MX279139B - Derivados de pirrolotriazina utiles para tratar trastornos hiper-proliferativos y enfermedades asociadas con angiogenesis. - Google Patents
Derivados de pirrolotriazina utiles para tratar trastornos hiper-proliferativos y enfermedades asociadas con angiogenesis.Info
- Publication number
- MX279139B MX279139B MXPA06013457A MX279139B MX 279139 B MX279139 B MX 279139B MX PA06013457 A MXPA06013457 A MX PA06013457A MX 279139 B MX279139 B MX 279139B
- Authority
- MX
- Mexico
- Prior art keywords
- angiogenesis
- diseases associated
- proliferative disorders
- derivatives useful
- pyrrolotriazine derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US57665204P | 2004-06-03 | 2004-06-03 | |
US62653104P | 2004-11-09 | 2004-11-09 | |
PCT/US2005/019472 WO2005121147A1 (en) | 2004-06-03 | 2005-06-03 | Pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis |
Publications (2)
Publication Number | Publication Date |
---|---|
MXPA06013457A MXPA06013457A (es) | 2007-03-01 |
MX279139B true MX279139B (es) | 2010-09-21 |
Family
ID=34971944
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA06013457 MX279139B (es) | 2004-06-03 | 2005-06-03 | Derivados de pirrolotriazina utiles para tratar trastornos hiper-proliferativos y enfermedades asociadas con angiogenesis. |
Country Status (31)
Country | Link |
---|---|
US (3) | US7563791B2 (es) |
EP (1) | EP1765823B1 (es) |
JP (1) | JP4958772B2 (es) |
KR (1) | KR101235602B1 (es) |
CN (1) | CN1993361B (es) |
AR (1) | AR049138A1 (es) |
AT (1) | ATE462708T1 (es) |
AU (1) | AU2005252217B2 (es) |
BR (1) | BRPI0510848A (es) |
CA (1) | CA2569396C (es) |
DE (1) | DE602005020293D1 (es) |
EC (1) | ECSP067043A (es) |
ES (1) | ES2342722T3 (es) |
GT (1) | GT200500137A (es) |
HK (1) | HK1109141A1 (es) |
HN (1) | HN2005000255A (es) |
IL (1) | IL179264A0 (es) |
MA (1) | MA28689B1 (es) |
MX (1) | MX279139B (es) |
MY (1) | MY145077A (es) |
NO (1) | NO20070049L (es) |
NZ (1) | NZ551742A (es) |
PE (1) | PE20060243A1 (es) |
PH (1) | PH12006502386B1 (es) |
RU (1) | RU2401269C2 (es) |
SG (1) | SG127661A1 (es) |
SV (1) | SV2006002134A (es) |
TW (1) | TW200608979A (es) |
UY (1) | UY28931A1 (es) |
WO (1) | WO2005121147A1 (es) |
ZA (1) | ZA200700011B (es) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UY28931A1 (es) | 2004-06-03 | 2005-12-30 | Bayer Pharmaceuticals Corp | Derivados de pirrolotriazina utiles para tratar trastornos hiper-proliferativos y enfermedades asociadas con angiogenesis |
GB0512324D0 (en) | 2005-06-16 | 2005-07-27 | Novartis Ag | Organic compounds |
DE102005037499A1 (de) * | 2005-08-09 | 2007-02-15 | Merck Patent Gmbh | Pyrazolderivate |
US7514435B2 (en) * | 2005-11-18 | 2009-04-07 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
PE20070855A1 (es) | 2005-12-02 | 2007-10-14 | Bayer Pharmaceuticals Corp | Derivados de 4-amino-pirrolotriazina sustituida como inhibidores de quinasas |
CA2631741C (en) | 2005-12-02 | 2014-01-28 | Bayer Healthcare Llc | Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis |
BRPI0620408B8 (pt) | 2005-12-21 | 2021-05-25 | Novartis Ag | derivados de pirimidinil aril uréia sendo inibidores de fgf, seus usos, e preparação farmacêutica |
EP1882475A1 (en) * | 2006-07-26 | 2008-01-30 | Novartis AG | Method of treating disorders mediated by the fibroblast growth factor receptor |
US7912582B1 (en) * | 2007-05-03 | 2011-03-22 | Innovation Associates, Inc. | Robotic prescription filling system |
EP2195286A2 (en) * | 2007-09-10 | 2010-06-16 | Cipla Limited | Process for the preparation of a raf kinase inhibitor and intermediates for use in the process |
WO2009042543A1 (en) * | 2007-09-25 | 2009-04-02 | Bayer Healthcare Llc | Pyrrolotriazine derivatives useful for treating cancer through inhibition of aurora kinase |
EP2085397A1 (en) * | 2008-01-21 | 2009-08-05 | Esteve Quimica, S.A. | Crystalline form of abacavir |
AR074830A1 (es) | 2008-12-19 | 2011-02-16 | Cephalon Inc | Pirrolotriazinas como inhibidores de alk y jak2 |
WO2012177782A1 (en) * | 2011-06-20 | 2012-12-27 | Myrexis, Inc. | Compounds and therapeutic uses thereof |
ES2598027T3 (es) | 2011-07-01 | 2017-01-24 | Bayer Intellectual Property Gmbh | Pirrolotriazinas sustituidas con hidroximetilarilo como inhibidores de ALK1 |
UY34484A (es) | 2011-12-15 | 2013-07-31 | Bayer Ip Gmbh | Benzotienilo-pirrolotriazinas disustituidas y sus usos |
JP6047582B2 (ja) * | 2011-12-15 | 2016-12-21 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングBayer Intellectual Property GmbH | 置換ベンゾチエニル−ピロロトリアジンおよび癌の処置におけるその使用 |
ES2581065T3 (es) | 2012-02-23 | 2016-08-31 | Bayer Intellectual Property Gmbh | Benzotienil-pirrolotriazinas sustituidas y usos de las mismas |
WO2015193263A1 (en) * | 2014-06-17 | 2015-12-23 | Chiesi Farmaceutici S.P.A. | Indolizine derivatives as phoshoinositide 3-kinases inhibitors |
WO2017035366A1 (en) | 2015-08-26 | 2017-03-02 | Incyte Corporation | Pyrrolopyrimidine derivatives as tam inhibitors |
EP3394056B1 (en) | 2015-12-22 | 2021-04-14 | Shy Therapeutics LLC | Compounds for the treatment of cancer and inflammatory disease |
WO2017152126A1 (en) | 2016-03-03 | 2017-09-08 | Cornell University | Small molecule ire1-alpha inhibitors |
EP4321513A3 (en) | 2016-03-28 | 2024-05-08 | Incyte Corporation | Pyrrolotriazine compounds as tam inhibitors |
WO2018161033A1 (en) * | 2017-03-02 | 2018-09-07 | Wright, Adrian | Small molecule ire1-alpha inhibitors |
JP7514005B2 (ja) | 2017-06-21 | 2024-07-10 | シャイ・セラピューティクス・エルエルシー | がん、炎症性疾患、ラソパシー、及び線維性疾患の治療のためのrasスーパーファミリーと相互作用する化合物 |
DK3687996T3 (da) | 2017-09-27 | 2022-01-10 | Incyte Corp | Salte af pyrrolotriazinderivater anvendelige som tam-inhibitorer |
CN117771250A (zh) | 2018-06-29 | 2024-03-29 | 因赛特公司 | Axl/mer抑制剂的制剂 |
TW202043205A (zh) | 2018-12-31 | 2020-12-01 | 美商拜歐米富士恩有限公司 | Menin-mll相互作用之抑制劑 |
AU2019417833A1 (en) | 2018-12-31 | 2021-06-24 | Biomea Fusion, Inc. | Irreversible inhibitors of menin-MLL interaction |
EP3968999B1 (en) | 2019-05-13 | 2023-12-27 | Relay Therapeutics, Inc. | Fgfr inhibitors and methods of use thereof |
AU2020355359B2 (en) * | 2019-09-26 | 2023-08-24 | Shenzhen Targetrx, Inc. | Substituted aromatic fused ring derivative and composition comprising same, and use thereof |
WO2022007921A1 (zh) * | 2020-07-10 | 2022-01-13 | 北京范恩柯尔生物科技有限公司 | 三嗪类化合物及其组合物和用途 |
AU2022331496A1 (en) | 2021-08-20 | 2024-02-29 | Biomea Fusion, Inc. | Crystalline form of n-[4-[4-(4-morpholinyl)-7h-pyrrolo[2,3-d]pyrimidin-6-yl]phenyl]-4-[[3(r)-[(1-oxo -2-propen-1-yl)amino]-1-piperidinyl]methyl]-2-pyridinecarboxamide, an irreversible menin-mll inhibitor for the treatment of cancer |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE60042620D1 (de) * | 1999-05-21 | 2009-09-03 | Bristol Myers Squibb Co | Pyrrolotriazine als Kinase Hemmer. |
BR0115446A (pt) * | 2000-11-17 | 2005-08-09 | Bristol Myers Squibb Co | Processos para tratamento de condições associadas a quinase p38 e compostos pirrolotriazina úteis como inibidores de quinase |
WO2004013145A1 (en) * | 2002-08-02 | 2004-02-12 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
JP2007514759A (ja) | 2003-12-19 | 2007-06-07 | タケダ サン ディエゴ インコーポレイテッド | キナーゼ阻害剤 |
UY28931A1 (es) * | 2004-06-03 | 2005-12-30 | Bayer Pharmaceuticals Corp | Derivados de pirrolotriazina utiles para tratar trastornos hiper-proliferativos y enfermedades asociadas con angiogenesis |
US7405213B2 (en) | 2005-07-01 | 2008-07-29 | Bristol-Myers Squibb Company | Pyrrolotriazine compounds useful as kinase inhibitors and methods of treating kinase-associated conditions therewith |
US7514435B2 (en) | 2005-11-18 | 2009-04-07 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
CA2631741C (en) * | 2005-12-02 | 2014-01-28 | Bayer Healthcare Llc | Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis |
PE20070855A1 (es) * | 2005-12-02 | 2007-10-14 | Bayer Pharmaceuticals Corp | Derivados de 4-amino-pirrolotriazina sustituida como inhibidores de quinasas |
WO2009042543A1 (en) * | 2007-09-25 | 2009-04-02 | Bayer Healthcare Llc | Pyrrolotriazine derivatives useful for treating cancer through inhibition of aurora kinase |
-
2005
- 2005-05-30 UY UY28931A patent/UY28931A1/es not_active Application Discontinuation
- 2005-06-01 HN HN2005000255A patent/HN2005000255A/es unknown
- 2005-06-01 MY MYPI20052508A patent/MY145077A/en unknown
- 2005-06-02 TW TW094118090A patent/TW200608979A/zh unknown
- 2005-06-02 AR ARP050102263A patent/AR049138A1/es not_active Application Discontinuation
- 2005-06-02 GT GT200500137A patent/GT200500137A/es unknown
- 2005-06-02 PE PE2005000618A patent/PE20060243A1/es not_active Application Discontinuation
- 2005-06-03 AT AT05758135T patent/ATE462708T1/de not_active IP Right Cessation
- 2005-06-03 ES ES05758135T patent/ES2342722T3/es active Active
- 2005-06-03 EP EP05758135A patent/EP1765823B1/en active Active
- 2005-06-03 BR BRPI0510848-9A patent/BRPI0510848A/pt not_active IP Right Cessation
- 2005-06-03 WO PCT/US2005/019472 patent/WO2005121147A1/en active Application Filing
- 2005-06-03 CN CN2005800260347A patent/CN1993361B/zh active Active
- 2005-06-03 SG SG200608387A patent/SG127661A1/en unknown
- 2005-06-03 SV SV2005002134A patent/SV2006002134A/es unknown
- 2005-06-03 NZ NZ551742A patent/NZ551742A/en unknown
- 2005-06-03 JP JP2007515588A patent/JP4958772B2/ja active Active
- 2005-06-03 DE DE602005020293T patent/DE602005020293D1/de active Active
- 2005-06-03 CA CA2569396A patent/CA2569396C/en active Active
- 2005-06-03 US US11/596,913 patent/US7563791B2/en active Active
- 2005-06-03 KR KR1020077000040A patent/KR101235602B1/ko active IP Right Grant
- 2005-06-03 AU AU2005252217A patent/AU2005252217B2/en not_active Ceased
- 2005-06-03 RU RU2006147237/04A patent/RU2401269C2/ru not_active IP Right Cessation
- 2005-06-03 MX MXPA06013457 patent/MX279139B/es active IP Right Grant
-
2006
- 2006-11-14 IL IL179264A patent/IL179264A0/en unknown
- 2006-11-28 PH PH12006502386A patent/PH12006502386B1/en unknown
- 2006-11-30 EC EC2006007043A patent/ECSP067043A/es unknown
- 2006-12-28 MA MA29573A patent/MA28689B1/fr unknown
-
2007
- 2007-01-02 ZA ZA2007/00011A patent/ZA200700011B/en unknown
- 2007-01-03 NO NO20070049A patent/NO20070049L/no not_active Application Discontinuation
- 2007-12-24 HK HK07114075.2A patent/HK1109141A1/xx unknown
-
2009
- 2009-07-20 US US12/506,033 patent/US8338595B2/en active Active
-
2012
- 2012-12-20 US US13/722,793 patent/US20130225809A1/en not_active Abandoned
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
GB | Transfer or rights | ||
FG | Grant or registration |