DE60122176D1 - Isoxazole und ihre verwendung als erk-inhibitoren - Google Patents

Isoxazole und ihre verwendung als erk-inhibitoren

Info

Publication number
DE60122176D1
DE60122176D1 DE60122176T DE60122176T DE60122176D1 DE 60122176 D1 DE60122176 D1 DE 60122176D1 DE 60122176 T DE60122176 T DE 60122176T DE 60122176 T DE60122176 T DE 60122176T DE 60122176 D1 DE60122176 D1 DE 60122176D1
Authority
DE
Germany
Prior art keywords
sup
isoxazole
erk inhibitors
compounds
useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60122176T
Other languages
English (en)
Other versions
DE60122176T2 (de
Inventor
Michael Hale
James Janetka
Francois Maltais
Jingrong Cao
Robert Mashal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vertex Pharmaceuticals Inc
Original Assignee
Vertex Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharmaceuticals Inc filed Critical Vertex Pharmaceuticals Inc
Publication of DE60122176D1 publication Critical patent/DE60122176D1/de
Application granted granted Critical
Publication of DE60122176T2 publication Critical patent/DE60122176T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Dermatology (AREA)
  • Psychology (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
DE60122176T 2000-09-15 2001-09-14 Isoxazole und ihre verwendung als erk-inhibitoren Expired - Lifetime DE60122176T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23295600P 2000-09-15 2000-09-15
US232956P 2000-09-15
PCT/US2001/028790 WO2002022610A1 (en) 2000-09-15 2001-09-14 Isoxazoles and their use as inhibitors of erk

Publications (2)

Publication Number Publication Date
DE60122176D1 true DE60122176D1 (de) 2006-09-21
DE60122176T2 DE60122176T2 (de) 2007-07-05

Family

ID=22875248

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60122176T Expired - Lifetime DE60122176T2 (de) 2000-09-15 2001-09-14 Isoxazole und ihre verwendung als erk-inhibitoren

Country Status (16)

Country Link
US (3) US6495582B1 (de)
EP (1) EP1317453B1 (de)
JP (1) JP4052573B2 (de)
AT (1) ATE335737T1 (de)
AU (1) AU2001290940A1 (de)
CA (1) CA2422376A1 (de)
DE (1) DE60122176T2 (de)
ES (1) ES2269458T3 (de)
HK (1) HK1052934B (de)
HU (1) HUP0302991A3 (de)
IL (1) IL154710A0 (de)
MX (1) MXPA03002296A (de)
NO (1) NO325089B1 (de)
NZ (1) NZ525016A (de)
WO (1) WO2002022610A1 (de)
ZA (1) ZA200301696B (de)

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US20020177618A1 (en) 2002-11-28
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