DE602005008224D1 - Verfahren zur herstellung von valsartan und vorstufen davon - Google Patents
Verfahren zur herstellung von valsartan und vorstufen davonInfo
- Publication number
- DE602005008224D1 DE602005008224D1 DE602005008224T DE602005008224T DE602005008224D1 DE 602005008224 D1 DE602005008224 D1 DE 602005008224D1 DE 602005008224 T DE602005008224 T DE 602005008224T DE 602005008224 T DE602005008224 T DE 602005008224T DE 602005008224 D1 DE602005008224 D1 DE 602005008224D1
- Authority
- DE
- Germany
- Prior art keywords
- preparing
- formula
- valsartan
- preventing
- useful
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000004072 C09CA03 - Valsartan Substances 0.000 title abstract 3
- SJSNUMAYCRRIOM-QFIPXVFZSA-N valsartan Chemical compound C1=CC(CN(C(=O)CCCC)[C@@H](C(C)C)C(O)=O)=CC=C1C1=CC=CC=C1C1=NN=N[N]1 SJSNUMAYCRRIOM-QFIPXVFZSA-N 0.000 title abstract 3
- 229960004699 valsartan Drugs 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 abstract 5
- 239000000543 intermediate Substances 0.000 abstract 4
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 230000006181 N-acylation Effects 0.000 abstract 1
- 208000037849 arterial hypertension Diseases 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Catalysts (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pyrrole Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200400949A ES2251292B1 (es) | 2004-04-20 | 2004-04-20 | Procedimiento para la obtencion de un compuesto farmaceuticamente activo y de sus intermedios de sintesis. |
| PCT/IB2005/001100 WO2005102987A1 (en) | 2004-04-20 | 2005-04-18 | Process for the preparation of valsartan and precursors thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602005008224D1 true DE602005008224D1 (de) | 2008-08-28 |
Family
ID=34966329
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602005008224T Expired - Fee Related DE602005008224D1 (de) | 2004-04-20 | 2005-04-18 | Verfahren zur herstellung von valsartan und vorstufen davon |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7728021B2 (de) |
| EP (1) | EP1747190B1 (de) |
| JP (1) | JP2007533727A (de) |
| KR (1) | KR20060135959A (de) |
| AT (1) | ATE401300T1 (de) |
| DE (1) | DE602005008224D1 (de) |
| ES (2) | ES2251292B1 (de) |
| PL (1) | PL1747190T3 (de) |
| PT (1) | PT1747190E (de) |
| SI (1) | SI1747190T1 (de) |
| TW (1) | TWI283576B (de) |
| WO (1) | WO2005102987A1 (de) |
| ZA (1) | ZA200608986B (de) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200505879A (en) | 2003-04-21 | 2005-02-16 | Teva Pharma | Process for the preparation of valsartan |
| KR20070100717A (ko) * | 2004-12-22 | 2007-10-11 | 이난티아, 에스. 엘. | 앤지오텐신 ⅱ 수용기 길항제의 제조를 위한 중간화합물 |
| ES2259909B1 (es) | 2005-02-28 | 2007-06-16 | Inke, S.A. | Procedimiento para la obtencion de un compuesto farmaceuticamente activo y de su intermedio de sintesis. |
| EP1812411A2 (de) * | 2005-07-05 | 2007-08-01 | Teva Pharmaceutical Industries Ltd. | Verfahren zur herstellung von valsartan |
| ITMI20051989A1 (it) * | 2005-10-20 | 2007-04-21 | Dipharma Spa | Procedimerntyo per la preparazione di composti antagonisti di angiotensina ii |
| ES2288376B1 (es) * | 2005-10-20 | 2008-11-01 | Inke, S.A. | Procedimiento para la obtencion de intermedios utiles en la obtencion de un compuesto farmaceuticamente activo. |
| WO2007071750A1 (en) * | 2005-12-22 | 2007-06-28 | Enantia, S.L. | Intermediates and processes for the preparation of valsartan |
| ES2300175B1 (es) * | 2006-02-14 | 2009-06-08 | Inke, S.A. | Procedimiento para la obtencion de intermedios utiles en la obtencion de un compuesto farmaceuticamente activo. |
| WO2008007391A2 (en) * | 2006-07-10 | 2008-01-17 | Manne Satyanarayana Reddy | An improved process for the preparation of valsartan |
| DE602007000211D1 (de) * | 2007-06-07 | 2008-12-11 | Inke Sa | Verfahren zur Gewinnung eines zur Gewinnung von Valsartan nützlichen Valsartan-Salzes |
| WO2009125416A2 (en) | 2008-04-07 | 2009-10-15 | Hetero Research Foundation | Process for preparation of valsartan intermediate |
| KR101012135B1 (ko) * | 2008-12-18 | 2011-02-07 | 주식회사 대희화학 | 발사르탄 메틸 에스테르의 제조방법 |
| CN102702118B (zh) * | 2012-06-11 | 2014-04-16 | 吉林三善恩科技开发有限公司 | 一种缬沙坦有机药物共晶及其制备方法 |
| CN103804313B (zh) * | 2014-01-27 | 2015-12-09 | 云南现代民族药工程技术研究中心 | 一种简洁的低成本高效率制备缬沙坦的方法 |
| US9675585B1 (en) | 2016-03-24 | 2017-06-13 | Ezra Pharma | Extended release pharmaceutical formulations |
| US9687475B1 (en) | 2016-03-24 | 2017-06-27 | Ezra Pharma Llc | Extended release pharmaceutical formulations with controlled impurity levels |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE134624T1 (de) * | 1990-02-19 | 1996-03-15 | Ciba Geigy Ag | Acylverbindungen |
| DE4319041A1 (de) * | 1992-10-23 | 1994-04-28 | Bayer Ag | Trisubstituierte Biphenyle |
| DE4319040A1 (de) | 1992-10-23 | 1994-04-28 | Bayer Ag | Alkoxymethylsubstituierte Pyridonbiphenyle |
| DE4313747A1 (de) * | 1993-04-27 | 1994-11-03 | Bayer Ag | Verfahren zur Herstellung von substituierten Biphenyltetrazolen |
| DE4320432A1 (de) * | 1993-06-21 | 1994-12-22 | Bayer Ag | Substituierte Mono- und Bipyridylmethylderivate |
| DE4407488A1 (de) | 1994-03-07 | 1995-09-14 | Bayer Ag | Verwendung von Biphenyl- und Pyridylmethylpyridonen |
| US5965738A (en) | 1994-09-20 | 1999-10-12 | Wakunaga Seiyaku Kabushiki Kaisha | Process for producing N-biphenylmethylthiadiazoline derivative or salt thereof and intermediate for producing the same |
| US6207665B1 (en) * | 1997-06-12 | 2001-03-27 | Schering Aktiengesellschaft | Piperazine derivatives and their use as anti-inflammatory agents |
| CA2434184A1 (en) * | 2001-01-19 | 2002-09-12 | Pharmacopeia, Inc. | Bisaryl derivatives having fsh receptor modulatory activity |
| GB0121033D0 (en) * | 2001-08-30 | 2001-10-24 | Novartis Ag | Organic compounds |
-
2004
- 2004-04-20 ES ES200400949A patent/ES2251292B1/es not_active Expired - Fee Related
-
2005
- 2005-04-18 AT AT05733764T patent/ATE401300T1/de not_active IP Right Cessation
- 2005-04-18 DE DE602005008224T patent/DE602005008224D1/de not_active Expired - Fee Related
- 2005-04-18 EP EP05733764A patent/EP1747190B1/de active Active
- 2005-04-18 ES ES05733764T patent/ES2309741T3/es active Active
- 2005-04-18 SI SI200530408T patent/SI1747190T1/sl unknown
- 2005-04-18 KR KR1020067024308A patent/KR20060135959A/ko not_active Application Discontinuation
- 2005-04-18 WO PCT/IB2005/001100 patent/WO2005102987A1/en active IP Right Grant
- 2005-04-18 JP JP2007509005A patent/JP2007533727A/ja active Pending
- 2005-04-18 US US11/568,054 patent/US7728021B2/en not_active Expired - Fee Related
- 2005-04-18 PT PT05733764T patent/PT1747190E/pt unknown
- 2005-04-18 PL PL05733764T patent/PL1747190T3/pl unknown
- 2005-04-18 TW TW094112179A patent/TWI283576B/zh not_active IP Right Cessation
- 2005-04-18 ZA ZA200608986A patent/ZA200608986B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE401300T1 (de) | 2008-08-15 |
| EP1747190B1 (de) | 2008-07-16 |
| US7728021B2 (en) | 2010-06-01 |
| ES2309741T3 (es) | 2008-12-16 |
| US20090221836A1 (en) | 2009-09-03 |
| SI1747190T1 (sl) | 2008-12-31 |
| KR20060135959A (ko) | 2006-12-29 |
| EP1747190A1 (de) | 2007-01-31 |
| ZA200608986B (en) | 2008-02-27 |
| PT1747190E (pt) | 2008-09-29 |
| WO2005102987A1 (en) | 2005-11-03 |
| ES2251292B1 (es) | 2007-07-01 |
| ES2251292A1 (es) | 2006-04-16 |
| TW200539873A (en) | 2005-12-16 |
| PL1747190T3 (pl) | 2009-01-30 |
| TWI283576B (en) | 2007-07-11 |
| JP2007533727A (ja) | 2007-11-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |