ATE462708T1 - Zur behandlung von hyperproliferationserkrankungen und mit angiogenese assoziierten krankheiten geeignete pyrrolotriazinderivate - Google Patents

Zur behandlung von hyperproliferationserkrankungen und mit angiogenese assoziierten krankheiten geeignete pyrrolotriazinderivate

Info

Publication number
ATE462708T1
ATE462708T1 AT05758135T AT05758135T ATE462708T1 AT E462708 T1 ATE462708 T1 AT E462708T1 AT 05758135 T AT05758135 T AT 05758135T AT 05758135 T AT05758135 T AT 05758135T AT E462708 T1 ATE462708 T1 AT E462708T1
Authority
AT
Austria
Prior art keywords
diseases
angiogenesis
treatment
hyperproliferation
derivatives suitable
Prior art date
Application number
AT05758135T
Other languages
English (en)
Inventor
Julie Dixon
Catherine Brennan
Karl Miranda
Brent Chandler
Barton Phillips
Jianmei Fan
Michael Brands
Andrea Mcclure
Benjamin Jones
Wenlang Fu
Donald Bierer
Steven Magnuson
Harold Kluender
Original Assignee
Bayer Pharmaceuticals Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34971944&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE462708(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Pharmaceuticals Corp filed Critical Bayer Pharmaceuticals Corp
Application granted granted Critical
Publication of ATE462708T1 publication Critical patent/ATE462708T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT05758135T 2004-06-03 2005-06-03 Zur behandlung von hyperproliferationserkrankungen und mit angiogenese assoziierten krankheiten geeignete pyrrolotriazinderivate ATE462708T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US57665204P 2004-06-03 2004-06-03
US62653104P 2004-11-09 2004-11-09
PCT/US2005/019472 WO2005121147A1 (en) 2004-06-03 2005-06-03 Pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis

Publications (1)

Publication Number Publication Date
ATE462708T1 true ATE462708T1 (de) 2010-04-15

Family

ID=34971944

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05758135T ATE462708T1 (de) 2004-06-03 2005-06-03 Zur behandlung von hyperproliferationserkrankungen und mit angiogenese assoziierten krankheiten geeignete pyrrolotriazinderivate

Country Status (31)

Country Link
US (3) US7563791B2 (de)
EP (1) EP1765823B1 (de)
JP (1) JP4958772B2 (de)
KR (1) KR101235602B1 (de)
CN (1) CN1993361B (de)
AR (1) AR049138A1 (de)
AT (1) ATE462708T1 (de)
AU (1) AU2005252217B2 (de)
BR (1) BRPI0510848A (de)
CA (1) CA2569396C (de)
DE (1) DE602005020293D1 (de)
EC (1) ECSP067043A (de)
ES (1) ES2342722T3 (de)
GT (1) GT200500137A (de)
HK (1) HK1109141A1 (de)
HN (1) HN2005000255A (de)
IL (1) IL179264A0 (de)
MA (1) MA28689B1 (de)
MX (1) MX279139B (de)
MY (1) MY145077A (de)
NO (1) NO20070049L (de)
NZ (1) NZ551742A (de)
PE (1) PE20060243A1 (de)
PH (1) PH12006502386B1 (de)
RU (1) RU2401269C2 (de)
SG (1) SG127661A1 (de)
SV (1) SV2006002134A (de)
TW (1) TW200608979A (de)
UY (1) UY28931A1 (de)
WO (1) WO2005121147A1 (de)
ZA (1) ZA200700011B (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY28931A1 (es) * 2004-06-03 2005-12-30 Bayer Pharmaceuticals Corp Derivados de pirrolotriazina utiles para tratar trastornos hiper-proliferativos y enfermedades asociadas con angiogenesis
GB0512324D0 (en) 2005-06-16 2005-07-27 Novartis Ag Organic compounds
DE102005037499A1 (de) * 2005-08-09 2007-02-15 Merck Patent Gmbh Pyrazolderivate
US7514435B2 (en) * 2005-11-18 2009-04-07 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
EP1957485B1 (de) 2005-12-02 2013-02-13 Bayer HealthCare, LLC Zur behandlung von hyperproliferationserkrankungen und mit angiogenese assoziierten krankheiten geeignete substituierte 4-aminopyrrolotriazinderivate
PE20070855A1 (es) * 2005-12-02 2007-10-14 Bayer Pharmaceuticals Corp Derivados de 4-amino-pirrolotriazina sustituida como inhibidores de quinasas
WO2007071752A2 (en) 2005-12-21 2007-06-28 Novartis Ag Pyrimidinyl aryl urea derivatives being fgf inhibitors
EP1882475A1 (de) * 2006-07-26 2008-01-30 Novartis AG Methoden zur Behandlung von Erkrankungen, die durch den Fibroblastwachstumsfaktorrezeptor vermittelt werden
US7912582B1 (en) * 2007-05-03 2011-03-22 Innovation Associates, Inc. Robotic prescription filling system
US8445687B2 (en) 2007-09-10 2013-05-21 Cipla Limited Process for the preparation of a RAF kinase inhibitor and intermediates for use in the process
US8138336B2 (en) * 2007-09-25 2012-03-20 Bayer Healthcare Llc Pyrrolotriazine derivatives useful for treating cancer through inhibition of aurora kinase
EP2085397A1 (de) * 2008-01-21 2009-08-05 Esteve Quimica, S.A. Kristalline Form von Abacavir
AR074830A1 (es) 2008-12-19 2011-02-16 Cephalon Inc Pirrolotriazinas como inhibidores de alk y jak2
CN103929961A (zh) * 2011-06-20 2014-07-16 美国阿尔茨海默病研究所公司 化合物及其治疗应用
UY34484A (es) 2011-12-15 2013-07-31 Bayer Ip Gmbh Benzotienilo-pirrolotriazinas disustituidas y sus usos
WO2013087647A1 (en) 2011-12-15 2013-06-20 Bayer Intellectual Property Gmbh Substituted benzothienyl - pyrrolotriazines and uses thereof in the treatment cancer
CA2865021C (en) * 2012-02-23 2020-06-30 Bayer Intellectual Property Gmbh Substituted benzothienyl-pyrrolotriazines and uses thereof
BR112014000049A2 (pt) 2012-03-27 2017-02-07 Bayer Ip Gmbh pirrolotriazinas substituídas com hidroximelilarilo e sua utilização
EA031409B1 (ru) * 2014-06-17 2018-12-28 КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. Производные индолизина в качестве ингибиторов фосфоинозитид-3-киназ
WO2017035366A1 (en) 2015-08-26 2017-03-02 Incyte Corporation Pyrrolopyrimidine derivatives as tam inhibitors
CA3008171A1 (en) 2015-12-22 2017-06-29 SHY Therapeutics LLC Compounds for the treatment of cancer and inflammatory disease
WO2017152126A1 (en) 2016-03-03 2017-09-08 Cornell University Small molecule ire1-alpha inhibitors
TWI753892B (zh) * 2016-03-28 2022-02-01 美商英塞特公司 作為ｔａｍ抑制劑之吡咯并三嗪化合物
WO2018161033A1 (en) * 2017-03-02 2018-09-07 Wright, Adrian Small molecule ire1-alpha inhibitors
EP4331679A3 (de) 2017-06-21 2024-04-03 Shy Therapeutics LLC Mit der ras-superfamilie interagierende verbindungen zur behandlung von krebs, entzündlichen erkrankungen, rasopathien und fibrotischen erkrankungen
MX2020003375A (es) 2017-09-27 2020-08-03 Incyte Corp Sales de inhibidores de macrofagos asociados a tumores (tam).
TWI832871B (zh) 2018-06-29 2024-02-21 美商英塞特公司 Axl/mer 抑制劑之調配物
US11174263B2 (en) 2018-12-31 2021-11-16 Biomea Fusion, Inc. Inhibitors of menin-MLL interaction
KR20210117261A (ko) 2018-12-31 2021-09-28 바이오메아 퓨전, 인크. 메닌-mll 상호작용의 비가역적 억제제
EP3968999B1 (de) 2019-05-13 2023-12-27 Relay Therapeutics, Inc. Fgfr-inhibitoren und verfahren zur verwendung davon
WO2021057877A1 (zh) * 2019-09-26 2021-04-01 深圳市塔吉瑞生物医药有限公司 取代的芳香稠合环衍生物及其组合物及用途
WO2022007921A1 (zh) * 2020-07-10 2022-01-13 北京范恩柯尔生物科技有限公司 三嗪类化合物及其组合物和用途
AU2022331496A1 (en) 2021-08-20 2024-02-29 Biomea Fusion, Inc. Crystalline form of n-[4-[4-(4-morpholinyl)-7h-pyrrolo[2,3-d]pyrimidin-6-yl]phenyl]-4-[[3(r)-[(1-oxo -2-propen-1-yl)amino]-1-piperidinyl]methyl]-2-pyridinecarboxamide, an irreversible menin-mll inhibitor for the treatment of cancer

