DE60220282D1 - Mehrzähnige, zur komplexierung von metallionen geeignete aza liganden und deren verwendung in diagnose und therapie - Google Patents
Mehrzähnige, zur komplexierung von metallionen geeignete aza liganden und deren verwendung in diagnose und therapieInfo
- Publication number
- DE60220282D1 DE60220282D1 DE60220282T DE60220282T DE60220282D1 DE 60220282 D1 DE60220282 D1 DE 60220282D1 DE 60220282 T DE60220282 T DE 60220282T DE 60220282 T DE60220282 T DE 60220282T DE 60220282 D1 DE60220282 D1 DE 60220282D1
- Authority
- DE
- Germany
- Prior art keywords
- cycloalkylalkyl
- cycloalkyl
- aryl
- alkyl
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000000536 complexating effect Effects 0.000 title 1
- 238000003745 diagnosis Methods 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- 229910021645 metal ion Inorganic materials 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 4
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 4
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000000732 arylene group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000021615 conjugation Effects 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 125000000524 functional group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 150000002500 ions Chemical class 0.000 abstract 1
- 229910052751 metal Inorganic materials 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Radiology & Medical Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2001MI001518A ITMI20011518A1 (it) | 2001-07-17 | 2001-07-17 | Leganti azotati multidentati capaci di complessare ioni metallici e loro uso in diagnostica e in terapia |
| ITMI20011518 | 2001-07-17 | ||
| PCT/EP2002/007658 WO2003008390A1 (en) | 2001-07-17 | 2002-07-10 | Multidentate aza ligands able to complex metal ions and the use thereof in diagnostics and therapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60220282D1 true DE60220282D1 (de) | 2007-07-05 |
| DE60220282T2 DE60220282T2 (de) | 2008-01-24 |
Family
ID=11448069
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60220282T Expired - Lifetime DE60220282T2 (de) | 2001-07-17 | 2002-07-10 | Mehrzähnige, zur komplexierung von metallionen geeignete aza liganden und deren verwendung in diagnose und therapie |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US7186400B2 (de) |
| EP (2) | EP1803711B1 (de) |
| JP (1) | JP4249610B2 (de) |
| KR (1) | KR100890471B1 (de) |
| CN (1) | CN100443476C (de) |
| AT (2) | ATE362921T1 (de) |
| AU (1) | AU2002331348B2 (de) |
| CA (1) | CA2453845C (de) |
| DE (1) | DE60220282T2 (de) |
| DK (1) | DK1417183T3 (de) |
| ES (1) | ES2286278T3 (de) |
| HK (1) | HK1061031A1 (de) |
| HU (1) | HU228830B1 (de) |
| IL (2) | IL159874A0 (de) |
| IT (1) | ITMI20011518A1 (de) |
| MX (1) | MXPA04000408A (de) |
| NO (1) | NO328840B1 (de) |
| PL (1) | PL202690B1 (de) |
| PT (1) | PT1417183E (de) |
| SI (1) | SI1417183T1 (de) |
| WO (1) | WO2003008390A1 (de) |
| ZA (1) | ZA200400318B (de) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7893223B2 (en) * | 2001-07-17 | 2011-02-22 | Bracco Imaging S.P.A. | Multidentate AZA ligands able to complex metal ions and the use thereof in diagnostics and therapy |
