DE60134899D1 - Herstellung von Risperidon - Google Patents

Herstellung von Risperidon

Info

Publication number
DE60134899D1
DE60134899D1 DE60134899T DE60134899T DE60134899D1 DE 60134899 D1 DE60134899 D1 DE 60134899D1 DE 60134899 T DE60134899 T DE 60134899T DE 60134899 T DE60134899 T DE 60134899T DE 60134899 D1 DE60134899 D1 DE 60134899D1
Authority
DE
Germany
Prior art keywords
risperidone
preparation
disclosed
methods
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Revoked
Application number
DE60134899T
Other languages
German (de)
English (en)
Inventor
Barnaba Krochmal
Dov Diller
Ben-Zion Dolitzky
Judith Aronhime
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Pharmaceutical Industries Ltd
Original Assignee
Teva Pharmaceutical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26919535&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60134899(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Teva Pharmaceutical Industries Ltd filed Critical Teva Pharmaceutical Industries Ltd
Application granted granted Critical
Publication of DE60134899D1 publication Critical patent/DE60134899D1/de
Anticipated expiration legal-status Critical
Revoked legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE60134899T 2000-08-14 2001-08-14 Herstellung von Risperidon Revoked DE60134899D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22536100P 2000-08-14 2000-08-14
US24326300P 2000-10-25 2000-10-25

Publications (1)

Publication Number Publication Date
DE60134899D1 true DE60134899D1 (de) 2008-08-28

Family

ID=26919535

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60134899T Revoked DE60134899D1 (de) 2000-08-14 2001-08-14 Herstellung von Risperidon

Country Status (20)

Country Link
US (2) US6750341B2 (https=)
EP (2) EP1982980A1 (https=)
JP (3) JP3751942B2 (https=)
KR (2) KR100818875B1 (https=)
AT (1) ATE401313T1 (https=)
AU (1) AU2001284880A1 (https=)
CA (1) CA2419314C (https=)
CZ (1) CZ2003668A3 (https=)
DE (1) DE60134899D1 (https=)
ES (1) ES2310410T3 (https=)
HR (1) HRP20030154B1 (https=)
HU (1) HUP0302874A2 (https=)
IL (2) IL154417A0 (https=)
IS (1) IS6713A (https=)
MX (1) MXPA03001337A (https=)
NZ (1) NZ524554A (https=)
PL (1) PL365608A1 (https=)
PT (1) PT1783118E (https=)
SK (1) SK2982003A3 (https=)
WO (1) WO2002014286A1 (https=)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7666445B2 (en) * 2000-10-20 2010-02-23 The Trustees Of The University Of Pennsylvania Polymer-based surgically implantable haloperidol delivery systems and methods for their production and use
AU2003256006A1 (en) * 2002-08-30 2004-03-19 Sunil Sadanand Nadkarni Improved process for preparation of risperidone
KR20040034996A (ko) * 2002-10-18 2004-04-29 한미약품 주식회사 리스페리돈의 개선된 제조방법
CN100390146C (zh) 2002-11-13 2008-05-28 斯索恩有限公司 制备利培酮的方法和用于该方法的中间体
US20040180935A1 (en) * 2003-02-28 2004-09-16 Dr. Reddy's Laboratories Limited Dr. Reddy's Laboratories Inc. Crystalline form Z of rabeprazole sodium and process for preparation thereof
WO2004092143A1 (en) * 2003-04-16 2004-10-28 Hetero Drugs Limited A novel crystalline form of risperidone
PT1673370E (pt) 2003-10-16 2009-11-05 Symed Labs Ltd Forma cristalina de linezolida
US8221778B2 (en) 2005-01-12 2012-07-17 The Trustees Of The University Of Pennsylvania Drug-containing implants and methods of use thereof
CA2553254C (en) * 2004-01-12 2013-12-17 The Trustees Of The University Of Pennsylvania Long-term delivery formulations and methods of use thereof
US8329203B2 (en) * 2004-01-12 2012-12-11 The Trustees Of The University Of Pennsylvania Drug-containing implants and methods of use thereof
WO2005099353A2 (en) * 2004-04-19 2005-10-27 Symed Labs Limited A novel process for the preparation of linezolid and related compounds
HUP0401379A3 (en) 2004-07-08 2006-04-28 Richter Gedeon Vegyeszet Process for the preparation of risperidon
JP2008512471A (ja) * 2004-09-08 2008-04-24 ダーマトレンズ，インコーポレイティド 疎水性生体活性物質の経皮送達
HUP0402163A2 (en) * 2004-10-25 2006-05-29 Richter Gedeon Vegyeszet Process for the preparation of risperidone
EP1879027B1 (en) * 2005-04-27 2013-06-12 CytoPathfinder, Inc. Agent for preventing and treating pancreatitis
US8852638B2 (en) 2005-09-30 2014-10-07 Durect Corporation Sustained release small molecule drug formulation
WO2007093870A2 (en) * 2006-02-15 2007-08-23 Orchid Chemicals & Pharmaceuticals Limited A process for the preparation of risperidone
US7820816B2 (en) * 2006-08-23 2010-10-26 Teva Pharmaceutical Industries Ltd. Process for the synthesis of CMHTP and intermediates thereof
ES2562878T3 (es) 2007-05-25 2016-03-08 Indivior Uk Limited Formulaciones de liberación sostenida de compuestos de risperidona
EP2389187B1 (en) 2009-01-20 2016-11-16 Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center Sorbic and benzoic acid and derivatives thereof enhance the activity of a neuropharmaceutical
CN102786521B (zh) * 2011-05-18 2016-01-13 中国医学科学院药物研究所 利培酮晶iii型物质及制备方法与在药品和保健品中应用
CN105367570B (zh) * 2015-12-08 2017-10-10 天津市亨必达化学合成物有限公司 一种利培酮晶i型物质的制备方法
US10815184B2 (en) 2016-06-13 2020-10-27 Syneurx International (Taiwan) Corp. Co-crystals of lithium benzoate and uses thereof
US11008277B2 (en) 2016-06-13 2021-05-18 Syneurx International (Taiwan) Corp. Co-crystals of sodium benzoate and uses thereof
KR20250054053A (ko) * 2023-01-04 2025-04-22 노바스테이지 파마슈티컬즈 (선전) 리미티드 리스페리돈 경피 투여 시스템 및 이의 제조 방법과 용도

