RU2272027C2 - Производные 3-гидроксипиперидина и фармацевтическая композиция на их основе - Google Patents

Производные 3-гидроксипиперидина и фармацевтическая композиция на их основе Download PDF

Info

Publication number
RU2272027C2
RU2272027C2 RU2003107572/04A RU2003107572A RU2272027C2 RU 2272027 C2 RU2272027 C2 RU 2272027C2 RU 2003107572/04 A RU2003107572/04 A RU 2003107572/04A RU 2003107572 A RU2003107572 A RU 2003107572A RU 2272027 C2 RU2272027 C2 RU 2272027C2
Authority
RU
Russia
Prior art keywords
ethanesulfonyl
benzyl
hydroxypiperidin
acid
compound
Prior art date
Application number
RU2003107572/04A
Other languages
English (en)
Russian (ru)
Other versions
RU2003107572A (ru
Inventor
Александер АЛАНЕН (FR)
Александер АЛАНЕН
Бернд БЮТТЕЛЛЬМАНН (DE)
Бернд БЮТТЕЛЛЬМАНН
Хольгер ФИШЕР (CH)
Хольгер ФИШЕР
Мари-Поль ЭТС-НЕДАР (FR)
Мари-Поль ЭТС-НЕДАР
Йёрг ХУВИЛЕР (CH)
Йёрг ХУВИЛЕР
Георг ЙЭШКЕ (CH)
Георг Йэшке
Эмманюэль ПИНАР (FR)
Эмманюэль Пинар
Рене ВИЛЕ (CH)
Рене Виле
Original Assignee
Ф.Хоффманн-Ля Рош Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ф.Хоффманн-Ля Рош Аг filed Critical Ф.Хоффманн-Ля Рош Аг
Publication of RU2003107572A publication Critical patent/RU2003107572A/ru
Application granted granted Critical
Publication of RU2272027C2 publication Critical patent/RU2272027C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/42—Oxygen atoms attached in position 3 or 5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/59—Hydrogenated pyridine rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
RU2003107572/04A 2000-08-21 2001-08-20 Производные 3-гидроксипиперидина и фармацевтическая композиция на их основе RU2272027C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00117918 2000-08-21
EP00117918.3 2000-08-21

Publications (2)

Publication Number Publication Date
RU2003107572A RU2003107572A (ru) 2004-08-10
RU2272027C2 true RU2272027C2 (ru) 2006-03-20

Family

ID=8169594

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2003107572/04A RU2272027C2 (ru) 2000-08-21 2001-08-20 Производные 3-гидроксипиперидина и фармацевтическая композиция на их основе

Country Status (35)

Country Link
US (1) US6407235B1 (https=)
EP (1) EP1313703B1 (https=)
JP (1) JP4162991B2 (https=)
KR (1) KR100589991B1 (https=)
CN (1) CN1227230C (https=)
AR (1) AR030373A1 (https=)
AT (1) ATE386022T1 (https=)
AU (2) AU8589401A (https=)
BR (1) BR0113348A (https=)
CA (1) CA2419279C (https=)
CY (1) CY1107937T1 (https=)
CZ (1) CZ303319B6 (https=)
DE (1) DE60132782T2 (https=)
DK (1) DK1313703T3 (https=)
EC (1) ECSP034489A (https=)
EG (1) EG24293A (https=)
ES (1) ES2299508T3 (https=)
HR (1) HRP20030125B1 (https=)
HU (1) HU229802B1 (https=)
IL (1) IL154254A0 (https=)
JO (1) JO2289B1 (https=)
MA (1) MA26947A1 (https=)
MX (1) MXPA03001311A (https=)
MY (1) MY136065A (https=)
NO (1) NO324941B1 (https=)
NZ (1) NZ523990A (https=)
PA (1) PA8525601A1 (https=)
PE (1) PE20020291A1 (https=)
PL (1) PL204215B1 (https=)
PT (1) PT1313703E (https=)
RS (1) RS51467B (https=)
RU (1) RU2272027C2 (https=)
SI (1) SI1313703T1 (https=)
WO (1) WO2002016321A1 (https=)
ZA (1) ZA200300894B (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ520657A (en) * 2000-03-21 2004-11-26 Procter & Gamble Heterocyclic side chain containing, N-substituted metalloprotease inhibitors
US6713490B2 (en) 2002-04-26 2004-03-30 Pfizer, Inc. 3,4-dihydroquinolin-2(1H)-one compounds as NR2B receptor antagonists
JP2009521424A (ja) * 2005-12-19 2009-06-04 メチルジーン インコーポレイテッド 抗真菌剤の活性を増強するためのヒストンデアセチラーゼ阻害剤
US8796330B2 (en) * 2006-12-19 2014-08-05 Methylgene Inc. Inhibitors of histone deacetylase and prodrugs thereof
MX2009006542A (es) 2006-12-19 2009-06-30 Methylgene Inc Inhibidores de histona desacetilasa y sus profarmacos.
RS58991B1 (sr) 2013-11-05 2019-08-30 Astrazeneca Ab Prolekovi nmda antagonista

