ATE492547T1 - Verfahren zur herstellung lipophiler pharmazeutisch akzeptabler salze aus pemetrexed- disäure - Google Patents
Verfahren zur herstellung lipophiler pharmazeutisch akzeptabler salze aus pemetrexed- disäureInfo
- Publication number
- ATE492547T1 ATE492547T1 AT07836879T AT07836879T ATE492547T1 AT E492547 T1 ATE492547 T1 AT E492547T1 AT 07836879 T AT07836879 T AT 07836879T AT 07836879 T AT07836879 T AT 07836879T AT E492547 T1 ATE492547 T1 AT E492547T1
- Authority
- AT
- Austria
- Prior art keywords
- pemetrexed
- pharmaceutically acceptable
- acceptable salts
- disacid
- lipophilic pharmaceutically
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (16)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US83730306P | 2006-08-14 | 2006-08-14 | |
US83763706P | 2006-08-15 | 2006-08-15 | |
US83955106P | 2006-08-22 | 2006-08-22 | |
US84503106P | 2006-09-14 | 2006-09-14 | |
US84729106P | 2006-09-25 | 2006-09-25 | |
US85513906P | 2006-10-30 | 2006-10-30 | |
US86055406P | 2006-11-21 | 2006-11-21 | |
US86055706P | 2006-11-21 | 2006-11-21 | |
US88017807P | 2007-01-11 | 2007-01-11 | |
US88017907P | 2007-01-11 | 2007-01-11 | |
US89992807P | 2007-02-06 | 2007-02-06 | |
US93655307P | 2007-06-20 | 2007-06-20 | |
US95832607P | 2007-07-02 | 2007-07-02 | |
US95821307P | 2007-07-03 | 2007-07-03 | |
US95841307P | 2007-07-05 | 2007-07-05 | |
PCT/US2007/018098 WO2008021411A2 (en) | 2006-08-14 | 2007-08-14 | Processes for the preparation of lyophilized pharmaceutically acceptable salts of pemetrexed diacid |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE492547T1 true ATE492547T1 (de) | 2011-01-15 |
Family
ID=49584971
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT07836879T ATE492547T1 (de) | 2006-08-14 | 2007-08-14 | Verfahren zur herstellung lipophiler pharmazeutisch akzeptabler salze aus pemetrexed- disäure |
Country Status (9)
Country | Link |
---|---|
US (1) | US8629152B2 (de) |
EP (1) | EP1943252B1 (de) |
JP (1) | JP2008543976A (de) |
KR (1) | KR101083230B1 (de) |
AT (1) | ATE492547T1 (de) |
DE (1) | DE602007011384D1 (de) |
ES (1) | ES2356792T3 (de) |
TW (1) | TWI377955B (de) |
WO (1) | WO2008021411A2 (de) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2129674A2 (de) | 2007-04-03 | 2009-12-09 | Dr. Reddy's Laboratories Ltd. | Feste formen von pemetrexed |
CN101684121B (zh) * | 2008-09-22 | 2013-04-03 | 重庆医药工业研究院有限责任公司 | 培美曲塞二酸的新晶型及其制备方法 |
CN102838602B (zh) * | 2011-06-21 | 2016-08-03 | 重庆医药工业研究院有限责任公司 | 培美曲塞氧化物及其制备方法 |
EP2854768B1 (de) | 2012-05-30 | 2017-03-22 | Fresenius Kabi Oncology Limited | Pharmazeutische zusammensetzungen aus pemetrexed |
EP2909208A4 (de) * | 2012-10-17 | 2016-07-13 | Shilpa Medicare Ltd | Verfahren zur herstellung von pemetrexed-dikalium und dessen hydraten |
KR101260636B1 (ko) * | 2012-11-29 | 2013-05-13 | 씨제이제일제당 (주) | 안정화된 페메트렉시드 제제 |
US20150359898A1 (en) | 2013-02-06 | 2015-12-17 | Cipla Limited | Pemetrexed Complexes and Pharmaceutical Compositions Containing Pemetrexed Complexes |
WO2014185797A1 (en) | 2013-05-17 | 2014-11-20 | Instytut Farmaceutyczny | Process for the preparation of high purity amorphous pemetrexed disodium and crystalline forms of n-[4-[2-(2-amino-4,7-dihydro-4-oxo-3h-pyrrolo[2,3- d] pyrimidin-5-yl)ethyl] benzoyl]-l-glutamic acid |
US20160145260A1 (en) | 2013-06-14 | 2016-05-26 | Synthon B.V. | Stable pemetrexed arginine salt and compositions comprising it |
KR101703980B1 (ko) | 2013-12-30 | 2017-02-08 | 주식회사 삼양바이오팜 | 항산화제를 함유하지 않는 약학 조성물 및 그의 제조방법 |
NZ630299A (en) * | 2014-06-30 | 2014-11-28 | Shilpa Medicare Ltd | Pemetrexed dipotassium formulations |
US20170239250A1 (en) | 2016-02-19 | 2017-08-24 | Eagle Pharmaceuticals, Inc. | Pemetrexed formulations |
MX2018010037A (es) * | 2016-02-19 | 2019-07-04 | Eagle Pharmaceuticals Inc | Formulaciones de pemetrexed. |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL96531A (en) | 1989-12-11 | 1995-08-31 | Univ Princeton | History of Acid N- (Diomeric-H1-Pyrolo] D-2,3 [Pyrimidine-3-Ilacyl (-glutamic, preparation and pharmaceutical preparations containing them) |
KR0162654B1 (ko) * | 1989-12-11 | 1998-11-16 | 알렌 제이. 시니스갤리 | N-(피롤로[2,3-d]피리미딘-3-일아크릴)-글루타민산 유도체 |
CA2032695A1 (en) | 1989-12-20 | 1991-06-21 | Hiroshi Akimoto | Condensed heterocyclic compounds, their production and use |
US5416211A (en) * | 1992-09-25 | 1995-05-16 | Eli Lilly And Company | Process for preparing 5-substituted pyrrolo-[2,3-d]pyrimidines |
US6262262B1 (en) * | 1997-09-26 | 2001-07-17 | Eli Lilly And Company | Processes and intermediates useful to make antifolates |
WO2001014379A2 (en) | 1999-08-23 | 2001-03-01 | Eli Lilly And Company | A novel crystalline form of disodium n-[4-[2-(2-amino-4,7-dihydro-4-oxo-3h-pyrrolo[2,3-d]-pyrimidin-5-yl)ethyl]benzoyl]-l-glutamic acid salt and processes therefor |
JP4846158B2 (ja) | 2000-02-25 | 2011-12-28 | イーライ リリー アンド カンパニー | N−[4−[2−(2−アミノ−4,7−ジヒドロ−4−オキソ−3H−ピロロ[2,3−d]ピリミジン−5−イル)エチル]ベンゾイル]−L−グルタミン酸の新規結晶形およびその製造方法 |
JP2008530216A (ja) * | 2005-02-16 | 2008-08-07 | シェーリング コーポレイション | Cxcr3アンタゴニスト活性を有する、複素環で置換された新規のピリジンまたはフェニル化合物 |
US8158152B2 (en) * | 2005-11-18 | 2012-04-17 | Scidose Llc | Lyophilization process and products obtained thereby |
EP2129674A2 (de) | 2007-04-03 | 2009-12-09 | Dr. Reddy's Laboratories Ltd. | Feste formen von pemetrexed |
-
2007
- 2007-08-14 EP EP07836879A patent/EP1943252B1/de active Active
- 2007-08-14 JP JP2008530049A patent/JP2008543976A/ja active Pending
- 2007-08-14 ES ES07836879T patent/ES2356792T3/es active Active
- 2007-08-14 AT AT07836879T patent/ATE492547T1/de not_active IP Right Cessation
- 2007-08-14 KR KR1020087029220A patent/KR101083230B1/ko active IP Right Grant
- 2007-08-14 DE DE602007011384T patent/DE602007011384D1/de active Active
- 2007-08-14 US US11/893,234 patent/US8629152B2/en active Active
- 2007-08-14 TW TW096130058A patent/TWI377955B/zh active
- 2007-08-14 WO PCT/US2007/018098 patent/WO2008021411A2/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
TWI377955B (en) | 2012-12-01 |
KR101083230B1 (ko) | 2011-11-11 |
WO2008021411A3 (en) | 2008-04-10 |
DE602007011384D1 (de) | 2011-02-03 |
WO2008021411A2 (en) | 2008-02-21 |
KR20090035478A (ko) | 2009-04-09 |
ES2356792T3 (es) | 2011-04-13 |
TW200824720A (en) | 2008-06-16 |
EP1943252A2 (de) | 2008-07-16 |
US20080139810A1 (en) | 2008-06-12 |
US8629152B2 (en) | 2014-01-14 |
EP1943252B1 (de) | 2010-12-22 |
JP2008543976A (ja) | 2008-12-04 |
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Legal Events
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RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |