DE602007013567D1 - Verfahren zur herstellung fester dispersionen von midostaurin - Google Patents

Verfahren zur herstellung fester dispersionen von midostaurin

Info

Publication number
DE602007013567D1
DE602007013567D1 DE602007013567T DE602007013567T DE602007013567D1 DE 602007013567 D1 DE602007013567 D1 DE 602007013567D1 DE 602007013567 T DE602007013567 T DE 602007013567T DE 602007013567 T DE602007013567 T DE 602007013567T DE 602007013567 D1 DE602007013567 D1 DE 602007013567D1
Authority
DE
Germany
Prior art keywords
solid dispersions
preparing solid
midostaurin
highly crystalline
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602007013567T
Other languages
German (de)
English (en)
Inventor
Indrajit Ghosh
Jennifer Snyder
Wei-Qin Tong
Sudha Vippagunta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Publication of DE602007013567D1 publication Critical patent/DE602007013567D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Colloid Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Glass Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Peptides Or Proteins (AREA)
DE602007013567T 2006-08-16 2007-08-14 Verfahren zur herstellung fester dispersionen von midostaurin Active DE602007013567D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US82255606P 2006-08-16 2006-08-16
PCT/US2007/017960 WO2008021347A2 (en) 2006-08-16 2007-08-14 Method for making solid dispersions of highly crystalline therapeutic compounds

Publications (1)

Publication Number Publication Date
DE602007013567D1 true DE602007013567D1 (de) 2011-05-12

Family

ID=38657762

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602007013567T Active DE602007013567D1 (de) 2006-08-16 2007-08-14 Verfahren zur herstellung fester dispersionen von midostaurin

Country Status (16)

Country Link
US (2) US20100038816A1 (https=)
EP (1) EP2054040B1 (https=)
JP (1) JP5546860B2 (https=)
KR (1) KR101462693B1 (https=)
CN (1) CN101516339B (https=)
AT (1) ATE503484T1 (https=)
AU (1) AU2007284615B2 (https=)
BR (1) BRPI0714963A2 (https=)
CA (1) CA2660086C (https=)
DE (1) DE602007013567D1 (https=)
ES (1) ES2363725T3 (https=)
MX (1) MX2009001636A (https=)
PL (1) PL2054040T3 (https=)
PT (1) PT2054040E (https=)
RU (1) RU2454220C2 (https=)
WO (1) WO2008021347A2 (https=)

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CN102525879B (zh) * 2010-12-31 2015-01-21 正大天晴药业集团股份有限公司 制备阿瑞匹坦固体分散组合物的方法
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CN108024939B (zh) 2015-08-20 2024-06-07 联合利华知识产权控股有限公司 包封的内酰胺
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EP3337451B1 (en) 2015-08-20 2018-12-26 Unilever PLC Improved lactam solubility
CN107848968B (zh) 2015-08-20 2021-06-18 荷兰联合利华有限公司 从乙醛酸制备内酰胺的方法
WO2017029093A1 (en) 2015-08-20 2017-02-23 Unilever Plc Improved lactam solubility
CN107920976A (zh) 2015-08-20 2018-04-17 荷兰联合利华有限公司 改善的内酰胺溶解度
BR112018003082B1 (pt) * 2015-08-20 2021-12-14 Unilever Ip Holdings B.V. Lactama em uma dispersão sólida, método de produção de uma composição compreendendo uma lactama e método de formação de lactama em uma dispersão sólida
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CN111615389A (zh) 2018-02-01 2020-09-01 科尔沃斯制药股份有限公司 药物调配物
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CN116887866A (zh) 2020-12-03 2023-10-13 巴特尔纪念研究院 聚合物纳米颗粒和dna纳米结构组合物及用于非病毒递送的方法
WO2022216977A1 (en) 2021-04-07 2022-10-13 Batelle Memorial Institute Rapid design, build, test, and learn technologies for identifying and using non-viral carriers
CN114796149A (zh) * 2022-04-27 2022-07-29 苏州中化药品工业有限公司 一种高生物利用度的双醋瑞因胶囊剂及其制备方法
WO2025072751A1 (en) 2023-09-29 2025-04-03 Battelle Memorial Institute Polymer nanoparticle compositions for in vivo expression of polypeptides
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Also Published As

Publication number Publication date
MX2009001636A (es) 2009-02-23
WO2008021347A3 (en) 2008-08-07
WO2008021347A2 (en) 2008-02-21
PL2054040T3 (pl) 2011-09-30
CN101516339B (zh) 2012-06-13
CA2660086A1 (en) 2008-02-21
EP2054040B1 (en) 2011-03-30
ES2363725T3 (es) 2011-08-12
US8641948B2 (en) 2014-02-04
KR20090042961A (ko) 2009-05-04
PT2054040E (pt) 2011-06-30
US20120190667A1 (en) 2012-07-26
JP2010500411A (ja) 2010-01-07
AU2007284615B2 (en) 2011-10-27
RU2454220C2 (ru) 2012-06-27
BRPI0714963A2 (pt) 2013-07-30
ATE503484T1 (de) 2011-04-15
AU2007284615A1 (en) 2008-02-21
RU2009109357A (ru) 2010-09-27
KR101462693B1 (ko) 2014-11-17
US20100038816A1 (en) 2010-02-18
CA2660086C (en) 2014-09-16
CN101516339A (zh) 2009-08-26
JP5546860B2 (ja) 2014-07-09
EP2054040A2 (en) 2009-05-06

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