JP2000509606A - Lif過剰発現および/またはgh発現低下に伴う下垂体障害のトランスジェニック非ヒト動物モデルおよび該状態の治療薬の試験を目的とするその使用 - Google Patents
Lif過剰発現および/またはgh発現低下に伴う下垂体障害のトランスジェニック非ヒト動物モデルおよび該状態の治療薬の試験を目的とするその使用Info
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- JP2000509606A JP2000509606A JP9539991A JP53999197A JP2000509606A JP 2000509606 A JP2000509606 A JP 2000509606A JP 9539991 A JP9539991 A JP 9539991A JP 53999197 A JP53999197 A JP 53999197A JP 2000509606 A JP2000509606 A JP 2000509606A
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- pituitary
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Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.下垂体で特異的に発現されうる、白血病抑制因子(LIF)をコードする外因 性の核酸を保有するトランスジェニック哺乳動物。 2.核酸が、下垂体特異的プロモーターによる発現制御下において、LIFをコー ドする、請求項1記載の哺乳動物。 3.下垂体特異的プロモーターが、一時的な制御を受けるラット成長ホルモン (rGH)プロモーターである、請求項2記載の哺乳動物。 4.核酸が、下垂体特異的な構成的プロモーターによる発現制御下において、L IFをコードする、請求項2記載の哺乳動物。 5.LIFが、ヒトまたはマウスのLIFより選択される、請求項2記載の哺乳動物 。 6.LIFがマウスのLIFである、請求項5記載の哺乳動物。 7.哺乳動物が齧歯類である、請求項6記載の哺乳動物。 8.齧歯類がマウスである、請求項7記載の哺乳動物。 9.下垂体においてLIFを特異的に過剰産生するトランスジェニック哺乳動物。 10.哺乳動物が、対応する野生型の哺乳動物と比較して、GHのレベルが実質的 に減少していることをさらに特徴とする、請求項9記載のトランスジェニック哺 乳動物。 11.GHレベルが、対応する野生型の哺乳動物におけるGHレベルの約50%末満で ある、請求項10記載のトランスジェニック哺乳動物。 12.請求項9記載のトランスジェニック哺乳動物を含む、下垂体障害の動物モ デル。 13.以下の段階を含む、成長ホルモンの産生を刺激するのに有用な化合物を同 定する方法: (a) 請求項1記載の哺乳動物に試験化合物(単数または複数)を投与す る段階、および (b) 該試験化合物が、対照のトランスジェニック哺乳動物と比較して、 該哺乳動物の血清中に存在する成長ホルモンレベルを上昇させるのに有用である ことを同定する段階。 14.哺乳動物が齧歯類である、請求項13記載の方法。 15.哺歯類がマウスである、請求項14記載の方法。 16.成長ホルモンレベルが、哺乳動物の相対的な成長を測定することにより検 出される、請求項13記載の方法。 17.以下の段階を含む、頭蓋咽頭腫に伴う生理学的障害を治療するために有用 な化合物を同定する方法: (a) 請求項1記載の哺乳動物に試験化合物を投与する段階、および (b) 該試験化合物が、下垂体病変に対する治療的反応を引き起こすのに 有用であることを同定する段階。 18.哺乳動物が齧歯類である、請求項17記載の方法。 19.以下の段階を含む、下垂体嚢胞に伴う生理学的障害を治療するために有用 な化合物を同定する方法: (a) 請求項1記載の哺乳動物に試験化合物を投与する段階、および (b) 該試験化合物が、下垂体前葉内の嚢胞腔のサイズを減少させるため に有用であることを同定する段階。 20.請求項1記載の哺乳動物から得られる単離細胞。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/647,401 US5824838A (en) | 1996-05-09 | 1996-05-09 | Transgenic mouse model for pituitary disorders associated with LIF overexpression and/or GH underexpression, and its use for testing therapeutic drugs for the conditions |
US08/647,401 | 1996-05-09 | ||
PCT/US1997/007177 WO1997042312A1 (en) | 1996-05-09 | 1997-04-29 | Transgenic mammals capable of expressing leukemia inhibitory factor |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2000509606A true JP2000509606A (ja) | 2000-08-02 |
Family
ID=24596845
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP9539991A Ceased JP2000509606A (ja) | 1996-05-09 | 1997-04-29 | Lif過剰発現および/またはgh発現低下に伴う下垂体障害のトランスジェニック非ヒト動物モデルおよび該状態の治療薬の試験を目的とするその使用 |
Country Status (9)
Country | Link |
---|---|
US (1) | US5824838A (ja) |
EP (1) | EP0914419B1 (ja) |
JP (1) | JP2000509606A (ja) |
AT (1) | ATE270328T1 (ja) |
DE (1) | DE69729730T2 (ja) |
DK (1) | DK0914419T3 (ja) |
ES (1) | ES2219764T3 (ja) |
PT (1) | PT914419E (ja) |
WO (1) | WO1997042312A1 (ja) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AUPP053197A0 (en) * | 1997-11-26 | 1997-12-18 | Amrad Operations Pty. Limited | Compositions |
AU744333B2 (en) * | 1997-11-26 | 2002-02-21 | Amrad Operations Pty. Limited | Compositions of leukaemia inhibitory factor |
AU753197B2 (en) | 1998-07-06 | 2002-10-10 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Compositions and methods for in vitro fertilization |
US6541244B1 (en) * | 1999-06-07 | 2003-04-01 | Cedars-Sinai Medical Center | Suppressor of cytokine signaling (SOCS)-3 promoter and methods for its use in genetic therapy in humans |
MXPA02004666A (es) | 1999-11-12 | 2003-06-24 | Fibrogen Inc | Gelatinas recombinantes. |
EP3224381B1 (en) | 2014-11-25 | 2019-09-04 | The Brigham and Women's Hospital, Inc. | Method of identifying a person having a predisposition to or afflicted with a cardiometabolic disease |
US10683552B2 (en) | 2014-11-25 | 2020-06-16 | Presidents And Fellows Of Harvard College | Clonal haematopoiesis |
WO2017053433A1 (en) | 2015-09-21 | 2017-03-30 | Modern Meadow, Inc. | Fiber reinforced tissue composites |
KR20170096094A (ko) | 2016-02-15 | 2017-08-23 | 브렌던 패트릭 퍼셀 | 복합체 물질을 생제작하는 방법 |
CA3008850A1 (en) | 2017-06-29 | 2018-12-29 | Modern Meadow, Inc. | Yeast strains and methods for producing collagen |
AU2018253595A1 (en) | 2017-11-13 | 2019-05-30 | Modern Meadow, Inc. | Biofabricated leather articles having zonal properties |
US11352497B2 (en) | 2019-01-17 | 2022-06-07 | Modern Meadow, Inc. | Layered collagen materials and methods of making the same |
WO2020252282A1 (en) * | 2019-06-14 | 2020-12-17 | The Regents Of The University Of California | Dna construct for targeting therapeutic molecules to diseased tissue by immune cells |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4736866B1 (en) * | 1984-06-22 | 1988-04-12 | Transgenic non-human mammals | |
PT87133B (pt) * | 1987-04-02 | 1992-07-31 | Amrad Corp Ltd | Metodo de purificacao do factor inibidor da leucemia (lif) e de composicoes farmaceuticas contendo polipeptidos com actividade do lif |
EP0289121B1 (en) * | 1987-05-01 | 1995-12-27 | Stratagene | Mutagenesis testing using transgenic non-human animals carrying test DNA sequences |
US5175385A (en) * | 1987-09-03 | 1992-12-29 | Ohio University/Edison Animal Biotechnolgy Center | Virus-resistant transgenic mice |
US5175384A (en) * | 1988-12-05 | 1992-12-29 | Genpharm International | Transgenic mice depleted in mature t-cells and methods for making transgenic mice |
US5215904A (en) * | 1989-01-27 | 1993-06-01 | Wisconsin Alumni Research Foundation | Method for producing a recombinant mammal in vivo |
US5175383A (en) * | 1989-02-17 | 1992-12-29 | President And Fellows Of Harvard College | Animal model for benign prostatic disease |
US5223610A (en) * | 1990-05-18 | 1993-06-29 | The Scripps Research Institute | Cholera toxin gene regulated by growth hormone promoter |
-
1996
- 1996-05-09 US US08/647,401 patent/US5824838A/en not_active Expired - Fee Related
-
1997
- 1997-04-29 AT AT97921444T patent/ATE270328T1/de not_active IP Right Cessation
- 1997-04-29 JP JP9539991A patent/JP2000509606A/ja not_active Ceased
- 1997-04-29 EP EP97921444A patent/EP0914419B1/en not_active Expired - Lifetime
- 1997-04-29 ES ES97921444T patent/ES2219764T3/es not_active Expired - Lifetime
- 1997-04-29 DE DE69729730T patent/DE69729730T2/de not_active Expired - Fee Related
- 1997-04-29 WO PCT/US1997/007177 patent/WO1997042312A1/en active IP Right Grant
- 1997-04-29 DK DK97921444T patent/DK0914419T3/da active
- 1997-04-29 PT PT97921444T patent/PT914419E/pt unknown
Also Published As
Publication number | Publication date |
---|---|
ES2219764T3 (es) | 2004-12-01 |
DK0914419T3 (da) | 2004-09-06 |
EP0914419A1 (en) | 1999-05-12 |
EP0914419B1 (en) | 2004-06-30 |
WO1997042312A1 (en) | 1997-11-13 |
ATE270328T1 (de) | 2004-07-15 |
PT914419E (pt) | 2004-10-29 |
DE69729730D1 (de) | 2004-08-05 |
DE69729730T2 (de) | 2005-07-07 |
US5824838A (en) | 1998-10-20 |
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