DE60133271D1 - Behandlung von knorpelerkrankungen - Google Patents

Behandlung von knorpelerkrankungen

Info

Publication number
DE60133271D1
DE60133271D1 DE60133271T DE60133271T DE60133271D1 DE 60133271 D1 DE60133271 D1 DE 60133271D1 DE 60133271 T DE60133271 T DE 60133271T DE 60133271 T DE60133271 T DE 60133271T DE 60133271 D1 DE60133271 D1 DE 60133271D1
Authority
DE
Germany
Prior art keywords
igf
treatment
cartilage
cordial
diseases
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60133271T
Other languages
English (en)
Other versions
DE60133271T2 (de
Inventor
Yves Dubaquie
Ellen H Filvaroff
Henry B Lowman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of DE60133271D1 publication Critical patent/DE60133271D1/de
Publication of DE60133271T2 publication Critical patent/DE60133271T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/30—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4743—Insulin-like growth factor binding protein
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE60133271T 2000-05-16 2001-05-16 Behandlung von knorpelerkrankungen Expired - Lifetime DE60133271T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US20449000P 2000-05-16 2000-05-16
US204490P 2000-05-16
US24898500P 2000-11-15 2000-11-15
US248985P 2000-11-15
PCT/US2001/015904 WO2001087323A2 (en) 2000-05-16 2001-05-16 Method for treating cartilage disorders

Publications (2)

Publication Number Publication Date
DE60133271D1 true DE60133271D1 (de) 2008-04-30
DE60133271T2 DE60133271T2 (de) 2009-04-23

Family

ID=26899527

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60133271T Expired - Lifetime DE60133271T2 (de) 2000-05-16 2001-05-16 Behandlung von knorpelerkrankungen

Country Status (9)

Country Link
US (4) US20030069177A1 (de)
EP (1) EP1282437B1 (de)
AT (1) ATE389416T1 (de)
AU (1) AU2001263215A1 (de)
DE (1) DE60133271T2 (de)
DK (1) DK1282437T3 (de)
ES (1) ES2301547T3 (de)
HK (1) HK1050321A1 (de)
WO (1) WO2001087323A2 (de)

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US8173162B2 (en) * 2003-02-26 2012-05-08 Zimmer Orthobiologics, Inc. Preparation for repairing cartilage tissue, especially articular cartilage defects
US20070275032A1 (en) * 2004-03-05 2007-11-29 Synthes (U.S.A.) Use Of A Mixture For The Production Of An Agent For Treating Defective Or Degenerated Cartilage In The Production Of Natural Cartilage Replacement In Vitro
US20080031819A1 (en) * 2004-06-09 2008-02-07 Beth Israel Deaconess Medical Center Compositions and Methods that Enhance Articular Cartilage Repair
EP1764117A1 (de) 2005-09-20 2007-03-21 Zimmer GmbH Implantat zur Wiederherstellung von Knorpeldefekten und Verfahren zu seiner Herstellung
WO2007092801A2 (en) 2006-02-07 2007-08-16 Spinalcyte, Llc Methods and compositions for repair of cartilage using an in vivo bioreactor
CL2007002502A1 (es) * 2006-08-31 2008-05-30 Hoffmann La Roche Variantes del factor de crecimiento similar a insulina-1 humano (igf-1) pegilados en lisina; metodo de produccion; proteina de fusion que la comprende; y su uso para tratar la enfermedad de alzheimer.
CA2674209A1 (en) * 2006-12-29 2008-07-10 Ipsen Pharma S.A.S. Glp-1 pharmaceutical compositions
ES2694000T3 (es) * 2008-10-06 2018-12-17 3-D Matrix Ltd. Tapón de tejido
CN102348462B (zh) 2008-12-19 2015-06-17 巴克斯特国际公司 Tfpi抑制剂和使用方法
CN105566490A (zh) 2010-03-19 2016-05-11 巴克斯特国际公司 Tfpi抑制剂及使用方法
US20140314726A1 (en) * 2011-11-09 2014-10-23 Spinalcyte, Llc Fibroblasts for treatment of degenerative disc disease
AU2013235741C1 (en) 2012-03-21 2017-12-21 Takeda Pharmaceutical Company Limited TFPI inhibitors and methods of use
EP2864353B1 (de) * 2012-06-25 2019-03-27 The Brigham and Women's Hospital, Inc. Selektive knorpeltherapie
WO2014008400A2 (en) 2012-07-06 2014-01-09 3-D Matrix, Inc. Fill-finish process for peptide solutions
CN105452447A (zh) 2013-06-19 2016-03-30 脊核细胞有限责任公司 用于软骨细胞应用的脂肪细胞
US10369237B2 (en) 2014-03-10 2019-08-06 3-D Matrix, Ltd. Sterilization and filtration of peptide compositions
US10245299B2 (en) 2014-03-10 2019-04-02 3-D Matrix, Ltd. Autoassembling peptides for the treatment of pulmonary bulla
ES2711728T3 (es) 2014-03-10 2019-05-07 3 D Matrix Ltd Composiciones de péptidos de autoensamblaje
WO2017120092A1 (en) 2016-01-06 2017-07-13 3-D Matrix, Ltd. Combination compositions
CN111712230B (zh) 2017-12-15 2024-04-26 立美基股份有限公司 表面活性剂肽纳米结构及在药物递送中的用途

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Also Published As

Publication number Publication date
US7947650B2 (en) 2011-05-24
DE60133271T2 (de) 2009-04-23
EP1282437A2 (de) 2003-02-12
AU2001263215A1 (en) 2001-11-26
EP1282437B1 (de) 2008-03-19
WO2001087323A2 (en) 2001-11-22
DK1282437T3 (da) 2008-06-30
US20030069177A1 (en) 2003-04-10
WO2001087323A3 (en) 2002-04-11
US7423017B2 (en) 2008-09-09
ES2301547T3 (es) 2008-07-01
US20100130411A1 (en) 2010-05-27
US20090011988A1 (en) 2009-01-08
US8110548B2 (en) 2012-02-07
ATE389416T1 (de) 2008-04-15
HK1050321A1 (en) 2003-06-20
US20030211992A1 (en) 2003-11-13

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