DE602004017729D1 - Verfahren zur herstellung von iohexol - Google Patents
Verfahren zur herstellung von iohexolInfo
- Publication number
- DE602004017729D1 DE602004017729D1 DE602004017729T DE602004017729T DE602004017729D1 DE 602004017729 D1 DE602004017729 D1 DE 602004017729D1 DE 602004017729 T DE602004017729 T DE 602004017729T DE 602004017729 T DE602004017729 T DE 602004017729T DE 602004017729 D1 DE602004017729 D1 DE 602004017729D1
- Authority
- DE
- Germany
- Prior art keywords
- sub
- iohexol
- preparation
- dihydroxypropyl
- triiodoisophtalamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- NTHXOOBQLCIOLC-UHFFFAOYSA-N iohexol Chemical compound OCC(O)CN(C(=O)C)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I NTHXOOBQLCIOLC-UHFFFAOYSA-N 0.000 title abstract 2
- 229960001025 iohexol Drugs 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/08—Preparation of carboxylic acid amides from amides by reaction at nitrogen atoms of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Glass Compositions (AREA)
- Iron Core Of Rotating Electric Machines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NO20033058A NO20033058D0 (no) | 2003-07-03 | 2003-07-03 | Prosess |
| PCT/NO2004/000199 WO2005003080A1 (en) | 2003-07-03 | 2004-07-01 | Process for iohexol manufacture |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602004017729D1 true DE602004017729D1 (de) | 2008-12-24 |
Family
ID=27800766
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602004017729T Expired - Lifetime DE602004017729D1 (de) | 2003-07-03 | 2004-07-01 | Verfahren zur herstellung von iohexol |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20060178533A1 (de) |
| EP (1) | EP1641743B1 (de) |
| JP (1) | JP4933253B2 (de) |
| KR (1) | KR101083147B1 (de) |
| CN (1) | CN100349858C (de) |
| AT (1) | ATE414057T1 (de) |
| DE (1) | DE602004017729D1 (de) |
| ES (1) | ES2314414T3 (de) |
| NO (1) | NO20033058D0 (de) |
| PT (1) | PT1641743E (de) |
| WO (1) | WO2005003080A1 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO20053676D0 (no) | 2005-07-29 | 2005-07-29 | Amersham Health As | Crystallisation Process |
| NO20053687D0 (no) * | 2005-07-29 | 2005-07-29 | Amersham Health As | Crystallisation Process. |
| NO342021B1 (no) * | 2005-07-29 | 2018-03-12 | Ge Healthcare As | Kontinuerlig krystalliseringsprosess |
| PT103391B (pt) * | 2005-11-24 | 2008-10-30 | Hovione Farmaciencia S A | Processo para fabrico de lohexol |
| CN101195587B (zh) * | 2006-12-19 | 2010-07-21 | 浙江尖峰海洲制药有限公司 | 一种碘克沙醇水解物的制备方法 |
| EP2483235A1 (de) * | 2009-09-30 | 2012-08-08 | Mallinckrodt LLC | Alkylierung triiod-substituierter arylamide in einem system für wässrige mischlösungen |
| EP2504298B1 (de) * | 2009-11-26 | 2016-09-21 | iMAX Diagnostic Imaging Holding Limited | Herstellung und aufreinigung von iodixanol |
| EP2655318B1 (de) * | 2010-12-21 | 2018-06-20 | GE Healthcare AS | Entsalzung einer zusammensetzung mit einem kontrastmittel |
| US20140065076A1 (en) * | 2012-08-30 | 2014-03-06 | Otsuka Pharmaceutical Co. Ltd. | Container with concentrated substance and method of using the same |
| CN110054569B (zh) * | 2019-05-17 | 2022-05-17 | 浙江海洲制药有限公司 | 一种制备碘海醇的方法 |
| CN110590591B (zh) * | 2019-09-25 | 2022-05-17 | 浙江海洲制药有限公司 | 一种碘克沙醇，碘海醇杂质的制备方法 |
| CN115403481A (zh) * | 2022-04-13 | 2022-11-29 | 江苏宇田医药有限公司 | 一种通过离子交换树脂纯化碘海醇的方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9618056D0 (en) * | 1996-08-29 | 1996-10-09 | Nycomed Imaging As | Process |
| US5847212A (en) * | 1997-04-21 | 1998-12-08 | Abbott Laboratories | Process for the preparation of iohexol |
| GB9725010D0 (en) * | 1997-11-26 | 1998-01-28 | Nycomed Imaging As | Process |
| ITMI20010773A1 (it) * | 2001-04-11 | 2002-10-11 | Chemi Spa | Processo per la produzione di ioexolo ad elevata purezza |
-
2003
- 2003-07-03 NO NO20033058A patent/NO20033058D0/no unknown
-
2004
- 2004-07-01 DE DE602004017729T patent/DE602004017729D1/de not_active Expired - Lifetime
- 2004-07-01 EP EP04748775A patent/EP1641743B1/de not_active Expired - Lifetime
- 2004-07-01 KR KR1020067000051A patent/KR101083147B1/ko active IP Right Grant
- 2004-07-01 AT AT04748775T patent/ATE414057T1/de not_active IP Right Cessation
- 2004-07-01 US US10/560,497 patent/US20060178533A1/en not_active Abandoned
- 2004-07-01 JP JP2006517004A patent/JP4933253B2/ja not_active Expired - Lifetime
- 2004-07-01 CN CNB2004800191766A patent/CN100349858C/zh not_active Expired - Lifetime
- 2004-07-01 WO PCT/NO2004/000199 patent/WO2005003080A1/en active Search and Examination
- 2004-07-01 ES ES04748775T patent/ES2314414T3/es not_active Expired - Lifetime
- 2004-07-01 PT PT04748775T patent/PT1641743E/pt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2005003080A1 (en) | 2005-01-13 |
| CN1816519A (zh) | 2006-08-09 |
| EP1641743B1 (de) | 2008-11-12 |
| CN100349858C (zh) | 2007-11-21 |
| US20060178533A1 (en) | 2006-08-10 |
| PT1641743E (pt) | 2008-12-30 |
| ATE414057T1 (de) | 2008-11-15 |
| ES2314414T3 (es) | 2009-03-16 |
| NO20033058D0 (no) | 2003-07-03 |
| EP1641743A1 (de) | 2006-04-05 |
| KR101083147B1 (ko) | 2011-11-11 |
| JP2007521262A (ja) | 2007-08-02 |
| JP4933253B2 (ja) | 2012-05-16 |
| KR20060041207A (ko) | 2006-05-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8328 | Change in the person/name/address of the agent |
Representative=s name: HAMMONDS LLP, LONDON, GB |
|
| R082 | Change of representative |
Ref document number: 1641743 Country of ref document: EP Representative=s name: J D REYNOLDS & CO., GB |