ITMI20011518A0 - Leganti azotati multidentati capaci di complessare ioni metallici e loro uso in diagnostica e in terapia - Google Patents

Leganti azotati multidentati capaci di complessare ioni metallici e loro uso in diagnostica e in terapia

Info

Publication number
ITMI20011518A0
ITMI20011518A0 IT2001MI001518A ITMI20011518A ITMI20011518A0 IT MI20011518 A0 ITMI20011518 A0 IT MI20011518A0 IT 2001MI001518 A IT2001MI001518 A IT 2001MI001518A IT MI20011518 A ITMI20011518 A IT MI20011518A IT MI20011518 A0 ITMI20011518 A0 IT MI20011518A0
Authority
IT
Italy
Prior art keywords
multiidentified
diagnosis
therapy
metal ions
complexing metal
Prior art date
Application number
IT2001MI001518A
Other languages
English (en)
Inventor
Silvio Aime
Luisella Calabi
Giovanni Battista Giovenzana
Giovanni Palmisano
Massimo Sisti
Camilla Cavallotti
Original Assignee
Bracco Imaging Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Imaging Spa filed Critical Bracco Imaging Spa
Priority to IT2001MI001518A priority Critical patent/ITMI20011518A1/it
Publication of ITMI20011518A0 publication Critical patent/ITMI20011518A0/it
Priority to KR1020047000593A priority patent/KR100890471B1/ko
Priority to AT07003558T priority patent/ATE529414T1/de
Priority to DK02767192T priority patent/DK1417183T3/da
Priority to AU2002331348A priority patent/AU2002331348B2/en
Priority to EP07003558A priority patent/EP1803711B1/en
Priority to PT02767192T priority patent/PT1417183E/pt
Priority to EP02767192A priority patent/EP1417183B1/en
Priority to CA2453845A priority patent/CA2453845C/en
Priority to PCT/EP2002/007658 priority patent/WO2003008390A1/en
Priority to SI200230566T priority patent/SI1417183T1/sl
Priority to CNB028142020A priority patent/CN100443476C/zh
Priority to MXPA04000408A priority patent/MXPA04000408A/es
Priority to JP2003513950A priority patent/JP4249610B2/ja
Priority to US10/484,111 priority patent/US7186400B2/en
Priority to PL367007A priority patent/PL202690B1/pl
Priority to DE60220282T priority patent/DE60220282T2/de
Priority to IL15987402A priority patent/IL159874A0/xx
Priority to ES02767192T priority patent/ES2286278T3/es
Priority to AT02767192T priority patent/ATE362921T1/de
Priority to HU0400997A priority patent/HU228830B1/hu
Publication of ITMI20011518A1 publication Critical patent/ITMI20011518A1/it
Priority to IL159874A priority patent/IL159874A/en
Priority to ZA200400318A priority patent/ZA200400318B/en
Priority to NO20040179A priority patent/NO328840B1/no
Priority to HK04104116A priority patent/HK1061031A1/xx
Priority to US11/165,793 priority patent/US7893223B2/en
Priority to US12/553,421 priority patent/US8105567B2/en
Priority to US12/949,306 priority patent/US20110082280A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Radiology & Medical Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
IT2001MI001518A 2001-07-17 2001-07-17 Leganti azotati multidentati capaci di complessare ioni metallici e loro uso in diagnostica e in terapia ITMI20011518A1 (it)

Priority Applications (28)

Application Number Priority Date Filing Date Title
IT2001MI001518A ITMI20011518A1 (it) 2001-07-17 2001-07-17 Leganti azotati multidentati capaci di complessare ioni metallici e loro uso in diagnostica e in terapia
HU0400997A HU228830B1 (hu) 2001-07-17 2002-07-10 Fémionokat komplexbe vinni képes többfogú aza-ligandumok, valamint alkalmazásuk a diagnosztikában és a terápiában
MXPA04000408A MXPA04000408A (es) 2001-07-17 2002-07-10 Ligandos aza multidentados capaces de formar complejos con iones metalicos y uso de los mismos en diagnostico y terapia.
US10/484,111 US7186400B2 (en) 2001-07-17 2002-07-10 Multidentate aza ligands able to complex metal ions and the use thereof in diagnostics and therapy
DK02767192T DK1417183T3 (da) 2001-07-17 2002-07-10 Multidentate aza-ligander i stand til at kompleksdanne metalioner og anvendelse heraf til diagnostik og terapi
AU2002331348A AU2002331348B2 (en) 2001-07-17 2002-07-10 Multidentate aza ligands able to complex metal ions and the use thereof in diagnostics and therapy
EP07003558A EP1803711B1 (en) 2001-07-17 2002-07-10 Process for the preparation of multidentate aza ligands able to complex metal ions
PT02767192T PT1417183E (pt) 2001-07-17 2002-07-10 Ligandos do tipo aza mutltidentados capazes de complexar com iões metálicos e a sua utilização em diagnósticos e terapêutica.
EP02767192A EP1417183B1 (en) 2001-07-17 2002-07-10 Multidentate aza ligands able to complex metal ions and the use thereof in diagnostics and therapy
CA2453845A CA2453845C (en) 2001-07-17 2002-07-10 Multidentate aza ligands able to complex metal ions and the use thereof in diagnostics and therapy
PCT/EP2002/007658 WO2003008390A1 (en) 2001-07-17 2002-07-10 Multidentate aza ligands able to complex metal ions and the use thereof in diagnostics and therapy
SI200230566T SI1417183T1 (sl) 2001-07-17 2002-07-10 Multidentatne aza spojine za kompleksacijo kovinskih ionov in uporaba omenjenih spojin v diagnostiki in terapiji
CNB028142020A CN100443476C (zh) 2001-07-17 2002-07-10 能够络合金属离子的多配基氮杂配体及其在诊断学和治疗学中的用途
KR1020047000593A KR100890471B1 (ko) 2001-07-17 2002-07-10 금속 이온을 배위할 수 있는 여러자리 아자 리간드 및진단 및 치료에 있어서의 그의 용도
JP2003513950A JP4249610B2 (ja) 2001-07-17 2002-07-10 金属イオンを錯化することができる多座アザ配位子ならびに診断及び治療におけるその使用
AT07003558T ATE529414T1 (de) 2001-07-17 2002-07-10 Verfahren zur herstellung von mehrzähnigen azaliganden zur komplexbildung mit metallionen
PL367007A PL202690B1 (pl) 2001-07-17 2002-07-10 Ligandy wielofunkcyjne typu aza zdolne do kompleksowania jonów metali i zawierające je kompozycje do stosowania w diagnostyce oraz terapii
DE60220282T DE60220282T2 (de) 2001-07-17 2002-07-10 Mehrzähnige, zur komplexierung von metallionen geeignete aza liganden und deren verwendung in diagnose und therapie
IL15987402A IL159874A0 (en) 2001-07-17 2002-07-10 Multidentate aza ligands able to complex metal ions and the use thereof in diagnostics and therapy
ES02767192T ES2286278T3 (es) 2001-07-17 2002-07-10 Ligandos aza multidentados que pueden complejarse con iones metalicos y uso de los mismos en diagnosticos y terapia.
AT02767192T ATE362921T1 (de) 2001-07-17 2002-07-10 Mehrzähnige, zur komplexierung von metallionen geeignete aza liganden und deren verwendung in diagnose und therapie
NO20040179A NO328840B1 (no) 2001-07-17 2004-01-15 Flertannet aza-ligander i stand til a kompleksere metallioner og anvendelse derav i diagnose og terapi
IL159874A IL159874A (en) 2001-07-17 2004-01-15 Aza multidentate linkages capable of binding metal ions and their use in diagnostics and medicine
ZA200400318A ZA200400318B (en) 2001-07-17 2004-01-15 Multidentate aza ligands able to complex metal ions and the use thereof in diagnostics and therapy
HK04104116A HK1061031A1 (en) 2001-07-17 2004-06-09 Multidentate aza ligands able to complex metal ions and the use thereof in diagnostics and therapy
US11/165,793 US7893223B2 (en) 2001-07-17 2005-06-24 Multidentate AZA ligands able to complex metal ions and the use thereof in diagnostics and therapy
US12/553,421 US8105567B2 (en) 2001-07-17 2009-09-03 Multidentate AZA ligands able to complex metal ions and the use thereof in diagnostics and therapy
US12/949,306 US20110082280A1 (en) 2001-07-17 2010-11-18 Methods Of Coupling Multidentate AZA Ligands To Targeting Molecules

