DE60219400T2 - Reaktionsblock für parallele Synthesechemie und Gefäss dafür - Google Patents

Reaktionsblock für parallele Synthesechemie und Gefäss dafür Download PDF

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Publication number
DE60219400T2
DE60219400T2 DE60219400T DE60219400T DE60219400T2 DE 60219400 T2 DE60219400 T2 DE 60219400T2 DE 60219400 T DE60219400 T DE 60219400T DE 60219400 T DE60219400 T DE 60219400T DE 60219400 T2 DE60219400 T2 DE 60219400T2
Authority
DE
Germany
Prior art keywords
reaction
reaction chamber
reaction vessel
channel
vessel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60219400T
Other languages
German (de)
English (en)
Other versions
DE60219400D1 (de
Inventor
Dieter Voegelin
Roman Bär
Claus Müller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of DE60219400D1 publication Critical patent/DE60219400D1/de
Publication of DE60219400T2 publication Critical patent/DE60219400T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29CSHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C45/00Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
    • B29C45/17Component parts, details or accessories; Auxiliary operations
    • B29C45/40Removing or ejecting moulded articles
    • B29C45/44Removing or ejecting moulded articles for undercut articles
    • B29C45/4471Removing or ejecting moulded articles for undercut articles using flexible or pivotable undercut forming elements
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00279Features relating to reactor vessels
    • B01J2219/00281Individual reactor vessels
    • B01J2219/00283Reactor vessels with top opening
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00279Features relating to reactor vessels
    • B01J2219/00306Reactor vessels in a multiple arrangement
    • B01J2219/00308Reactor vessels in a multiple arrangement interchangeably mounted in racks or blocks
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00279Features relating to reactor vessels
    • B01J2219/00306Reactor vessels in a multiple arrangement
    • B01J2219/00308Reactor vessels in a multiple arrangement interchangeably mounted in racks or blocks
    • B01J2219/0031Reactor vessels in a multiple arrangement interchangeably mounted in racks or blocks the racks or blocks being mounted in stacked arrangements
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00279Features relating to reactor vessels
    • B01J2219/00331Details of the reactor vessels
    • B01J2219/00333Closures attached to the reactor vessels
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00351Means for dispensing and evacuation of reagents
    • B01J2219/00389Feeding through valves
    • B01J2219/00405Sliding valves
    • B01J2219/00407In multiple arrangements
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00351Means for dispensing and evacuation of reagents
    • B01J2219/00414Means for dispensing and evacuation of reagents using suction
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00351Means for dispensing and evacuation of reagents
    • B01J2219/00418Means for dispensing and evacuation of reagents using pressure
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00351Means for dispensing and evacuation of reagents
    • B01J2219/00423Means for dispensing and evacuation of reagents using filtration, e.g. through porous frits
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00585Parallel processes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00596Solid-phase processes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02Adapting objects or devices to another
    • B01L2200/026Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/04Closures and closing means
    • B01L2300/041Connecting closures to device or container
    • B01L2300/045Connecting closures to device or container whereby the whole cover is slidable
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/06Auxiliary integrated devices, integrated components
    • B01L2300/0681Filter
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mechanical Engineering (AREA)
  • Manufacturing & Machinery (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Moulds For Moulding Plastics Or The Like (AREA)
DE60219400T 2001-09-07 2002-08-19 Reaktionsblock für parallele Synthesechemie und Gefäss dafür Expired - Lifetime DE60219400T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01810859A EP1291074A1 (en) 2001-09-07 2001-09-07 Reaction block for parallel synthetic chemistry and vessel therefor
EP01810859 2001-09-07

Publications (2)

Publication Number Publication Date
DE60219400D1 DE60219400D1 (de) 2007-05-24
DE60219400T2 true DE60219400T2 (de) 2007-12-27

Family

ID=8184124

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60219400T Expired - Lifetime DE60219400T2 (de) 2001-09-07 2002-08-19 Reaktionsblock für parallele Synthesechemie und Gefäss dafür

Country Status (7)

Country Link
US (2) US20030170147A1 (OSRAM)
EP (1) EP1291074A1 (OSRAM)
JP (1) JP4681793B2 (OSRAM)
AT (1) ATE359117T1 (OSRAM)
CA (1) CA2397827C (OSRAM)
DE (1) DE60219400T2 (OSRAM)
ES (1) ES2284782T3 (OSRAM)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3805352B1 (ja) * 2005-05-25 2006-08-02 株式会社エンプラス 流体取扱装置およびそれに用いる流体取扱ユニット
JP4680037B2 (ja) * 2005-11-14 2011-05-11 株式会社エンプラス 流体取扱装置およびそれに用いる流体取扱ユニット
EP1872855A1 (en) * 2006-06-27 2008-01-02 F.Hoffmann-La Roche Ag Plate for equilibrating a fluid
DE102006030068A1 (de) * 2006-06-28 2008-01-03 M2P-Labs Gmbh Vorrichtung und Verfahren zur Zu- und Abfuhr von Fluiden in geschüttelten Mikroreaktoren Arrays
CN108367290B (zh) * 2015-10-01 2021-06-04 伯克利之光生命科技公司 井孔板培养器
WO2018102781A1 (en) 2016-12-01 2018-06-07 Berkeley Lights, Inc. Well-plate incubator
CN108819126B (zh) * 2018-07-25 2024-08-02 东莞广泽汽车饰件有限公司 一种汽车装饰件的注塑模具
WO2023039404A1 (en) * 2021-09-08 2023-03-16 Meso Scale Technologies, Llc. Sample collection device

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1171178B (de) * 1960-02-06 1964-05-27 Martin Christ Fa Zentrifugenzelle
GB1064901A (en) * 1965-01-19 1967-04-12 Alfred George Wright Improvements relating to centrifuges
JPS5866852A (ja) * 1981-10-19 1983-04-21 Olympus Optical Co Ltd U字形反応容器
US4605536A (en) * 1984-05-29 1986-08-12 Veb Metaplast Quedlinburg Cuvette for projection display of chemical experiments
JPS6356420A (ja) * 1986-08-27 1988-03-11 Fukuraito Kk 歯科用デイスポ−ザブルシリンジの製造法
JPH01317733A (ja) * 1988-06-20 1989-12-22 Terumo Corp 有底筒状成形物、有底筒状成形物製造用金型および有底筒状成形物の製造方法
US5395006A (en) * 1993-04-29 1995-03-07 Verma; Kuldeep Fermentation vessels and closures therefor
US5641681A (en) * 1995-04-17 1997-06-24 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Device and method for screening crystallization conditions in solution crystal growth
GB9515831D0 (en) * 1995-08-02 1995-10-04 The Technology Partnership Plc Automated chemical synthesis system
US5746982A (en) * 1996-02-29 1998-05-05 Advanced Chemtech, Inc. Apparatus for automated synthesis of chemical compounds
US5972694A (en) * 1997-02-11 1999-10-26 Mathus; Gregory Multi-well plate
CA2294941A1 (en) * 1997-06-16 1998-12-23 Chemspeed Ltd. Reaction vessel holding device
US5801055A (en) * 1997-09-10 1998-09-01 Becton Dickinson And Company Multi-well culture dish assembly
JP2001522714A (ja) * 1997-11-08 2001-11-20 ケムスピード・リミテッド 温度制御され揺りが与えられる反応容器を保持する装置
DE19915811C2 (de) * 1999-04-08 2001-05-03 Boehringer Ingelheim Pharma Reaktionsgefäß
US6811752B2 (en) * 2001-05-15 2004-11-02 Biocrystal, Ltd. Device having microchambers and microfluidics
US20070140925A1 (en) * 2005-11-11 2007-06-21 Phelps David Y Automated chemical synthesizer and method for synthesis using same

Also Published As

Publication number Publication date
US20060263273A1 (en) 2006-11-23
EP1291074A1 (en) 2003-03-12
JP2003190773A (ja) 2003-07-08
JP4681793B2 (ja) 2011-05-11
DE60219400D1 (de) 2007-05-24
US20030170147A1 (en) 2003-09-11
CA2397827C (en) 2008-04-29
ES2284782T3 (es) 2007-11-16
ATE359117T1 (de) 2007-05-15
CA2397827A1 (en) 2003-03-07
US7794668B2 (en) 2010-09-14

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