DE60129672T2 - Tyrosinkinase inhibitoren - Google Patents

Tyrosinkinase inhibitoren Download PDF

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Publication number
DE60129672T2
DE60129672T2 DE60129672T DE60129672T DE60129672T2 DE 60129672 T2 DE60129672 T2 DE 60129672T2 DE 60129672 T DE60129672 T DE 60129672T DE 60129672 T DE60129672 T DE 60129672T DE 60129672 T2 DE60129672 T2 DE 60129672T2
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DE
Germany
Prior art keywords
optionally substituted
alkyl
substituents selected
aryl
alkenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60129672T
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German (de)
English (en)
Other versions
DE60129672D1 (de
Inventor
Mark E. Rahway FRALEY
George D. Rahway HARTMAN
Randall W. Rahway HUNGATE
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Merck and Co Inc
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Merck and Co Inc
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Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
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Publication of DE60129672D1 publication Critical patent/DE60129672D1/de
Publication of DE60129672T2 publication Critical patent/DE60129672T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE60129672T 2000-02-25 2001-02-21 Tyrosinkinase inhibitoren Expired - Fee Related DE60129672T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18502300P 2000-02-25 2000-02-25
US185023P 2000-02-25
PCT/US2001/005482 WO2001062251A1 (en) 2000-02-25 2001-02-21 Tyrosine kinase inhibitors

Publications (2)

Publication Number Publication Date
DE60129672D1 DE60129672D1 (de) 2007-09-13
DE60129672T2 true DE60129672T2 (de) 2008-04-30

Family

ID=22679236

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60129672T Expired - Fee Related DE60129672T2 (de) 2000-02-25 2001-02-21 Tyrosinkinase inhibitoren

Country Status (9)

Country Link
US (1) US6420382B2 (enExample)
EP (1) EP1259235B1 (enExample)
JP (1) JP2003523389A (enExample)
AT (1) ATE368457T1 (enExample)
AU (2) AU3857501A (enExample)
CA (1) CA2400875A1 (enExample)
DE (1) DE60129672T2 (enExample)
ES (1) ES2288928T3 (enExample)
WO (1) WO2001062251A1 (enExample)

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ES2274075T3 (es) 2001-06-29 2007-05-16 Ab Science Utilizacion de inhibidores de c-kit para tratar enfermedades inflamatorias intestinales (eii).
CA2452368A1 (en) * 2001-06-29 2003-01-09 Ab Science New potent, selective and non toxic c-kit inhibitors
ATE404202T1 (de) * 2001-09-20 2008-08-15 Ab Science Die verwendung von potenten, selektiven und nontoxischen c-kithemmern zur behandlung von interstitieller blasenentzündung
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Also Published As

Publication number Publication date
EP1259235B1 (en) 2007-08-01
WO2001062251A1 (en) 2001-08-30
AU2001238575B2 (en) 2005-04-07
CA2400875A1 (en) 2001-08-30
JP2003523389A (ja) 2003-08-05
DE60129672D1 (de) 2007-09-13
ES2288928T3 (es) 2008-02-01
ATE368457T1 (de) 2007-08-15
US6420382B2 (en) 2002-07-16
AU3857501A (en) 2001-09-03
EP1259235A1 (en) 2002-11-27
EP1259235A4 (en) 2004-11-03
US20010044451A1 (en) 2001-11-22

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