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000071129A1 (en) * 1999-05-21 2000-11-30 Bristol-Myers Squibb Company Pyrrolotriazine inhibitors of kinases
NZ525334A (en) * 2000-11-17 2005-07-29 Bristol Myers Squibb Co Methods of treating p38 kinase-associated conditions and pyrrolotriazine compounds useful as kinase inhibitors
EP1543009A4 (de) * 2002-08-02 2007-08-08 Bristol Myers Squibb Co Pyrrolotriazin-kinaseinhibitoren
WO2005061519A1 (en) 2003-12-19 2005-07-07 Takeda San Diego, Inc. Kinase inhibitors
UY28931A1 (es) 2004-06-03 2005-12-30 Bayer Pharmaceuticals Corp Derivados de pirrolotriazina utiles para tratar trastornos hiper-proliferativos y enfermedades asociadas con angiogenesis
US7405213B2 (en) 2005-07-01 2008-07-29 Bristol-Myers Squibb Company Pyrrolotriazine compounds useful as kinase inhibitors and methods of treating kinase-associated conditions therewith
US7514435B2 (en) 2005-11-18 2009-04-07 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
EP1957485B1 (de) * 2005-12-02 2013-02-13 Bayer HealthCare, LLC Zur behandlung von hyperproliferationserkrankungen und mit angiogenese assoziierten krankheiten geeignete substituierte 4-aminopyrrolotriazinderivate
PE20070855A1 (es) * 2005-12-02 2007-10-14 Bayer Pharmaceuticals Corp Derivados de 4-amino-pirrolotriazina sustituida como inhibidores de quinasas
US8138336B2 (en) * 2007-09-25 2012-03-20 Bayer Healthcare Llc Pyrrolotriazine derivatives useful for treating cancer through inhibition of aurora kinase

Also Published As

Publication number Publication date
AU2005252217B2 (en) 2011-05-12
EP1765823B1 (de) 2010-03-31
US20130225809A1 (en) 2013-08-29
CA2569396C (en) 2011-12-20
GT200500137A (es) 2006-05-18
RU2401269C2 (ru) 2010-10-10
MXPA06013457A (es) 2007-03-01
KR20070035028A (ko) 2007-03-29
US20070208013A1 (en) 2007-09-06
MA28689B1 (fr) 2007-06-01
ECSP067043A (es) 2006-12-29
HK1109141A1 (en) 2008-05-30
CN1993361B (zh) 2010-05-26
AR049138A1 (es) 2006-06-28
NZ551742A (en) 2010-08-27
PH12006502386B1 (en) 2010-12-23
JP2008501703A (ja) 2008-01-24
DE602005020293D1 (de) 2010-05-12
MY145077A (en) 2011-12-15
ZA200700011B (en) 2008-11-26
CN1993361A (zh) 2007-07-04
NO20070049L (no) 2007-01-30
WO2005121147A1 (en) 2005-12-22
CA2569396A1 (en) 2005-12-22
IL179264A0 (en) 2007-03-08
EP1765823A1 (de) 2007-03-28
US8338595B2 (en) 2012-12-25
RU2006147237A (ru) 2008-07-20
US20100075958A1 (en) 2010-03-25
UY28931A1 (es) 2005-12-30
US7563791B2 (en) 2009-07-21
AU2005252217A1 (en) 2005-12-22
TW200608979A (en) 2006-03-16
ES2342722T3 (es) 2010-07-13
KR101235602B1 (ko) 2013-02-21
MX279139B (es) 2010-09-21
PE20060243A1 (es) 2006-04-21
HN2005000255A (es) 2010-09-17
JP4958772B2 (ja) 2012-06-20
SG127661A1 (en) 2007-01-30
BRPI0510848A (pt) 2007-11-27
SV2006002134A (es) 2006-10-04

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