ATE420664T1 - Mittel für magnetisches bildformungsverfahren - Google Patents

Mittel für magnetisches bildformungsverfahren

Info

Publication number
ATE420664T1
ATE420664T1 AT03735518T AT03735518T ATE420664T1 AT E420664 T1 ATE420664 T1 AT E420664T1 AT 03735518 T AT03735518 T AT 03735518T AT 03735518 T AT03735518 T AT 03735518T AT E420664 T1 ATE420664 T1 AT E420664T1
Authority
AT
Austria
Prior art keywords
integer
tumor
mri detectable
agent
image forming
Prior art date
Application number
AT03735518T
Other languages
English (en)
Inventor
S Aime
V Mainero
Chrich S Geninatti
C Cabella
Original Assignee
Bracco Imaging Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Imaging Spa filed Critical Bracco Imaging Spa
Application granted granted Critical
Publication of ATE420664T1 publication Critical patent/ATE420664T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/12—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/009—Neutron capture therapy, e.g. using uranium or non-boron material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/009—Neutron capture therapy, e.g. using uranium or non-boron material
    • A61K41/0095—Boron neutron capture therapy, i.e. BNCT, e.g. using boronated porphyrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/10—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/12—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Soft Magnetic Materials (AREA)
  • Magnetic Record Carriers (AREA)
  • Measuring Magnetic Variables (AREA)
AT03735518T 2002-06-05 2003-06-02 Mittel für magnetisches bildformungsverfahren ATE420664T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP02012531A EP1369134A1 (de) 2002-06-05 2002-06-05 Mittel fur magnetisches Bildformungsverfahren

Publications (1)

Publication Number Publication Date
ATE420664T1 true ATE420664T1 (de) 2009-01-15

Family

ID=29433117

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03735518T ATE420664T1 (de) 2002-06-05 2003-06-02 Mittel für magnetisches bildformungsverfahren

Country Status (7)

Country Link
US (2) US7780952B2 (de)
EP (2) EP1369134A1 (de)
JP (1) JP4469273B2 (de)
AT (1) ATE420664T1 (de)
AU (1) AU2003238192A1 (de)
DE (1) DE60325849D1 (de)
WO (1) WO2003103722A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1369134A1 (de) * 2002-06-05 2003-12-10 Bracco Imaging S.p.A. Mittel fur magnetisches Bildformungsverfahren
JP2004307356A (ja) * 2003-04-02 2004-11-04 Hamamatsu Kagaku Gijutsu Kenkyu Shinkokai 新規なデンドリマーおよび造影剤
WO2006027244A2 (en) * 2004-09-10 2006-03-16 Bracco Imaging S.P.A. Paramagnetic metal polyamino complexes for mri visualization of internalized polynucleotides
EP2436409A1 (de) * 2004-09-28 2012-04-04 Mallinckrodt LLC Behälter mit eingeschränktem Qualitätswahrungsmittel
WO2006095745A1 (ja) * 2005-03-07 2006-09-14 National University Corporation Shizuoka University ジエチレントリアミン五酢酸誘導体、ガドリニウム－ジエチレントリアミン五酢酸誘導体の錯体及びｍｒｉ造影剤並びに富血性腫瘍特異性造影剤
WO2007142804A2 (en) * 2006-06-01 2007-12-13 Mallinckrodt Inc. Preparation of complexing agents and metal ion complexes in aqueous media
JPWO2008044443A1 (ja) * 2006-10-06 2010-02-04 国立大学法人静岡大学 ガドリニウム化合物及びｍｒｉ用造影剤
US7875747B2 (en) * 2006-10-10 2011-01-25 Afton Chemical Corporation Branched succinimide dispersant compounds and methods of making the compounds
CN100560138C (zh) * 2007-02-02 2009-11-18 厦门大学 一种核磁共振成像造影剂及其制备方法
KR101098136B1 (ko) * 2009-09-02 2011-12-26 경북대학교 산학협력단 높은 자기 이완율을 가지는 상자성 다핵금속착물, 이의 제조방법 및 이를 포함하는 조영제
WO2011133115A1 (en) * 2010-04-22 2011-10-27 Singapore Health Services Pte. Ltd. Tumour radiolabelling imaging agents comprising ornithine and derivatives thereof
FR2986332A1 (fr) * 2012-01-30 2013-08-02 Centre Nat Rech Scient Nanoparticules a luminescence persistante pour l'imagerie optique en temps reel, l'imagerie multimodale optique-irm in vivo, et la theranostique
US20150015252A1 (en) * 2012-03-09 2015-01-15 New York University Methods and Kits for Detecting Non-Luminescent or Weakly Luminescent Metals
FR3046172B1 (fr) * 2015-12-24 2019-05-31 Guerbet Ligands macrocycliques avec groupement(s) picolinate(s), leurs complexes ainsi que leurs utilisations medicales
WO2017178301A1 (en) * 2016-04-13 2017-10-19 Bracco Imaging Spa Contrast agents
CN115894301B (zh) * 2022-10-25 2024-08-13 武汉大学中南医院 一种二聚化钆基t1磁共振对比造影剂及其制备方法和用途

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* Cited by examiner, † Cited by third party
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US4622420A (en) * 1980-03-18 1986-11-11 The Regents Of The University Of California Chelating agents and method
US5672334A (en) * 1991-01-16 1997-09-30 Access Pharmaceuticals, Inc. Invivo agents comprising cationic metal chelators with acidic saccharides and glycosaminoglycans
US4822594A (en) 1987-01-27 1989-04-18 Gibby Wendell A Contrast enhancing agents for magnetic resonance images
US5364613A (en) * 1989-04-07 1994-11-15 Sieving Paul F Polychelants containing macrocyclic chelant moieties
EP0504322B1 (de) 1989-12-11 1996-02-14 E.I. Du Pont De Nemours And Company Teilweise fluorierte verbindungen und polymere
US5162109A (en) * 1990-09-13 1992-11-10 Mallinckrodt Medical, Inc. Magnetic resonance imaging agents
CA2115275A1 (en) 1991-08-09 1993-02-18 David L. White Amino acid, ester and/or catechol contrast agents for mri
US5562894A (en) * 1991-08-09 1996-10-08 Regents Of The University Of California Amino-acyl-type and catecholamine-type contrast agents for MRI
US5620675A (en) * 1992-06-23 1997-04-15 Diatech, Inc. Radioactive peptides
WO1994002068A1 (en) * 1992-07-21 1994-02-03 The General Hospital Corporation System of drug delivery to the lymphatic tissues
US5330743A (en) * 1992-11-12 1994-07-19 Magnetic Research, Inc. Aminosaccharide contrast agents for magnetic resonance images
ES2156143T3 (es) 1993-12-30 2001-06-16 Guerbet Sa Ligandos poliaminados, complejos metalicos, procedimiento de preparacion, aplicaciones diagnosticas y terapeuticas.
JPH07330773A (ja) * 1994-06-07 1995-12-19 Toyo Hatsuka Kogyo Kk ポルフィリン誘導体とその用途
IT1283218B1 (it) 1996-03-08 1998-04-16 Bracco Spa Polichelanti, loro complessi con ioni metallici, loro preparazione e loro usi
IT1283651B1 (it) 1996-08-02 1998-04-23 Bracco Spa Chelati paramagnetici ad alta relassivita' in siero
GB9708265D0 (en) 1997-04-24 1997-06-18 Nycomed Imaging As Contrast agents
DE19652387A1 (de) 1996-12-04 1998-06-10 Schering Ag Macrocyclische Metallkomplexcarbonsäuren, ihre Verwendung sowie Verfahren zu ihrer Herstellung
EP1032430A2 (de) 1997-11-17 2000-09-06 Research Corporation Technologies, Inc. Mri-mittel zum nachweis von physiologischen mitteln
US6093382A (en) 1998-05-16 2000-07-25 Bracco Research Usa Inc. Metal complexes derivatized with folate for use in diagnostic and therapeutic applications
IL145723A0 (en) 2000-10-11 2002-07-25 Nihon Mediphysics Co Ltd Process for producing an amide compound
EP1369134A1 (de) * 2002-06-05 2003-12-10 Bracco Imaging S.p.A. Mittel fur magnetisches Bildformungsverfahren

Also Published As

Publication number Publication date
JP2005528453A (ja) 2005-09-22
US20050175543A1 (en) 2005-08-11
AU2003238192A1 (en) 2003-12-22
EP1369134A1 (de) 2003-12-10
EP1509254A1 (de) 2005-03-02
EP1509254B1 (de) 2009-01-14
DE60325849D1 (de) 2009-03-05
WO2003103722A1 (en) 2003-12-18
US7780952B2 (en) 2010-08-24
US8961927B2 (en) 2015-02-24
JP4469273B2 (ja) 2010-05-26
US20100311962A1 (en) 2010-12-09

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