DE60201525D1 - Verfahren zur herstellung eines an wirkstoffen hochangereicherten extraktes der blätter von ginkgo biloba - Google Patents

Verfahren zur herstellung eines an wirkstoffen hochangereicherten extraktes der blätter von ginkgo biloba

Info

Publication number
DE60201525D1
DE60201525D1 DE60201525T DE60201525T DE60201525D1 DE 60201525 D1 DE60201525 D1 DE 60201525D1 DE 60201525 T DE60201525 T DE 60201525T DE 60201525 T DE60201525 T DE 60201525T DE 60201525 D1 DE60201525 D1 DE 60201525D1
Authority
DE
Germany
Prior art keywords
extract
ginkgo biloba
ethyl acetate
liquid
producing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60201525T
Other languages
English (en)
Other versions
DE60201525T8 (de
DE60201525T2 (de
Inventor
Beng-Poon Teng
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ipsen Pharma SAS
Original Assignee
Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS filed Critical Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS
Application granted granted Critical
Publication of DE60201525D1 publication Critical patent/DE60201525D1/de
Publication of DE60201525T2 publication Critical patent/DE60201525T2/de
Publication of DE60201525T8 publication Critical patent/DE60201525T8/de
Active legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/16—Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Vascular Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE60201525T 2001-04-10 2002-04-09 Verfahren zur herstellung eines an wirkstoffen hochangereicherten extraktes der blätter von ginkgo biloba Active DE60201525T8 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0104942 2001-04-10
FR0104942A FR2823116B1 (fr) 2001-04-10 2001-04-10 Procede de preparation d'une extrait de feuilles de ginkgo biloba hautement enrichi en principes actifs
PCT/FR2002/001219 WO2002083158A1 (fr) 2001-04-10 2002-04-09 Procede de preparation d'un extrait de feuilles de ginkgo biloba hautement enrichi en principes actifs

Publications (3)

Publication Number Publication Date
DE60201525D1 true DE60201525D1 (de) 2004-11-11
DE60201525T2 DE60201525T2 (de) 2006-03-02
DE60201525T8 DE60201525T8 (de) 2006-08-24

Family

ID=8862215

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60201525T Active DE60201525T8 (de) 2001-04-10 2002-04-09 Verfahren zur herstellung eines an wirkstoffen hochangereicherten extraktes der blätter von ginkgo biloba

Country Status (20)

Country Link
US (1) US7048954B2 (de)
EP (1) EP1379262B1 (de)
JP (1) JP4416404B2 (de)
KR (1) KR100876233B1 (de)
CN (1) CN1245167C (de)
AT (1) ATE278411T1 (de)
AU (1) AU2002307981B2 (de)
CA (1) CA2443302C (de)
CZ (1) CZ299652B6 (de)
DE (1) DE60201525T8 (de)
DK (1) DK1379262T3 (de)
ES (1) ES2230512T3 (de)
FR (1) FR2823116B1 (de)
HK (1) HK1066164A1 (de)
HU (1) HUP0303797A3 (de)
NZ (1) NZ528571A (de)
PL (1) PL204867B1 (de)
PT (1) PT1379262E (de)
RU (1) RU2297235C2 (de)
WO (1) WO2002083158A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20040031772A (ko) 2001-07-11 2004-04-13 더 트러스티스 오브 컬럼비아 유니버시티 인 더 시티 오브 뉴욕 은행의 잎 및 약제학적 분말로부터 테르펜트리락톤(징코라이드, 빌로바라이드)을 분리하는 방법
US7145021B2 (en) 2002-03-29 2006-12-05 The Trustees Of Columbia University In The City Of New York Analogs of terpene trilactones from Ginkgo biloba and related compounds and uses thereof
JP2004307396A (ja) * 2003-04-07 2004-11-04 Kao Corp デオドラント剤
WO2005021496A2 (en) 2003-08-27 2005-03-10 The Trustees Of Columbia University In The City Of New York Synthesis of derivatives of ginkgolide c
WO2005046829A2 (en) 2003-11-12 2005-05-26 The Trustees Of Columbia University In The City Of New York Separation of ginkgolides and bilobalide from g. biloba
EP1537874B1 (de) * 2003-12-04 2007-06-13 Cognis IP Management GmbH Verfahren zur Herstellung von Extrakten des Ginkgo Biloba
WO2006004386A1 (es) * 2004-07-02 2006-01-12 Rojas Castaneda Patricia Uso de un extracto del ginkgo biloba para preparar una medicina para tratar la enfermedad de parkinson
CN1891242B (zh) * 2005-07-06 2012-01-04 徐州技源天然保健品有限公司 一种从银杏叶提取物中脱除多环芳烃的生产工艺
FR2904222A1 (fr) * 2006-07-27 2008-02-01 Sod Conseils Rech Applic Utilisation d4extraits de ginkgo biloba pour le traitement de maladies mitochondriales
CZ299802B6 (cs) * 2006-10-12 2008-11-26 Kalvoda@Jaroslav Príprava zálivky obsahující extrakt z náprstníku cerveného, extrakt z jinanu dvoulalocného a dusicnan draselný, a její vliv na rostliny
HUE041715T2 (hu) * 2007-12-21 2019-05-28 Dr Willmar Schwabe Gmbh & Co Kg Ginkgo biloba levél-kivonat alkalmazása
FR2926994B1 (fr) * 2008-02-06 2010-08-27 Sod Conseils Rech Applic Nouveau procede pour la preparation d'extraits de ginkgo biloba
EP2459205A1 (de) * 2009-07-28 2012-06-06 Velleja Research SRL Ginkgo-biloba-extrakt mit einem standardisierten ginkgo-flavonglykosid-gehalt ohne paf-antagonistische terpenfraktion und zusammensetzungen damit zur vorbeugung und behandlung von kreislauf-, kognitiven, geriatrischen und sensorischen erkrankungen
CN110893183A (zh) * 2018-09-13 2020-03-20 成都百裕制药股份有限公司 银杏萜内酯在制备预防、缓解或治疗肌萎缩侧索硬化药物中的应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1044659C (zh) * 1987-06-30 1999-08-18 吴羽化学工业株式会社 含有唑类衍生物的农业和园艺用的农药组合物
DE3832056A1 (de) * 1988-09-21 1990-03-22 Scholle Helmut Dr Med Verwendung eines ginkgo-extraktes
JPH02193907A (ja) * 1989-01-19 1990-07-31 Daicel Chem Ind Ltd イチョウエキスの製法
KR940002796B1 (ko) * 1989-06-16 1994-04-02 주식회사 선경인더스트리 은행잎에서 징코라이드를 분리 및 정제하는 방법
DE3940094A1 (de) * 1989-12-04 1991-06-06 Montana Ltd Wirkstoffkonzentrate und neue wirkstoff-kombinationen aus blaettern von ginkgo biloba, ein verfahren zu ihrer herstellung und die wirkstoff-konzentrate bzw. die wirkstoff-kombinationen enthaltenden arzneimittel
DE3940092A1 (de) * 1989-12-04 1991-06-06 Schwabe Willmar Gmbh & Co Extrakt aus blaettern von ginkgo biloba, verfahren zu seiner herstellung und den extrakt enthaltende arzneimittel
GB9107425D0 (en) * 1991-04-09 1991-05-22 Scras Preparation of ginkgolide b
GB9408044D0 (en) * 1994-04-22 1994-06-15 Sod Conseils Rech Applic Conversion of ginkgolide c to ginkgolide b
DE19756848C2 (de) * 1997-12-19 2003-01-16 Schwabe Willmar Gmbh & Co Extrakte aus Blättern von Ginkgo biloba mit vermindertem Gehalt an 4'-O-Methylpyridoxin und Biflavonen
US6030621A (en) * 1998-03-19 2000-02-29 De Long; Xie Ginkgo biloba composition, method to prepare the same and uses thereof
CN1124275C (zh) * 2000-06-02 2003-10-15 天津大学 由银杏叶或银杏叶浸膏制备药物银杏内酯a、b的方法
EP1163908B1 (de) * 2000-06-16 2004-05-06 Linnea S.A. Wasserlöslicher Komplex eines Ginkgo biloba Extrakts, Verfahren zu dessen Herstellung und diesen enthaltende Zusammensetzung
KR20040031772A (ko) * 2001-07-11 2004-04-13 더 트러스티스 오브 컬럼비아 유니버시티 인 더 시티 오브 뉴욕 은행의 잎 및 약제학적 분말로부터 테르펜트리락톤(징코라이드, 빌로바라이드)을 분리하는 방법

Also Published As

Publication number Publication date
AU2002307981B2 (en) 2006-11-23
HUP0303797A3 (en) 2005-05-30
DE60201525T8 (de) 2006-08-24
FR2823116A1 (fr) 2002-10-11
KR100876233B1 (ko) 2008-12-26
ATE278411T1 (de) 2004-10-15
ES2230512T3 (es) 2005-05-01
JP4416404B2 (ja) 2010-02-17
HK1066164A1 (en) 2005-03-18
FR2823116B1 (fr) 2004-11-19
CA2443302C (fr) 2012-09-18
RU2003132470A (ru) 2005-03-10
CA2443302A1 (fr) 2002-10-24
DE60201525T2 (de) 2006-03-02
KR20030087068A (ko) 2003-11-12
PT1379262E (pt) 2005-02-28
EP1379262B1 (de) 2004-10-06
PL366938A1 (en) 2005-02-07
US7048954B2 (en) 2006-05-23
CZ299652B6 (cs) 2008-10-01
EP1379262A1 (de) 2004-01-14
NZ528571A (en) 2005-06-24
CZ20033055A3 (cs) 2004-06-16
US20040109907A1 (en) 2004-06-10
CN1501806A (zh) 2004-06-02
RU2297235C2 (ru) 2007-04-20
PL204867B1 (pl) 2010-02-26
CN1245167C (zh) 2006-03-15
WO2002083158A1 (fr) 2002-10-24
DK1379262T3 (da) 2005-02-14
JP2004538263A (ja) 2004-12-24
HUP0303797A2 (hu) 2004-03-29

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Owner name: IPSEN PHARMA S.A.S., BOULOGNE-BILLANCOURT, FR