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995025721A1 (de) * 1994-03-24 1995-09-28 Schering Aktiengesellschaft Neue 1,4-disubstituierte piperidin-derivate als auf den glutamat-rezeptor wirkende arzneimittel
EP0824098A1 (en) * 1996-07-19 1998-02-18 F. Hoffmann-La Roche Ag 4-hydroxy-piperidine derivatives
RU2126404C1 (ru) * 1994-01-31 1999-02-20 Пфайзер Инк. 3r*, 4s* -3-[4-(4-фторфенил-4-гидроксипиперидин-1-ил] хроман- 4,7-диол, его оптические изомеры и фармацевтическая композиция на его основе и способы лечения
RU2152930C2 (ru) * 1995-08-24 2000-07-20 Пфайзер Инк. Замещенные бензиламинопиперидины и их фармацевтически приемлемые соли, способ лечения и фармацевтическая композиция на их основе

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI254043B (en) 1999-06-08 2006-05-01 Hoffmann La Roche Ethanesulfonyl-piperidine derivatives having good affinity to N-methyl-D-aspartate (NMDA) receptor

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2126404C1 (ru) * 1994-01-31 1999-02-20 Пфайзер Инк. 3r*, 4s* -3-[4-(4-фторфенил-4-гидроксипиперидин-1-ил] хроман- 4,7-диол, его оптические изомеры и фармацевтическая композиция на его основе и способы лечения
WO1995025721A1 (de) * 1994-03-24 1995-09-28 Schering Aktiengesellschaft Neue 1,4-disubstituierte piperidin-derivate als auf den glutamat-rezeptor wirkende arzneimittel
RU2152930C2 (ru) * 1995-08-24 2000-07-20 Пфайзер Инк. Замещенные бензиламинопиперидины и их фармацевтически приемлемые соли, способ лечения и фармацевтическая композиция на их основе
EP0824098A1 (en) * 1996-07-19 1998-02-18 F. Hoffmann-La Roche Ag 4-hydroxy-piperidine derivatives

Also Published As

Publication number Publication date
CY1107937T1 (el) 2013-09-04
BR0113348A (pt) 2003-07-08
EP1313703B1 (en) 2008-02-13
RS51467B (sr) 2011-04-30
DE60132782D1 (de) 2008-03-27
PL204215B1 (pl) 2009-12-31
JP4162991B2 (ja) 2008-10-08
DE60132782T2 (de) 2009-02-05
HRP20030125A2 (en) 2005-02-28
NO324941B1 (no) 2008-01-07
PT1313703E (pt) 2008-03-25
PA8525601A1 (es) 2002-04-25
NO20030781D0 (no) 2003-02-19
ATE386022T1 (de) 2008-03-15
AU2001285894B2 (en) 2006-06-15
EP1313703A1 (en) 2003-05-28
HUP0301548A3 (en) 2010-03-29
CA2419279C (en) 2008-10-14
ZA200300894B (en) 2004-04-30
ECSP034489A (es) 2003-03-31
HRP20030125B1 (en) 2011-07-31
CA2419279A1 (en) 2002-02-28
US6407235B1 (en) 2002-06-18
WO2002016321A1 (en) 2002-02-28
IL154254A0 (en) 2003-09-17
MY136065A (en) 2008-08-29
US20020040037A1 (en) 2002-04-04
CN1227230C (zh) 2005-11-16
SI1313703T1 (sl) 2008-06-30
JP2004506715A (ja) 2004-03-04
JO2289B1 (en) 2005-09-12
ES2299508T3 (es) 2008-06-01
CZ303319B6 (cs) 2012-08-01
YU13003A (sh) 2006-05-25
HU229802B1 (hu) 2014-07-28
KR100589991B1 (ko) 2006-06-15
NZ523990A (en) 2004-09-24
HK1059083A1 (en) 2004-06-18
CZ2003492A3 (cs) 2004-01-14
AU8589401A (en) 2002-03-04
HUP0301548A2 (hu) 2003-08-28
PL361387A1 (en) 2004-10-04
EG24293A (en) 2009-01-08
DK1313703T3 (da) 2008-05-19
NO20030781L (no) 2003-02-19
MXPA03001311A (es) 2003-06-30
AR030373A1 (es) 2003-08-20
PE20020291A1 (es) 2002-04-17
KR20030022417A (ko) 2003-03-15
CN1447793A (zh) 2003-10-08
MA26947A1 (fr) 2004-12-20

Similar Documents

Publication Publication Date Title
CH685630A5 (fr) Dérivés de l'indole.
JP2000516252A (ja) １，４―複素環式メタロプロテアーゼ阻害剤
RU2272027C2 (ru) Производные 3-гидроксипиперидина и фармацевтическая композиция на их основе
US9463187B2 (en) Methylphenidate derivatives and uses of them
RU2242464C2 (ru) Производные этансульфонилпиперидина и лекарственное средство на их основе
AU2001285894A1 (en) Prodrugs to NMDA receptor ligands
US5288898A (en) N-methylphenylserine alkyl ester derivatives and uses thereof
CN114685519B (zh) 一类吡喃并咔唑生物碱衍生物及其治疗阿尔茨海默症的用途
EP0228314A2 (en) Use of ethanol/amine derivatives in treating or preventing hyperlipemia
EP1736474A1 (en) Piperidine derivative
RU2610275C2 (ru) Производное глутаримидов, его применение, фармацевтическая композиция на его основе, способ его получения
CN117682966B (zh) 一种手性芳基丙酸衍生物及其药物组合物和用途
RU2610274C2 (ru) Производное глутаримидов, его применение, фармацевтическая композиция на его основе, способ его получения
RU2610276C1 (ru) Производное глутаримидов, его применение, фармацевтическая композиция на его основе, способ его получения
JP4011780B2 (ja) ジヒドロキノリン誘導体
CN121202835A (zh) 一类胺烷氧基可替宁类化合物及其制备方法和用途
RU2562773C2 (ru) Производные глутаримидов, их применение, фармацевтическая композиция на их основе, способы их получения
US20100305159A1 (en) Crystalline form of piperidine compound
EP0218440A2 (en) N-Methylphenylserine alkyl ester derivatives and uses thereof
JPH068267B2 (ja) Ｎ，ｎ−二置換フエニルセリン誘導体及びそれを有効成分とする中枢神経系用剤
WO2010087980A2 (en) Bicyclic amide derivatives for the treatment of respiratory depression

Legal Events

Date Code Title Description
PC41 Official registration of the transfer of exclusive right

Effective date: 20131003

MM4A The patent is invalid due to non-payment of fees

Effective date: 20150821