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4804663A (en) * 1985-03-27 1989-02-14 Janssen Pharmaceutica N.V. 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
US5158952A (en) * 1988-11-07 1992-10-27 Janssen Pharmaceutica N.V. 3-[2-[4-(6-fluoro-1,2-benzisoxozol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9 tetrahydro-9-hydroxy-2-methyl-4H-pyrido [1,2-a]pyrimidin-4-one, compositions and method of use
ES2050069B1 (es) 1992-07-10 1994-12-16 Vita Invest Sa Procedimiento para la obtencion de 3-(2-(4-(6-fluoro-1,2-benzisoxazol-3-il)piperidino)etil)-2-metil-6,7,8,9-tetrahidro-4h-pirido(1,2-a) pirimidin-4-ona.
ES2074966B1 (es) 1994-02-11 1996-06-16 Vita Invest Sa Procedimiento para la obtencion de 3-(2-(4-(6-fluoro-benzo(d)isoxazol-3-il)piperidin-1-il)-etil)-2-metil-6,7,8,9-tetrahidro-4h-pirido-(1,2-a)pirimidin-4-ona.
WO1997026880A2 (en) * 1996-01-26 1997-07-31 Pharmacia & Upjohn Company Use of a combination of delavirdine and one or more protease inhibitors in hiv-1 infected patients
TW487572B (en) * 1996-05-20 2002-05-21 Janssen Pharmaceutica Nv Aqueous suspensions of 9-hydroxyrisperidone fatty acid esters
IT1294931B1 (it) * 1997-09-22 1999-04-23 Sigma Tau Ind Farmaceuti Derivati della 2-amminotetralina procedimento per la loro preparazione e composizioni farmaceutiche che li contengono, attive nella
DE60009959T2 (de) 2000-05-05 2005-03-31 Rpg Life Sciences Limited Verfahren zur herstellung von antipsychotischem 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4h-pyrido[1,2-a]pyrimidin-4-on
WO2002012200A1 (en) * 2000-08-08 2002-02-14 Teva Pharmaceutical Industries Ltd. Preparation of risperidone
US20020193386A1 (en) 2002-03-28 2002-12-19 Inigo Pfeiffer Polymorphic form of 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-alpha]pyrimidin-4-one and formulations thereof

Also Published As

Publication number Publication date
US6750341B2 (en) 2004-06-15
HRP20030154A2 (en) 2005-04-30
KR20030022389A (ko) 2003-03-15
IS6713A (is) 2003-02-11
EP1317434A1 (en) 2003-06-11
SK2982003A3 (en) 2004-10-05
CA2419314C (en) 2006-07-11
WO2002014286A1 (en) 2002-02-21
KR20080028513A (ko) 2008-03-31
JP2006028192A (ja) 2006-02-02
US20040229905A1 (en) 2004-11-18
PT1783118E (pt) 2008-08-19
EP1317434A4 (en) 2005-06-22
MXPA03001337A (es) 2005-06-30
IL154417A0 (en) 2003-09-17
US20020115673A1 (en) 2002-08-22
KR100818875B1 (ko) 2008-04-01
HUP0302874A2 (hu) 2003-12-29
WO2002014286A9 (en) 2003-03-27
JP2008056699A (ja) 2008-03-13
IL154417A (en) 2008-11-03
JP3751942B2 (ja) 2006-03-08
ATE401313T1 (de) 2008-08-15
HRP20030154B1 (en) 2009-03-31
ES2310410T3 (es) 2009-01-01
AU2001284880A1 (en) 2002-02-25
JP2004506622A (ja) 2004-03-04
PL365608A1 (en) 2005-01-10
US7256195B2 (en) 2007-08-14
EP1982980A1 (en) 2008-10-22
CA2419314A1 (en) 2002-02-21
NZ524554A (en) 2005-07-29
CZ2003668A3 (en) 2004-04-14

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Legal Events

Date Code Title Description
8363 Opposition against the patent
8331 Complete revocation