MXPA04000408A - Ligandos aza multidentados capaces de formar complejos con iones metalicos y uso de los mismos en diagnostico y terapia. - Google Patents

Ligandos aza multidentados capaces de formar complejos con iones metalicos y uso de los mismos en diagnostico y terapia.

Info

Publication number
MXPA04000408A
MXPA04000408A MXPA04000408A MXPA04000408A MXPA04000408A MX PA04000408 A MXPA04000408 A MX PA04000408A MX PA04000408 A MXPA04000408 A MX PA04000408A MX PA04000408 A MXPA04000408 A MX PA04000408A MX PA04000408 A MXPA04000408 A MX PA04000408A
Authority
MX
Mexico
Prior art keywords
aryl
alkyl
cycloalkylalkyl
cycloalkyl
hydrogen
Prior art date
Application number
MXPA04000408A
Other languages
English (en)
Inventor
Battista Giovenzana Giovanni
Original Assignee
Bracco Imaging Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Imaging Spa filed Critical Bracco Imaging Spa
Publication of MXPA04000408A publication Critical patent/MXPA04000408A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

La presente invencion se refiere a compuestos de formula general (I), en la cual: R1 es hidrogeno, alquilo de 1 a 20 atomos de carbono, cicloalquilo de 3 a 10 atomos de carbono, cicloalquilalquilo de 4 a 20 atomos de carbono, arilo, arilalquilo o los dos grupos R1, tomados juntos, forman un grupo alquileno de 2 a 10 atomos de carbono ciclico o lineal o un arileno orto-disubstituido; R2 es hidrogeno, alquilo de 1 a 20 atomos de carbono, cicloalquilo de 3 a 10 atomos de carbono, cicloalquilalquilo de 4 a 20 atomos de carbono, arilo o arilalquilo opcionalmente substituido con grupos funcionales los cuales permiten la conjugacion con una molecula adecuada capaz de interactuar con sistemas fisiologicos; R3, R4 y R5 son hidrogeno, alquilo de 1 a 20 atomos de carbono, cicloalquilo de 3 a 10 atomos de carbono, cicloalquilalquilo de 4 a 20 atomos de carbono, arilo, arilalquilo; y sus quelatos con iones bi-trivalentes de los elementos metalicos que tienen un numero atomico que varia entre 20 y 31, 39, 42, 43, 44, 49 y entre 57 y 83, y radioisotopos seleccionados entre 203Pb, 67Ga, 68Ga, 72As,111In,113In , 90Y, 97Ru, 62Cu, 64Cu, 52Fe, 52mMn, 140La, 175Yb, 153Sm, 166Ho, 149Pm, 177Lu, 142Pr, 159Gd, 212Bi , 47Sc, 149Pm, 67Cu, 111Ag, 199Au, 161Tb, y 51Cr, asi como las sales de los mismos con bases o acidos fisiologicamente compatibles.
MXPA04000408A 2001-07-17 2002-07-10 Ligandos aza multidentados capaces de formar complejos con iones metalicos y uso de los mismos en diagnostico y terapia. MXPA04000408A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2001MI001518A ITMI20011518A1 (it) 2001-07-17 2001-07-17 Leganti azotati multidentati capaci di complessare ioni metallici e loro uso in diagnostica e in terapia
PCT/EP2002/007658 WO2003008390A1 (en) 2001-07-17 2002-07-10 Multidentate aza ligands able to complex metal ions and the use thereof in diagnostics and therapy

Publications (1)

Publication Number Publication Date
MXPA04000408A true MXPA04000408A (es) 2004-03-18

Family

ID=11448069

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA04000408A MXPA04000408A (es) 2001-07-17 2002-07-10 Ligandos aza multidentados capaces de formar complejos con iones metalicos y uso de los mismos en diagnostico y terapia.

Country Status (22)

Country Link
US (1) US7186400B2 (es)
EP (2) EP1417183B1 (es)
JP (1) JP4249610B2 (es)
KR (1) KR100890471B1 (es)
CN (1) CN100443476C (es)
AT (2) ATE362921T1 (es)
AU (1) AU2002331348B2 (es)
CA (1) CA2453845C (es)
DE (1) DE60220282T2 (es)
DK (1) DK1417183T3 (es)
ES (1) ES2286278T3 (es)
HK (1) HK1061031A1 (es)
HU (1) HU228830B1 (es)
IL (2) IL159874A0 (es)
IT (1) ITMI20011518A1 (es)
MX (1) MXPA04000408A (es)
NO (1) NO328840B1 (es)
PL (1) PL202690B1 (es)
PT (1) PT1417183E (es)
SI (1) SI1417183T1 (es)
WO (1) WO2003008390A1 (es)
ZA (1) ZA200400318B (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7893223B2 (en) * 2001-07-17 2011-02-22 Bracco Imaging S.P.A. Multidentate AZA ligands able to complex metal ions and the use thereof in diagnostics and therapy
US7922998B2 (en) * 2003-01-13 2011-04-12 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US7850947B2 (en) 2003-01-13 2010-12-14 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US8420050B2 (en) 2003-01-13 2013-04-16 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US7611692B2 (en) 2003-01-13 2009-11-03 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US7226577B2 (en) 2003-01-13 2007-06-05 Bracco Imaging, S. P. A. Gastrin releasing peptide compounds
WO2006002873A2 (en) * 2004-07-02 2006-01-12 Bracco Imaging Spa 1 , 4 -bis (carboxymethyl) -6- ' bis ( carboxymethyl) amino ! -6 -methyl- perhydro-1 , 4 diazepine (aazta) derivatives as ligands in high relaxivity contrast agents for use in magnetic resonance imaging (mri )
FR2883562B1 (fr) 2005-03-24 2009-02-27 Guerbet Sa Chelates lipophiles et leur utilisation en imagerie
US8986650B2 (en) 2005-10-07 2015-03-24 Guerbet Complex folate-NOTA-Ga68
WO2007042504A2 (fr) 2005-10-07 2007-04-19 Guerbet Composes comprenant une partie de reconnaissance d'une cible biologique, couplee a une partie de signal capable de complexer le gallium
FR2891830B1 (fr) 2005-10-07 2011-06-24 Guerbet Sa Composes a chaines aminoalcools courtes et complexes metalliques pour l'imagerie medicale
EP2111237B1 (en) 2006-12-11 2015-03-18 BRACCO IMAGING S.p.A. Fibrin-binding peptides and conjugates thereof
EP2476703A1 (en) 2011-01-14 2012-07-18 Bracco Imaging S.p.A Human antibodies cross-reacting with a bacterial and a self antigen from atherosclerotic plaques
EP2147684A1 (en) 2008-07-22 2010-01-27 Bracco Imaging S.p.A Diagnostic Agents Selective Against Metalloproteases
JP5376130B2 (ja) * 2009-03-24 2013-12-25 独立行政法人日本原子力研究開発機構 抗体標識が可能な無担体１７７Ｌｕの分離精製法
WO2012095516A1 (en) 2011-01-14 2012-07-19 Bracco Imaging Spa Human antibodies cross-reacting with a bacterial and a self antigen from atherosclerotic plaques
EP2822605A1 (en) 2012-03-05 2015-01-14 Bracco Imaging S.p.A Dynamic contrast enhanced mri method and agents for the assessment of the macromolecular transport within pathologic tissues
EP2639227A1 (en) 2012-03-14 2013-09-18 Bracco Imaging S.p.A A new class of diazepine derivative chelating agents and complexes with paramagnetic metals as MRI contrast agents
CN104602715A (zh) 2012-09-07 2015-05-06 伯拉考成像股份公司 用于MRI的包含金属两亲配合物的顺磁性固体脂质纳米颗粒(pSLN)
DE102013106066A1 (de) 2013-06-11 2014-12-11 Johannes-Gutenberg-Universität Mainz Bifunktionelle Chelatbildner auf der Basis des 1,4-Diazepin-Gerüsts (DAZA) für die nicht invasive molekulare Bilddarstellung
US9259725B2 (en) * 2013-10-10 2016-02-16 Lawrence Livermore National Security, Llc Acyclic aza-containing ligands for use as catalytic carbon capture systems
US11370826B2 (en) 2016-02-09 2022-06-28 Bracco Suisse Sa Recombinant chimeric protein for selectins targeting
DE102017129405A1 (de) 2017-12-11 2019-06-13 Universitätsklinikum Jena Neue DAZA-Chelatoren als Liganden in der Leberbildgebung
CN112996764B (zh) 2018-11-12 2023-11-21 伯拉考成像股份公司 螯合aazta缀合物及其配合物
CN114262351B (zh) * 2022-03-01 2022-05-13 宜宾锂宝新材料有限公司 一种普鲁士蓝正极材料及其制备方法与应用、电池

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3107260A (en) * 1960-11-29 1963-10-15 Geigy Chem Corp Triaminopropane hexa-acetic acid and metal chelates thereof
DE3938992A1 (de) * 1989-11-21 1991-05-23 Schering Ag Kaskadenpolymer-gebundene komplexbildner, deren komplexe und konjugate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
CA2074484A1 (en) * 1990-11-26 1992-05-27 Edward J. Carlin Stabilized hexahydro-5-pyrimidinamine compounds in aqueous solution and methods for preparing same
IT1283650B1 (it) * 1996-08-02 1998-04-23 Bracco Spa Chelati paramagnetici ad alta relassivita' in siero
US6403055B1 (en) * 1996-08-02 2002-06-11 Dibra S.P.A. Diagnostic imaging contrast agent with improved in serum relaxivity

Also Published As

Publication number Publication date
CA2453845A1 (en) 2003-01-30
IL159874A0 (en) 2004-06-20
DE60220282T2 (de) 2008-01-24
WO2003008390A1 (en) 2003-01-30
PT1417183E (pt) 2007-07-31
HUP0400997A3 (en) 2010-03-29
IL159874A (en) 2008-11-03
PL202690B1 (pl) 2009-07-31
NO328840B1 (no) 2010-05-25
JP2005504027A (ja) 2005-02-10
ITMI20011518A0 (it) 2001-07-17
KR20040018461A (ko) 2004-03-03
ZA200400318B (en) 2006-04-26
EP1417183A1 (en) 2004-05-12
KR100890471B1 (ko) 2009-03-26
DE60220282D1 (de) 2007-07-05
HU228830B1 (hu) 2013-05-28
HK1061031A1 (en) 2004-09-03
ES2286278T3 (es) 2007-12-01
US20040156786A1 (en) 2004-08-12
HUP0400997A2 (hu) 2004-09-28
AU2002331348B2 (en) 2008-04-10
DK1417183T3 (da) 2007-10-01
EP1417183B1 (en) 2007-05-23
NO20040179L (no) 2004-03-15
CN1533381A (zh) 2004-09-29
JP4249610B2 (ja) 2009-04-02
EP1803711A1 (en) 2007-07-04
ATE362921T1 (de) 2007-06-15
PL367007A1 (en) 2005-02-07
ATE529414T1 (de) 2011-11-15
EP1803711B1 (en) 2011-10-19
ITMI20011518A1 (it) 2003-01-17
CN100443476C (zh) 2008-12-17
US7186400B2 (en) 2007-03-06
SI1417183T1 (sl) 2007-10-31
CA2453845C (en) 2011-07-05

Similar Documents

Publication Publication Date Title
MXPA04000408A (es) Ligandos aza multidentados capaces de formar complejos con iones metalicos y uso de los mismos en diagnostico y terapia.
HU9302310D0 (en) Process for producing bicyclo-polyaza-macrocyclo-phosphonic acid complexes and conjugates and pharmaceutical compositions containing them
RU93052883A (ru) Комплексы бициклополиазамакроциклофосфоновой кислоты, их получение, коньюгаты и радиоактивные фармацевтические препараты
KR102052571B1 (ko) 저친화도 혈액-뇌 장벽 수용체 항체 및 그의 용도
ES2533695T3 (es) Anticuerpos cargados parcialmente y métodos para su conjugación
Rhodes Direct labeling of proteins with 99mTc
WO2005023866A3 (en) Peptides that inhibit complement activation
FI117424B (fi) Peptidejä
CA2835298A1 (en) Pretargeting kit for imaging or therapy comprising a trans - cyclooctene dienophile and a diene
CA2224153A1 (en) Radiolabeled peptide compositions for site-specific targeting
CA3026815A1 (en) Cell targeting conjugates
WO2004067027A3 (en) Osteogenic composition
TR200101366T2 (tr) Farmasötik kompozisyonların muhtevasında bulunan bazı substitüte kaprolaktamlar ve tümör tedavisinde kullanımları.
EP1151089A4 (en) CATALYTIC MOLECULES
MY134745A (en) Bicyclopolyazamacrocyclophosphonic acid complexes their preparation, conjugates and radiopharmaceuticals
MX9802107A (es) Derivados de biotina marcados radiactivamente.
RU93054509A (ru) Комплексы бициклополиазамакроциклофосфоновой кислоты их получение, конъюгаты, фармацевтические композиции - набор для диагностики и лечения
CA2506091A1 (en) Agents for the diagnosis and treatment of tumours that expose altered proteins on the cell surface
HUP9902664A2 (hu) Jelzett biotinszármazékok, eljárás e vegyületek előállítására, valamint e vegyületeket tartalmazó gyógyászati készítmények, ilyen készítmény előállítására szolgáló készlet, továbbá eljárás tumorok detektálására és lokalizálására
PT811068E (pt) Variantes da adnase i humana
RU2003135123A (ru) Способ лечения наркотических зависимостей
AU698763B2 (en) Process for preparing macrocyclic chelating agents and formation of chelates and conjugates thereof
CN104662042A (zh) 防止生物膜形成的方法
WO2023250463A2 (en) Combination therapies with an anti-factor xi/factor xia antibody
Arteaga de Murphy et al. Phosphine reduced IgG: A new method for 99m Tc labeling immunoglobulins

Legal Events

Date Code Title Description
FG Grant or registration