DE60105144D1 - Pyrrolidin und piperidin derivate für die behandlung von neurodegenerativen erkrankungen - Google Patents
Pyrrolidin und piperidin derivate für die behandlung von neurodegenerativen erkrankungenInfo
- Publication number
- DE60105144D1 DE60105144D1 DE60105144T DE60105144T DE60105144D1 DE 60105144 D1 DE60105144 D1 DE 60105144D1 DE 60105144 T DE60105144 T DE 60105144T DE 60105144 T DE60105144 T DE 60105144T DE 60105144 D1 DE60105144 D1 DE 60105144D1
- Authority
- DE
- Germany
- Prior art keywords
- pyrrolidine
- treatment
- piperidine derivatives
- neurodeegenerative
- diseases
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/54—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00108610 | 2000-04-20 | ||
EP00108610 | 2000-04-20 | ||
PCT/EP2001/004171 WO2001081303A1 (en) | 2000-04-20 | 2001-04-11 | Pyrrolidine and piperidine derivatives and their use for the treament of neurodegenerative disorders |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60105144D1 true DE60105144D1 (de) | 2004-09-30 |
DE60105144T2 DE60105144T2 (de) | 2005-09-08 |
Family
ID=8168522
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60105144T Expired - Fee Related DE60105144T2 (de) | 2000-04-20 | 2001-04-11 | Pyrrolidin und piperidin derivate für die behandlung von neurodegenerativen erkrankungen |
Country Status (18)
Country | Link |
---|---|
US (1) | US6451819B2 (de) |
EP (1) | EP1278728B1 (de) |
JP (1) | JP4219590B2 (de) |
KR (1) | KR100501606B1 (de) |
CN (1) | CN1178911C (de) |
AR (1) | AR028343A1 (de) |
AT (1) | ATE274494T1 (de) |
AU (2) | AU2001273942B2 (de) |
BR (1) | BR0110112A (de) |
CA (1) | CA2404464C (de) |
DE (1) | DE60105144T2 (de) |
ES (1) | ES2225553T3 (de) |
MX (1) | MXPA02010261A (de) |
PE (1) | PE20011185A1 (de) |
PT (1) | PT1278728E (de) |
TR (1) | TR200402442T4 (de) |
WO (1) | WO2001081303A1 (de) |
ZA (1) | ZA200208015B (de) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE260240T1 (de) * | 1998-04-01 | 2004-03-15 | Nortran Pharmaceuticals Inc | Aminocyclohexylverbindungen und deren verwendung |
US6979685B1 (en) * | 1999-02-12 | 2005-12-27 | Cardiome Pharma Corp. | Cycloalkyl amine compounds and uses thereof |
US7507545B2 (en) | 1999-03-31 | 2009-03-24 | Cardiome Pharma Corp. | Ion channel modulating activity method |
US7057053B2 (en) | 2000-10-06 | 2006-06-06 | Cardiome Pharma Corp. | Ion channel modulating compounds and uses thereof |
US7524879B2 (en) * | 2000-10-06 | 2009-04-28 | Cardiome Pharma Corp. | Ion channel modulating compounds and uses thereof |
WO2002100833A1 (fr) * | 2001-06-12 | 2002-12-19 | Sumitomo Pharmaceuticals Company, Limited | Inhibiteurs de rho kinase |
US6885903B2 (en) * | 2001-07-10 | 2005-04-26 | General Electric Company | Method and system for tracking repair of components |
EP1467986A1 (de) | 2002-01-17 | 2004-10-20 | Eli Lilly And Company | Azacyclische verbindungen als modulatoren von acetylcholinrezeptoren |
US7005432B2 (en) * | 2002-05-16 | 2006-02-28 | Hoffman-La Roche Inc. | Substituted imidazol-pyridazine derivatives |
JP2006504567A (ja) * | 2002-10-31 | 2006-02-09 | ペドリーニ、ファビオ | 車載用具キャリア |
US7345086B2 (en) * | 2003-05-02 | 2008-03-18 | Cardiome Pharma Corp. | Uses of ion channel modulating compounds |
SI1560812T1 (sl) * | 2003-05-02 | 2006-10-31 | Cardiome Pharma Corp | Aminocikloheksil etrske spojine in njihove uporabe |
US20090041841A1 (en) * | 2003-05-02 | 2009-02-12 | Cardiome Pharma Corp. | Controlled release tablet formulations for the prevention of arrhythmias |
WO2005018635A2 (en) * | 2003-08-07 | 2005-03-03 | Cardiome Pharma Corp. | Ion channel modulating activity i |
US7345087B2 (en) * | 2003-10-31 | 2008-03-18 | Cardiome Pharma Corp. | Aminocyclohexyl ether compounds and uses thereof |
GB0325956D0 (en) * | 2003-11-06 | 2003-12-10 | Addex Pharmaceuticals Sa | Novel compounds |
WO2005097087A2 (en) * | 2004-04-01 | 2005-10-20 | Cardiome Pharma Corp. | Merged ion channel modulating compounds and uses thereof |
MXPA06011419A (es) | 2004-04-01 | 2007-04-20 | Cardiome Pharma Corp | Profarmacos de compuestos moduladores de canales ionicos y usos de los mismos. |
CA2586918C (en) * | 2004-11-08 | 2021-01-19 | Cardiome Pharma Corp. | Use of ion channel modulating compounds for treating acute atrial fibrillation in a human |
JP2011516417A (ja) * | 2008-03-27 | 2011-05-26 | エヴォテック・ノイロサイエンシーズ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | Nmdanr2b−サブタイプ選択的アンタゴニストを使用する障害の処置方法 |
RU2015151857A (ru) | 2008-12-02 | 2019-01-15 | Уэйв Лайф Сайенсес Джапан, Инк. | Способ синтеза модифицированных по атому фосфора нуклеиновых кислот |
WO2011005761A1 (en) | 2009-07-06 | 2011-01-13 | Ontorii, Inc | Novel nucleic acid prodrugs and methods use thereof |
EP2620428B1 (de) | 2010-09-24 | 2019-05-22 | Wave Life Sciences Ltd. | Asymmetrische hilfsgruppe |
MX347361B (es) | 2011-07-19 | 2017-04-12 | Wave Life Sciences Ltd | Metodos para la sintesis de acidos nucleicos funcionalizados. |
CA2879023C (en) | 2012-07-13 | 2017-03-28 | Wave Life Sciences Japan | Asymmetric auxiliary group |
WO2014012081A2 (en) | 2012-07-13 | 2014-01-16 | Ontorii, Inc. | Chiral control |
SG11201500243WA (en) | 2012-07-13 | 2015-04-29 | Shin Nippon Biomedical Lab Ltd | Chiral nucleic acid adjuvant |
WO2015108046A1 (ja) | 2014-01-15 | 2015-07-23 | 株式会社新日本科学 | 抗アレルギー作用を有するキラル核酸アジュバンド及び抗アレルギー剤 |
WO2015108047A1 (ja) | 2014-01-15 | 2015-07-23 | 株式会社新日本科学 | 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤 |
US10149905B2 (en) | 2014-01-15 | 2018-12-11 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having antitumor effect and antitumor agent |
EP4137572A1 (de) | 2014-01-16 | 2023-02-22 | Wave Life Sciences Ltd. | Chirales design |
BR112017000417B1 (pt) | 2014-07-10 | 2021-06-08 | SpecGx LLC | processo para preparação de fenilalcanos substituídos |
WO2024099403A1 (zh) * | 2022-11-10 | 2024-05-16 | 北京普祺医药科技股份有限公司 | 一种具有软药性质的硫醚类化合物、药物组合物及其用途 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL74140A (en) * | 1984-04-10 | 1988-05-31 | Robins Co Inc A H | Substituted n-((amino)alkyl)-1-pyrrolidine,-1-piperidine and-1-homopiperidine-carboxamides and pharmaceutical compositions containing them |
ZA9610736B (en) * | 1995-12-22 | 1997-06-27 | Warner Lambert Co | 2-Substituted piperidine analogs and their use as subtypeselective nmda receptor antagonists |
US6015824A (en) * | 1998-02-10 | 2000-01-18 | Hoffmann-La Roche Ag | Pyrrolidine and piperidine derivatives and treatment of neurodegenerative disorders |
TWI254043B (en) * | 1999-06-08 | 2006-05-01 | Hoffmann La Roche | Ethanesulfonyl-piperidine derivatives having good affinity to N-methyl-D-aspartate (NMDA) receptor |
-
2001
- 2001-04-11 TR TR2004/02442T patent/TR200402442T4/xx unknown
- 2001-04-11 AU AU2001273942A patent/AU2001273942B2/en not_active Ceased
- 2001-04-11 CA CA002404464A patent/CA2404464C/en not_active Expired - Fee Related
- 2001-04-11 CN CNB018083099A patent/CN1178911C/zh not_active Expired - Fee Related
- 2001-04-11 KR KR10-2002-7014043A patent/KR100501606B1/ko not_active IP Right Cessation
- 2001-04-11 DE DE60105144T patent/DE60105144T2/de not_active Expired - Fee Related
- 2001-04-11 BR BR0110112-9A patent/BR0110112A/pt not_active IP Right Cessation
- 2001-04-11 AU AU7394201A patent/AU7394201A/xx active Pending
- 2001-04-11 ES ES01940321T patent/ES2225553T3/es not_active Expired - Lifetime
- 2001-04-11 AT AT01940321T patent/ATE274494T1/de not_active IP Right Cessation
- 2001-04-11 EP EP01940321A patent/EP1278728B1/de not_active Expired - Lifetime
- 2001-04-11 WO PCT/EP2001/004171 patent/WO2001081303A1/en active IP Right Grant
- 2001-04-11 PT PT01940321T patent/PT1278728E/pt unknown
- 2001-04-11 MX MXPA02010261A patent/MXPA02010261A/es active IP Right Grant
- 2001-04-11 JP JP2001578398A patent/JP4219590B2/ja not_active Expired - Fee Related
- 2001-04-12 US US09/833,450 patent/US6451819B2/en not_active Expired - Fee Related
- 2001-04-18 PE PE2001000354A patent/PE20011185A1/es not_active Application Discontinuation
- 2001-04-18 AR ARP010101809A patent/AR028343A1/es unknown
-
2002
- 2002-10-04 ZA ZA200208015A patent/ZA200208015B/en unknown
Also Published As
Publication number | Publication date |
---|---|
TR200402442T4 (tr) | 2004-12-21 |
EP1278728A1 (de) | 2003-01-29 |
JP2003531190A (ja) | 2003-10-21 |
ATE274494T1 (de) | 2004-09-15 |
ZA200208015B (en) | 2004-02-10 |
MXPA02010261A (es) | 2003-04-25 |
ES2225553T3 (es) | 2005-03-16 |
WO2001081303A1 (en) | 2001-11-01 |
US6451819B2 (en) | 2002-09-17 |
CA2404464A1 (en) | 2001-11-01 |
PE20011185A1 (es) | 2001-11-14 |
PT1278728E (pt) | 2004-10-29 |
AU2001273942B2 (en) | 2005-09-01 |
JP4219590B2 (ja) | 2009-02-04 |
CN1178911C (zh) | 2004-12-08 |
AR028343A1 (es) | 2003-05-07 |
EP1278728B1 (de) | 2004-08-25 |
KR100501606B1 (ko) | 2005-07-18 |
CA2404464C (en) | 2008-03-11 |
CN1425002A (zh) | 2003-06-18 |
KR20030013387A (ko) | 2003-02-14 |
US20010047031A1 (en) | 2001-11-29 |
DE60105144T2 (de) | 2005-09-08 |
BR0110112A (pt) | 2003-02-11 |
AU7394201A (en) | 2001-11-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |