DE602004017588D1 - 2-phenoxy- und 2-phenylsulfanyl-benzenesulfonamid derivate mit ccr3 antagonistischer aktivität zur behandlung von asthma und anderen entzündlichen oder immunologischen erkrankungen - Google Patents
2-phenoxy- und 2-phenylsulfanyl-benzenesulfonamid derivate mit ccr3 antagonistischer aktivität zur behandlung von asthma und anderen entzündlichen oder immunologischen erkrankungenInfo
- Publication number
- DE602004017588D1 DE602004017588D1 DE602004017588T DE602004017588T DE602004017588D1 DE 602004017588 D1 DE602004017588 D1 DE 602004017588D1 DE 602004017588 T DE602004017588 T DE 602004017588T DE 602004017588 T DE602004017588 T DE 602004017588T DE 602004017588 D1 DE602004017588 D1 DE 602004017588D1
- Authority
- DE
- Germany
- Prior art keywords
- phenylsulfanyl
- flammable
- asthma
- phenoxy
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- GCSIJZVYEPPSDF-UHFFFAOYSA-N 2-phenoxybenzenesulfonamide Chemical compound NS(=O)(=O)C1=CC=CC=C1OC1=CC=CC=C1 GCSIJZVYEPPSDF-UHFFFAOYSA-N 0.000 title 1
- URDPMPGGXZVVPD-UHFFFAOYSA-N 2-phenylsulfanylbenzenesulfonamide Chemical class NS(=O)(=O)C1=CC=CC=C1SC1=CC=CC=C1 URDPMPGGXZVVPD-UHFFFAOYSA-N 0.000 title 1
- 102100024167 C-C chemokine receptor type 3 Human genes 0.000 title 1
- 101710149862 C-C chemokine receptor type 3 Proteins 0.000 title 1
- 230000003042 antagnostic effect Effects 0.000 title 1
- 208000006673 asthma Diseases 0.000 title 1
- 208000026278 immune system disease Diseases 0.000 title 1
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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|---|---|---|---|
| EP03006293 | 2003-03-24 | ||
| PCT/EP2004/002496 WO2004084898A1 (en) | 2003-03-24 | 2004-03-11 | 2-phenoxy- and 2-phenylsulfomamide derivatives with ccr3 antagonistic activity for the treatment of asthma and other inflammatory or immunological disorders |
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| DE602004017588D1 true DE602004017588D1 (de) | 2008-12-18 |
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| RU2539591C2 (ru) | 2009-04-22 | 2015-01-20 | Аксикин Фармасьютикалз, Инк. | Антагонисты арилсульфонамида ccr3 |
| PE20120810A1 (es) * | 2009-04-22 | 2012-07-08 | Axikin Pharmaceuticals Inc | Compuestos derivados de 5-ciano-2-(feniltio)bencensulfonamida como antagonistas de ccr3 |
| TW201041583A (en) * | 2009-04-22 | 2010-12-01 | Axikin Pharmaceuticals Inc | 2,5-disubstituted arylsulfonamide CCR3 antagonists |
| US10487148B2 (en) | 2010-01-28 | 2019-11-26 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for treating aging-associated impairments |
| WO2017120461A1 (en) * | 2016-01-08 | 2017-07-13 | The Board Of Trustees Of The Leland Stanford Junior University | Ccr3 modulation in the treatment of aging-associated impairments, and compositions for practicing the same |
| US20160208011A1 (en) | 2010-01-28 | 2016-07-21 | The Board Of Trustees Of The Leland Stanford Junior University | Ccr3 modulation in the treatment of aging-associated impairments, and compositions for practicing the same |
| WO2011094535A2 (en) * | 2010-01-28 | 2011-08-04 | The Board Of Trustees Of The Leland Stanford Junior University | Biomarkers of aging for detection and treatment of disorders |
| EP2542542B1 (en) * | 2010-03-02 | 2015-04-22 | Axikin Pharmaceuticals, Inc. | Isotopically enriched arylsulfonamide ccr3 antagonists |
| CN102892754A (zh) | 2010-03-17 | 2013-01-23 | 埃克希金医药品有限公司 | 芳基磺酰胺ccr3拮抗剂 |
| GB201009603D0 (en) * | 2010-06-08 | 2010-07-21 | Cambridge Entpr Ltd | Anti-inflammatory agent |
| JP5860045B2 (ja) | 2010-07-09 | 2016-02-16 | ファイザー・リミテッドPfizer Limited | 化合物 |
| ES2532356T3 (es) | 2010-07-09 | 2015-03-26 | Pfizer Limited | N-sulfonilbenzamidas como inhibidores de los canales de sodio dependientes de voltaje |
| CN103298786B (zh) * | 2010-10-11 | 2016-01-20 | 埃克希金医药品有限公司 | 芳基磺酰胺盐ccr3拮抗剂 |
| US9161968B2 (en) | 2011-04-08 | 2015-10-20 | The Board Of Trustees Of The Leland Stanford Junior University | Methods of neuroprotection involving macrophage colony stimulating factor receptor agonists |
| CN104781240A (zh) | 2012-09-07 | 2015-07-15 | 埃克希金医药品有限公司 | 同位素富集的芳基磺酰胺ccr3拮抗剂 |
| TW201512171A (zh) | 2013-04-19 | 2015-04-01 | Pfizer Ltd | 化學化合物 |
| US10905779B2 (en) | 2013-12-09 | 2021-02-02 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for screening human blood products comprising plasma using immunocompromised rodent models |
| CN106163530A (zh) | 2013-12-09 | 2016-11-23 | 小利兰·斯坦福大学托管委员会 | 用于治疗衰老相关病症的方法和组合物 |
| MA39822A (fr) | 2014-04-03 | 2018-02-06 | Janssen Pharmaceutica Nv | Dérivés de pyrimidine bicycle |
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| CN105884674B (zh) * | 2015-01-05 | 2019-07-26 | 南开大学 | 色氨酸衍生物及制备方法和在防治植物病毒、杀菌、杀虫方面的应用 |
| EA201890020A1 (ru) | 2015-06-15 | 2018-05-31 | Зе Боард Оф Трастиз Оф Зе Леланд Стэнфорд Джуниор Юниверсити | Способы и композиции для лечения ассоциированных со старением состояний |
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| DE3751728T2 (de) | 1987-12-14 | 1996-10-31 | Dow Chemical Co | Abs-zusammensetzungen mit trimodalkautschukteilchenverteilungen |
| US5041498A (en) * | 1990-01-02 | 1991-08-20 | The Dow Chemical Company | Trimodal ABS compositions having good gloss and reduced gloss sensitivity |
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Owner name: AXIKIN PHARMACEUTICALS, INC., SAN DIEGO, CALIF, US |