DE60205564T2 - N-Adamantylalkyl Benzamide Derivativen als p2x7-rezeptor antagonisten - Google Patents
N-Adamantylalkyl Benzamide Derivativen als p2x7-rezeptor antagonisten Download PDFInfo
- Publication number
- DE60205564T2 DE60205564T2 DE60205564T DE60205564T DE60205564T2 DE 60205564 T2 DE60205564 T2 DE 60205564T2 DE 60205564 T DE60205564 T DE 60205564T DE 60205564 T DE60205564 T DE 60205564T DE 60205564 T2 DE60205564 T2 DE 60205564T2
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- Germany
- Prior art keywords
- arthritis
- compounds
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- alkyl
- disease
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- 0 C*(CNC1(CC(C)(C2)C3)CC3(*)CC2(*)C1)NC(c1c(*)ccc(N(C(N2*)=O)N=CC2=O)c1*)=O Chemical compound C*(CNC1(CC(C)(C2)C3)CC3(*)CC2(*)C1)NC(c1c(*)ccc(N(C(N2*)=O)N=CC2=O)c1*)=O 0.000 description 3
- HBZKNIFOFWHCJJ-UHFFFAOYSA-N C#CN(C(C=NN1)=O)C1=O Chemical compound C#CN(C(C=NN1)=O)C1=O HBZKNIFOFWHCJJ-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D253/075—Two hetero atoms, in positions 3 and 5
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Virology (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Psychiatry (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33689201P | 2001-11-12 | 2001-11-12 | |
US336892P | 2001-11-12 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60205564D1 DE60205564D1 (de) | 2005-09-22 |
DE60205564T2 true DE60205564T2 (de) | 2006-06-01 |
Family
ID=23318138
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60205564T Expired - Lifetime DE60205564T2 (de) | 2001-11-12 | 2002-11-07 | N-Adamantylalkyl Benzamide Derivativen als p2x7-rezeptor antagonisten |
Country Status (10)
Families Citing this family (66)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020182646A1 (en) * | 2001-04-30 | 2002-12-05 | Ke Huazhu | Methods and products for identifying modulators of P2X7 receptor activity, and their use in the treatment of skeletal disorders |
PA8557501A1 (es) * | 2001-11-12 | 2003-06-30 | Pfizer Prod Inc | Benzamida, heteroarilamida y amidas inversas |
SE0200920D0 (sv) * | 2002-03-25 | 2002-03-25 | Astrazeneca Ab | Novel compounds |
PA8591801A1 (es) * | 2002-12-31 | 2004-07-26 | Pfizer Prod Inc | Inhibidores benzamidicos del receptor p2x7. |
US7071223B1 (en) * | 2002-12-31 | 2006-07-04 | Pfizer, Inc. | Benzamide inhibitors of the P2X7 receptor |
SE0300480D0 (sv) * | 2003-02-21 | 2003-02-21 | Astrazeneca Ab | Novel compounds |
PL1473367T3 (pl) * | 2003-04-17 | 2007-11-30 | Affectis Pharmaceuticals Ag | Środki i sposoby diagnozowania zaburzeń afektywnych |
WO2004099146A1 (en) * | 2003-05-12 | 2004-11-18 | Pfizer Products Inc. | Benzamide inhibitors of the p2x7 receptor |
EP1644042A1 (en) * | 2003-05-29 | 2006-04-12 | AstraZeneca AB | A pharmaceutical composition containing a p2x7 receptor antagonist and methotrexate |
WO2004105797A1 (en) * | 2003-05-29 | 2004-12-09 | Astrazeneca Ab | A pharmaceutical composition comprising a p2x7 antagonist and sulfasalazine |
RU2350354C2 (ru) * | 2003-05-29 | 2009-03-27 | Астразенека Аб | ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СОДЕРЖАЩАЯ АНТАГОНИСТ Р2Х7 РЕЦЕПТОРА И ФАКТОР НЕКРОЗА ОПУХОЛИ α |
GB0312609D0 (en) | 2003-06-02 | 2003-07-09 | Astrazeneca Ab | Novel compounds |
SE0302192D0 (sv) * | 2003-08-08 | 2003-08-08 | Astrazeneca Ab | Novel compounds |
SE0302488D0 (sv) * | 2003-09-18 | 2003-09-18 | Astrazeneca Ab | New combination |
ITMI20040255A1 (it) * | 2004-02-17 | 2004-05-17 | Univ Degli Studi Milano | Sostanze ad attivita' antiangiogenica |
EP2343282B1 (en) * | 2004-03-05 | 2015-07-22 | F. Hoffmann-La Roche AG | Diaminopyrimidines as P2X3 and P2X2/3 antagonists |
JPWO2005107804A1 (ja) * | 2004-05-06 | 2008-03-21 | 小野薬品工業株式会社 | 呼吸器疾患治療剤 |
EP1763353A1 (en) * | 2004-06-29 | 2007-03-21 | Warner-Lambert Company LLC | COMBINATION THERAPIES UTILIZING BENZAMIDE INHIBITORS OF THE P2X<sb>7</sb> RECEPTOR |
BRPI0512781A (pt) * | 2004-06-29 | 2008-04-08 | Pfizer Prod Inc | método para preparação de derivados de 5-{4-(2-hidroxi-propil)-3,5-dioxo-4,5-diidro-3h-[1,2,4]tria zin-2-il}-benzamida através da desproteção dos precursores de protetores de hidroxila |
WO2006003513A1 (en) * | 2004-06-29 | 2006-01-12 | Pfizer Products Inc. | Method for preparing 5-`4-(2-hydroxy-ethyl)-3,5-dioxo-4,5-dihydro-3h-`1,2,4!-triazin-2-yl!benzamide derivatives with p2x7 inhibiting activity by reaction of the derivative unsubstituted in 4-position of the triazine with an oxiran in the presence of a lewis acid |
SA05260265A (ar) * | 2004-08-30 | 2005-12-03 | استرازينيكا ايه بي | مركبات جديدة |
WO2006035876A1 (ja) * | 2004-09-29 | 2006-04-06 | Kowa Co., Ltd. | 関節リウマチの予防及び/又は治療薬 |
SE0402925D0 (sv) * | 2004-11-30 | 2004-11-30 | Astrazeneca Ab | Novel Compounds |
WO2006083214A1 (en) * | 2005-02-02 | 2006-08-10 | Astrazeneca Ab | Pharmaceutical composition comprising a p2x7 receptor antagonist and a hmg-coa reductase inhibitor |
JPWO2006104172A1 (ja) * | 2005-03-29 | 2008-09-11 | 興和株式会社 | 関節リウマチの予防及び/又は治療薬 |
WO2007008157A1 (en) * | 2005-07-11 | 2007-01-18 | Astrazeneca Ab | New combination 2 |
US20080207577A1 (en) * | 2005-07-11 | 2008-08-28 | Astrazeneca Ab | Combination I |
EP1924564B1 (en) | 2005-09-01 | 2016-11-09 | F.Hoffmann-La Roche Ag | Diaminopyrimidines as p2x3 and p2x2/3 modulators |
CN101300235B (zh) | 2005-09-01 | 2011-12-07 | 弗·哈夫曼-拉罗切有限公司 | 作为p2x3和p2x2/3调节剂的二氨基嘧啶类化合物 |
MX2008002731A (es) | 2005-09-01 | 2008-03-26 | Hoffmann La Roche | Diaminopirimidinas como moduladores de p2x3 y p3x2/3. |
JPWO2007049732A1 (ja) * | 2005-10-28 | 2009-04-30 | 興和株式会社 | 関節リウマチの予防及び/又は治療法 |
EP2033646A4 (en) * | 2006-06-29 | 2009-11-18 | Kowa Co | PROPHYLACTIC AND / OR THERAPEUTIC AGENT FOR THE TREATMENT OF RHEUMATOID ARTHRITIS |
WO2008114002A1 (en) | 2007-03-22 | 2008-09-25 | Astrazeneca Ab | Quinoline derivatives for the treatment of inflammatory diseases |
WO2009019503A2 (en) * | 2007-08-03 | 2009-02-12 | Astrazeneca Ab | P2x7 antagonists for use in the treatment of mood disorders |
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2002
- 2002-09-30 WO PCT/IB2002/004043 patent/WO2003042190A1/en not_active Application Discontinuation
- 2002-10-03 MX MXPA02009783A patent/MXPA02009783A/es active IP Right Grant
- 2002-11-07 AT AT02257719T patent/ATE302196T1/de not_active IP Right Cessation
- 2002-11-07 ES ES02257719T patent/ES2244733T3/es not_active Expired - Lifetime
- 2002-11-07 EP EP02257719A patent/EP1310493B1/en not_active Expired - Lifetime
- 2002-11-07 BR BR0204588-5A patent/BR0204588A/pt not_active IP Right Cessation
- 2002-11-07 DE DE60205564T patent/DE60205564T2/de not_active Expired - Lifetime
- 2002-11-08 CA CA002411544A patent/CA2411544C/en not_active Expired - Fee Related
- 2002-11-12 US US10/292,886 patent/US6927219B2/en not_active Expired - Fee Related
- 2002-11-12 JP JP2002327661A patent/JP4001542B2/ja not_active Expired - Fee Related
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US6927219B2 (en) | 2005-08-09 |
CA2411544C (en) | 2008-10-07 |
DE60205564D1 (de) | 2005-09-22 |
WO2003042190A1 (en) | 2003-05-22 |
EP1310493A1 (en) | 2003-05-14 |
US20030144293A1 (en) | 2003-07-31 |
BR0204588A (pt) | 2003-09-16 |
EP1310493B1 (en) | 2005-08-17 |
JP4001542B2 (ja) | 2007-10-31 |
JP2003183263A (ja) | 2003-07-03 |
ATE302196T1 (de) | 2005-09-15 |
ES2244733T3 (es) | 2005-12-16 |
CA2411544A1 (en) | 2003-05-12 |
MXPA02009783A (es) | 2003-05-21 |
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