DE60102232D1 - Kosteneffektive methode zur selektiven methylierung von erythromycin a-derivaten - Google Patents
Kosteneffektive methode zur selektiven methylierung von erythromycin a-derivatenInfo
- Publication number
- DE60102232D1 DE60102232D1 DE60102232T DE60102232T DE60102232D1 DE 60102232 D1 DE60102232 D1 DE 60102232D1 DE 60102232 T DE60102232 T DE 60102232T DE 60102232 T DE60102232 T DE 60102232T DE 60102232 D1 DE60102232 D1 DE 60102232D1
- Authority
- DE
- Germany
- Prior art keywords
- erythromycin
- cost
- derivatives
- effective method
- selective methylation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical class O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 238000011935 selective methylation Methods 0.000 title abstract 2
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 abstract 3
- 239000000010 aprotic solvent Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000012022 methylating agents Substances 0.000 abstract 1
- 230000001035 methylating effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| INDE051500 | 2000-05-15 | ||
| IN515DE2000 | 2000-05-15 | ||
| PCT/IB2001/000770 WO2001087807A2 (en) | 2000-05-15 | 2001-05-07 | A cost effective method for selective methylation of erythromycin a derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60102232D1 true DE60102232D1 (de) | 2004-04-08 |
| DE60102232T2 DE60102232T2 (de) | 2005-02-24 |
Family
ID=11097052
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60102232T Expired - Fee Related DE60102232T2 (de) | 2000-05-15 | 2001-05-07 | Kosteneffektive methode zur selektiven methylierung von erythromycin a-derivaten |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6900296B2 (de) |
| EP (1) | EP1283821B1 (de) |
| CN (1) | CN1205218C (de) |
| AT (1) | ATE260929T1 (de) |
| AU (1) | AU6256301A (de) |
| BR (1) | BR0110925A (de) |
| CA (1) | CA2409247A1 (de) |
| CZ (1) | CZ20023855A3 (de) |
| DE (1) | DE60102232T2 (de) |
| DK (1) | DK1283821T3 (de) |
| ES (1) | ES2217153T3 (de) |
| MY (1) | MY133929A (de) |
| PT (1) | PT1283821E (de) |
| TR (1) | TR200401093T4 (de) |
| WO (1) | WO2001087807A2 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007029265A2 (en) * | 2005-04-29 | 2007-03-15 | Kopran Research Laboratories Ltd | A process for preparing clarithromycin and clarithromycin intermediate |
| EP1744278B1 (de) * | 2005-07-13 | 2008-05-21 | LaserSoft Imaging AG | Bereitstellung einer digitalen Kopie eines Quellbildes |
| US20090054634A1 (en) * | 2007-08-09 | 2009-02-26 | Vinod Kumar Kansal | Process for the preparation of clarithromycin |
| WO2010122571A2 (en) * | 2009-04-23 | 2010-10-28 | Elder Pharmaceuticals Ltd. | A process for the selective methylation of erythromycin a derivatives. |
| CN102942507A (zh) * | 2012-11-30 | 2013-02-27 | 迈克斯(如东)化工有限公司 | 一种制备利谷隆的新方法 |
| CN106905204B (zh) * | 2017-02-24 | 2018-07-20 | 杭州新桂实业有限公司 | 一种克拉霉素合成过程中甲基化反应溶剂的回收套用方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4331803A (en) * | 1980-06-04 | 1982-05-25 | Taisho Pharmaceutical Co., Ltd. | Novel erythromycin compounds |
| JPS60214796A (ja) | 1984-04-06 | 1985-10-28 | Taisho Pharmaceut Co Ltd | ６−０−メチルエリスロマイシン類の製法 |
| US4670549A (en) * | 1985-03-18 | 1987-06-02 | Taisho Pharmaceutical Co., Ltd. | Method for selective methylation of erythromycin a derivatives |
-
2001
- 2001-05-07 CZ CZ20023855A patent/CZ20023855A3/cs unknown
- 2001-05-07 BR BR0110925-1A patent/BR0110925A/pt not_active IP Right Cessation
- 2001-05-07 CA CA002409247A patent/CA2409247A1/en not_active Abandoned
- 2001-05-07 AT AT01936695T patent/ATE260929T1/de not_active IP Right Cessation
- 2001-05-07 US US10/276,505 patent/US6900296B2/en not_active Expired - Fee Related
- 2001-05-07 ES ES01936695T patent/ES2217153T3/es not_active Expired - Lifetime
- 2001-05-07 DK DK01936695T patent/DK1283821T3/da active
- 2001-05-07 CN CNB018114628A patent/CN1205218C/zh not_active Expired - Fee Related
- 2001-05-07 PT PT01936695T patent/PT1283821E/pt unknown
- 2001-05-07 AU AU62563/01A patent/AU6256301A/en not_active Abandoned
- 2001-05-07 TR TR2004/01093T patent/TR200401093T4/xx unknown
- 2001-05-07 WO PCT/IB2001/000770 patent/WO2001087807A2/en active IP Right Grant
- 2001-05-07 DE DE60102232T patent/DE60102232T2/de not_active Expired - Fee Related
- 2001-05-07 EP EP01936695A patent/EP1283821B1/de not_active Expired - Lifetime
- 2001-05-14 MY MYPI20012248 patent/MY133929A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1283821A2 (de) | 2003-02-19 |
| US6900296B2 (en) | 2005-05-31 |
| ES2217153T3 (es) | 2004-11-01 |
| AU6256301A (en) | 2001-11-26 |
| CA2409247A1 (en) | 2001-11-22 |
| WO2001087807A3 (en) | 2002-09-06 |
| DE60102232T2 (de) | 2005-02-24 |
| CZ20023855A3 (cs) | 2003-09-17 |
| US20040010128A1 (en) | 2004-01-15 |
| CN1458934A (zh) | 2003-11-26 |
| DK1283821T3 (da) | 2004-07-12 |
| EP1283821A4 (de) | 2003-06-11 |
| PT1283821E (pt) | 2004-06-30 |
| EP1283821B1 (de) | 2004-03-03 |
| BR0110925A (pt) | 2003-07-22 |
| ATE260929T1 (de) | 2004-03-15 |
| CN1205218C (zh) | 2005-06-08 |
| TR200401093T4 (tr) | 2004-11-22 |
| MY133929A (en) | 2007-11-30 |
| WO2001087807A2 (en) | 2001-11-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |