HK1109141A1 - Pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis - Google Patents
Pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesisInfo
- Publication number
- HK1109141A1 HK1109141A1 HK07114075.2A HK07114075A HK1109141A1 HK 1109141 A1 HK1109141 A1 HK 1109141A1 HK 07114075 A HK07114075 A HK 07114075A HK 1109141 A1 HK1109141 A1 HK 1109141A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- angiogenesis
- diseases associated
- proliferative disorders
- derivatives useful
- pyrrolotriazine derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US57665204P | 2004-06-03 | 2004-06-03 | |
US62653104P | 2004-11-09 | 2004-11-09 | |
PCT/US2005/019472 WO2005121147A1 (en) | 2004-06-03 | 2005-06-03 | Pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1109141A1 true HK1109141A1 (en) | 2008-05-30 |
Family
ID=34971944
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK07114075.2A HK1109141A1 (en) | 2004-06-03 | 2007-12-24 | Pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis |
Country Status (31)
Country | Link |
---|---|
US (3) | US7563791B2 (xx) |
EP (1) | EP1765823B1 (xx) |
JP (1) | JP4958772B2 (xx) |
KR (1) | KR101235602B1 (xx) |
CN (1) | CN1993361B (xx) |
AR (1) | AR049138A1 (xx) |
AT (1) | ATE462708T1 (xx) |
AU (1) | AU2005252217B2 (xx) |
BR (1) | BRPI0510848A (xx) |
CA (1) | CA2569396C (xx) |
DE (1) | DE602005020293D1 (xx) |
EC (1) | ECSP067043A (xx) |
ES (1) | ES2342722T3 (xx) |
GT (1) | GT200500137A (xx) |
HK (1) | HK1109141A1 (xx) |
HN (1) | HN2005000255A (xx) |
IL (1) | IL179264A0 (xx) |
MA (1) | MA28689B1 (xx) |
MX (1) | MX279139B (xx) |
MY (1) | MY145077A (xx) |
NO (1) | NO20070049L (xx) |
NZ (1) | NZ551742A (xx) |
PE (1) | PE20060243A1 (xx) |
PH (1) | PH12006502386B1 (xx) |
RU (1) | RU2401269C2 (xx) |
SG (1) | SG127661A1 (xx) |
SV (1) | SV2006002134A (xx) |
TW (1) | TW200608979A (xx) |
UY (1) | UY28931A1 (xx) |
WO (1) | WO2005121147A1 (xx) |
ZA (1) | ZA200700011B (xx) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UY28931A1 (es) * | 2004-06-03 | 2005-12-30 | Bayer Pharmaceuticals Corp | Derivados de pirrolotriazina utiles para tratar trastornos hiper-proliferativos y enfermedades asociadas con angiogenesis |
GB0512324D0 (en) | 2005-06-16 | 2005-07-27 | Novartis Ag | Organic compounds |
DE102005037499A1 (de) * | 2005-08-09 | 2007-02-15 | Merck Patent Gmbh | Pyrazolderivate |
US7514435B2 (en) * | 2005-11-18 | 2009-04-07 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
AU2006320440B2 (en) * | 2005-12-02 | 2012-04-05 | Bayer Healthcare Llc | Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis |
PE20070855A1 (es) * | 2005-12-02 | 2007-10-14 | Bayer Pharmaceuticals Corp | Derivados de 4-amino-pirrolotriazina sustituida como inhibidores de quinasas |
EP1976847B1 (en) | 2005-12-21 | 2015-06-17 | Novartis AG | Pyrimidinyl aryl urea derivatives being fgf inhibitors |
EP1882475A1 (en) * | 2006-07-26 | 2008-01-30 | Novartis AG | Method of treating disorders mediated by the fibroblast growth factor receptor |
US7912582B1 (en) * | 2007-05-03 | 2011-03-22 | Innovation Associates, Inc. | Robotic prescription filling system |
KR101553211B1 (ko) | 2007-09-10 | 2015-09-15 | 씨아이피엘에이 엘티디. | Raf 키나아제 저해제의 제조방법 및 상기 제조방법에 사용되는 중간체 |
EP2203060A4 (en) * | 2007-09-25 | 2010-12-22 | Bayer Healthcare Llc | PYRROLOTRIAZINE DERIVATIVES USEFUL FOR THE TREATMENT OF CANCER BY INHIBITING AURORA KINASE |
EP2085397A1 (en) * | 2008-01-21 | 2009-08-05 | Esteve Quimica, S.A. | Crystalline form of abacavir |
AR074830A1 (es) | 2008-12-19 | 2011-02-16 | Cephalon Inc | Pirrolotriazinas como inhibidores de alk y jak2 |
CN103929961A (zh) * | 2011-06-20 | 2014-07-16 | 美国阿尔茨海默病研究所公司 | 化合物及其治疗应用 |
AP3529A (en) | 2011-07-01 | 2016-01-11 | Bayer Ip Gmbh | Hydroxymethylaryl-substituted pyrrolotriazines as alk1 inhibitors |
UY34484A (es) | 2011-12-15 | 2013-07-31 | Bayer Ip Gmbh | Benzotienilo-pirrolotriazinas disustituidas y sus usos |
JP6047582B2 (ja) * | 2011-12-15 | 2016-12-21 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングBayer Intellectual Property GmbH | 置換ベンゾチエニル−ピロロトリアジンおよび癌の処置におけるその使用 |
CA2865021C (en) | 2012-02-23 | 2020-06-30 | Bayer Intellectual Property Gmbh | Substituted benzothienyl-pyrrolotriazines and uses thereof |
PE20170303A1 (es) * | 2014-06-17 | 2017-04-19 | Chiesi Farm Spa | Derivados de la indolizina como inhibidores de las fosfoinositido-3 quinasas |
WO2017035366A1 (en) | 2015-08-26 | 2017-03-02 | Incyte Corporation | Pyrrolopyrimidine derivatives as tam inhibitors |
AU2016378723B2 (en) | 2015-12-22 | 2021-09-30 | SHY Therapeutics LLC | Compounds for the treatment of cancer and inflammatory disease |
CA3016161A1 (en) | 2016-03-03 | 2017-09-08 | Cornell University | Small molecule ire1-alpha inhibitors |
JP7034084B2 (ja) * | 2016-03-28 | 2022-03-11 | インサイト・コーポレイション | Tam阻害剤としてのピロロトリアジン化合物 |
WO2018161033A1 (en) * | 2017-03-02 | 2018-09-07 | Wright, Adrian | Small molecule ire1-alpha inhibitors |
IL310023A (en) | 2017-06-21 | 2024-03-01 | SHY Therapeutics LLC | Compounds interacting with the RAS superfamily for the treatment of cancer, inflammation, RAS pathology and fibrotic diseases |
TWI821200B (zh) | 2017-09-27 | 2023-11-11 | 美商英塞特公司 | Tam抑制劑之鹽 |
MX2021000127A (es) | 2018-06-29 | 2021-03-29 | Incyte Corp | Formulaciones de un inhibidor de axl/mer. |
CN114040760A (zh) | 2018-12-31 | 2022-02-11 | 拜欧米富士恩公司 | Menin-mll相互作用的不可逆抑制剂 |
EP3906029A4 (en) | 2018-12-31 | 2022-09-21 | Biomea Fusion, LLC | INHIBITORS OF MENIN-MLL INTERACTION |
JP2022533570A (ja) * | 2019-05-13 | 2022-07-25 | リレー セラピューティクス, インコーポレイテッド | Fgfr阻害剤およびそれらの使用 |
KR20220062366A (ko) | 2019-09-26 | 2022-05-16 | 센젠 타겟알엑스, 아이엔씨. | 치환된 방향족 융합 고리 유도체, 및 이를 포함하는 조성물, 및 이의 용도 |
JP2023533771A (ja) * | 2020-07-10 | 2023-08-04 | ベイジン ファインドキュア バイオサイエンシーズ リミテッド | トリアジン系化合物およびその組成物と用途 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU770377B2 (en) * | 1999-05-21 | 2004-02-19 | Bristol-Myers Squibb Company | Pyrrolotriazine inhibitors of kinases |
KR100847605B1 (ko) * | 2000-11-17 | 2008-07-21 | 브리스톨-마이어스스퀴브컴파니 | p38 키나제 관련 질병의 치료 방법 및 키나제 억제제로서유용한 피롤로트리아진 화합물 |
AU2003265349A1 (en) * | 2002-08-02 | 2004-02-23 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
EP1694686A1 (en) | 2003-12-19 | 2006-08-30 | Takeda San Diego, Inc. | Kinase inhibitors |
UY28931A1 (es) | 2004-06-03 | 2005-12-30 | Bayer Pharmaceuticals Corp | Derivados de pirrolotriazina utiles para tratar trastornos hiper-proliferativos y enfermedades asociadas con angiogenesis |
US7405213B2 (en) | 2005-07-01 | 2008-07-29 | Bristol-Myers Squibb Company | Pyrrolotriazine compounds useful as kinase inhibitors and methods of treating kinase-associated conditions therewith |
US7514435B2 (en) | 2005-11-18 | 2009-04-07 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
AU2006320440B2 (en) * | 2005-12-02 | 2012-04-05 | Bayer Healthcare Llc | Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis |
PE20070855A1 (es) * | 2005-12-02 | 2007-10-14 | Bayer Pharmaceuticals Corp | Derivados de 4-amino-pirrolotriazina sustituida como inhibidores de quinasas |
EP2203060A4 (en) * | 2007-09-25 | 2010-12-22 | Bayer Healthcare Llc | PYRROLOTRIAZINE DERIVATIVES USEFUL FOR THE TREATMENT OF CANCER BY INHIBITING AURORA KINASE |
-
2005
- 2005-05-30 UY UY28931A patent/UY28931A1/es not_active Application Discontinuation
- 2005-06-01 HN HN2005000255A patent/HN2005000255A/es unknown
- 2005-06-01 MY MYPI20052508A patent/MY145077A/en unknown
- 2005-06-02 PE PE2005000618A patent/PE20060243A1/es not_active Application Discontinuation
- 2005-06-02 TW TW094118090A patent/TW200608979A/zh unknown
- 2005-06-02 GT GT200500137A patent/GT200500137A/es unknown
- 2005-06-02 AR ARP050102263A patent/AR049138A1/es not_active Application Discontinuation
- 2005-06-03 AU AU2005252217A patent/AU2005252217B2/en not_active Ceased
- 2005-06-03 MX MXPA06013457 patent/MX279139B/es active IP Right Grant
- 2005-06-03 EP EP05758135A patent/EP1765823B1/en active Active
- 2005-06-03 SV SV2005002134A patent/SV2006002134A/es unknown
- 2005-06-03 BR BRPI0510848-9A patent/BRPI0510848A/pt not_active IP Right Cessation
- 2005-06-03 US US11/596,913 patent/US7563791B2/en active Active
- 2005-06-03 NZ NZ551742A patent/NZ551742A/en unknown
- 2005-06-03 DE DE602005020293T patent/DE602005020293D1/de active Active
- 2005-06-03 ES ES05758135T patent/ES2342722T3/es active Active
- 2005-06-03 CN CN2005800260347A patent/CN1993361B/zh active Active
- 2005-06-03 AT AT05758135T patent/ATE462708T1/de not_active IP Right Cessation
- 2005-06-03 CA CA2569396A patent/CA2569396C/en active Active
- 2005-06-03 SG SG200608387A patent/SG127661A1/en unknown
- 2005-06-03 JP JP2007515588A patent/JP4958772B2/ja active Active
- 2005-06-03 WO PCT/US2005/019472 patent/WO2005121147A1/en active Application Filing
- 2005-06-03 KR KR1020077000040A patent/KR101235602B1/ko active IP Right Grant
- 2005-06-03 RU RU2006147237/04A patent/RU2401269C2/ru not_active IP Right Cessation
-
2006
- 2006-11-14 IL IL179264A patent/IL179264A0/en unknown
- 2006-11-28 PH PH12006502386A patent/PH12006502386B1/en unknown
- 2006-11-30 EC EC2006007043A patent/ECSP067043A/es unknown
- 2006-12-28 MA MA29573A patent/MA28689B1/fr unknown
-
2007
- 2007-01-02 ZA ZA2007/00011A patent/ZA200700011B/en unknown
- 2007-01-03 NO NO20070049A patent/NO20070049L/no not_active Application Discontinuation
- 2007-12-24 HK HK07114075.2A patent/HK1109141A1/xx unknown
-
2009
- 2009-07-20 US US12/506,033 patent/US8338595B2/en active Active
-
2012
- 2012-12-20 US US13/722,793 patent/US20130225809A1/en not_active Abandoned
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