DE60205377D1 - Verfahren zur arylierung von funktionalisierten o-allyl erythromycin derivaten - Google Patents

Verfahren zur arylierung von funktionalisierten o-allyl erythromycin derivaten

Info

Publication number
DE60205377D1
DE60205377D1 DE60205377T DE60205377T DE60205377D1 DE 60205377 D1 DE60205377 D1 DE 60205377D1 DE 60205377 T DE60205377 T DE 60205377T DE 60205377 T DE60205377 T DE 60205377T DE 60205377 D1 DE60205377 D1 DE 60205377D1
Authority
DE
Germany
Prior art keywords
erythromycin
heck reaction
derivative
alkenylaryl
arylating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60205377T
Other languages
English (en)
Other versions
DE60205377T2 (de
Inventor
Weijiang Zhang
Chi-Ping Hsu
R Haight
John Peterson
A Narayanan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of DE60205377D1 publication Critical patent/DE60205377D1/de
Application granted granted Critical
Publication of DE60205377T2 publication Critical patent/DE60205377T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE60205377T 2001-05-30 2002-05-21 Verfahren zur arylierung von funktionalisierten o-allyl erythromycin derivaten Expired - Fee Related DE60205377T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29432601P 2001-05-30 2001-05-30
US294326P 2001-05-30
PCT/US2002/018348 WO2002096922A1 (en) 2001-05-30 2002-05-21 An arylation method for the functionalization of o-allyl erythromycin derivatives

Publications (2)

Publication Number Publication Date
DE60205377D1 true DE60205377D1 (de) 2005-09-08
DE60205377T2 DE60205377T2 (de) 2006-05-24

Family

ID=23132927

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60205377T Expired - Fee Related DE60205377T2 (de) 2001-05-30 2002-05-21 Verfahren zur arylierung von funktionalisierten o-allyl erythromycin derivaten

Country Status (16)

Country Link
US (1) US7071314B2 (de)
EP (1) EP1399458B1 (de)
JP (1) JP2004536075A (de)
KR (1) KR20040014537A (de)
CN (1) CN100422201C (de)
AT (1) ATE301128T1 (de)
BR (1) BR0206106A (de)
CA (1) CA2449173A1 (de)
DE (1) DE60205377T2 (de)
DK (1) DK1399458T3 (de)
ES (1) ES2246403T3 (de)
HK (1) HK1064390A1 (de)
IL (1) IL159004A0 (de)
MX (1) MXPA03010939A (de)
TW (1) TWI246515B (de)
WO (1) WO2002096922A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101309903B (zh) * 2005-11-16 2012-10-03 弗·哈夫曼-拉罗切有限公司 制备thoc的新方法
US7595300B2 (en) * 2005-12-13 2009-09-29 Kosan Biosciences Incorporated 7-quinolyl ketolide antibacterial agents
JPWO2009019868A1 (ja) 2007-08-06 2010-10-28 大正製薬株式会社 １０ａ、１２位架橋型１０ａ−アザライド化合物
US8299035B2 (en) 2008-05-15 2012-10-30 Taisho Pharmaceutucal Co., Ltd. 10a-azalide compound having 4-membered ring structure
KR200457752Y1 (ko) * 2008-12-02 2012-01-02 다폰 일렉트로닉스 코퍼레이션 변압기 및 백라이트 장치
CN102766181A (zh) * 2011-05-06 2012-11-07 上海医药工业研究院 6-o-取代的红霉素衍生物的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4331803A (en) 1980-06-04 1982-05-25 Taisho Pharmaceutical Co., Ltd. Novel erythromycin compounds
JPS5896097A (ja) 1981-12-01 1983-06-07 Taisho Pharmaceut Co Ltd エリスロマイシンｂ誘導体
US5872229A (en) 1995-11-21 1999-02-16 Abbott Laboratories Process for 6-O-alkylation of erythromycin derivatives
EP0918783A1 (de) 1996-05-07 1999-06-02 Abbott Laboratories 6-0-substituierte erythromycin und verfahren zu ihrer herstellung
UA51730C2 (uk) 1996-09-04 2002-12-16 Ебботт Лабораторіз 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців
ZA987689B (en) * 1997-09-02 1999-02-24 Abbott Lab 3-descladinose 6-O substituted erythromycin derivatives
US6124269A (en) 1997-10-29 2000-09-26 Abbott Laboratories 2-Halo-6-O-substituted ketolide derivatives
US5932710A (en) 1997-12-01 1999-08-03 Abbott Laboratories Process for preparing 6-O-alkyl-9-oxime erythromycin B
IL135792A0 (en) 1997-12-01 2001-05-20 Abbott Lab 6-o-alkyl derivatives of erythronolide b
US6040440A (en) 1998-03-06 2000-03-21 Abbott Laboratories Hypophosphite deoxygenation reactions in the synthesis of erythromycin derivatives
CZ20013223A3 (cs) * 1999-03-15 2002-01-16 Abbott Laboratories 6-0-Substituované makrolidy mající antibakteriální aktivitu
US6437106B1 (en) * 1999-06-24 2002-08-20 Abbott Laboratories Process for preparing 6-o-substituted erythromycin derivatives

Also Published As

Publication number Publication date
IL159004A0 (en) 2004-05-12
ES2246403T3 (es) 2006-02-16
TWI246515B (en) 2006-01-01
BR0206106A (pt) 2003-10-14
EP1399458B1 (de) 2005-08-03
MXPA03010939A (es) 2004-02-27
KR20040014537A (ko) 2004-02-14
EP1399458A1 (de) 2004-03-24
WO2002096922A1 (en) 2002-12-05
JP2004536075A (ja) 2004-12-02
DE60205377T2 (de) 2006-05-24
CN100422201C (zh) 2008-10-01
US7071314B2 (en) 2006-07-04
CA2449173A1 (en) 2002-12-05
US20030125531A1 (en) 2003-07-03
ATE301128T1 (de) 2005-08-15
HK1064390A1 (en) 2005-01-28
DK1399458T3 (da) 2005-12-12
CN1633443A (zh) 2005-06-29

Similar Documents

Publication Publication Date Title
ATE294809T1 (de) Verfahren zur herstellung von 6-o-alkenyl- subsitutierten erythromycin-derivativen
MY112488A (en) Process for preparing 1-(2''-deoxy-2'',2''-difluoro-d- ribofuranosyl)-4-aminopyrimidin-one) hydrochloride
ATE288758T1 (de) Verfahren zur herstellung von polymorphen des clarithromycins
ATE277068T1 (de) 2'-modifizierte oligonucleotide mit rns wirkung, die konformell eingeschränkt sind
DE69806003T2 (de) Dna polymerasen, die verbesserte fähigkeiten zum einbau markierter nukleotide besitzen
ATE551352T1 (de) Peptidakzeptorbindungsverfahren
ATE427357T1 (de) Nukleinsauremolekule, welche fur proteine kodieren, die fructosyltransferase-aktivitat aufweisen und verfahren zur herstellung von langkettigem inulin
DK1053355T3 (da) PNA- og DNA-konjugater og metoder til fremstilling heraf
ATE263181T1 (de) Chemische synthese von 6-o-alkyl erythromycin a
DE60205377D1 (de) Verfahren zur arylierung von funktionalisierten o-allyl erythromycin derivaten
EP1264894A4 (de) REAKTIONSSYSTEME ZUR REGENERATION VON ATP UND METHODE ZUR PRüFUNG VON ADENIN NUKLEOTIDEN, METHODE ZUR DETEKTION VON RNA UND METHODE ZUR AMPLIFIKATION VON ATP UNTER VERWENDUNG DESSELBEN
DE60031154D1 (de) Verfahren zur herstellung von clarithromycin
ATE266037T1 (de) Verfahren zur herstellung von phoshphorothioate triestere
DE60026354D1 (de) Verfahren zur herstellung von methylcobalamin
KR960703938A (ko) 카르바메이트 누클레오시드간 결합을 갖는 축적 블록 및 이로부터 유도된 올리고누클레오티드(building blocks with carbamate internucleoside linkages and novel oligonucleotides derived therefrom)
DE69902063T2 (de) Verfahren zur Katalysatorherstellung
DE69910669D1 (de) Abgasreinigungskatalysator und Verfahren zu dessen Herstellung
DE69917305D1 (de) Substanz zur behandlung von abgasen, verfahren zu ihrer herstellung und verfahren zur behandlung von abgas
ATE212382T1 (de) Verfahren zur sequenzierung durch oligomerhybridisierung
ATE223499T1 (de) Von kreisförmiger matrize abhängige kettenreaktion
DE60102232D1 (de) Kosteneffektive methode zur selektiven methylierung von erythromycin a-derivaten
ATE224907T1 (de) Verfahren zur reinigung von roxithromycin
TR200101645T2 (tr) Klaritromisinin hazırlanmasındaki makrolid ara ürünleri.
DE69811871D1 (de) Verfahren zur herstellung von uridine diphosphat-n-acetylglucosamine (13.04.99)
DE69609654D1 (de) Lanze zum Einblasen fluider Substanzen in Öfen, insbesondere in Öfen zur Stahlerzeugung

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee