IL154417A0 - Preparation of risperidone - Google Patents
Preparation of risperidoneInfo
- Publication number
- IL154417A0 IL154417A0 IL15441701A IL15441701A IL154417A0 IL 154417 A0 IL154417 A0 IL 154417A0 IL 15441701 A IL15441701 A IL 15441701A IL 15441701 A IL15441701 A IL 15441701A IL 154417 A0 IL154417 A0 IL 154417A0
- Authority
- IL
- Israel
- Prior art keywords
- risperidone
- preparation
- disclosed
- methods
- present
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
The present invention is directed to the novel forms of risperidone, designated Form A, Fomi B and Fonn E. Methods for their preparation are also disclosed. The present invention also relates to processes for making risperidone. Pharmaceutical compositions containing the new forms of zisperidone and methods of using them are also disclosed.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22536100P | 2000-08-14 | 2000-08-14 | |
US24326300P | 2000-10-25 | 2000-10-25 | |
PCT/US2001/025387 WO2002014286A1 (en) | 2000-08-14 | 2001-08-14 | Preparation of risperidone |
Publications (1)
Publication Number | Publication Date |
---|---|
IL154417A0 true IL154417A0 (en) | 2003-09-17 |
Family
ID=26919535
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL15441701A IL154417A0 (en) | 2000-08-14 | 2001-08-14 | Preparation of risperidone |
IL154417A IL154417A (en) | 2000-08-14 | 2003-02-12 | Preparation of risperidone |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL154417A IL154417A (en) | 2000-08-14 | 2003-02-12 | Preparation of risperidone |
Country Status (20)
Country | Link |
---|---|
US (2) | US6750341B2 (en) |
EP (2) | EP1982980A1 (en) |
JP (3) | JP3751942B2 (en) |
KR (2) | KR20080028513A (en) |
AT (1) | ATE401313T1 (en) |
AU (1) | AU2001284880A1 (en) |
CA (1) | CA2419314C (en) |
CZ (1) | CZ2003668A3 (en) |
DE (1) | DE60134899D1 (en) |
ES (1) | ES2310410T3 (en) |
HR (1) | HRP20030154B1 (en) |
HU (1) | HUP0302874A2 (en) |
IL (2) | IL154417A0 (en) |
IS (1) | IS6713A (en) |
MX (1) | MXPA03001337A (en) |
NZ (1) | NZ524554A (en) |
PL (1) | PL365608A1 (en) |
PT (1) | PT1783118E (en) |
SK (1) | SK2982003A3 (en) |
WO (1) | WO2002014286A1 (en) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7666445B2 (en) * | 2000-10-20 | 2010-02-23 | The Trustees Of The University Of Pennsylvania | Polymer-based surgically implantable haloperidol delivery systems and methods for their production and use |
WO2004020439A2 (en) * | 2002-08-30 | 2004-03-11 | Sunil Sadanand Nadkarni | Improved process for preparation of risperidone |
KR20040034996A (en) * | 2002-10-18 | 2004-04-29 | 한미약품 주식회사 | Improved method for the preparation of risperidone |
EP1560814A1 (en) | 2002-11-13 | 2005-08-10 | Synthon B.V. | Process for making risperidone and intermediates therefor |
US20040180935A1 (en) * | 2003-02-28 | 2004-09-16 | Dr. Reddy's Laboratories Limited Dr. Reddy's Laboratories Inc. | Crystalline form Z of rabeprazole sodium and process for preparation thereof |
WO2004092143A1 (en) * | 2003-04-16 | 2004-10-28 | Hetero Drugs Limited | A novel crystalline form of risperidone |
WO2005035530A1 (en) | 2003-10-16 | 2005-04-21 | Symed Labs Limited | A novel crystalline form of linezolid |
US8221778B2 (en) | 2005-01-12 | 2012-07-17 | The Trustees Of The University Of Pennsylvania | Drug-containing implants and methods of use thereof |
WO2005070332A1 (en) * | 2004-01-12 | 2005-08-04 | The Trustees Of The University Of Pennsylvania | Long-term delivery formulations and methods of use thereof |
