PT914419E - Ratinhos transgenicos capazes de expressar o factor de inibicao de leucemia - Google Patents
Ratinhos transgenicos capazes de expressar o factor de inibicao de leucemiaInfo
- Publication number
- PT914419E PT914419E PT97921444T PT97921444T PT914419E PT 914419 E PT914419 E PT 914419E PT 97921444 T PT97921444 T PT 97921444T PT 97921444 T PT97921444 T PT 97921444T PT 914419 E PT914419 E PT 914419E
- Authority
- PT
- Portugal
- Prior art keywords
- pituitary
- ratines
- transgenic
- express
- inhibition factor
- Prior art date
Links
- 230000005764 inhibitory process Effects 0.000 title 1
- 208000032839 leukemia Diseases 0.000 title 1
- 230000009261 transgenic effect Effects 0.000 title 1
- 102000004058 Leukemia inhibitory factor Human genes 0.000 abstract 2
- 108090000581 Leukemia inhibitory factor Proteins 0.000 abstract 2
- 241000699660 Mus musculus Species 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 230000001817 pituitary effect Effects 0.000 abstract 2
- 238000011830 transgenic mouse model Methods 0.000 abstract 2
- 102000018997 Growth Hormone Human genes 0.000 abstract 1
- 108010051696 Growth Hormone Proteins 0.000 abstract 1
- 206010053759 Growth retardation Diseases 0.000 abstract 1
- 206010051687 Pituitary cyst Diseases 0.000 abstract 1
- 208000014993 Pituitary disease Diseases 0.000 abstract 1
- 238000010171 animal model Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 231100000020 developmental retardation Toxicity 0.000 abstract 1
- 239000000122 growth hormone Substances 0.000 abstract 1
- 231100000001 growth retardation Toxicity 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5415—Leukaemia inhibitory factor [LIF]
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Environmental Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Animal Husbandry (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Plant Pathology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Eye Examination Apparatus (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/647,401 US5824838A (en) | 1996-05-09 | 1996-05-09 | Transgenic mouse model for pituitary disorders associated with LIF overexpression and/or GH underexpression, and its use for testing therapeutic drugs for the conditions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT914419E true PT914419E (pt) | 2004-10-29 |
Family
ID=24596845
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT97921444T PT914419E (pt) | 1996-05-09 | 1997-04-29 | Ratinhos transgenicos capazes de expressar o factor de inibicao de leucemia |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5824838A (pt) |
| EP (1) | EP0914419B1 (pt) |
| JP (1) | JP2000509606A (pt) |
| AT (1) | ATE270328T1 (pt) |
| DE (1) | DE69729730T2 (pt) |
| DK (1) | DK0914419T3 (pt) |
| ES (1) | ES2219764T3 (pt) |
| PT (1) | PT914419E (pt) |
| WO (1) | WO1997042312A1 (pt) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPP053197A0 (en) * | 1997-11-26 | 1997-12-18 | Amrad Operations Pty. Limited | Compositions |
| AU744333B2 (en) * | 1997-11-26 | 2002-02-21 | Amrad Operations Pty. Limited | Compositions of leukaemia inhibitory factor |
| AU753197B2 (en) | 1998-07-06 | 2002-10-10 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Compositions and methods for in vitro fertilization |
| US6541244B1 (en) * | 1999-06-07 | 2003-04-01 | Cedars-Sinai Medical Center | Suppressor of cytokine signaling (SOCS)-3 promoter and methods for its use in genetic therapy in humans |