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2001MI001518A ITMI20011518A1 (it) 2001-07-17 2001-07-17 Leganti azotati multidentati capaci di complessare ioni metallici e loro uso in diagnostica e in terapia

Publications (2)

Publication Number Publication Date
ITMI20011518A0 true ITMI20011518A0 (it) 2001-07-17
ITMI20011518A1 ITMI20011518A1 (it) 2003-01-17

Family

ID=11448069

Family Applications (1)

Application Number Title Priority Date Filing Date
IT2001MI001518A ITMI20011518A1 (it) 2001-07-17 2001-07-17 Leganti azotati multidentati capaci di complessare ioni metallici e loro uso in diagnostica e in terapia

Country Status (22)

Country Link
US (1) US7186400B2 (it)
EP (2) EP1417183B1 (it)
JP (1) JP4249610B2 (it)
KR (1) KR100890471B1 (it)
CN (1) CN100443476C (it)
AT (2) ATE362921T1 (it)
AU (1) AU2002331348B2 (it)
CA (1) CA2453845C (it)
DE (1) DE60220282T2 (it)
DK (1) DK1417183T3 (it)
ES (1) ES2286278T3 (it)
HK (1) HK1061031A1 (it)
HU (1) HU228830B1 (it)
IL (2) IL159874A0 (it)
IT (1) ITMI20011518A1 (it)
MX (1) MXPA04000408A (it)
NO (1) NO328840B1 (it)
PL (1) PL202690B1 (it)
PT (1) PT1417183E (it)
SI (1) SI1417183T1 (it)
WO (1) WO2003008390A1 (it)
ZA (1) ZA200400318B (it)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114262351A (zh) * 2022-03-01 2022-04-01 宜宾锂宝新材料有限公司 一种普鲁士蓝正极材料及其制备方法与应用、电池

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7893223B2 (en) * 2001-07-17 2011-02-22 Bracco Imaging S.P.A. Multidentate AZA ligands able to complex metal ions and the use thereof in diagnostics and therapy
US7922998B2 (en) * 2003-01-13 2011-04-12 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US7850947B2 (en) 2003-01-13 2010-12-14 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US8420050B2 (en) 2003-01-13 2013-04-16 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US7611692B2 (en) 2003-01-13 2009-11-03 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US7226577B2 (en) 2003-01-13 2007-06-05 Bracco Imaging, S. P. A. Gastrin releasing peptide compounds
WO2006002873A2 (en) * 2004-07-02 2006-01-12 Bracco Imaging Spa 1 , 4 -bis (carboxymethyl) -6- ' bis ( carboxymethyl) amino ! -6 -methyl- perhydro-1 , 4 diazepine (aazta) derivatives as ligands in high relaxivity contrast agents for use in magnetic resonance imaging (mri )
FR2883562B1 (fr) 2005-03-24 2009-02-27 Guerbet Sa Chelates lipophiles et leur utilisation en imagerie
US8986650B2 (en) 2005-10-07 2015-03-24 Guerbet Complex folate-NOTA-Ga68
WO2007042504A2 (fr) 2005-10-07 2007-04-19 Guerbet Composes comprenant une partie de reconnaissance d'une cible biologique, couplee a une partie de signal capable de complexer le gallium
FR2891830B1 (fr) 2005-10-07 2011-06-24 Guerbet Sa Composes a chaines aminoalcools courtes et complexes metalliques pour l'imagerie medicale
EP2111237B1 (en) 2006-12-11 2015-03-18 BRACCO IMAGING S.p.A. Fibrin-binding peptides and conjugates thereof
EP2476703A1 (en) 2011-01-14 2012-07-18 Bracco Imaging S.p.A Human antibodies cross-reacting with a bacterial and a self antigen from atherosclerotic plaques
EP2147684A1 (en) 2008-07-22 2010-01-27 Bracco Imaging S.p.A Diagnostic Agents Selective Against Metalloproteases
JP5376130B2 (ja) * 2009-03-24 2013-12-25 独立行政法人日本原子力研究開発機構 抗体標識が可能な無担体１７７Ｌｕの分離精製法
WO2012095516A1 (en) 2011-01-14 2012-07-19 Bracco Imaging Spa Human antibodies cross-reacting with a bacterial and a self antigen from atherosclerotic plaques
EP2822605A1 (en) 2012-03-05 2015-01-14 Bracco Imaging S.p.A Dynamic contrast enhanced mri method and agents for the assessment of the macromolecular transport within pathologic tissues
EP2639227A1 (en) 2012-03-14 2013-09-18 Bracco Imaging S.p.A A new class of diazepine derivative chelating agents and complexes with paramagnetic metals as MRI contrast agents
CN104602715A (zh) 2012-09-07 2015-05-06 伯拉考成像股份公司 用于MRI的包含金属两亲配合物的顺磁性固体脂质纳米颗粒(pSLN)
DE102013106066A1 (de) 2013-06-11 2014-12-11 Johannes-Gutenberg-Universität Mainz Bifunktionelle Chelatbildner auf der Basis des 1,4-Diazepin-Gerüsts (DAZA) für die nicht invasive molekulare Bilddarstellung
US9259725B2 (en) * 2013-10-10 2016-02-16 Lawrence Livermore National Security, Llc Acyclic aza-containing ligands for use as catalytic carbon capture systems
US11370826B2 (en) 2016-02-09 2022-06-28 Bracco Suisse Sa Recombinant chimeric protein for selectins targeting
DE102017129405A1 (de) 2017-12-11 2019-06-13 Universitätsklinikum Jena Neue DAZA-Chelatoren als Liganden in der Leberbildgebung
CN112996764B (zh) 2018-11-12 2023-11-21 伯拉考成像股份公司 螯合aazta缀合物及其配合物

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US3107260A (en) * 1960-11-29 1963-10-15 Geigy Chem Corp Triaminopropane hexa-acetic acid and metal chelates thereof
DE3938992A1 (de) * 1989-11-21 1991-05-23 Schering Ag Kaskadenpolymer-gebundene komplexbildner, deren komplexe und konjugate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
CA2074484A1 (en) * 1990-11-26 1992-05-27 Edward J. Carlin Stabilized hexahydro-5-pyrimidinamine compounds in aqueous solution and methods for preparing same
IT1283650B1 (it) * 1996-08-02 1998-04-23 Bracco Spa Chelati paramagnetici ad alta relassivita' in siero
US6403055B1 (en) * 1996-08-02 2002-06-11 Dibra S.P.A. Diagnostic imaging contrast agent with improved in serum relaxivity

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114262351A (zh) * 2022-03-01 2022-04-01 宜宾锂宝新材料有限公司 一种普鲁士蓝正极材料及其制备方法与应用、电池

Also Published As

Publication number Publication date
CA2453845A1 (en) 2003-01-30
IL159874A0 (en) 2004-06-20
DE60220282T2 (de) 2008-01-24
WO2003008390A1 (en) 2003-01-30
MXPA04000408A (es) 2004-03-18
PT1417183E (pt) 2007-07-31
HUP0400997A3 (en) 2010-03-29
IL159874A (en) 2008-11-03
PL202690B1 (pl) 2009-07-31
NO328840B1 (no) 2010-05-25
JP2005504027A (ja) 2005-02-10
KR20040018461A (ko) 2004-03-03
ZA200400318B (en) 2006-04-26
EP1417183A1 (en) 2004-05-12
KR100890471B1 (ko) 2009-03-26
DE60220282D1 (de) 2007-07-05
HU228830B1 (hu) 2013-05-28
HK1061031A1 (en) 2004-09-03
ES2286278T3 (es) 2007-12-01
US20040156786A1 (en) 2004-08-12
HUP0400997A2 (hu) 2004-09-28
AU2002331348B2 (en) 2008-04-10
DK1417183T3 (da) 2007-10-01
EP1417183B1 (en) 2007-05-23
NO20040179L (no) 2004-03-15
CN1533381A (zh) 2004-09-29
JP4249610B2 (ja) 2009-04-02
EP1803711A1 (en) 2007-07-04
ATE362921T1 (de) 2007-06-15
PL367007A1 (en) 2005-02-07
ATE529414T1 (de) 2011-11-15
EP1803711B1 (en) 2011-10-19
ITMI20011518A1 (it) 2003-01-17
CN100443476C (zh) 2008-12-17
US7186400B2 (en) 2007-03-06
SI1417183T1 (sl) 2007-10-31
CA2453845C (en) 2011-07-05

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