US8329203B2 (en) * | 2004-01-12 | 2012-12-11 | The Trustees Of The University Of Pennsylvania | Drug-containing implants and methods of use thereof |
PL1737850T3 (en) * | 2004-04-19 | 2008-02-29 | Symed Labs Ltd | A novel process for the preparation of linezolid and related compounds |
HUP0401379A3 (en) * | 2004-07-08 | 2006-04-28 | Richter Gedeon Vegyeszet | Process for the preparation of risperidon |
US20080262445A1 (en) * | 2004-09-08 | 2008-10-23 | Dermatrends, Inc. | Transdermal Delivery of Hydrophobic Bioactive Agents |
HUP0402163A2 (en) * | 2004-10-25 | 2006-05-29 | Richter Gedeon Vegyeszet | Process for the preparation of risperidone |
CA2607524A1 (en) * | 2005-04-27 | 2006-11-09 | Umn Pharma Inc. | Agent for prophylaxis and treating of pancreatitis |
US8852638B2 (en) | 2005-09-30 | 2014-10-07 | Durect Corporation | Sustained release small molecule drug formulation |
WO2007093870A2 (en) * | 2006-02-15 | 2007-08-23 | Orchid Chemicals & Pharmaceuticals Limited | A process for the preparation of risperidone |
US7820816B2 (en) * | 2006-08-23 | 2010-10-26 | Teva Pharmaceutical Industries Ltd. | Process for the synthesis of CMHTP and intermediates thereof |
CA2687979C (en) | 2007-05-25 | 2017-07-04 | Tolmar Therapeutics, Inc. | Sustained delivery formulations of risperidone compounds |
ES2731228T3 (en) | 2009-01-20 | 2019-11-14 | Los Angeles Biomedical Res Inst Harbor Ucla Medical Ct | Benzoic acid or salts thereof to improve the activity of a pharmaceutical product |
CN102786521B (en) * | 2011-05-18 | 2016-01-13 | 中国医学科学院药物研究所 | Risperidone brilliant type III material and preparation method and apply in medicine and healthcare products |
CN105367570B (en) * | 2015-12-08 | 2017-10-10 | 天津市亨必达化学合成物有限公司 | A kind of preparation method of Risperidone crystalline substance I type materials |
CN109563024B (en) | 2016-06-13 | 2023-06-06 | 心悦生医股份有限公司 | Eutectic of lithium benzoate and use thereof |
US11008277B2 (en) | 2016-06-13 | 2021-05-18 | Syneurx International (Taiwan) Corp. | Co-crystals of sodium benzoate and uses thereof |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4804663A (en) * | 1985-03-27 | 1989-02-14 | Janssen Pharmaceutica N.V. | 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles |
US5158952A (en) * | 1988-11-07 | 1992-10-27 | Janssen Pharmaceutica N.V. | 3-[2-[4-(6-fluoro-1,2-benzisoxozol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9 tetrahydro-9-hydroxy-2-methyl-4H-pyrido [1,2-a]pyrimidin-4-one, compositions and method of use |
ES2050069B1 (en) | 1992-07-10 | 1994-12-16 | Vita Invest Sa | PROCEDURE FOR OBTAINING 3- (2- (4- (6-FLUORO-1,2-BENZISOXAZOL-3-IL) PIPERIDINO) ETIL) -2-METHYL-6,7,8,9-TETRAHIDRO-4H-PIRIDO (1,2-A) PIRIMIDIN-4-ONA. |
ES2074966B1 (en) | 1994-02-11 | 1996-06-16 | Vita Invest Sa | PROCEDURE FOR OBTAINING 3- (2- (4- (6-FLUORO-BENZO (D) ISOXAZOL-3-IL) PIPERIDIN-1-IL) -ETIL) -2-METHYL-6,7,8,9- TETRAHIDRO-4H-PIRIDO- (1,2-A) PIRIMIDIN-4-ONA. |
WO1997026880A2 (en) * | 1996-01-26 | 1997-07-31 | Pharmacia & Upjohn Company | Use of a combination of delavirdine and one or more protease inhibitors in hiv-1 infected patients |
TW487572B (en) * | 1996-05-20 | 2002-05-21 | Janssen Pharmaceutica Nv | Aqueous suspensions of 9-hydroxyrisperidone fatty acid esters |
IT1294931B1 (en) * | 1997-09-22 | 1999-04-23 | Sigma Tau Ind Farmaceuti | DERIVATIVES OF 2-AMINOTETHRALIN PROCEDURE FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, ACTIVE IN THE |
ATE264329T1 (en) | 2000-05-05 | 2004-04-15 | Rpg Life Sciences Ltd | METHOD FOR PRODUCING ANTIPSYCHOTIC 3-(2-(4-(6-FLUORO-1,2-BENZISOXAZOLE-3-YL)-1- |
AU2001284763A1 (en) * | 2000-08-08 | 2002-02-18 | Teva Pharmaceutical Industries Ltd. | Preparation of risperidone |
US20020193386A1 (en) | 2002-03-28 | 2002-12-19 | Inigo Pfeiffer | Polymorphic form of 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-alpha]pyrimidin-4-one and formulations thereof |
-
2001
- 2001-08-14 MX MXPA03001337A patent/MXPA03001337A/en active IP Right Grant
- 2001-08-14 PL PL01365608A patent/PL365608A1/en not_active Application Discontinuation
- 2001-08-14 CA CA002419314A patent/CA2419314C/en not_active Expired - Fee Related
- 2001-08-14 EP EP08011131A patent/EP1982980A1/en not_active Withdrawn
- 2001-08-14 JP JP2002519429A patent/JP3751942B2/en not_active Expired - Fee Related
- 2001-08-14 KR KR1020087005461A patent/KR20080028513A/en not_active Application Discontinuation
- 2001-08-14 DE DE60134899T patent/DE60134899D1/en not_active Revoked
- 2001-08-14 PT PT07001138T patent/PT1783118E/en unknown
- 2001-08-14 WO PCT/US2001/025387 patent/WO2002014286A1/en not_active Application Discontinuation
- 2001-08-14 HU HU0302874A patent/HUP0302874A2/en unknown
- 2001-08-14 SK SK2982003A patent/SK2982003A3/en not_active Application Discontinuation
- 2001-08-14 KR KR1020037002036A patent/KR100818875B1/en not_active IP Right Cessation
- 2001-08-14 EP EP01963971A patent/EP1317434A4/en not_active Withdrawn
- 2001-08-14 IL IL15441701A patent/IL154417A0/en unknown
- 2001-08-14 AU AU2001284880A patent/AU2001284880A1/en not_active Abandoned
- 2001-08-14 NZ NZ524554A patent/NZ524554A/en unknown
- 2001-08-14 US US09/929,808 patent/US6750341B2/en not_active Expired - Fee Related
- 2001-08-14 CZ CZ2003668A patent/CZ2003668A3/en unknown
- 2001-08-14 ES ES07001138T patent/ES2310410T3/en not_active Expired - Lifetime
- 2001-08-14 AT AT07001138T patent/ATE401313T1/en not_active IP Right Cessation
-
2003
- 2003-02-11 IS IS6713A patent/IS6713A/en unknown
- 2003-02-12 IL IL154417A patent/IL154417A/en not_active IP Right Cessation
- 2003-03-04 HR HR20030154A patent/HRP20030154B1/en not_active IP Right Cessation
- 2003-09-23 US US10/669,272 patent/US7256195B2/en not_active Expired - Fee Related
-
2005
- 2005-08-25 JP JP2005244095A patent/JP2006028192A/en not_active Withdrawn
-
2007
- 2007-11-14 JP JP2007296023A patent/JP2008056699A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
HRP20030154A2 (en) | 2005-04-30 |
KR20080028513A (en) | 2008-03-31 |
US20040229905A1 (en) | 2004-11-18 |
CZ2003668A3 (en) | 2004-04-14 |
ES2310410T3 (en) | 2009-01-01 |
WO2002014286A1 (en) | 2002-02-21 |
DE60134899D1 (en) | 2008-08-28 |
WO2002014286A9 (en) | 2003-03-27 |
KR20030022389A (en) | 2003-03-15 |
CA2419314A1 (en) | 2002-02-21 |
US7256195B2 (en) | 2007-08-14 |
PT1783118E (en) | 2008-08-19 |
JP3751942B2 (en) | 2006-03-08 |
IS6713A (en) | 2003-02-11 |
EP1317434A1 (en) | 2003-06-11 |
JP2004506622A (en) | 2004-03-04 |
JP2008056699A (en) | 2008-03-13 |
PL365608A1 (en) | 2005-01-10 |
HUP0302874A2 (en) | 2003-12-29 |
IL154417A (en) | 2008-11-03 |
EP1317434A4 (en) | 2005-06-22 |
SK2982003A3 (en) | 2004-10-05 |
US20020115673A1 (en) | 2002-08-22 |
HRP20030154B1 (en) | 2009-03-31 |
KR100818875B1 (en) | 2008-04-01 |
US6750341B2 (en) | 2004-06-15 |
AU2001284880A1 (en) | 2002-02-25 |
EP1982980A1 (en) | 2008-10-22 |
MXPA03001337A (en) | 2005-06-30 |
ATE401313T1 (en) | 2008-08-15 |
CA2419314C (en) | 2006-07-11 |
NZ524554A (en) | 2005-07-29 |
JP2006028192A (en) | 2006-02-02 |
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