DE602004010172T2 - Pharmazeutische zusammensetzungen zur behandlung von nierenfunktionsstörungen - Google Patents
Pharmazeutische zusammensetzungen zur behandlung von nierenfunktionsstörungen Download PDFInfo
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- DE602004010172T2 DE602004010172T2 DE602004010172T DE602004010172T DE602004010172T2 DE 602004010172 T2 DE602004010172 T2 DE 602004010172T2 DE 602004010172 T DE602004010172 T DE 602004010172T DE 602004010172 T DE602004010172 T DE 602004010172T DE 602004010172 T2 DE602004010172 T2 DE 602004010172T2
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- 230000037356 lipid metabolism Effects 0.000 description 1
- 238000011866 long-term treatment Methods 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
- MEFBJEMVZONFCJ-UHFFFAOYSA-N molybdate Chemical compound [O-][Mo]([O-])(=O)=O MEFBJEMVZONFCJ-UHFFFAOYSA-N 0.000 description 1
- 230000003562 morphometric effect Effects 0.000 description 1
- 238000013425 morphometry Methods 0.000 description 1
- 210000000663 muscle cell Anatomy 0.000 description 1
- 230000002107 myocardial effect Effects 0.000 description 1
- 125000004998 naphthylethyl group Chemical group C1(=CC=CC2=CC=CC=C12)CC* 0.000 description 1
- 230000000926 neurological effect Effects 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 230000007119 pathological manifestation Effects 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- 239000008024 pharmaceutical diluent Substances 0.000 description 1
- 229940124531 pharmaceutical excipient Drugs 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 239000000902 placebo Substances 0.000 description 1
- 229940068196 placebo Drugs 0.000 description 1
- 230000036470 plasma concentration Effects 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 238000010837 poor prognosis Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 208000037920 primary disease Diseases 0.000 description 1
- 230000009290 primary effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 208000037821 progressive disease Diseases 0.000 description 1
- 208000002815 pulmonary hypertension Diseases 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 229940079877 pyrogallol Drugs 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000008085 renal dysfunction Effects 0.000 description 1
- 210000005241 right ventricle Anatomy 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000012453 sprague-dawley rat model Methods 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 239000007885 tablet disintegrant Substances 0.000 description 1
- YBRBMKDOPFTVDT-UHFFFAOYSA-N tert-butylamine Chemical compound CC(C)(C)N YBRBMKDOPFTVDT-UHFFFAOYSA-N 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 208000019553 vascular disease Diseases 0.000 description 1
- 230000004218 vascular function Effects 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 108010002139 very low density lipoprotein triglyceride Proteins 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Child & Adolescent Psychology (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03104264 | 2003-11-18 | ||
| EP03104264 | 2003-11-18 | ||
| PCT/EP2004/052963 WO2005049035A1 (en) | 2003-11-18 | 2004-11-15 | Pharmaceutical compositions for the treatment of renal dysfunction, disease or disorder, in particular in diabetic patients |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE602004010172D1 DE602004010172D1 (de) | 2007-12-27 |
| DE602004010172T2 true DE602004010172T2 (de) | 2008-09-11 |
Family
ID=34610099
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602004010172T Expired - Lifetime DE602004010172T2 (de) | 2003-11-18 | 2004-11-15 | Pharmazeutische zusammensetzungen zur behandlung von nierenfunktionsstörungen |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7273860B2 (https=) |
| EP (1) | EP1687006B1 (https=) |
| JP (1) | JP4824573B2 (https=) |
| CN (1) | CN100566719C (https=) |
| AR (1) | AR046454A1 (https=) |
| AT (1) | ATE378053T1 (https=) |
| AU (1) | AU2004290925B2 (https=) |
| BR (1) | BRPI0416706A (https=) |
| CA (1) | CA2545802A1 (https=) |
| DE (1) | DE602004010172T2 (https=) |
| ES (1) | ES2297536T3 (https=) |
| MX (1) | MXPA06005547A (https=) |
| PL (1) | PL1687006T3 (https=) |
| TW (1) | TWI344366B (https=) |
| WO (1) | WO2005049035A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60040089D1 (de) * | 1999-11-19 | 2008-10-09 | Solvay Pharm Bv | Menschliches homolog aus der familie der metalloproteasen |
| AR049401A1 (es) | 2004-06-18 | 2006-07-26 | Novartis Ag | Aza-biciclononanos |
| GB0415746D0 (en) | 2004-07-14 | 2004-08-18 | Novartis Ag | Organic compounds |
| US20060159748A1 (en) * | 2004-12-23 | 2006-07-20 | Rajesh Jain | Oral immediate release formulation of a poorly water-soluble active substance |
| TWI741240B (zh) * | 2017-12-11 | 2021-10-01 | 日商埃塔斯製藥股份有限公司 | 含有1,4-苯并硫氮呯-1-氧化物衍生物之光學異構物之腎功能障礙的改善藥 |
| PL424453A1 (pl) * | 2018-01-31 | 2019-08-12 | Forty-Four Pharmaceuticals Spółka Z Ograniczoną Odpowiedzialnością | Sposoby zmniejszania szkodliwego działania niedoboru perfuzji narządów miąższowych przez inhibitory obojętnej endopeptydazy (NEP) i ludzkiej rozpuszczalnej endopeptydazy (hSEP) |
| CN112292125B (zh) * | 2018-06-22 | 2023-10-31 | 西奈克制药有限公司 | 蛋白尿的治疗 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0254032A3 (en) * | 1986-06-20 | 1990-09-05 | Schering Corporation | Neutral metalloendopeptidase inhibitors in the treatment of hypertension |
| DE19510566A1 (de) * | 1995-03-23 | 1996-09-26 | Kali Chemie Pharma Gmbh | Benzazepin-, Benzoxazepin- und Benzothiazepin-N-essigsäurederivate sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
| DE19638020A1 (de) * | 1996-09-18 | 1998-03-19 | Solvay Pharm Gmbh | Die gastrointestinale Durchblutung fördernde Arzneimittel |
| DE19906310A1 (de) * | 1999-02-16 | 2000-08-17 | Solvay Pharm Gmbh | Arzneimittel zur Behandlung von Bluthochdruck |
| DE19932555A1 (de) * | 1999-07-13 | 2001-01-18 | Solvay Pharm Gmbh | Arzneimittel mit protektiver Wirkung gegen oxidativ-toxische und insbesondere gegen kardiotoxische Substanzen |
| SE9903028D0 (sv) * | 1999-08-27 | 1999-08-27 | Astra Ab | New use |
| RU2303041C2 (ru) * | 2002-01-16 | 2007-07-20 | Солвей Фармасьютикалс Б.В. | Твердые соли бензазепиновых соединений и их применение при получении фармацевтических соединений |
| PE20040468A1 (es) * | 2002-05-17 | 2004-09-14 | Novartis Ag | Combinacion de compuestos organicos |
-
2004
- 2004-11-15 JP JP2006540446A patent/JP4824573B2/ja not_active Expired - Fee Related
- 2004-11-15 TW TW093134862A patent/TWI344366B/zh not_active IP Right Cessation
- 2004-11-15 CN CNB2004800330307A patent/CN100566719C/zh not_active Expired - Fee Related
- 2004-11-15 CA CA002545802A patent/CA2545802A1/en not_active Abandoned
- 2004-11-15 AT AT04818828T patent/ATE378053T1/de not_active IP Right Cessation
- 2004-11-15 ES ES04818828T patent/ES2297536T3/es not_active Expired - Lifetime
- 2004-11-15 MX MXPA06005547A patent/MXPA06005547A/es active IP Right Grant
- 2004-11-15 WO PCT/EP2004/052963 patent/WO2005049035A1/en not_active Ceased
- 2004-11-15 AR ARP040104208A patent/AR046454A1/es not_active Application Discontinuation
- 2004-11-15 PL PL04818828T patent/PL1687006T3/pl unknown
- 2004-11-15 EP EP04818828A patent/EP1687006B1/en not_active Expired - Lifetime
- 2004-11-15 BR BRPI0416706-6A patent/BRPI0416706A/pt not_active IP Right Cessation
- 2004-11-15 DE DE602004010172T patent/DE602004010172T2/de not_active Expired - Lifetime
- 2004-11-15 AU AU2004290925A patent/AU2004290925B2/en not_active Ceased
- 2004-11-16 US US10/988,847 patent/US7273860B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP2007511582A (ja) | 2007-05-10 |
| AR046454A1 (es) | 2005-12-07 |
| DE602004010172D1 (de) | 2007-12-27 |
| PL1687006T3 (pl) | 2008-01-31 |
| HK1097762A1 (zh) | 2007-07-06 |
| ATE378053T1 (de) | 2007-11-15 |
| TW200526228A (en) | 2005-08-16 |
| JP4824573B2 (ja) | 2011-11-30 |
| AU2004290925A1 (en) | 2005-06-02 |
| AU2004290925B2 (en) | 2010-07-01 |
| CN100566719C (zh) | 2009-12-09 |
| CN1878557A (zh) | 2006-12-13 |
| US20050137183A1 (en) | 2005-06-23 |
| US7273860B2 (en) | 2007-09-25 |
| EP1687006B1 (en) | 2007-11-14 |
| MXPA06005547A (es) | 2006-08-17 |
| TWI344366B (en) | 2011-07-01 |
| CA2545802A1 (en) | 2005-06-02 |
| BRPI0416706A (pt) | 2007-01-16 |
| EP1687006A1 (en) | 2006-08-09 |
| WO2005049035A1 (en) | 2005-06-02 |
| ES2297536T3 (es) | 2008-05-01 |
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| 8364 | No opposition during term of opposition |