| US7226577B2 (en) | 2003-01-13 | 2007-06-05 | Bracco Imaging, S. P. A. | Gastrin releasing peptide compounds |
| US7611692B2 (en) | 2003-01-13 | 2009-11-03 | Bracco Imaging S.P.A. | Gastrin releasing peptide compounds |
| US7850947B2 (en) | 2003-01-13 | 2010-12-14 | Bracco Imaging S.P.A. | Gastrin releasing peptide compounds |
| US7922998B2 (en) * | 2003-01-13 | 2011-04-12 | Bracco Imaging S.P.A. | Gastrin releasing peptide compounds |
| US8420050B2 (en) | 2003-01-13 | 2013-04-16 | Bracco Imaging S.P.A. | Gastrin releasing peptide compounds |
| DE602005014248D1 (de) | 2004-07-02 | 2009-06-10 | Bracco Imaging Spa | 1,4-bis(carboxymethyl)-6-äbis(carboxymethyl)aminoü-6-methyl-perhydro-1,4-diazepin (aazta)-derivate als liganden in kontrastmitteln mit hoher relaxivität zur verwendung bei der magnetresonanztomographie (mrt) |
| FR2883562B1 (fr) | 2005-03-24 | 2009-02-27 | Guerbet Sa | Chelates lipophiles et leur utilisation en imagerie |
| US8986650B2 (en) | 2005-10-07 | 2015-03-24 | Guerbet | Complex folate-NOTA-Ga68 |
| FR2891830B1 (fr) | 2005-10-07 | 2011-06-24 | Guerbet Sa | Composes a chaines aminoalcools courtes et complexes metalliques pour l'imagerie medicale |
| EP1940841B9 (de) | 2005-10-07 | 2017-04-19 | Guerbet | Verbindungen mit einem eine biologische zielstruktur erkennenden teil, das mit einem zum komplexieren von gallium fähigen signalteil gekoppelt ist |
| WO2008071679A1 (en) | 2006-12-11 | 2008-06-19 | Bracco Imaging Spa | Fibrin binding peptide conjugates for diagnostic and therapeutic applications. |
| EP2476703A1 (de) | 2011-01-14 | 2012-07-18 | Bracco Imaging S.p.A | Mit einem Bakterium kreuzreagierende menschliche Antikörper und ein Autoantigen aus atherosklerotischen Plaques |
| EP2147684A1 (de) | 2008-07-22 | 2010-01-27 | Bracco Imaging S.p.A | Selektiv gegen Metallproteasen wirkende Diagnosemittel |
| JP5376130B2 (ja) * | 2009-03-24 | 2013-12-25 | 独立行政法人日本原子力研究開発機構 | 抗体標識が可能な無担体１７７Ｌｕの分離精製法 |
| WO2012095516A1 (en) | 2011-01-14 | 2012-07-19 | Bracco Imaging Spa | Human antibodies cross-reacting with a bacterial and a self antigen from atherosclerotic plaques |
| AU2013229631B2 (en) | 2012-03-05 | 2017-09-14 | Bracco Imaging Spa | Dynamic Contrast Enhanced MRI method and agents for the assessment of the macromolecular transport within pathologic tissues |
| EP2639227A1 (de) | 2012-03-14 | 2013-09-18 | Bracco Imaging S.p.A | Neue Klasse von Diazepinderivatchelatbildnern und Komplexe mit paramagnetischen Metallen als MRI-Kontrastmittel |
| JP6251744B2 (ja) * | 2012-09-07 | 2017-12-20 | ブラッコ・イメージング・ソシエタ・ペル・アチオニＢｒａｃｃｏ Ｉｍａｇｉｎｇ Ｓ．Ｐ．Ａ． | ＭＲＩ用の両親媒性錯体を含む常磁性固体脂質ナノ粒子（ｐＳＬＮ） |
| DE102013106066A1 (de) | 2013-06-11 | 2014-12-11 | Johannes-Gutenberg-Universität Mainz | Bifunktionelle Chelatbildner auf der Basis des 1,4-Diazepin-Gerüsts (DAZA) für die nicht invasive molekulare Bilddarstellung |
| US9259725B2 (en) * | 2013-10-10 | 2016-02-16 | Lawrence Livermore National Security, Llc | Acyclic aza-containing ligands for use as catalytic carbon capture systems |
| US11370826B2 (en) | 2016-02-09 | 2022-06-28 | Bracco Suisse Sa | Recombinant chimeric protein for selectins targeting |
| DE102017129405A1 (de) | 2017-12-11 | 2019-06-13 | Universitätsklinikum Jena | Neue DAZA-Chelatoren als Liganden in der Leberbildgebung |
| US11684682B2 (en) | 2018-11-12 | 2023-06-27 | Bracco Imaging S.P.A. | Chelating AAZTA conjugates and complexes thereof |
| CN114262351B (zh) * | 2022-03-01 | 2022-05-13 | 宜宾锂宝新材料有限公司 | 一种普鲁士蓝正极材料及其制备方法与应用、电池 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3107260A (en) * | 1960-11-29 | 1963-10-15 | Geigy Chem Corp | Triaminopropane hexa-acetic acid and metal chelates thereof |
| DE3938992A1 (de) * | 1989-11-21 | 1991-05-23 | Schering Ag | Kaskadenpolymer-gebundene komplexbildner, deren komplexe und konjugate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
| CA2074484A1 (en) * | 1990-11-26 | 1992-05-27 | Edward J. Carlin | Stabilized hexahydro-5-pyrimidinamine compounds in aqueous solution and methods for preparing same |
| US6403055B1 (en) * | 1996-08-02 | 2002-06-11 | Dibra S.P.A. | Diagnostic imaging contrast agent with improved in serum relaxivity |
| IT1283650B1 (it) | 1996-08-02 | 1998-04-23 | Bracco Spa | Chelati paramagnetici ad alta relassivita' in siero |
-
2001
- 2001-07-17 IT IT2001MI001518A patent/ITMI20011518A1/it unknown
-
2002
- 2002-07-10 AT AT02767192T patent/ATE362921T1/de active
- 2002-07-10 ES ES02767192T patent/ES2286278T3/es not_active Expired - Lifetime
- 2002-07-10 DE DE60220282T patent/DE60220282T2/de not_active Expired - Lifetime
- 2002-07-10 CA CA2453845A patent/CA2453845C/en not_active Expired - Lifetime
- 2002-07-10 EP EP07003558A patent/EP1803711B1/de not_active Expired - Lifetime
- 2002-07-10 EP EP02767192A patent/EP1417183B1/de not_active Expired - Lifetime
- 2002-07-10 WO PCT/EP2002/007658 patent/WO2003008390A1/en active IP Right Grant
- 2002-07-10 PT PT02767192T patent/PT1417183E/pt unknown
- 2002-07-10 AU AU2002331348A patent/AU2002331348B2/en not_active Ceased
- 2002-07-10 MX MXPA04000408A patent/MXPA04000408A/es active IP Right Grant
- 2002-07-10 HU HU0400997A patent/HU228830B1/hu not_active IP Right Cessation
- 2002-07-10 JP JP2003513950A patent/JP4249610B2/ja not_active Expired - Fee Related
- 2002-07-10 KR KR1020047000593A patent/KR100890471B1/ko active IP Right Grant
- 2002-07-10 DK DK02767192T patent/DK1417183T3/da active
- 2002-07-10 IL IL15987402A patent/IL159874A0/xx unknown
- 2002-07-10 SI SI200230566T patent/SI1417183T1/sl unknown
- 2002-07-10 US US10/484,111 patent/US7186400B2/en not_active Expired - Lifetime
- 2002-07-10 AT AT07003558T patent/ATE529414T1/de not_active IP Right Cessation
- 2002-07-10 CN CNB028142020A patent/CN100443476C/zh not_active Expired - Fee Related
- 2002-07-10 PL PL367007A patent/PL202690B1/pl unknown
-
2004
- 2004-01-15 IL IL159874A patent/IL159874A/en active IP Right Grant
- 2004-01-15 NO NO20040179A patent/NO328840B1/no not_active IP Right Cessation
- 2004-01-15 ZA ZA200400318A patent/ZA200400318B/en unknown
- 2004-06-09 HK HK04104116A patent/HK1061031A1/xx not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |