DE602005020014D1 - Kristallines mycophenolat-natrium - Google Patents
Kristallines mycophenolat-natriumInfo
- Publication number
- DE602005020014D1 DE602005020014D1 DE602005020014T DE602005020014T DE602005020014D1 DE 602005020014 D1 DE602005020014 D1 DE 602005020014D1 DE 602005020014 T DE602005020014 T DE 602005020014T DE 602005020014 T DE602005020014 T DE 602005020014T DE 602005020014 D1 DE602005020014 D1 DE 602005020014D1
- Authority
- DE
- Germany
- Prior art keywords
- mycophenolate sodium
- crystalline mycophenolate
- crystalline
- sodium
- processes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/83—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
- C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Transplantation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Furan Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US58990904P | 2004-07-20 | 2004-07-20 | |
US63184904P | 2004-11-29 | 2004-11-29 | |
PCT/US2005/025816 WO2006012385A2 (en) | 2004-07-20 | 2005-07-20 | Crystalline mycophenolate sodium |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602005020014D1 true DE602005020014D1 (de) | 2010-04-29 |
Family
ID=35385154
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602005020014T Active DE602005020014D1 (de) | 2004-07-20 | 2005-07-20 | Kristallines mycophenolat-natrium |
Country Status (10)
Country | Link |
---|---|
US (4) | US7439373B2 (de) |
EP (2) | EP1699773A2 (de) |
JP (2) | JP2008506783A (de) |
CN (2) | CN101052631A (de) |
AT (1) | ATE461182T1 (de) |
CA (2) | CA2573781A1 (de) |
DE (1) | DE602005020014D1 (de) |
ES (1) | ES2340184T3 (de) |
TW (2) | TW200611692A (de) |
WO (2) | WO2006012379A2 (de) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK2032712T3 (da) * | 2006-06-29 | 2010-05-25 | Ivax Pharmaceuticals Sro | Regulering af syremetabolitproduktion |
US20080176937A1 (en) * | 2007-01-23 | 2008-07-24 | Apotex Fermentation Inc. | Novel crystalline mycophenolate sodium polymorph and processes to manufacture same |
US20080182998A1 (en) * | 2007-01-25 | 2008-07-31 | Apotex Fermentation Inc. | Novel crystalline mycophenolate sodium polymorph and processes to manufacture same |
BRPI0803097A2 (pt) * | 2007-04-11 | 2011-11-08 | Teva Gyogyszergyar ... | método para redução do nìvel de impurezas na fermentação do ácido micofenólico |
US20100010082A1 (en) * | 2008-07-09 | 2010-01-14 | Aspreva International Ltd. | Formulations for treating eye disorders |
WO2010041269A1 (en) * | 2008-09-10 | 2010-04-15 | Ipca Laboratories Limited | Process for preparation of mycophenolic acid, its salt and ester derivatives |
CN102464639A (zh) * | 2010-11-16 | 2012-05-23 | 北京京卫信康医药科技发展有限公司 | 麦考酚酸钠的新晶型及其制备方法 |
CN103923044A (zh) * | 2010-11-16 | 2014-07-16 | 北京京卫信康医药科技发展有限公司 | 麦考酚酸钠的新晶型及其制备方法 |
CN103880800A (zh) * | 2010-11-16 | 2014-06-25 | 北京京卫信康医药科技发展有限公司 | 麦考酚酸钠的新晶型及其制备方法 |
CN103880799A (zh) * | 2010-11-16 | 2014-06-25 | 北京京卫信康医药科技发展有限公司 | 麦考酚酸钠的新晶型及其制备方法 |
AR099354A1 (es) | 2013-11-15 | 2016-07-20 | Akebia Therapeutics Inc | Formas sólidas de ácido {[5-(3-clorofenil)-3-hidroxipiridin-2-carbonil]amino}acético, composiciones, y sus usos |
CN106350550B (zh) * | 2016-11-28 | 2019-05-07 | 无锡福祈制药有限公司 | 一种自麦考酚酸菌株制备麦考酚钠的方法 |
CN106866594A (zh) * | 2017-02-17 | 2017-06-20 | 上海华源医药科技发展有限公司 | 适用于麦考酚钠工业化生产的优化工艺 |
RU2723255C2 (ru) * | 2018-11-14 | 2020-06-09 | Общество с ограниченной ответственностью "Изварино Фарма" | Экструдат с микофенолятом натрия для получения пероральной твердой лекарственной формы |
CN110922371B (zh) * | 2019-12-27 | 2020-08-11 | 广东蓝宝制药有限公司 | 一种m2晶型麦考酚钠的制备方法 |
CN112645912B (zh) * | 2020-12-27 | 2022-05-13 | 广东蓝宝制药有限公司 | 一种高纯度m2晶型麦考酚钠的制备方法 |
CN114478452B (zh) * | 2022-02-22 | 2024-02-06 | 广东蓝宝制药有限公司 | 一种麦考酚钠的制备方法 |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1157099A (en) | 1966-09-27 | 1969-07-02 | Ici Ltd | Fermentation Process |
GB1158387A (en) | 1967-06-13 | 1969-07-16 | Ici Ltd | Procedure for Isolation of Mycophenolic Acid |
ZA684959B (en) | 1967-11-22 | 1969-05-22 | Lilly Co Eli | Agents and methods for inhibiting the growth of malignant tumor cells in warm-blooded mammals |
US4452891A (en) * | 1980-09-08 | 1984-06-05 | Ajinomoto Company Incorporated | Method for production of mycophenolic acid by fermentation |
US4861776A (en) * | 1987-01-30 | 1989-08-29 | Syntex (U.S.A) Inc. | Heterocyclic aminoalkyl esters of mycophenolic acid and derivatives thereof, compositions and use |
US4753935A (en) | 1987-01-30 | 1988-06-28 | Syntex (U.S.A.) Inc. | Morpholinoethylesters of mycophenolic acid and pharmaceutical compositions |
US4748173A (en) | 1987-01-30 | 1988-05-31 | Syntex (U.S.A.) Inc. | Heterocyclic aminoalkyl esters of mycophenolic acid and derivatives thereof and pharmaceutical compositions |
US5247083A (en) | 1992-07-10 | 1993-09-21 | Syntex (U.S.A.) Inc. | Direct esterification of mycophenolic acid |
US5455045A (en) * | 1993-05-13 | 1995-10-03 | Syntex (U.S.A.) Inc. | High dose formulations |
DK0724581T3 (da) * | 1993-09-15 | 1999-08-02 | Syntex Inc | Krystallinsk vandfri mycophenolatmofetil og intravenøs formulering deraf |
JP3844491B2 (ja) | 1993-10-01 | 2006-11-15 | シンテックス(ユー・エス・エイ)インコーポレイテッド | ミコフェノール酸モフェチル高用量経口用懸濁剤 |
ID18663A (id) | 1996-04-12 | 1998-04-30 | Novartis Ag | Komposisi farmasi berlapis enterik |
GB9812413D0 (en) * | 1998-06-10 | 1998-08-05 | Glaxo Group Ltd | Compound and its use |
IN188985B (de) * | 1998-12-09 | 2002-11-30 | Biocon Ltd | |
HUP9903226A2 (en) | 1999-09-23 | 2002-08-28 | Gyogyszerki | Process for producing mycophenolic acid and derivatives thereof |
AU2000233225A1 (en) | 2000-02-29 | 2001-09-12 | Biocon India Limited | Manufacture and purification of mycophenolic acid |
CZ292123B6 (cs) | 2001-06-08 | 2003-08-13 | Ivax Pharmaceuticals S.R.O. | Způsob přípravy mykofenolátu mofetilu |
GB0124953D0 (en) * | 2001-10-17 | 2001-12-05 | Novartis Ag | Organic Compounds |
CA2468435C (en) | 2002-08-29 | 2008-02-19 | Biocon Limited | Process for the production of an immunosuppressant |
GB0301259D0 (en) | 2003-01-20 | 2003-02-19 | Novartis Ag | Organic compounds |
TWI221414B (en) * | 2003-02-21 | 2004-10-01 | Chunghwa Chemical Synthesis & | Method of making mycophenolate mofetil using transesterification |
GB0307553D0 (en) | 2003-04-01 | 2003-05-07 | Novartis Ag | Organic compounds |
-
2005
- 2005-07-20 CA CA002573781A patent/CA2573781A1/en not_active Abandoned
- 2005-07-20 WO PCT/US2005/025808 patent/WO2006012379A2/en active Application Filing
- 2005-07-20 US US11/186,560 patent/US7439373B2/en not_active Expired - Fee Related
- 2005-07-20 DE DE602005020014T patent/DE602005020014D1/de active Active
- 2005-07-20 AT AT05773805T patent/ATE461182T1/de not_active IP Right Cessation
- 2005-07-20 US US11/186,164 patent/US20060069150A1/en not_active Abandoned
- 2005-07-20 JP JP2007522720A patent/JP2008506783A/ja active Pending
- 2005-07-20 CN CNA2005800239539A patent/CN101052631A/zh active Pending
- 2005-07-20 ES ES05773805T patent/ES2340184T3/es active Active
- 2005-07-20 TW TW094124541A patent/TW200611692A/zh unknown
- 2005-07-20 TW TW094124619A patent/TWI322147B/zh not_active IP Right Cessation
- 2005-07-20 CA CA002573784A patent/CA2573784A1/en not_active Abandoned
- 2005-07-20 CN CNA2005800240659A patent/CN101014584A/zh active Pending
- 2005-07-20 EP EP05775059A patent/EP1699773A2/de not_active Ceased
- 2005-07-20 EP EP07023241A patent/EP1908756A1/de not_active Withdrawn
- 2005-07-20 WO PCT/US2005/025816 patent/WO2006012385A2/en active Application Filing
- 2005-07-20 JP JP2007522726A patent/JP2008506784A/ja active Pending
-
2007
- 2007-12-14 US US12/002,069 patent/US20080097096A1/en not_active Abandoned
- 2007-12-14 US US12/002,049 patent/US20080103317A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2006012385A3 (en) | 2006-06-22 |
CN101014584A (zh) | 2007-08-08 |
US20080097096A1 (en) | 2008-04-24 |
EP1908756A1 (de) | 2008-04-09 |
ES2340184T3 (es) | 2010-05-31 |
CN101052631A (zh) | 2007-10-10 |
TW200611692A (en) | 2006-04-16 |
WO2006012379A8 (en) | 2006-04-20 |
US20060069150A1 (en) | 2006-03-30 |
US7439373B2 (en) | 2008-10-21 |
JP2008506784A (ja) | 2008-03-06 |
ATE461182T1 (de) | 2010-04-15 |
US20080103317A1 (en) | 2008-05-01 |
TW200615272A (en) | 2006-05-16 |
EP1699773A2 (de) | 2006-09-13 |
TWI322147B (en) | 2010-03-21 |
CA2573784A1 (en) | 2006-02-02 |
JP2008506783A (ja) | 2008-03-06 |
US20060069152A1 (en) | 2006-03-30 |
WO2006012379A3 (en) | 2006-06-22 |
WO2006012385A2 (en) | 2006-02-02 |
WO2006012379A2 (en) | 2006-02-02 |
CA2573781A1 (en) | 2006-02-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |