CA2397827C - Reaction block for parallel synthetic chemistry and vessel therefor - Google Patents
Reaction block for parallel synthetic chemistry and vessel therefor Download PDFInfo
- Publication number
- CA2397827C CA2397827C CA002397827A CA2397827A CA2397827C CA 2397827 C CA2397827 C CA 2397827C CA 002397827 A CA002397827 A CA 002397827A CA 2397827 A CA2397827 A CA 2397827A CA 2397827 C CA2397827 C CA 2397827C
- Authority
- CA
- Canada
- Prior art keywords
- reaction
- discharge channel
- reaction chamber
- reaction vessel
- vessels
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000006243 chemical reaction Methods 0.000 title claims abstract description 231
- 238000001746 injection moulding Methods 0.000 claims abstract description 13
- 238000000465 moulding Methods 0.000 claims abstract description 7
- 239000000463 material Substances 0.000 claims description 16
- 239000012429 reaction media Substances 0.000 claims description 9
- 238000004519 manufacturing process Methods 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 6
- 238000003786 synthesis reaction Methods 0.000 claims description 5
- 238000002347 injection Methods 0.000 claims description 4
- 239000007924 injection Substances 0.000 claims description 4
- 230000000284 resting effect Effects 0.000 claims description 4
- 230000003247 decreasing effect Effects 0.000 claims description 3
- 239000004743 Polypropylene Substances 0.000 claims description 2
- 229920000840 ethylene tetrafluoroethylene copolymer Polymers 0.000 claims description 2
- 229920002313 fluoropolymer Polymers 0.000 claims description 2
- -1 polypropylene Polymers 0.000 claims description 2
- 229920001155 polypropylene Polymers 0.000 claims description 2
- 239000012815 thermoplastic material Substances 0.000 claims description 2
- 238000001914 filtration Methods 0.000 claims 4
- 239000007788 liquid Substances 0.000 abstract description 10
- 108091006146 Channels Proteins 0.000 description 83
- 238000007789 sealing Methods 0.000 description 12
- 239000011261 inert gas Substances 0.000 description 5
- 239000011888 foil Substances 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 238000013022 venting Methods 0.000 description 2
- 229920006355 Tefzel Polymers 0.000 description 1
- 229910052786 argon Inorganic materials 0.000 description 1
- 238000003491 array Methods 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- RKTYLMNFRDHKIL-UHFFFAOYSA-N copper;5,10,15,20-tetraphenylporphyrin-22,24-diide Chemical compound [Cu+2].C1=CC(C(=C2C=CC([N-]2)=C(C=2C=CC=CC=2)C=2C=CC(N=2)=C(C=2C=CC=CC=2)C2=CC=C3[N-]2)C=2C=CC=CC=2)=NC1=C3C1=CC=CC=C1 RKTYLMNFRDHKIL-UHFFFAOYSA-N 0.000 description 1
- 238000012631 diagnostic technique Methods 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- QHSJIZLJUFMIFP-UHFFFAOYSA-N ethene;1,1,2,2-tetrafluoroethene Chemical compound C=C.FC(F)=C(F)F QHSJIZLJUFMIFP-UHFFFAOYSA-N 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 239000012065 filter cake Substances 0.000 description 1
- NBVXSUQYWXRMNV-UHFFFAOYSA-N fluoromethane Chemical compound FC NBVXSUQYWXRMNV-UHFFFAOYSA-N 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000009499 grossing Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
- B29C45/17—Component parts, details or accessories; Auxiliary operations
- B29C45/40—Removing or ejecting moulded articles
- B29C45/44—Removing or ejecting moulded articles for undercut articles
- B29C45/4471—Removing or ejecting moulded articles for undercut articles using flexible or pivotable undercut forming elements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00281—Individual reactor vessels
- B01J2219/00283—Reactor vessels with top opening
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00306—Reactor vessels in a multiple arrangement
- B01J2219/00308—Reactor vessels in a multiple arrangement interchangeably mounted in racks or blocks
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00306—Reactor vessels in a multiple arrangement
- B01J2219/00308—Reactor vessels in a multiple arrangement interchangeably mounted in racks or blocks
- B01J2219/0031—Reactor vessels in a multiple arrangement interchangeably mounted in racks or blocks the racks or blocks being mounted in stacked arrangements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00331—Details of the reactor vessels
- B01J2219/00333—Closures attached to the reactor vessels
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00389—Feeding through valves
- B01J2219/00405—Sliding valves
- B01J2219/00407—In multiple arrangements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00414—Means for dispensing and evacuation of reagents using suction
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00418—Means for dispensing and evacuation of reagents using pressure
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00423—Means for dispensing and evacuation of reagents using filtration, e.g. through porous frits
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00585—Parallel processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00596—Solid-phase processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/04—Closures and closing means
- B01L2300/041—Connecting closures to device or container
- B01L2300/045—Connecting closures to device or container whereby the whole cover is slidable
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0681—Filter
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
- C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mechanical Engineering (AREA)
- Manufacturing & Machinery (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Moulds For Moulding Plastics Or The Like (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01810859A EP1291074A1 (en) | 2001-09-07 | 2001-09-07 | Reaction block for parallel synthetic chemistry and vessel therefor |
| EP01810859.7 | 2001-09-07 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2397827A1 CA2397827A1 (en) | 2003-03-07 |
| CA2397827C true CA2397827C (en) | 2008-04-29 |
Family
ID=8184124
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002397827A Expired - Lifetime CA2397827C (en) | 2001-09-07 | 2002-08-13 | Reaction block for parallel synthetic chemistry and vessel therefor |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20030170147A1 (OSRAM) |
| EP (1) | EP1291074A1 (OSRAM) |
| JP (1) | JP4681793B2 (OSRAM) |
| AT (1) | ATE359117T1 (OSRAM) |
| CA (1) | CA2397827C (OSRAM) |
| DE (1) | DE60219400T2 (OSRAM) |
| ES (1) | ES2284782T3 (OSRAM) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3805352B1 (ja) * | 2005-05-25 | 2006-08-02 | 株式会社エンプラス | 流体取扱装置およびそれに用いる流体取扱ユニット |
| JP4680037B2 (ja) * | 2005-11-14 | 2011-05-11 | 株式会社エンプラス | 流体取扱装置およびそれに用いる流体取扱ユニット |
| EP1872855A1 (en) * | 2006-06-27 | 2008-01-02 | F.Hoffmann-La Roche Ag | Plate for equilibrating a fluid |
| DE102006030068A1 (de) * | 2006-06-28 | 2008-01-03 | M2P-Labs Gmbh | Vorrichtung und Verfahren zur Zu- und Abfuhr von Fluiden in geschüttelten Mikroreaktoren Arrays |
| CN108367290B (zh) * | 2015-10-01 | 2021-06-04 | 伯克利之光生命科技公司 | 井孔板培养器 |
| WO2018102781A1 (en) | 2016-12-01 | 2018-06-07 | Berkeley Lights, Inc. | Well-plate incubator |
| CN108819126B (zh) * | 2018-07-25 | 2024-08-02 | 东莞广泽汽车饰件有限公司 | 一种汽车装饰件的注塑模具 |
| WO2023039404A1 (en) * | 2021-09-08 | 2023-03-16 | Meso Scale Technologies, Llc. | Sample collection device |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1171178B (de) * | 1960-02-06 | 1964-05-27 | Martin Christ Fa | Zentrifugenzelle |
| GB1064901A (en) * | 1965-01-19 | 1967-04-12 | Alfred George Wright | Improvements relating to centrifuges |
| JPS5866852A (ja) * | 1981-10-19 | 1983-04-21 | Olympus Optical Co Ltd | Ｕ字形反応容器 |
| US4605536A (en) * | 1984-05-29 | 1986-08-12 | Veb Metaplast Quedlinburg | Cuvette for projection display of chemical experiments |
| JPS6356420A (ja) * | 1986-08-27 | 1988-03-11 | Fukuraito Kk | 歯科用デイスポ−ザブルシリンジの製造法 |
| JPH01317733A (ja) * | 1988-06-20 | 1989-12-22 | Terumo Corp | 有底筒状成形物、有底筒状成形物製造用金型および有底筒状成形物の製造方法 |
| US5395006A (en) * | 1993-04-29 | 1995-03-07 | Verma; Kuldeep | Fermentation vessels and closures therefor |
| US5641681A (en) * | 1995-04-17 | 1997-06-24 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Device and method for screening crystallization conditions in solution crystal growth |
| GB9515831D0 (en) * | 1995-08-02 | 1995-10-04 | The Technology Partnership Plc | Automated chemical synthesis system |
| US5746982A (en) * | 1996-02-29 | 1998-05-05 | Advanced Chemtech, Inc. | Apparatus for automated synthesis of chemical compounds |
| US5972694A (en) * | 1997-02-11 | 1999-10-26 | Mathus; Gregory | Multi-well plate |
| CA2294941A1 (en) * | 1997-06-16 | 1998-12-23 | Chemspeed Ltd. | Reaction vessel holding device |
| US5801055A (en) * | 1997-09-10 | 1998-09-01 | Becton Dickinson And Company | Multi-well culture dish assembly |
| JP2001522714A (ja) * | 1997-11-08 | 2001-11-20 | ケムスピード・リミテッド | 温度制御され揺りが与えられる反応容器を保持する装置 |
| DE19915811C2 (de) * | 1999-04-08 | 2001-05-03 | Boehringer Ingelheim Pharma | Reaktionsgefäß |
| US6811752B2 (en) * | 2001-05-15 | 2004-11-02 | Biocrystal, Ltd. | Device having microchambers and microfluidics |
| US20070140925A1 (en) * | 2005-11-11 | 2007-06-21 | Phelps David Y | Automated chemical synthesizer and method for synthesis using same |
-
2001
- 2001-09-07 EP EP01810859A patent/EP1291074A1/en not_active Withdrawn
-
2002
- 2002-08-13 CA CA002397827A patent/CA2397827C/en not_active Expired - Lifetime
- 2002-08-19 DE DE60219400T patent/DE60219400T2/de not_active Expired - Lifetime
- 2002-08-19 AT AT02078424T patent/ATE359117T1/de not_active IP Right Cessation
- 2002-08-19 ES ES02078424T patent/ES2284782T3/es not_active Expired - Lifetime
- 2002-09-05 US US10/235,055 patent/US20030170147A1/en not_active Abandoned
- 2002-09-06 JP JP2002261545A patent/JP4681793B2/ja not_active Expired - Lifetime
-
2006
- 2006-07-21 US US11/491,447 patent/US7794668B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US20060263273A1 (en) | 2006-11-23 |
| EP1291074A1 (en) | 2003-03-12 |
| DE60219400T2 (de) | 2007-12-27 |
| JP2003190773A (ja) | 2003-07-08 |
| JP4681793B2 (ja) | 2011-05-11 |
| DE60219400D1 (de) | 2007-05-24 |
| US20030170147A1 (en) | 2003-09-11 |
| ES2284782T3 (es) | 2007-11-16 |
| ATE359117T1 (de) | 2007-05-15 |
| CA2397827A1 (en) | 2003-03-07 |
| US7794668B2 (en) | 2010-09-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKEX | Expiry |
Effective date: 20220815 |