MXPA03010939A - Un metodo de arilacion para la funcionalizacion de derivados de eritromicina de o-alilo. - Google Patents
Un metodo de arilacion para la funcionalizacion de derivados de eritromicina de o-alilo.Info
- Publication number
- MXPA03010939A MXPA03010939A MXPA03010939A MXPA03010939A MXPA03010939A MX PA03010939 A MXPA03010939 A MX PA03010939A MX PA03010939 A MXPA03010939 A MX PA03010939A MX PA03010939 A MXPA03010939 A MX PA03010939A MX PA03010939 A MXPA03010939 A MX PA03010939A
- Authority
- MX
- Mexico
- Prior art keywords
- erythromycin
- heck reaction
- derivative
- alkenylaryl
- arylation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Se describe una tecnica de arilacion eficiente para usarse en la sintesis de derivados de eritromicina, que envuelve una reaccion de Heck modificada, que emplea menos de seis por ciento en moles de catalizador de paladio y ninguna fosfina. Con esta reaccion de Heck modificada, se puede obtener un macrolido de O-alquenilarilo en un tiempo de reaccion mucho mas corto que bajo las condiciones de la reaccion de Heck convencionales. La reaccion de Heck modificada se puede utilizar en un metodo para la arilacion libre de fosfinas de un derivado O-alilico de eritromicina, en un metodo para preparar un derivado de O-alquenilarileritromicina, o en un metodo para preparar un derivado de 6-O-alquenilarileritromicina A protegido en 2¦- 15 4¦¦-hidroxilo.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US29432601P | 2001-05-30 | 2001-05-30 | |
PCT/US2002/018348 WO2002096922A1 (en) | 2001-05-30 | 2002-05-21 | An arylation method for the functionalization of o-allyl erythromycin derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA03010939A true MXPA03010939A (es) | 2004-02-27 |
Family
ID=23132927
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA03010939A MXPA03010939A (es) | 2001-05-30 | 2002-05-21 | Un metodo de arilacion para la funcionalizacion de derivados de eritromicina de o-alilo. |
Country Status (16)
Country | Link |
---|---|
US (1) | US7071314B2 (es) |
EP (1) | EP1399458B1 (es) |
JP (1) | JP2004536075A (es) |
KR (1) | KR20040014537A (es) |
CN (1) | CN100422201C (es) |
AT (1) | ATE301128T1 (es) |
BR (1) | BR0206106A (es) |
CA (1) | CA2449173A1 (es) |
DE (1) | DE60205377T2 (es) |
DK (1) | DK1399458T3 (es) |
ES (1) | ES2246403T3 (es) |
HK (1) | HK1064390A1 (es) |
IL (1) | IL159004A0 (es) |
MX (1) | MXPA03010939A (es) |
TW (1) | TWI246515B (es) |
WO (1) | WO2002096922A1 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101309903B (zh) * | 2005-11-16 | 2012-10-03 | 弗·哈夫曼-拉罗切有限公司 | 制备thoc的新方法 |
US7595300B2 (en) * | 2005-12-13 | 2009-09-29 | Kosan Biosciences Incorporated | 7-quinolyl ketolide antibacterial agents |
JPWO2009019868A1 (ja) | 2007-08-06 | 2010-10-28 | 大正製薬株式会社 | 10a、12位架橋型10a−アザライド化合物 |
US8299035B2 (en) | 2008-05-15 | 2012-10-30 | Taisho Pharmaceutucal Co., Ltd. | 10a-azalide compound having 4-membered ring structure |
KR200457752Y1 (ko) * | 2008-12-02 | 2012-01-02 | 다폰 일렉트로닉스 코퍼레이션 | 변압기 및 백라이트 장치 |
CN102766181A (zh) * | 2011-05-06 | 2012-11-07 | 上海医药工业研究院 | 6-o-取代的红霉素衍生物的制备方法 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4331803A (en) | 1980-06-04 | 1982-05-25 | Taisho Pharmaceutical Co., Ltd. | Novel erythromycin compounds |
JPS5896097A (ja) | 1981-12-01 | 1983-06-07 | Taisho Pharmaceut Co Ltd | エリスロマイシンb誘導体 |
US5872229A (en) | 1995-11-21 | 1999-02-16 | Abbott Laboratories | Process for 6-O-alkylation of erythromycin derivatives |
EP0918783A1 (en) | 1996-05-07 | 1999-06-02 | Abbott Laboratories | 6-o-substituted erythromycins and method for making them |
UA51730C2 (uk) | 1996-09-04 | 2002-12-16 | Ебботт Лабораторіз | 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців |
ZA987689B (en) * | 1997-09-02 | 1999-02-24 | Abbott Lab | 3-descladinose 6-O substituted erythromycin derivatives |
US6124269A (en) | 1997-10-29 | 2000-09-26 | Abbott Laboratories | 2-Halo-6-O-substituted ketolide derivatives |
US5932710A (en) | 1997-12-01 | 1999-08-03 | Abbott Laboratories | Process for preparing 6-O-alkyl-9-oxime erythromycin B |
IL135792A0 (en) | 1997-12-01 | 2001-05-20 | Abbott Lab | 6-o-alkyl derivatives of erythronolide b |
US6040440A (en) | 1998-03-06 | 2000-03-21 | Abbott Laboratories | Hypophosphite deoxygenation reactions in the synthesis of erythromycin derivatives |
CZ20013223A3 (cs) * | 1999-03-15 | 2002-01-16 | Abbott Laboratories | 6-0-Substituované makrolidy mající antibakteriální aktivitu |
US6437106B1 (en) * | 1999-06-24 | 2002-08-20 | Abbott Laboratories | Process for preparing 6-o-substituted erythromycin derivatives |
-
2002
- 2002-05-20 TW TW091110509A patent/TWI246515B/zh not_active IP Right Cessation
- 2002-05-21 ES ES02741957T patent/ES2246403T3/es not_active Expired - Lifetime
- 2002-05-21 MX MXPA03010939A patent/MXPA03010939A/es active IP Right Grant
- 2002-05-21 EP EP02741957A patent/EP1399458B1/en not_active Expired - Lifetime
- 2002-05-21 CN CNB028149688A patent/CN100422201C/zh not_active Expired - Fee Related
- 2002-05-21 DE DE60205377T patent/DE60205377T2/de not_active Expired - Fee Related
- 2002-05-21 WO PCT/US2002/018348 patent/WO2002096922A1/en active IP Right Grant
- 2002-05-21 DK DK02741957T patent/DK1399458T3/da active
- 2002-05-21 JP JP2003500101A patent/JP2004536075A/ja active Pending
- 2002-05-21 AT AT02741957T patent/ATE301128T1/de not_active IP Right Cessation
- 2002-05-21 IL IL15900402A patent/IL159004A0/xx unknown
- 2002-05-21 BR BR0206106-6A patent/BR0206106A/pt not_active IP Right Cessation
- 2002-05-21 KR KR10-2003-7015640A patent/KR20040014537A/ko not_active Application Discontinuation
- 2002-05-21 CA CA002449173A patent/CA2449173A1/en not_active Abandoned
- 2002-05-28 US US10/156,404 patent/US7071314B2/en not_active Expired - Lifetime
-
2004
- 2004-09-15 HK HK04107052A patent/HK1064390A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
IL159004A0 (en) | 2004-05-12 |
ES2246403T3 (es) | 2006-02-16 |
TWI246515B (en) | 2006-01-01 |
BR0206106A (pt) | 2003-10-14 |
EP1399458B1 (en) | 2005-08-03 |
KR20040014537A (ko) | 2004-02-14 |
DE60205377D1 (de) | 2005-09-08 |
EP1399458A1 (en) | 2004-03-24 |
WO2002096922A1 (en) | 2002-12-05 |
JP2004536075A (ja) | 2004-12-02 |
DE60205377T2 (de) | 2006-05-24 |
CN100422201C (zh) | 2008-10-01 |
US7071314B2 (en) | 2006-07-04 |
CA2449173A1 (en) | 2002-12-05 |
US20030125531A1 (en) | 2003-07-03 |
ATE301128T1 (de) | 2005-08-15 |
HK1064390A1 (en) | 2005-01-28 |
DK1399458T3 (da) | 2005-12-12 |
CN1633443A (zh) | 2005-06-29 |
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Legal Events
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FG | Grant or registration |