| MXPA02004666A (es) | 1999-11-12 | 2003-06-24 | Fibrogen Inc | Gelatinas recombinantes. |
| EP3224381B1 (en) | 2014-11-25 | 2019-09-04 | The Brigham and Women's Hospital, Inc. | Method of identifying a person having a predisposition to or afflicted with a cardiometabolic disease |
| US10683552B2 (en) | 2014-11-25 | 2020-06-16 | Presidents And Fellows Of Harvard College | Clonal haematopoiesis |
| WO2017053433A1 (en) | 2015-09-21 | 2017-03-30 | Modern Meadow, Inc. | Fiber reinforced tissue composites |
| KR20170096094A (ko) | 2016-02-15 | 2017-08-23 | 브렌던 패트릭 퍼셀 | 복합체 물질을 생제작하는 방법 |
| CA3008850A1 (en) | 2017-06-29 | 2018-12-29 | Modern Meadow, Inc. | Yeast strains and methods for producing collagen |
| AU2018253595A1 (en) | 2017-11-13 | 2019-05-30 | Modern Meadow, Inc. | Biofabricated leather articles having zonal properties |
| US11352497B2 (en) | 2019-01-17 | 2022-06-07 | Modern Meadow, Inc. | Layered collagen materials and methods of making the same |
| WO2020252282A1 (en) * | 2019-06-14 | 2020-12-17 | The Regents Of The University Of California | Dna construct for targeting therapeutic molecules to diseased tissue by immune cells |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4736866B1 (en) * | 1984-06-22 | 1988-04-12 | Transgenic non-human mammals | |
| PT87133B (pt) * | 1987-04-02 | 1992-07-31 | Amrad Corp Ltd | Metodo de purificacao do factor inibidor da leucemia (lif) e de composicoes farmaceuticas contendo polipeptidos com actividade do lif |
| EP0289121B1 (en) * | 1987-05-01 | 1995-12-27 | Stratagene | Mutagenesis testing using transgenic non-human animals carrying test DNA sequences |
| US5175385A (en) * | 1987-09-03 | 1992-12-29 | Ohio University/Edison Animal Biotechnolgy Center | Virus-resistant transgenic mice |
| US5175384A (en) * | 1988-12-05 | 1992-12-29 | Genpharm International | Transgenic mice depleted in mature t-cells and methods for making transgenic mice |
| US5215904A (en) * | 1989-01-27 | 1993-06-01 | Wisconsin Alumni Research Foundation | Method for producing a recombinant mammal in vivo |
| US5175383A (en) * | 1989-02-17 | 1992-12-29 | President And Fellows Of Harvard College | Animal model for benign prostatic disease |
| US5223610A (en) * | 1990-05-18 | 1993-06-29 | The Scripps Research Institute | Cholera toxin gene regulated by growth hormone promoter |
-
1996
- 1996-05-09 US US08/647,401 patent/US5824838A/en not_active Expired - Fee Related
-
1997
- 1997-04-29 AT AT97921444T patent/ATE270328T1/de not_active IP Right Cessation
- 1997-04-29 JP JP9539991A patent/JP2000509606A/ja not_active Ceased
- 1997-04-29 EP EP97921444A patent/EP0914419B1/en not_active Expired - Lifetime
- 1997-04-29 ES ES97921444T patent/ES2219764T3/es not_active Expired - Lifetime
- 1997-04-29 DE DE69729730T patent/DE69729730T2/de not_active Expired - Fee Related
- 1997-04-29 WO PCT/US1997/007177 patent/WO1997042312A1/en active IP Right Grant
- 1997-04-29 DK DK97921444T patent/DK0914419T3/da active
- 1997-04-29 PT PT97921444T patent/PT914419E/pt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2219764T3 (es) | 2004-12-01 |
| DK0914419T3 (da) | 2004-09-06 |
| EP0914419A1 (en) | 1999-05-12 |
| EP0914419B1 (en) | 2004-06-30 |
| WO1997042312A1 (en) | 1997-11-13 |
| ATE270328T1 (de) | 2004-07-15 |
| DE69729730D1 (de) | 2004-08-05 |
| JP2000509606A (ja) | 2000-08-02 |
| DE69729730T2 (de) | 2005-07-07 |
| US5824838A (en) | 1998-10-20 |
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