DE602005006101T2 - Substituierte chinoline und deren verwendung als inhibitoren von mycobakterien - Google Patents
Substituierte chinoline und deren verwendung als inhibitoren von mycobakterien Download PDFInfo
- Publication number
- DE602005006101T2 DE602005006101T2 DE602005006101T DE602005006101T DE602005006101T2 DE 602005006101 T2 DE602005006101 T2 DE 602005006101T2 DE 602005006101 T DE602005006101 T DE 602005006101T DE 602005006101 T DE602005006101 T DE 602005006101T DE 602005006101 T2 DE602005006101 T2 DE 602005006101T2
- Authority
- DE
- Germany
- Prior art keywords
- alkyl
- hydrogen
- halogen
- alkyloxy
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 0 C*N1CC*CC1 Chemical compound C*N1CC*CC1 0.000 description 6
- VWAPVVBOODNDOO-UHFFFAOYSA-N CCN(CCC(C(c1ccccc1)c1cc(cc(cc2)Br)c2nc1OC)(c(c(F)c1)ccc1F)O)Cc1ccccc1 Chemical compound CCN(CCC(C(c1ccccc1)c1cc(cc(cc2)Br)c2nc1OC)(c(c(F)c1)ccc1F)O)Cc1ccccc1 VWAPVVBOODNDOO-UHFFFAOYSA-N 0.000 description 1
- IEKQBUJCZMYIJV-XLJNKUFUSA-N CN(CC1)CO[C@@]1([C@H](c(cc1)ccc1Cl)c1cc2cc(Br)ccc2nc1OC)c1cccc2c1cccc2 Chemical compound CN(CC1)CO[C@@]1([C@H](c(cc1)ccc1Cl)c1cc2cc(Br)ccc2nc1OC)c1cccc2c1cccc2 IEKQBUJCZMYIJV-XLJNKUFUSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53876804P | 2004-01-23 | 2004-01-23 | |
| US538768P | 2004-01-23 | ||
| PCT/EP2005/050267 WO2005070924A1 (en) | 2004-01-23 | 2005-01-21 | Substituted quinolines and their use as mycobacterial inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE602005006101D1 DE602005006101D1 (de) | 2008-05-29 |
| DE602005006101T2 true DE602005006101T2 (de) | 2009-07-02 |
Family
ID=34807224
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602005006101T Active DE602005006101T2 (de) | 2004-01-23 | 2005-01-21 | Substituierte chinoline und deren verwendung als inhibitoren von mycobakterien |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US7338949B2 (ko) |
| EP (1) | EP1711492B1 (ko) |
| JP (1) | JP4773975B2 (ko) |
| KR (1) | KR101150172B1 (ko) |
| CN (1) | CN1910177B (ko) |
| AP (1) | AP2188A (ko) |
| AT (1) | ATE392423T1 (ko) |
| AU (1) | AU2005206330B2 (ko) |
| BR (1) | BRPI0507076B8 (ko) |
| CA (1) | CA2553266C (ko) |
| DE (1) | DE602005006101T2 (ko) |
| EA (1) | EA011359B1 (ko) |
| ES (1) | ES2306082T3 (ko) |
| HK (1) | HK1100927A1 (ko) |
| IL (1) | IL177013A0 (ko) |
| NO (1) | NO337705B1 (ko) |
| NZ (1) | NZ547277A (ko) |
| UA (1) | UA85570C2 (ko) |
| WO (1) | WO2005070924A1 (ko) |
| ZA (1) | ZA200606070B (ko) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1713776B1 (en) * | 2004-01-29 | 2008-05-14 | Janssen Pharmaceutica N.V. | Quinoline derivatives for use as mycobacterial inhibitors |
| EE05697B1 (et) | 2005-06-08 | 2014-02-17 | Janssen Pharmaceutica N.V. | Kinoliini derivaadid kui antibakteriaalsed toimeained |
| JO2855B1 (en) | 2005-08-03 | 2015-03-15 | شركة جانسين فارماسوتيكا ان. في | Quinoline derivatives acting as antibacterial agents |
| JO2837B1 (en) * | 2005-08-03 | 2014-09-15 | جانسن فارمسيتكا ان في | Quinoline derivatives acting as antibacterial agents |
| US8686002B2 (en) | 2005-08-21 | 2014-04-01 | AbbVie Deutschland GmbH & Co. KG | Heterocyclic compounds and their use as binding partners for 5-HT5 receptors |
| JO3271B1 (ar) | 2006-12-06 | 2018-09-16 | Janssen Pharmaceutica Nv | مشتقات الكوينولين المضادة للجراثيم |
| JO2970B1 (en) | 2006-12-06 | 2016-03-15 | جانسين فارماسوتيكا ان. في | Quinoline antibacterial derivatives |
| JO2684B1 (en) * | 2006-12-06 | 2013-03-03 | جانسين فارماسوتيكا ان في | Quinoline antibacterial derivatives |
| JO2685B1 (en) | 2006-12-06 | 2013-03-03 | جانسين فارماسوتيكا ان في | Quinoline antibacterial derivatives |
| CA2711912A1 (en) * | 2008-01-14 | 2009-07-23 | Jyoti Chattopadhyaya | Quinoline, naphthalene and conformationally constrained quinoline or naphthalene derivates as anti-mycobacterial agents |
| ES2576491T3 (es) * | 2012-04-27 | 2016-07-07 | Janssen Pharmaceutica, N.V. | Derivados de quinolina antibacterianos |
| MX358506B (es) * | 2012-04-27 | 2018-08-22 | Janssen Pharmaceutica Nv | Derivados de quinolina antibacterianos. |
| AU2016255724B2 (en) * | 2015-04-29 | 2020-05-14 | The State of Israel, Ministry of Agriculture and Rural Development Agricultural Research Organization (ARO) (Volcani Center) | Anti-phytopathogenic compositions |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001503411A (ja) * | 1996-10-28 | 2001-03-13 | ディパートメント オブ ジ アーミー，ユー．エス．ガバメント | 抗生物質耐性感染症の処置のための化合物、組成物および方法 |
| JP4209472B2 (ja) * | 1997-06-02 | 2009-01-14 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 平滑筋細胞増殖のインヒビターとしての（イミダゾール−５−イル）メチル−２−キノリノン誘導体 |
| US6103905A (en) * | 1997-06-19 | 2000-08-15 | Sepracor, Inc. | Quinoline-indole antimicrobial agents, uses and compositions related thereto |
| JP2002505689A (ja) * | 1997-06-19 | 2002-02-19 | セプレイコー インコーポレイテッド | キノリン−インドール抗菌剤、それらに関する用途及び組成物 |
| WO2001062234A2 (en) * | 2000-02-24 | 2001-08-30 | Janssen Pharmaceutica N.V. | Dosing regimen |
| DE60134762D1 (de) * | 2000-10-02 | 2008-08-21 | Janssen Pharmaceutica Nv | Metabotropische glutamatrezeptor-antagonisten |
| DK2301544T3 (da) | 2002-07-25 | 2013-01-02 | Janssen Pharmaceutica Nv | Quinolinderivater som mellemprodukter til mykobakterielle inhibitorer |
-
2005
- 2005-01-21 NZ NZ547277A patent/NZ547277A/xx not_active IP Right Cessation
- 2005-01-21 EP EP05701586A patent/EP1711492B1/en active Active
- 2005-01-21 AP AP2006003693A patent/AP2188A/xx active
- 2005-01-21 ES ES05701586T patent/ES2306082T3/es active Active
- 2005-01-21 US US10/596,386 patent/US7338949B2/en active Active
- 2005-01-21 AT AT05701586T patent/ATE392423T1/de active
- 2005-01-21 KR KR1020067013237A patent/KR101150172B1/ko active IP Right Grant
- 2005-01-21 EA EA200601363A patent/EA011359B1/ru not_active IP Right Cessation
- 2005-01-21 CN CN2005800026797A patent/CN1910177B/zh not_active Expired - Fee Related
- 2005-01-21 CA CA2553266A patent/CA2553266C/en not_active Expired - Fee Related
- 2005-01-21 AU AU2005206330A patent/AU2005206330B2/en not_active Ceased
- 2005-01-21 WO PCT/EP2005/050267 patent/WO2005070924A1/en active IP Right Grant
- 2005-01-21 DE DE602005006101T patent/DE602005006101T2/de active Active
- 2005-01-21 UA UAA200605780A patent/UA85570C2/uk unknown
- 2005-01-21 JP JP2006550174A patent/JP4773975B2/ja not_active Expired - Fee Related
- 2005-01-21 BR BRPI0507076A patent/BRPI0507076B8/pt not_active IP Right Cessation
-
2006
- 2006-07-20 IL IL177013A patent/IL177013A0/en active IP Right Grant
- 2006-07-21 ZA ZA200606070A patent/ZA200606070B/xx unknown
- 2006-08-22 NO NO20063747A patent/NO337705B1/no not_active IP Right Cessation
-
2007
- 2007-06-06 HK HK07106003.5A patent/HK1100927A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| KR20060127016A (ko) | 2006-12-11 |
| BRPI0507076B1 (pt) | 2019-06-25 |
| UA85570C2 (uk) | 2009-02-10 |
| NZ547277A (en) | 2009-08-28 |
| KR101150172B1 (ko) | 2012-05-25 |
| DE602005006101D1 (de) | 2008-05-29 |
| EA200601363A1 (ru) | 2006-12-29 |
| JP4773975B2 (ja) | 2011-09-14 |
| NO337705B1 (no) | 2016-06-06 |
| ZA200606070B (en) | 2007-12-27 |
| US20070082895A1 (en) | 2007-04-12 |
| NO20063747L (no) | 2006-08-22 |
| EP1711492A1 (en) | 2006-10-18 |
| AP2188A (en) | 2010-12-14 |
| HK1100927A1 (en) | 2007-10-05 |
| BRPI0507076A (pt) | 2007-06-19 |
| AP2006003693A0 (en) | 2006-08-31 |
| IL177013A0 (en) | 2006-12-10 |
| CA2553266C (en) | 2013-03-12 |
| WO2005070924A1 (en) | 2005-08-04 |
| CA2553266A1 (en) | 2005-08-04 |
| EP1711492B1 (en) | 2008-04-16 |
| CN1910177A (zh) | 2007-02-07 |
| ES2306082T3 (es) | 2008-11-01 |
| WO2005070924A8 (en) | 2006-05-11 |
| CN1910177B (zh) | 2010-05-05 |
| ATE392423T1 (de) | 2008-05-15 |
| JP2007518775A (ja) | 2007-07-12 |
| EA011359B1 (ru) | 2009-02-27 |
| AU2005206330A1 (en) | 2005-08-04 |
| AU2005206330B2 (en) | 2010-09-16 |
| BRPI0507076B8 (pt) | 2021-05-25 |
| US7338949B2 (en) | 2008-03-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |