DE60124577T2 - Aza- und polyaza-naphthalenylcarbonsäureamide als hiv-integrase-hemmer - Google Patents

Aza- und polyaza-naphthalenylcarbonsäureamide als hiv-integrase-hemmer Download PDF

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Publication number
DE60124577T2
DE60124577T2 DE60124577T DE60124577T DE60124577T2 DE 60124577 T2 DE60124577 T2 DE 60124577T2 DE 60124577 T DE60124577 T DE 60124577T DE 60124577 T DE60124577 T DE 60124577T DE 60124577 T2 DE60124577 T2 DE 60124577T2
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Germany
Prior art keywords
alkyl
substituted
fluoroalkyl
halogen
independently selected
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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DE60124577T
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German (de)
English (en)
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DE60124577D1 (en
Inventor
Neville J. Rahway ANTHONY
Robert P. Rahway GOMEZ
Jennifer J. Rahway BENNETT
Steven D. Rahway YOUNG
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Merck and Co Inc
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Merck and Co Inc
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Publication of DE60124577D1 publication Critical patent/DE60124577D1/de
Application granted granted Critical
Publication of DE60124577T2 publication Critical patent/DE60124577T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Decoration By Transfer Pictures (AREA)
  • Compression Or Coding Systems Of Tv Signals (AREA)
DE60124577T 2000-10-12 2001-10-09 Aza- und polyaza-naphthalenylcarbonsäureamide als hiv-integrase-hemmer Expired - Fee Related DE60124577T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23967900P 2000-10-12 2000-10-12
US239679P 2000-10-12
PCT/US2001/042565 WO2002055079A2 (en) 2000-10-12 2001-10-09 Aza-and polyaza-naphthalenyl carboxamides useful as hiv integrase inhibitors

Publications (2)

Publication Number Publication Date
DE60124577D1 DE60124577D1 (en) 2006-12-28
DE60124577T2 true DE60124577T2 (de) 2007-09-27

Family

ID=22903252

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60124577T Expired - Fee Related DE60124577T2 (de) 2000-10-12 2001-10-09 Aza- und polyaza-naphthalenylcarbonsäureamide als hiv-integrase-hemmer

Country Status (9)

Country Link
US (1) US6841558B2 (enExample)
EP (1) EP1326610B1 (enExample)
JP (1) JP2004517860A (enExample)
AT (1) ATE345129T1 (enExample)
AU (1) AU2002246499B2 (enExample)
CA (1) CA2425625A1 (enExample)
DE (1) DE60124577T2 (enExample)
ES (1) ES2274913T3 (enExample)
WO (1) WO2002055079A2 (enExample)

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EP3406596A1 (en) 2002-11-20 2018-11-28 Japan Tobacco Inc. 4-oxoquinoline compound and use thereof as hiv integrase inhibitor
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WO2004101512A2 (en) * 2003-05-13 2004-11-25 Smithkline Beecham Corporation Naphthyridine integrase inhibitors
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BRPI0507628A (pt) 2004-02-11 2007-07-03 Smithkline Beecham Corp composto ou sal farmaceuticamente aceitável do mesmo, método de tratamento de uma infecção viral em um ser humano, uso de um composto composição farmacêutica, e, processo para a preparação de um composto
AU2005222391B2 (en) * 2004-03-09 2010-11-11 Merck Sharp & Dohme Corp. HIV integrase inhibitors
CN1930161A (zh) 2004-03-09 2007-03-14 P·安杰莱蒂分子生物学研究所 Hiv整合酶抑制剂
AU2005220767A1 (en) 2004-03-09 2005-09-22 Merck & Co., Inc. HIV integrase inhibitors
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US7538112B2 (en) * 2004-05-07 2009-05-26 Merck & Co., Inc. HIV integrase inhibitors
WO2005113509A1 (en) 2004-05-20 2005-12-01 Japan Tobacco Inc. Novel 4-oxoquinoline compound and use thereof as hiv integrase inhibitor
MY134672A (en) 2004-05-20 2007-12-31 Japan Tobacco Inc Stable crystal of 4-oxoquinoline compound
US8633219B2 (en) 2004-05-21 2014-01-21 Japan Tobacco Inc. Combination therapy
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US7981879B2 (en) * 2005-03-31 2011-07-19 Instituto di Ricerchi di Biologia Molecolare P. Angeletti S.p.A. HIV integrase inhibitors
EP1881825B1 (en) * 2005-05-10 2013-07-24 Merck Sharp & Dohme Corp. Hiv integrase inhibitors
AU2006299042B8 (en) * 2005-10-04 2011-09-15 Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa HIV integrase inhibitors
AU2006306355A1 (en) * 2005-10-27 2007-05-03 Merck & Co., Inc. HIV integrase inhibitors
EP1790342A1 (de) 2005-11-11 2007-05-30 Zentaris GmbH Pyridopyrazin-Derivate und deren Verwendung als Modulatoren der Signaltransduktionswege
US8217042B2 (en) 2005-11-11 2012-07-10 Zentaris Gmbh Pyridopyrazines and their use as modulators of kinases
US7902182B2 (en) * 2005-11-16 2011-03-08 Bristol-Myers Squibb Company HIV integrase inhibitors
RS54047B1 (sr) 2006-03-06 2015-10-30 Japan Tobacco Inc. Postupak za dobijanje jedinjenja 4-oksohinolina
CA2651579A1 (en) 2006-05-16 2007-11-29 Gilead Sciences, Inc. Integrase inhibitors
EP2044068A4 (en) * 2006-07-17 2010-07-21 Merck Sharp & Dohme 1-HYDROXY Naphthyridine Compounds as Anti- HIV Drugs
BRPI0717511A2 (pt) 2006-09-29 2013-11-19 Idenix Pharmaceuticals Inc Composto puro, composição farmacêutica, métodos para tratar uma infecção por hiv, para prevenir uma infecção por hiv, para inibir a replicação de hiv, e, uso de um composto
JP2010506913A (ja) * 2006-10-18 2010-03-04 メルク エンド カムパニー インコーポレーテッド Ｈｉｖインテグラーゼ阻害剤
EP1972627A1 (en) * 2007-03-19 2008-09-24 Technische Universität Carolo-Wilhelmina zu Braunschweig Amino-napthyridine derivatives
US8513420B2 (en) * 2007-03-19 2013-08-20 Monika Mazik Amino-naphthyridine derivatives
CN105055432A (zh) 2008-01-25 2015-11-18 奇默里克斯公司 治疗病毒感染的方法
DE102009038123A1 (de) * 2009-08-17 2011-02-24 Aicuris Gmbh & Co. Kg Substituierte (Thiazolyl-carbonyl)imidazolidinone und ihre Verwendung
WO2011045330A1 (en) 2009-10-13 2011-04-21 Tibotec Pharmaceuticals Macrocyclic integrase inhibitors
EP2534150B1 (en) 2010-02-12 2017-04-05 Chimerix, Inc. Methods of treating viral infection
CN102958935B (zh) 2010-04-02 2015-12-09 爱尔兰詹森科学公司 大环整合酶抑制剂
US9029391B2 (en) 2011-01-24 2015-05-12 Viiv Healthcare Uk Limited Isoquinoline compounds and methods for treating HIV
EP2996691A1 (en) 2013-05-16 2016-03-23 The U.S.A. as represented by the Secretary, Department of Health and Human Services Compounds for inhibiting drug-resistant strains of hiv-1 integrase

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Also Published As

Publication number Publication date
EP1326610A2 (en) 2003-07-16
DE60124577D1 (en) 2006-12-28
CA2425625A1 (en) 2002-07-18
WO2002055079A3 (en) 2002-09-06
US20040044207A1 (en) 2004-03-04
AU2002246499B2 (en) 2005-12-22
EP1326610B1 (en) 2006-11-15
ATE345129T1 (de) 2006-12-15
ES2274913T3 (es) 2007-06-01
US6841558B2 (en) 2005-01-11
EP1326610A4 (en) 2004-06-09
JP2004517860A (ja) 2004-06-17
WO2002055079A2 (en) 2002-07-18

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Legal Events

Date Code Title Description
8381 Inventor (new situation)

Inventor name: ANTHONY, NEVILLE, J., RAHWAY, NJ 07065-0907, US

Inventor name: GOMEZ, ROBERT, P., RAHWAY, NJ 07065-0907, US

Inventor name: BENNETT, JENNIFER, J., RAHWAY, NJ 07065-0907, US

Inventor name: YOUNG, STEVEN, D., RAHWAY, NJ 07065-0907, US

8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: MERCK & CO., INC., RAHWAY, N.J., US

8339 Ceased/non-payment of the annual fee