DE602004008300D1 - Thiazolinderivate als selektive androgenrezeptormodulatoren (sarms) - Google Patents
Thiazolinderivate als selektive androgenrezeptormodulatoren (sarms)Info
- Publication number
- DE602004008300D1 DE602004008300D1 DE602004008300T DE602004008300T DE602004008300D1 DE 602004008300 D1 DE602004008300 D1 DE 602004008300D1 DE 602004008300 T DE602004008300 T DE 602004008300T DE 602004008300 T DE602004008300 T DE 602004008300T DE 602004008300 D1 DE602004008300 D1 DE 602004008300D1
- Authority
- DE
- Germany
- Prior art keywords
- androgen receptor
- sarms
- receptor modulators
- selective androgen
- thiazoline derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000003549 thiazolines Chemical class 0.000 title abstract 2
- 239000000849 selective androgen receptor modulator Substances 0.000 title 2
- 102000001307 androgen receptors Human genes 0.000 abstract 1
- 108010080146 androgen receptors Proteins 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/26—Androgens
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Virology (AREA)
- Dermatology (AREA)
- Reproductive Health (AREA)
- Pregnancy & Childbirth (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Gynecology & Obstetrics (AREA)
- Diabetes (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Nutrition Science (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47871203P | 2003-06-13 | 2003-06-13 | |
| US478712P | 2003-06-13 | ||
| PCT/US2004/018665 WO2004113309A1 (en) | 2003-06-13 | 2004-06-12 | Thiazoline derivatives as selective androgen receptor modulators (sarms) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE602004008300D1 true DE602004008300D1 (de) | 2007-09-27 |
| DE602004008300T2 DE602004008300T2 (de) | 2008-05-08 |
Family
ID=33539114
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602004008300T Expired - Lifetime DE602004008300T2 (de) | 2003-06-13 | 2004-06-12 | Thiazolinderivate als selektive androgenrezeptormodulatoren (sarms) |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20050014952A1 (de) |
| EP (1) | EP1656360B1 (de) |
| JP (1) | JP4898446B2 (de) |
| CN (1) | CN1835937B (de) |
| AT (1) | ATE370133T1 (de) |
| AU (1) | AU2004249697B2 (de) |
| CA (1) | CA2528764A1 (de) |
| CY (1) | CY1106973T1 (de) |
| DE (1) | DE602004008300T2 (de) |
| DK (1) | DK1656360T3 (de) |
| ES (1) | ES2291906T3 (de) |
| PL (1) | PL1656360T3 (de) |
| PT (1) | PT1656360E (de) |
| WO (1) | WO2004113309A1 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104803916B (zh) | 2004-11-16 | 2017-08-11 | 詹森药业有限公司 | 用作选择性雄激素受体调节剂(sarms)的杂环衍生物 |
| US7709516B2 (en) | 2005-06-17 | 2010-05-04 | Endorecherche, Inc. | Helix 12 directed non-steroidal antiandrogens |
| US9284345B2 (en) | 2007-04-12 | 2016-03-15 | Endorecherche, Inc. | 17alpha-substituted steroids as systemic antiandrogens and selective androgen receptor modulators |
| EP2802608A4 (de) * | 2012-01-12 | 2015-08-05 | Univ Yale | Verbindungen und verfahren für den verstärkten abbau von gezielten proteinen und anderen polypeptiden durch eine e3-ubiquitinligase |
| CN103450112B (zh) * | 2013-08-07 | 2019-09-13 | 华东理工大学 | 一种n-桥连接的含氮五元杂环化合物及其制备与用途 |
| US9682960B2 (en) | 2013-12-19 | 2017-06-20 | Endorecherche, Inc. | Non-steroidal antiandrogens and selective androgen receptor modulators with a pyridyl moiety |
| CN113811333B (zh) | 2019-05-14 | 2024-03-12 | 诺维逊生物股份有限公司 | 靶向抗癌核激素受体的化合物 |
| US11952349B2 (en) | 2019-11-13 | 2024-04-09 | Nuvation Bio Inc. | Anti-cancer nuclear hormone receptor-targeting compounds |
| IL306010A (en) | 2021-03-23 | 2023-11-01 | Nuvation Bio Inc | Anticancer compounds against the nuclear hormone receptor |
| US12006314B2 (en) | 2021-05-03 | 2024-06-11 | Nuvation Bio Inc. | Anti-cancer nuclear hormone receptor-targeting compounds |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9506625A (pt) * | 1994-01-24 | 1997-09-30 | Du Pont | Composto composição artropodicida e método para controle de artrópodos |
| US6403623B1 (en) * | 1999-05-27 | 2002-06-11 | Unuversity Of Notre Dame Du Lac | Heterocyclic antituberculosis agents |
| EA014224B1 (ru) * | 2000-08-24 | 2010-10-29 | Юниверсити Оф Теннесси Рисерч Фаундейшн | Селективные модуляторы андрогенового рецептора и способы их применения |
-
2004
- 2004-06-12 CA CA002528764A patent/CA2528764A1/en not_active Abandoned
- 2004-06-12 US US10/866,591 patent/US20050014952A1/en not_active Abandoned
- 2004-06-12 AT AT04755044T patent/ATE370133T1/de active
- 2004-06-12 AU AU2004249697A patent/AU2004249697B2/en not_active Ceased
- 2004-06-12 JP JP2006533745A patent/JP4898446B2/ja not_active Expired - Fee Related
- 2004-06-12 ES ES04755044T patent/ES2291906T3/es not_active Expired - Lifetime
- 2004-06-12 DE DE602004008300T patent/DE602004008300T2/de not_active Expired - Lifetime
- 2004-06-12 EP EP04755044A patent/EP1656360B1/de not_active Expired - Lifetime
- 2004-06-12 WO PCT/US2004/018665 patent/WO2004113309A1/en active IP Right Grant
- 2004-06-12 PT PT04755044T patent/PT1656360E/pt unknown
- 2004-06-12 CN CN2004800230915A patent/CN1835937B/zh not_active Expired - Fee Related
- 2004-06-12 PL PL04755044T patent/PL1656360T3/pl unknown
- 2004-06-12 DK DK04755044T patent/DK1656360T3/da active
-
2007
- 2007-11-05 CY CY20071101413T patent/CY1106973T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP4898446B2 (ja) | 2012-03-14 |
| EP1656360B1 (de) | 2007-08-15 |
| JP2007501287A (ja) | 2007-01-25 |
| CN1835937B (zh) | 2012-07-18 |
| CY1106973T1 (el) | 2012-09-26 |
| AU2004249697B2 (en) | 2010-04-22 |
| CN1835937A (zh) | 2006-09-20 |
| ES2291906T3 (es) | 2008-03-01 |
| DE602004008300T2 (de) | 2008-05-08 |
| CA2528764A1 (en) | 2004-12-29 |
| DK1656360T3 (da) | 2007-12-27 |
| US20050014952A1 (en) | 2005-01-20 |
| AU2004249697A1 (en) | 2004-12-29 |
| PL1656360T3 (pl) | 2008-01-31 |
| EP1656360A1 (de) | 2006-05-17 |
| ATE370133T1 (de) | 2007-09-15 |
| WO2004113309A1 (en) | 2004-12-29 |
| PT1656360E (pt) | 2007-10-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8381 | Inventor (new situation) |
Inventor name: NG, RAYMOND A., RARITAN, NJ 08869-0602, US Inventor name: SUI, ZHIHUA, RARITAN, NJ 08869-0602, US |
|
| 8364 | No opposition during term of opposition |