DE60132782T2 - Prodrugs zu nmda-rezeptorliganden - Google Patents
Prodrugs zu nmda-rezeptorliganden Download PDFInfo
- Publication number
- DE60132782T2 DE60132782T2 DE60132782T DE60132782T DE60132782T2 DE 60132782 T2 DE60132782 T2 DE 60132782T2 DE 60132782 T DE60132782 T DE 60132782T DE 60132782 T DE60132782 T DE 60132782T DE 60132782 T2 DE60132782 T2 DE 60132782T2
- Authority
- DE
- Germany
- Prior art keywords
- compound
- formula
- hydroxy
- benzyl
- ethanesulfonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 0 *c(cc1)ccc1S(CCN(CCC1Cc2ccccc2)C[C@@]1O)(=O)=O Chemical compound *c(cc1)ccc1S(CCN(CCC1Cc2ccccc2)C[C@@]1O)(=O)=O 0.000 description 4
- UDLDPIPQVZOCPK-YLJYHZDGSA-N O[C@H]1[C@@H](Cc2ccccc2)CCN(CCS(c(cc2)ccc2O)(=O)=O)C1 Chemical compound O[C@H]1[C@@H](Cc2ccccc2)CCN(CCS(c(cc2)ccc2O)(=O)=O)C1 UDLDPIPQVZOCPK-YLJYHZDGSA-N 0.000 description 2
- UYWHOJBUGVPOQS-JYXXCUDISA-N CC1(CN2CCOCC2)C=CC(C(Oc(cc2)ccc2S(CCN(CC[C@@H]2Cc3ccccc3)C[C@H]2O)=O)=O)=CC=C1 Chemical compound CC1(CN2CCOCC2)C=CC(C(Oc(cc2)ccc2S(CCN(CC[C@@H]2Cc3ccccc3)C[C@H]2O)=O)=O)=CC=C1 UYWHOJBUGVPOQS-JYXXCUDISA-N 0.000 description 1
- PVOAHINGSUIXLS-UHFFFAOYSA-N CN1CCNCC1 Chemical compound CN1CCNCC1 PVOAHINGSUIXLS-UHFFFAOYSA-N 0.000 description 1
- NCKITHRIEYTWEO-YLJYHZDGSA-N O[C@H]1[C@@H](Cc2ccccc2)CCN(CCS(c(cc2)ccc2OC([IH]C(O)=O)=O)(=O)=O)C1 Chemical compound O[C@H]1[C@@H](Cc2ccccc2)CCN(CCS(c(cc2)ccc2OC([IH]C(O)=O)=O)(=O)=O)C1 NCKITHRIEYTWEO-YLJYHZDGSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/42—Oxygen atoms attached in position 3 or 5
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/59—Hydrogenated pyridine rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00117918 | 2000-08-21 | ||
| EP00117918 | 2000-08-21 | ||
| PCT/EP2001/009561 WO2002016321A1 (en) | 2000-08-21 | 2001-08-20 | Prodrugs to nmda receptor ligands |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60132782D1 DE60132782D1 (de) | 2008-03-27 |
| DE60132782T2 true DE60132782T2 (de) | 2009-02-05 |
Family
ID=8169594
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60132782T Expired - Lifetime DE60132782T2 (de) | 2000-08-21 | 2001-08-20 | Prodrugs zu nmda-rezeptorliganden |
Country Status (35)
| Country | Link |
|---|---|
| US (1) | US6407235B1 (https=) |
| EP (1) | EP1313703B1 (https=) |
| JP (1) | JP4162991B2 (https=) |
| KR (1) | KR100589991B1 (https=) |
| CN (1) | CN1227230C (https=) |
| AR (1) | AR030373A1 (https=) |
| AT (1) | ATE386022T1 (https=) |
| AU (2) | AU8589401A (https=) |
| BR (1) | BR0113348A (https=) |
| CA (1) | CA2419279C (https=) |
| CY (1) | CY1107937T1 (https=) |
| CZ (1) | CZ303319B6 (https=) |
| DE (1) | DE60132782T2 (https=) |
| DK (1) | DK1313703T3 (https=) |
| EC (1) | ECSP034489A (https=) |
| EG (1) | EG24293A (https=) |
| ES (1) | ES2299508T3 (https=) |
| HR (1) | HRP20030125B1 (https=) |
| HU (1) | HU229802B1 (https=) |
| IL (1) | IL154254A0 (https=) |
| JO (1) | JO2289B1 (https=) |
| MA (1) | MA26947A1 (https=) |
| MX (1) | MXPA03001311A (https=) |
| MY (1) | MY136065A (https=) |
| NO (1) | NO324941B1 (https=) |
| NZ (1) | NZ523990A (https=) |
| PA (1) | PA8525601A1 (https=) |
| PE (1) | PE20020291A1 (https=) |
| PL (1) | PL204215B1 (https=) |
| PT (1) | PT1313703E (https=) |
| RS (1) | RS51467B (https=) |
| RU (1) | RU2272027C2 (https=) |
| SI (1) | SI1313703T1 (https=) |
| WO (1) | WO2002016321A1 (https=) |
| ZA (1) | ZA200300894B (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ520657A (en) * | 2000-03-21 | 2004-11-26 | Procter & Gamble | Heterocyclic side chain containing, N-substituted metalloprotease inhibitors |
| US6713490B2 (en) | 2002-04-26 | 2004-03-30 | Pfizer, Inc. | 3,4-dihydroquinolin-2(1H)-one compounds as NR2B receptor antagonists |
| JP2009521424A (ja) * | 2005-12-19 | 2009-06-04 | メチルジーン インコーポレイテッド | 抗真菌剤の活性を増強するためのヒストンデアセチラーゼ阻害剤 |
| US8796330B2 (en) * | 2006-12-19 | 2014-08-05 | Methylgene Inc. | Inhibitors of histone deacetylase and prodrugs thereof |
| MX2009006542A (es) | 2006-12-19 | 2009-06-30 | Methylgene Inc | Inhibidores de histona desacetilasa y sus profarmacos. |
| RS58991B1 (sr) | 2013-11-05 | 2019-08-30 | Astrazeneca Ab | Prolekovi nmda antagonista |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995020587A1 (en) * | 1994-01-31 | 1995-08-03 | Pfizer Inc. | Neuroprotective chroman compounds |
| DE4410822A1 (de) | 1994-03-24 | 1995-09-28 | Schering Ag | Neue Piperidin-Derivate |
| TW340842B (en) * | 1995-08-24 | 1998-09-21 | Pfizer | Substituted benzylaminopiperidine compounds |
| TW498067B (en) | 1996-07-19 | 2002-08-11 | Hoffmann La Roche | 4-hydroxy-piperidine derivatives |
| TWI254043B (en) | 1999-06-08 | 2006-05-01 | Hoffmann La Roche | Ethanesulfonyl-piperidine derivatives having good affinity to N-methyl-D-aspartate (NMDA) receptor |
-
2001
- 2001-08-16 PE PE2001000820A patent/PE20020291A1/es not_active Application Discontinuation
- 2001-08-16 PA PA20018525601A patent/PA8525601A1/es unknown
- 2001-08-16 US US09/931,431 patent/US6407235B1/en not_active Expired - Lifetime
- 2001-08-17 AR ARP010103939A patent/AR030373A1/es active IP Right Grant
- 2001-08-17 MY MYPI20013876A patent/MY136065A/en unknown
- 2001-08-19 JO JO2001136A patent/JO2289B1/en active
- 2001-08-20 DE DE60132782T patent/DE60132782T2/de not_active Expired - Lifetime
- 2001-08-20 JP JP2002521197A patent/JP4162991B2/ja not_active Expired - Fee Related
- 2001-08-20 RU RU2003107572/04A patent/RU2272027C2/ru not_active IP Right Cessation
- 2001-08-20 MX MXPA03001311A patent/MXPA03001311A/es active IP Right Grant
- 2001-08-20 NZ NZ523990A patent/NZ523990A/en not_active IP Right Cessation
- 2001-08-20 CN CNB01814361XA patent/CN1227230C/zh not_active Expired - Fee Related
- 2001-08-20 ES ES01965201T patent/ES2299508T3/es not_active Expired - Lifetime
- 2001-08-20 AT AT01965201T patent/ATE386022T1/de active
- 2001-08-20 SI SI200130812T patent/SI1313703T1/sl unknown
- 2001-08-20 CA CA002419279A patent/CA2419279C/en not_active Expired - Fee Related
- 2001-08-20 WO PCT/EP2001/009561 patent/WO2002016321A1/en not_active Ceased
- 2001-08-20 HR HR20030125A patent/HRP20030125B1/xx not_active IP Right Cessation
- 2001-08-20 RS YUP-130/03A patent/RS51467B/sr unknown
- 2001-08-20 AU AU8589401A patent/AU8589401A/xx active Pending
- 2001-08-20 BR BR0113348-9A patent/BR0113348A/pt not_active Application Discontinuation
- 2001-08-20 IL IL15425401A patent/IL154254A0/xx not_active IP Right Cessation
- 2001-08-20 CZ CZ20030492A patent/CZ303319B6/cs not_active IP Right Cessation
- 2001-08-20 PL PL361387A patent/PL204215B1/pl unknown
- 2001-08-20 EG EG20010906A patent/EG24293A/xx active
- 2001-08-20 HU HU0301548A patent/HU229802B1/hu not_active IP Right Cessation
- 2001-08-20 DK DK01965201T patent/DK1313703T3/da active
- 2001-08-20 KR KR1020037002485A patent/KR100589991B1/ko not_active Expired - Fee Related
- 2001-08-20 PT PT01965201T patent/PT1313703E/pt unknown
- 2001-08-20 AU AU2001285894A patent/AU2001285894B2/en not_active Ceased
- 2001-08-20 EP EP01965201A patent/EP1313703B1/en not_active Expired - Lifetime
-
2003
- 2003-01-31 ZA ZA200300894A patent/ZA200300894B/en unknown
- 2003-02-19 NO NO20030781A patent/NO324941B1/no not_active IP Right Cessation
- 2003-02-20 EC EC2003004489A patent/ECSP034489A/es unknown
- 2003-02-21 MA MA27052A patent/MA26947A1/fr unknown
-
2008
- 2008-05-08 CY CY20081100485T patent/CY1107937T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |