AU2007284615B2 - Method for making solid dispersions of highly crystalline therapeutic compounds - Google Patents

Method for making solid dispersions of highly crystalline therapeutic compounds Download PDF

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Publication number
AU2007284615B2
AU2007284615B2 AU2007284615A AU2007284615A AU2007284615B2 AU 2007284615 B2 AU2007284615 B2 AU 2007284615B2 AU 2007284615 A AU2007284615 A AU 2007284615A AU 2007284615 A AU2007284615 A AU 2007284615A AU 2007284615 B2 AU2007284615 B2 AU 2007284615B2
Authority
AU
Australia
Prior art keywords
poloxamer
mixture
therapeutic compound
midostaurin
extrudate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2007284615A
Other languages
English (en)
Other versions
AU2007284615A1 (en
Inventor
Indrajit Ghosh
Jennifer Snyder
Wei-Qin Tong
Sudha Vippagunta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Publication of AU2007284615A1 publication Critical patent/AU2007284615A1/en
Application granted granted Critical
Publication of AU2007284615B2 publication Critical patent/AU2007284615B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Colloid Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Glass Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Peptides Or Proteins (AREA)
AU2007284615A 2006-08-16 2007-08-14 Method for making solid dispersions of highly crystalline therapeutic compounds Ceased AU2007284615B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US82255606P 2006-08-16 2006-08-16
US60/822,556 2006-08-16
PCT/US2007/017960 WO2008021347A2 (en) 2006-08-16 2007-08-14 Method for making solid dispersions of highly crystalline therapeutic compounds

Publications (2)

Publication Number Publication Date
AU2007284615A1 AU2007284615A1 (en) 2008-02-21
AU2007284615B2 true AU2007284615B2 (en) 2011-10-27

Family

ID=38657762

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2007284615A Ceased AU2007284615B2 (en) 2006-08-16 2007-08-14 Method for making solid dispersions of highly crystalline therapeutic compounds

Country Status (16)

Country Link
US (2) US20100038816A1 (https=)
EP (1) EP2054040B1 (https=)
JP (1) JP5546860B2 (https=)
KR (1) KR101462693B1 (https=)
CN (1) CN101516339B (https=)
AT (1) ATE503484T1 (https=)
AU (1) AU2007284615B2 (https=)
BR (1) BRPI0714963A2 (https=)
CA (1) CA2660086C (https=)
DE (1) DE602007013567D1 (https=)
ES (1) ES2363725T3 (https=)
MX (1) MX2009001636A (https=)
PL (1) PL2054040T3 (https=)
PT (1) PT2054040E (https=)
RU (1) RU2454220C2 (https=)
WO (1) WO2008021347A2 (https=)

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UA113500C2 (xx) 2010-10-29 2017-02-10 Одержані екструзією розплаву тверді дисперсії, що містять індукуючий апоптоз засіб
CN102525879B (zh) * 2010-12-31 2015-01-21 正大天晴药业集团股份有限公司 制备阿瑞匹坦固体分散组合物的方法
BR112016021739B1 (pt) * 2014-03-25 2021-11-03 Genentech, Inc Método para preparar um poloxâmero para uso em um meio de cultura de célula
CN107001322B (zh) 2014-12-18 2020-07-28 默沙东公司 用于药物制剂的组合物
GB201502073D0 (en) * 2015-02-09 2015-03-25 Cubic Pharmaceuticals Ltd And Delta Pharmaceuticals Ltd HDEG technology
CN108024939B (zh) 2015-08-20 2024-06-07 联合利华知识产权控股有限公司 包封的内酰胺
ES2758300T3 (es) 2015-08-20 2020-05-05 Unilever Nv Solubilidad de lactama mejorada
EP3337451B1 (en) 2015-08-20 2018-12-26 Unilever PLC Improved lactam solubility
CN107848968B (zh) 2015-08-20 2021-06-18 荷兰联合利华有限公司 从乙醛酸制备内酰胺的方法
WO2017029093A1 (en) 2015-08-20 2017-02-23 Unilever Plc Improved lactam solubility
CN107920976A (zh) 2015-08-20 2018-04-17 荷兰联合利华有限公司 改善的内酰胺溶解度
BR112018003082B1 (pt) * 2015-08-20 2021-12-14 Unilever Ip Holdings B.V. Lactama em uma dispersão sólida, método de produção de uma composição compreendendo uma lactama e método de formação de lactama em uma dispersão sólida
JP7021182B2 (ja) * 2016-03-24 2022-02-16 ロケート・バイオ・リミテッド 足場材料、方法および使用
MX383740B (es) * 2016-05-13 2025-03-14 Merck Patent Gmbh Composición de extrusión fundida en caliente que usa un excipiente compresible directo como plastificante.
CN111615389A (zh) 2018-02-01 2020-09-01 科尔沃斯制药股份有限公司 药物调配物
EP3520782A3 (en) * 2018-02-01 2019-11-13 Corvus Pharmaceuticals, Inc. Pharmaceutical formulations containing adenosine a2a receptor antagonists
CN113573712A (zh) 2019-02-18 2021-10-29 斯莱班克制药有限责任公司 尼洛替尼的药物组合物
CN116887866A (zh) 2020-12-03 2023-10-13 巴特尔纪念研究院 聚合物纳米颗粒和dna纳米结构组合物及用于非病毒递送的方法
WO2022216977A1 (en) 2021-04-07 2022-10-13 Batelle Memorial Institute Rapid design, build, test, and learn technologies for identifying and using non-viral carriers
CN114796149A (zh) * 2022-04-27 2022-07-29 苏州中化药品工业有限公司 一种高生物利用度的双醋瑞因胶囊剂及其制备方法
WO2025072751A1 (en) 2023-09-29 2025-04-03 Battelle Memorial Institute Polymer nanoparticle compositions for in vivo expression of polypeptides
US12441996B2 (en) 2023-12-08 2025-10-14 Battelle Memorial Institute Use of DNA origami nanostructures for molecular information based data storage systems

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Also Published As

Publication number Publication date
MX2009001636A (es) 2009-02-23
WO2008021347A3 (en) 2008-08-07
WO2008021347A2 (en) 2008-02-21
PL2054040T3 (pl) 2011-09-30
CN101516339B (zh) 2012-06-13
CA2660086A1 (en) 2008-02-21
EP2054040B1 (en) 2011-03-30
ES2363725T3 (es) 2011-08-12
DE602007013567D1 (de) 2011-05-12
US8641948B2 (en) 2014-02-04
KR20090042961A (ko) 2009-05-04
PT2054040E (pt) 2011-06-30
US20120190667A1 (en) 2012-07-26
JP2010500411A (ja) 2010-01-07
RU2454220C2 (ru) 2012-06-27
BRPI0714963A2 (pt) 2013-07-30
ATE503484T1 (de) 2011-04-15
AU2007284615A1 (en) 2008-02-21
RU2009109357A (ru) 2010-09-27
KR101462693B1 (ko) 2014-11-17
US20100038816A1 (en) 2010-02-18
CA2660086C (en) 2014-09-16
CN101516339A (zh) 2009-08-26
JP5546860B2 (ja) 2014-07-09
EP2054040A2 (en) 2009-05-06

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Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired