DE602004026051D1 - Pharmazeutisch verträgliches verfahren zur reinigung intakter bakterienminizellen - Google Patents
Pharmazeutisch verträgliches verfahren zur reinigung intakter bakterienminizellenInfo
- Publication number
- DE602004026051D1 DE602004026051D1 DE602004026051T DE602004026051T DE602004026051D1 DE 602004026051 D1 DE602004026051 D1 DE 602004026051D1 DE 602004026051 T DE602004026051 T DE 602004026051T DE 602004026051 T DE602004026051 T DE 602004026051T DE 602004026051 D1 DE602004026051 D1 DE 602004026051D1
- Authority
- DE
- Germany
- Prior art keywords
- minicells
- provides
- minimities
- minicell preparations
- purified minicell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 6
- 241000894006 Bacteria Species 0.000 title 1
- 238000004140 cleaning Methods 0.000 title 1
- 230000001580 bacterial effect Effects 0.000 abstract 5
- 238000002360 preparation method Methods 0.000 abstract 3
- 238000001914 filtration Methods 0.000 abstract 2
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 238000000432 density-gradient centrifugation Methods 0.000 abstract 1
- 238000001085 differential centrifugation Methods 0.000 abstract 1
- 239000002158 endotoxin Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/02—Separating microorganisms from their culture media
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Animal Behavior & Ethology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/602,021 US7611885B2 (en) | 2003-06-24 | 2003-06-24 | Pharmaceutically compatible method for purifying intact bacterial minicells |
| PCT/IB2004/002091 WO2004113507A1 (en) | 2003-06-24 | 2004-06-23 | Pharmaceutically compatible method for purifying intact bacterial minicells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602004026051D1 true DE602004026051D1 (de) | 2010-04-29 |
Family
ID=33539477
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602004026051T Expired - Lifetime DE602004026051D1 (de) | 2003-06-24 | 2004-06-23 | Pharmazeutisch verträgliches verfahren zur reinigung intakter bakterienminizellen |
Country Status (19)
| Country | Link |
|---|---|
| US (4) | US7611885B2 (da) |
| EP (3) | EP1636344B1 (da) |
| JP (1) | JP4834544B2 (da) |
| CN (2) | CN1809629B (da) |
| AT (2) | ATE513032T1 (da) |
| AU (2) | AU2004249970B2 (da) |
| CA (2) | CA2780843C (da) |
| CY (1) | CY1118218T1 (da) |
| DE (1) | DE602004026051D1 (da) |
| DK (3) | DK2333044T3 (da) |
| ES (3) | ES2602572T3 (da) |
| HK (3) | HK1089207A1 (da) |
| HU (1) | HUE030642T2 (da) |
| MX (1) | MXPA05013620A (da) |
| NZ (1) | NZ544653A (da) |
| PL (2) | PL1947171T3 (da) |
| PT (2) | PT2333044T (da) |
| SI (1) | SI2333044T1 (da) |
| WO (1) | WO2004113507A1 (da) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2380612T3 (es) * | 2001-10-15 | 2012-05-16 | Engeneic Molecular Delivery Pty Ltd. | Minicélulas intactas como vectores para transferencia de ADN y terapia génica in vitro e in vivo |
| US7611885B2 (en) * | 2003-06-24 | 2009-11-03 | Engeneic Molecular Delivery Pty, Ltd. | Pharmaceutically compatible method for purifying intact bacterial minicells |
| EP1694361B1 (en) | 2003-12-09 | 2011-03-16 | EnGeneIC Molecular Delivery Pty Ltd. | Targeted gene delivery to non-phagocytic mammalian cells via bacterially derived intact minicells |
| US8772013B2 (en) * | 2004-02-02 | 2014-07-08 | Engeneic Molecular Delivery Pty Ltd | Methods for targeted in vitro and in vivo drug delivery to mammalian cells via bacterially derived intact minicells |
| EP1718338B1 (en) | 2004-02-02 | 2015-05-06 | EnGeneIC Molecular Delivery Pty Ltd. | Compositions and methods for targeted in vitro and in vivo drug delivery to mammalian cells via bacterially derived intact minicells |
| DK2386640T3 (da) | 2004-08-26 | 2015-04-27 | Engeneic Molecular Delivery Pty Ltd | Afgivelse af funktionelle nukleinsyrer til pattedyrceller via bakterielt afledte, intakte miniceller |
| HUE033007T2 (en) | 2006-06-23 | 2017-11-28 | Engeneic Molecular Delivery Pty Ltd | Targeted drug, therapeutic nucleic acid and functional nucleic acid delivery to mammalian cells via intact killed bacterial cells |
| PT2865755T (pt) | 2007-03-30 | 2017-05-26 | Engeneic Molecular Delivery Pty Ltd | Minicélulas intactas derivadas de bactéria compreendendo arn regulatório |
| KR20180013993A (ko) | 2008-06-25 | 2018-02-07 | 벡션 테라퓨틱스 엘엘씨 | 조절된 유전자 자살 메커니즘 조성물 및 방법 |
| US8653236B2 (en) | 2008-07-17 | 2014-02-18 | Inter-K Pty Limited | Therapeutic agents |
| WO2010129779A1 (en) | 2009-05-07 | 2010-11-11 | Biomerieux, Inc. | Methods for antimicrobial resistance determination |
| US20120142089A1 (en) * | 2010-12-01 | 2012-06-07 | Samsung Electronics Co., Ltd. | Method of separating target cell in biological sample |
| US9624474B2 (en) * | 2010-12-01 | 2017-04-18 | Samsung Electronics Co, Ltd. | Method of separating target cell in biological sample |
| SG10201601349XA (en) | 2011-12-13 | 2016-03-30 | Engeneic Molecular Delivery Pty Ltd | Bacterially derived, intact minicells for delivery of therapeutic agents to brain tumors |
| EP2807180B1 (en) | 2012-01-24 | 2018-03-28 | InterK Peptide Therapeutics Limited | Peptide agents for cancer therapy |
| EA032740B1 (ru) | 2013-10-04 | 2019-07-31 | Энджинеик Молекьюлар Деливери Пти Лтд | Способ лечения опухоли у индивидуума и набор для осуществления способа |
| US10328159B2 (en) | 2014-10-03 | 2019-06-25 | Engenic Molecular Delivery Pty Ltd. | Enhanced loading of intact, bacterially derived vesicles with small molecule compounds |
| CN113577323B (zh) | 2015-08-04 | 2024-02-20 | 瓦克星治疗有限责任公司 | 基于细菌小细胞的生物药物的电离辐射灭菌以及使用方法 |
| SG11201902940RA (en) | 2016-10-06 | 2019-05-30 | Engeneic Molecular Delivery Pty Ltd | Bacterial minicells for delivering nucleic acid adjuvants and methods of using the same |
| JP2021532106A (ja) | 2018-07-23 | 2021-11-25 | エンジーンアイシー モレキュラー デリバリー ピーティーワイ リミテッド | 細菌由来ミニ細胞を含む組成物およびそれを使用する方法 |
| US20230242867A1 (en) * | 2020-06-17 | 2023-08-03 | Flagship Pioneering Innovations Vi, Llc | Methods for manufacturing adas |
| CN113186100B (zh) * | 2021-05-11 | 2022-10-04 | 中国科学院青岛生物能源与过程研究所 | 一种富集污水微生物以用于单细胞精度表型测量和分选的试剂盒及方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4311797A (en) | 1979-09-18 | 1982-01-19 | University Of Saskatchewan | Anucleated live E. coli vaccine |
| CA2370628A1 (en) | 1999-04-21 | 2000-10-26 | American Home Products Corporation | Methods and compositions for inhibiting the function of polynucleotide sequences |
| US6635448B2 (en) * | 2000-08-21 | 2003-10-21 | Clonexdevelopment, Inc. | Methods and compositions for increasing protein yield from a cell culture |
| US7125679B2 (en) * | 2001-03-07 | 2006-10-24 | Children's Medical Center Corporation | Methods to screen peptide libraries using minicell display |
| US7011946B2 (en) * | 2001-05-22 | 2006-03-14 | Trustees Of Tufts College | In vivo assay for identification of antimicrobial agents |
| US20030194798A1 (en) * | 2001-05-24 | 2003-10-16 | Surber Mark W. | Minicell compositions and methods |
| ES2380612T3 (es) | 2001-10-15 | 2012-05-16 | Engeneic Molecular Delivery Pty Ltd. | Minicélulas intactas como vectores para transferencia de ADN y terapia génica in vitro e in vivo |
| EP2272946B9 (en) | 2002-02-25 | 2015-06-24 | Vaxiion Therapeutics, LLC | Minicell compositions and methods |
| US7611885B2 (en) * | 2003-06-24 | 2009-11-03 | Engeneic Molecular Delivery Pty, Ltd. | Pharmaceutically compatible method for purifying intact bacterial minicells |
| EP1694361B1 (en) * | 2003-12-09 | 2011-03-16 | EnGeneIC Molecular Delivery Pty Ltd. | Targeted gene delivery to non-phagocytic mammalian cells via bacterially derived intact minicells |
| US8772013B2 (en) * | 2004-02-02 | 2014-07-08 | Engeneic Molecular Delivery Pty Ltd | Methods for targeted in vitro and in vivo drug delivery to mammalian cells via bacterially derived intact minicells |
| DK2386640T3 (da) * | 2004-08-26 | 2015-04-27 | Engeneic Molecular Delivery Pty Ltd | Afgivelse af funktionelle nukleinsyrer til pattedyrceller via bakterielt afledte, intakte miniceller |
| KR100967868B1 (ko) | 2004-12-17 | 2010-07-05 | 베쓰 이스라엘 디코니스 메디칼 센터 | 박테리아 매개 유전자 침묵을 위한 조성물 및 이것을이용하는 방법 |
| HUE033007T2 (en) * | 2006-06-23 | 2017-11-28 | Engeneic Molecular Delivery Pty Ltd | Targeted drug, therapeutic nucleic acid and functional nucleic acid delivery to mammalian cells via intact killed bacterial cells |
-
2003
- 2003-06-24 US US10/602,021 patent/US7611885B2/en active Active
-
2004
- 2004-06-23 NZ NZ544653A patent/NZ544653A/en not_active IP Right Cessation
- 2004-06-23 CA CA2780843A patent/CA2780843C/en not_active Expired - Fee Related
- 2004-06-23 MX MXPA05013620A patent/MXPA05013620A/es active IP Right Grant
- 2004-06-23 JP JP2006516573A patent/JP4834544B2/ja not_active Expired - Lifetime
- 2004-06-23 AT AT08101712T patent/ATE513032T1/de active
- 2004-06-23 DK DK10180971.3T patent/DK2333044T3/da active
- 2004-06-23 PT PT101809713T patent/PT2333044T/pt unknown
- 2004-06-23 DK DK08101712.1T patent/DK1947171T3/da active
- 2004-06-23 PL PL08101712T patent/PL1947171T3/pl unknown
- 2004-06-23 CA CA2530055A patent/CA2530055C/en not_active Expired - Fee Related
- 2004-06-23 WO PCT/IB2004/002091 patent/WO2004113507A1/en active Application Filing
- 2004-06-23 ES ES10180971.3T patent/ES2602572T3/es not_active Expired - Lifetime
- 2004-06-23 PT PT08101712T patent/PT1947171E/pt unknown
- 2004-06-23 EP EP04743793A patent/EP1636344B1/en not_active Expired - Lifetime
- 2004-06-23 PL PL10180971T patent/PL2333044T3/pl unknown
- 2004-06-23 EP EP10180971.3A patent/EP2333044B1/en not_active Expired - Lifetime
- 2004-06-23 EP EP08101712A patent/EP1947171B1/en not_active Expired - Lifetime
- 2004-06-23 ES ES04743793T patent/ES2342830T3/es not_active Expired - Lifetime
- 2004-06-23 DK DK04743793.4T patent/DK1636344T3/da active
- 2004-06-23 ES ES08101712T patent/ES2367535T3/es not_active Expired - Lifetime
- 2004-06-23 CN CN2004800175496A patent/CN1809629B/zh not_active Expired - Lifetime
- 2004-06-23 SI SI200432358A patent/SI2333044T1/sl unknown
- 2004-06-23 HU HUE10180971A patent/HUE030642T2/en unknown
- 2004-06-23 AT AT04743793T patent/ATE461269T1/de not_active IP Right Cessation
- 2004-06-23 AU AU2004249970A patent/AU2004249970B2/en not_active Expired
- 2004-06-23 CN CN201310201614.1A patent/CN103361286B/zh not_active Expired - Lifetime
- 2004-06-23 DE DE602004026051T patent/DE602004026051D1/de not_active Expired - Lifetime
-
2006
- 2006-09-13 HK HK06110160.7A patent/HK1089207A1/xx not_active IP Right Cessation
-
2007
- 2007-03-27 US US11/691,698 patent/US8003091B2/en not_active Expired - Lifetime
-
2009
- 2009-01-22 HK HK09100680.6A patent/HK1121190A1/xx not_active IP Right Cessation
- 2009-11-24 AU AU2009239519A patent/AU2009239519B2/en not_active Expired
-
2011
- 2011-04-04 US US13/079,079 patent/US8449877B2/en not_active Expired - Lifetime
- 2011-11-18 HK HK11112555.9A patent/HK1158261A1/zh not_active IP Right Cessation
-
2013
- 2013-04-17 US US13/864,972 patent/US10076545B2/en not_active Expired - Lifetime
-
2016
- 2016-11-09 CY CY20161101151T patent/CY1118218T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |