DE60229422D1 - Kombinations-motif-immunstimulierende oligonukleotide mit verbesserter wirkung - Google Patents

Kombinations-motif-immunstimulierende oligonukleotide mit verbesserter wirkung

Info

Publication number
DE60229422D1
DE60229422D1 DE60229422T DE60229422T DE60229422D1 DE 60229422 D1 DE60229422 D1 DE 60229422D1 DE 60229422 T DE60229422 T DE 60229422T DE 60229422 T DE60229422 T DE 60229422T DE 60229422 D1 DE60229422 D1 DE 60229422D1
Authority
DE
Germany
Prior art keywords
nucleic acids
improved effect
combination motif
class
immunostimulating oligonucleotides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60229422T
Other languages
German (de)
English (en)
Inventor
Arthur M Krieg
Joerg Vollmer
Eugen Uhlmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Coley Pharmaceutical GmbH
University of Iowa Research Foundation UIRF
Original Assignee
Coley Pharmaceutical GmbH
University of Iowa Research Foundation UIRF
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Coley Pharmaceutical GmbH, University of Iowa Research Foundation UIRF filed Critical Coley Pharmaceutical GmbH
Application granted granted Critical
Publication of DE60229422D1 publication Critical patent/DE60229422D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6811—Selection methods for production or design of target specific oligonucleotides or binding molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Pulmonology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Analytical Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE60229422T 2001-08-17 2002-08-19 Kombinations-motif-immunstimulierende oligonukleotide mit verbesserter wirkung Expired - Lifetime DE60229422D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US31327301P 2001-08-17 2001-08-17
US39395202P 2002-07-03 2002-07-03
PCT/US2002/026468 WO2003015711A2 (en) 2001-08-17 2002-08-19 Combination motif immune stimulatory oligonucleotides with improved activity

Publications (1)

Publication Number Publication Date
DE60229422D1 true DE60229422D1 (de) 2008-11-27

Family

ID=26978772

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60229422T Expired - Lifetime DE60229422D1 (de) 2001-08-17 2002-08-19 Kombinations-motif-immunstimulierende oligonukleotide mit verbesserter wirkung

Country Status (22)

Country Link
US (1) US8834900B2 (https=)
EP (1) EP1446162B1 (https=)
JP (2) JP4383534B2 (https=)
KR (1) KR100991644B1 (https=)
CN (1) CN1604795B (https=)
AT (1) ATE411054T1 (https=)
AU (1) AU2002331643B2 (https=)
BR (1) BR0211962A (https=)
CA (1) CA2457485C (https=)
CY (1) CY1109398T1 (https=)
DE (1) DE60229422D1 (https=)
DK (1) DK1446162T3 (https=)
EA (1) EA007232B1 (https=)
ES (1) ES2314099T3 (https=)
IL (2) IL160157A0 (https=)
MX (1) MXPA04001458A (https=)
NZ (2) NZ552377A (https=)
PT (1) PT1446162E (https=)
SG (1) SG177000A1 (https=)
SI (1) SI1446162T1 (https=)
WO (1) WO2003015711A2 (https=)
ZA (1) ZA200401531B (https=)

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PT1446162E (pt) 2009-01-27
CN1604795A (zh) 2005-04-06
AU2002331643B2 (en) 2007-10-11
DK1446162T3 (da) 2008-12-08
BR0211962A (pt) 2005-04-19
EA200400319A1 (ru) 2004-12-30
JP2005502338A (ja) 2005-01-27
WO2003015711A2 (en) 2003-02-27
IL160157A0 (en) 2004-07-25
CA2457485C (en) 2012-08-14
JP4383534B2 (ja) 2009-12-16
WO2003015711A3 (en) 2004-06-10
NZ552377A (en) 2008-08-29
JP2009028051A (ja) 2009-02-12
CA2457485A1 (en) 2003-02-27
ES2314099T3 (es) 2009-03-16
US20030148976A1 (en) 2003-08-07
SG177000A1 (en) 2012-01-30
WO2003015711A9 (en) 2003-04-10
CN1604795B (zh) 2010-05-26
MXPA04001458A (es) 2005-02-17
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