DE60226710D1 - Kombination von docetaxel mit flavopiridol - Google Patents
Kombination von docetaxel mit flavopiridolInfo
- Publication number
- DE60226710D1 DE60226710D1 DE60226710T DE60226710T DE60226710D1 DE 60226710 D1 DE60226710 D1 DE 60226710D1 DE 60226710 T DE60226710 T DE 60226710T DE 60226710 T DE60226710 T DE 60226710T DE 60226710 D1 DE60226710 D1 DE 60226710D1
- Authority
- DE
- Germany
- Prior art keywords
- flavopiridol
- docetaxel
- combination
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 title 1
- BIIVYFLTOXDAOV-YVEFUNNKSA-N alvocidib Chemical compound O[C@@H]1CN(C)CC[C@@H]1C1=C(O)C=C(O)C2=C1OC(C=1C(=CC=CC=1)Cl)=CC2=O BIIVYFLTOXDAOV-YVEFUNNKSA-N 0.000 title 1
- 229950010817 alvocidib Drugs 0.000 title 1
- 229960003668 docetaxel Drugs 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/453—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27794801P | 2001-03-23 | 2001-03-23 | |
| US30269201P | 2001-07-05 | 2001-07-05 | |
| US33491601P | 2001-12-04 | 2001-12-04 | |
| PCT/EP2002/004083 WO2002076484A2 (en) | 2001-03-23 | 2002-03-22 | Combination of a taxane and a cyclin-dependent kinase inhibitor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60226710D1 true DE60226710D1 (de) | 2008-07-03 |
Family
ID=27402954
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60226710T Expired - Lifetime DE60226710D1 (de) | 2001-03-23 | 2002-03-22 | Kombination von docetaxel mit flavopiridol |
Country Status (33)
| Country | Link |
|---|---|
| US (2) | US20020182204A1 (https=) |
| EP (1) | EP1372652B1 (https=) |
| JP (1) | JP2004521140A (https=) |
| KR (1) | KR100879712B1 (https=) |
| CN (1) | CN1498107A (https=) |
| AR (1) | AR034222A1 (https=) |
| AT (1) | ATE395917T1 (https=) |
| AU (1) | AU2002312815B2 (https=) |
| BR (1) | BR0208221A (https=) |
| CA (1) | CA2441441C (https=) |
| CY (1) | CY1110449T1 (https=) |
| CZ (1) | CZ301423B6 (https=) |
| DE (1) | DE60226710D1 (https=) |
| DK (1) | DK1372652T3 (https=) |
| EA (1) | EA007815B1 (https=) |
| ES (1) | ES2305253T3 (https=) |
| HR (1) | HRPK20030766B3 (https=) |
| HU (1) | HU229258B1 (https=) |
| IL (2) | IL158058A0 (https=) |
| ME (1) | MEP16408A (https=) |
| MX (1) | MXPA03007743A (https=) |
| NO (1) | NO332441B1 (https=) |
| NZ (1) | NZ527655A (https=) |
| PE (1) | PE20020907A1 (https=) |
| PL (1) | PL206118B1 (https=) |
| PT (1) | PT1372652E (https=) |
| RS (1) | RS50681B (https=) |
| SI (1) | SI1372652T1 (https=) |
| SK (1) | SK287481B6 (https=) |
| TW (1) | TWI355935B (https=) |
| UY (1) | UY27220A1 (https=) |
| WO (1) | WO2002076484A2 (https=) |
| ZA (1) | ZA200307381B (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60313754T2 (de) * | 2002-03-06 | 2008-01-24 | The Medical Research and Education Trust, San Diego | Botanischer extrakt mit antikrebs-aktivität enthaltend isoliquiritigenin |
| AU2003287081A1 (en) * | 2002-10-16 | 2004-05-04 | Ilex Products, Inc. | Clofarabine and taxane chemotherapy combination |
| ATE418333T1 (de) * | 2002-11-06 | 2009-01-15 | Cyclacel Ltd | Kombination aus docetaxel und einem cdk-hemmer |
| BRPI0707580A2 (pt) * | 2006-02-10 | 2011-05-10 | Nerviano Medical Sciences Srl | combinaÇÕes compreendendo um inibidor cdk e um anticorpo do fator de crescimento ou antimitàtico |
| AU2011330733A1 (en) * | 2010-11-19 | 2013-06-06 | Piramal Enterprises Limited | Pharmaceutical combination of paclitaxel and a CDK inhibitor |
| EA027506B1 (ru) | 2011-04-01 | 2017-08-31 | Астразенека Аб | Способ лечения рака молочной железы |
| HRP20191982T4 (hr) | 2011-11-30 | 2023-01-06 | Astrazeneca Ab | Kombinacijsko liječenje raka |
| AU2013204533B2 (en) | 2012-04-17 | 2017-02-02 | Astrazeneca Ab | Crystalline forms |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2601675B1 (fr) * | 1986-07-17 | 1988-09-23 | Rhone Poulenc Sante | Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent |
| MX9102128A (es) * | 1990-11-23 | 1992-07-08 | Rhone Poulenc Rorer Sa | Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene |
| FR2697752B1 (fr) * | 1992-11-10 | 1995-04-14 | Rhone Poulenc Rorer Sa | Compositions antitumorales contenant des dérivés du taxane. |
| EP0888458A4 (en) * | 1996-02-20 | 2004-05-06 | Sloan Kettering Institutefor C | COMBINATION OF PKC INHIBITORS AND THERAPEUTIC AGENTS FOR TREATING CANCER |
-
2002
- 2002-03-21 US US10/101,947 patent/US20020182204A1/en not_active Abandoned
- 2002-03-21 UY UY27220A patent/UY27220A1/es not_active Application Discontinuation
- 2002-03-22 IL IL15805802A patent/IL158058A0/xx unknown
- 2002-03-22 EA EA200301053A patent/EA007815B1/ru not_active IP Right Cessation
- 2002-03-22 NZ NZ527655A patent/NZ527655A/xx not_active IP Right Cessation
- 2002-03-22 SI SI200230711T patent/SI1372652T1/sl unknown
- 2002-03-22 PE PE2002000230A patent/PE20020907A1/es not_active Application Discontinuation
- 2002-03-22 AU AU2002312815A patent/AU2002312815B2/en not_active Ceased
- 2002-03-22 CN CNA028070380A patent/CN1498107A/zh active Pending
- 2002-03-22 JP JP2002574997A patent/JP2004521140A/ja active Pending
- 2002-03-22 DE DE60226710T patent/DE60226710D1/de not_active Expired - Lifetime
- 2002-03-22 CZ CZ20032551A patent/CZ301423B6/cs not_active IP Right Cessation
- 2002-03-22 MX MXPA03007743A patent/MXPA03007743A/es active IP Right Grant
- 2002-03-22 KR KR1020037012338A patent/KR100879712B1/ko not_active Expired - Fee Related
- 2002-03-22 AT AT02737950T patent/ATE395917T1/de active
- 2002-03-22 EP EP02737950A patent/EP1372652B1/en not_active Expired - Lifetime
- 2002-03-22 TW TW091105567A patent/TWI355935B/zh not_active IP Right Cessation
- 2002-03-22 PL PL367702A patent/PL206118B1/pl not_active IP Right Cessation
- 2002-03-22 PT PT02737950T patent/PT1372652E/pt unknown
- 2002-03-22 CA CA002441441A patent/CA2441441C/en not_active Expired - Fee Related
- 2002-03-22 BR BR0208221-7A patent/BR0208221A/pt not_active Application Discontinuation
- 2002-03-22 RS YUP-695/03A patent/RS50681B/sr unknown
- 2002-03-22 HR HR20030766A patent/HRPK20030766B3/xx not_active IP Right Cessation
- 2002-03-22 HU HU0303589A patent/HU229258B1/hu not_active IP Right Cessation
- 2002-03-22 WO PCT/EP2002/004083 patent/WO2002076484A2/en not_active Ceased
- 2002-03-22 ME MEP-164/08A patent/MEP16408A/xx unknown
- 2002-03-22 DK DK02737950T patent/DK1372652T3/da active
- 2002-03-22 ES ES02737950T patent/ES2305253T3/es not_active Expired - Lifetime
- 2002-03-22 SK SK1169-2003A patent/SK287481B6/sk not_active IP Right Cessation
- 2002-03-22 AR ARP020101061A patent/AR034222A1/es unknown
-
2003
- 2003-09-16 NO NO20034124A patent/NO332441B1/no not_active IP Right Cessation
- 2003-09-22 ZA ZA2003/07381A patent/ZA200307381B/en unknown
- 2003-09-22 IL IL158058A patent/IL158058A/en not_active IP Right Cessation
-
2006
- 2006-01-27 US US11/341,840 patent/US20060128640A1/en not_active Abandoned
-
2008
- 2008-08-11 CY CY20081100843T patent/CY1110449T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |