkrankungen
NO20070878L (no) Dimere piperidinderivater
DE602004021399D1 (de) Aminobenzimidazole als selektive melanin-konzentrierende hormon-rezeptorantagonisten zur behandlung von fettsucht und verwandten erkrankungen
ATE335500T1 (de) Die verwendung von antagonisten des bradykinin-b2 rezeptors zur behandlung von osteoarthrose
ITMI20020693A0 (it) Sostanze composizioni e metodi per il trattamento dell'alopecia androgenetica e dell'ipersecrezione sebacea
ATE357441T1 (de) Substituierte 2-pyrrolidin-2-yl-1h-indol- derivative für die behandlung von migräne
DE112005002957A5 (de) Vorrichtung für die Unterstützung der Bildung von Knochensubstanz am Kieferknochen
HK1100176A1 (en) Heterocyclyls as selective melanin concentrating hormone receptor antagonists for the treatment of obesity and related disorders

Legal Events

Date Code Title Description
8364 No opposition during term of opposition