DE69729730D1 - Transgene mäuse, die den leukämie inhibierungsfaktor exprimieren können - Google Patents
Transgene mäuse, die den leukämie inhibierungsfaktor exprimieren könnenInfo
- Publication number
- DE69729730D1 DE69729730D1 DE69729730T DE69729730T DE69729730D1 DE 69729730 D1 DE69729730 D1 DE 69729730D1 DE 69729730 T DE69729730 T DE 69729730T DE 69729730 T DE69729730 T DE 69729730T DE 69729730 D1 DE69729730 D1 DE 69729730D1
- Authority
- DE
- Germany
- Prior art keywords
- transgenic mice
- pituitary
- express
- inhibition factor
- disorders
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
- A01K67/027—New breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5415—Leukaemia inhibitory factor [LIF]
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Environmental Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Animal Husbandry (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Plant Pathology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Eye Examination Apparatus (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US647401 | 1996-05-09 | ||
US08/647,401 US5824838A (en) | 1996-05-09 | 1996-05-09 | Transgenic mouse model for pituitary disorders associated with LIF overexpression and/or GH underexpression, and its use for testing therapeutic drugs for the conditions |
PCT/US1997/007177 WO1997042312A1 (en) | 1996-05-09 | 1997-04-29 | Transgenic mammals capable of expressing leukemia inhibitory factor |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69729730D1 true DE69729730D1 (de) | 2004-08-05 |
DE69729730T2 DE69729730T2 (de) | 2005-07-07 |
Family
ID=24596845
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69729730T Expired - Fee Related DE69729730T2 (de) | 1996-05-09 | 1997-04-29 | Transgene mäuse, die den leukämie inhibierungsfaktor exprimieren können |
Country Status (9)
Country | Link |
---|---|
US (1) | US5824838A (de) |
EP (1) | EP0914419B1 (de) |
JP (1) | JP2000509606A (de) |
AT (1) | ATE270328T1 (de) |
DE (1) | DE69729730T2 (de) |
DK (1) | DK0914419T3 (de) |
ES (1) | ES2219764T3 (de) |
PT (1) | PT914419E (de) |
WO (1) | WO1997042312A1 (de) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AUPP053197A0 (en) * | 1997-11-26 | 1997-12-18 | Amrad Operations Pty. Limited | Compositions |
AU744333B2 (en) * | 1997-11-26 | 2002-02-21 | Amrad Operations Pty. Limited | Compositions of leukaemia inhibitory factor |
CA2333307A1 (en) | 1998-07-06 | 2000-01-13 | The Government Of The United States Of America As Represented By The Sec Retary, Department Of Health And Human Services | Compositions and methods for in vitro fertilization |
US6541244B1 (en) | 1999-06-07 | 2003-04-01 | Cedars-Sinai Medical Center | Suppressor of cytokine signaling (SOCS)-3 promoter and methods for its use in genetic therapy in humans |
MXPA02004666A (es) | 1999-11-12 | 2003-06-24 | Fibrogen Inc | Gelatinas recombinantes. |
EP3224380A1 (de) | 2014-11-25 | 2017-10-04 | The Broad Institute Inc. | Klonale hämatopoese |
US11168369B2 (en) | 2014-11-25 | 2021-11-09 | The Brigham And Women's Hospital, Inc. | Method of identifying and treating a person having a predisposition to or afflicted with a cardiometabolic disease |
ES2842501T5 (es) | 2015-09-21 | 2023-04-13 | Modern Meadow Inc | Materiales compuestos de tejido reforzados con fibras |
ES2807727T3 (es) | 2016-02-15 | 2021-02-24 | Modern Meadow Inc | Material compuesto biofabricado |
CA3008850A1 (en) | 2017-06-29 | 2018-12-29 | Modern Meadow, Inc. | Yeast strains and methods for producing collagen |
AU2018253595A1 (en) | 2017-11-13 | 2019-05-30 | Modern Meadow, Inc. | Biofabricated leather articles having zonal properties |
US11352497B2 (en) | 2019-01-17 | 2022-06-07 | Modern Meadow, Inc. | Layered collagen materials and methods of making the same |
EP3983551A4 (de) * | 2019-06-14 | 2023-10-18 | The Regents Of The University Of California | Dna-konstrukt zum targeting therapeutischer moleküle gegen krankes gewebe durch immunzellen |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4736866A (en) * | 1984-06-22 | 1988-04-12 | President And Fellows Of Harvard College | Transgenic non-human mammals |
PT87133B (pt) * | 1987-04-02 | 1992-07-31 | Amrad Corp Ltd | Metodo de purificacao do factor inibidor da leucemia (lif) e de composicoes farmaceuticas contendo polipeptidos com actividade do lif |
ATE132266T1 (de) * | 1987-05-01 | 1996-01-15 | Stratagene Inc | Mutagenesetest durch verwendung von nicht menschlichen lebewesen, die test-dns-sequenzen enthalten |
US5175385A (en) * | 1987-09-03 | 1992-12-29 | Ohio University/Edison Animal Biotechnolgy Center | Virus-resistant transgenic mice |
US5175384A (en) * | 1988-12-05 | 1992-12-29 | Genpharm International | Transgenic mice depleted in mature t-cells and methods for making transgenic mice |
US5215904A (en) * | 1989-01-27 | 1993-06-01 | Wisconsin Alumni Research Foundation | Method for producing a recombinant mammal in vivo |
US5175383A (en) * | 1989-02-17 | 1992-12-29 | President And Fellows Of Harvard College | Animal model for benign prostatic disease |
US5223610A (en) * | 1990-05-18 | 1993-06-29 | The Scripps Research Institute | Cholera toxin gene regulated by growth hormone promoter |
-
1996
- 1996-05-09 US US08/647,401 patent/US5824838A/en not_active Expired - Fee Related
-
1997
- 1997-04-29 DK DK97921444T patent/DK0914419T3/da active
- 1997-04-29 DE DE69729730T patent/DE69729730T2/de not_active Expired - Fee Related
- 1997-04-29 AT AT97921444T patent/ATE270328T1/de not_active IP Right Cessation
- 1997-04-29 PT PT97921444T patent/PT914419E/pt unknown
- 1997-04-29 JP JP9539991A patent/JP2000509606A/ja not_active Ceased
- 1997-04-29 ES ES97921444T patent/ES2219764T3/es not_active Expired - Lifetime
- 1997-04-29 EP EP97921444A patent/EP0914419B1/de not_active Expired - Lifetime
- 1997-04-29 WO PCT/US1997/007177 patent/WO1997042312A1/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
DK0914419T3 (da) | 2004-09-06 |
JP2000509606A (ja) | 2000-08-02 |
US5824838A (en) | 1998-10-20 |
ATE270328T1 (de) | 2004-07-15 |
EP0914419B1 (de) | 2004-06-30 |
PT914419E (pt) | 2004-10-29 |
DE69729730T2 (de) | 2005-07-07 |
WO1997042312A1 (en) | 1997-11-13 |
ES2219764T3 (es) | 2004-12-01 |
EP0914419A1 (de) | 1999-05-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |