DE60113509D1 - Herstellungsverfahren für wirkstoffträgerteilchen - Google Patents

Herstellungsverfahren für wirkstoffträgerteilchen

Info

Publication number
DE60113509D1
DE60113509D1 DE60113509T DE60113509T DE60113509D1 DE 60113509 D1 DE60113509 D1 DE 60113509D1 DE 60113509 T DE60113509 T DE 60113509T DE 60113509 T DE60113509 T DE 60113509T DE 60113509 D1 DE60113509 D1 DE 60113509D1
Authority
DE
Germany
Prior art keywords
particulars
manufacturing
active ingredients
physiologically tolerable
spay
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60113509T
Other languages
English (en)
Other versions
DE60113509T2 (de
Inventor
Eva Lynenskjold
Norgaard Jorgensen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Xellia Pharmaceuticals ApS
Original Assignee
Alpharma ApS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alpharma ApS filed Critical Alpharma ApS
Application granted granted Critical
Publication of DE60113509D1 publication Critical patent/DE60113509D1/de
Publication of DE60113509T2 publication Critical patent/DE60113509T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin

Landscapes

  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Seeds, Soups, And Other Foods (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Glass Compositions (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE60113509T 2000-02-17 2001-02-19 Herstellungsverfahren für wirkstoffträgerteilchen Expired - Lifetime DE60113509T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0003782.0A GB0003782D0 (en) 2000-02-17 2000-02-17 Process
GB0003782 2000-02-17
PCT/GB2001/000704 WO2001060338A1 (en) 2000-02-17 2001-02-19 Drug carrier pellet production process

Publications (2)

Publication Number Publication Date
DE60113509D1 true DE60113509D1 (de) 2005-10-27
DE60113509T2 DE60113509T2 (de) 2006-06-22

Family

ID=9885881

Family Applications (2)

Application Number Title Priority Date Filing Date
DE60113509T Expired - Lifetime DE60113509T2 (de) 2000-02-17 2001-02-19 Herstellungsverfahren für wirkstoffträgerteilchen
DE60142259T Expired - Lifetime DE60142259D1 (de) 2000-02-17 2001-02-19 Herstellungsverfahren für Wirkstoffträgerteilchen

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE60142259T Expired - Lifetime DE60142259D1 (de) 2000-02-17 2001-02-19 Herstellungsverfahren für Wirkstoffträgerteilchen

Country Status (9)

Country Link
US (2) US7338668B2 (de)
EP (2) EP1579852B1 (de)
AT (2) ATE304843T1 (de)
AU (1) AU784105B2 (de)
CA (1) CA2396376C (de)
DE (2) DE60113509T2 (de)
DK (2) DK1257256T3 (de)
GB (1) GB0003782D0 (de)
WO (1) WO2001060338A1 (de)

Families Citing this family (26)

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Publication number Priority date Publication date Assignee Title
GB9825033D0 (en) * 1998-11-13 1999-01-13 Nycomed Pharma As Process
DE10026698A1 (de) 2000-05-30 2001-12-06 Basf Ag Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung
US8071133B2 (en) * 2001-08-20 2011-12-06 Stiefel Laboratories, Inc. Oral dosage forms of water insoluble drugs and methods of making the same
US20040091528A1 (en) * 2002-11-12 2004-05-13 Yamanouchi Pharma Technologies, Inc. Soluble drug extended release system
US8025899B2 (en) 2003-08-28 2011-09-27 Abbott Laboratories Solid pharmaceutical dosage form
US8377952B2 (en) 2003-08-28 2013-02-19 Abbott Laboratories Solid pharmaceutical dosage formulation
CZ20032854A3 (cs) * 2003-10-17 2005-05-18 Pliva - Lachema A.S. Způsob přípravy dávkových jednotek pevné lékové formy obsahujících jako účinnou látku sodnou sůl warfarinu
MY144631A (en) * 2004-05-24 2011-10-14 Nycomed Pharma As Particulate comprising a calcium-containing compound and a sugar alcohol
DE602006001295D1 (de) 2005-02-03 2008-07-03 Nycomed Pharma As Schmelzgranulation einer zusammensetzung mit einer calziumhaltigen verbindung
PT1861073E (pt) * 2005-03-04 2009-06-08 Nycomed Pharma As Processo para a produção de composições de cálcio num leito fluidizado contínuo
UA95093C2 (uk) * 2005-12-07 2011-07-11 Нікомед Фарма Ас Спосіб одержання кальцієвмісної сполуки
JP5420907B2 (ja) * 2005-12-07 2014-02-19 タケダ ニコメド エイエス 予備圧縮されたカルシウム含有化合物
TR200605624A2 (tr) * 2006-10-10 2008-05-21 Nobel İlaç Sanayi̇ Ve Ti̇caret Aş. Farmasötik dozaj şekli
EP2223702B1 (de) * 2007-12-03 2019-05-08 Tomita Pharmaceutical Co., Ltd. Kernteilchen für eine pharmazeutische zubereitung
DE102008004893A1 (de) * 2008-01-17 2009-07-23 Add Technologies Ltd. Trägerpellets, Verfahren zu deren Herstellung und deren Verwendung
EP2288335A1 (de) * 2008-03-28 2011-03-02 Boehringer Ingelheim International GmbH Verfahren zur herstellung von oral verabreichten formulierungen von dabigatran
TWI436994B (zh) * 2008-07-14 2014-05-11 Boehringer Ingelheim Int 製備含有達比加群（ｄａｂｉｇａｔｒａｎ）之藥物組合物的新穎方法
RU2497679C2 (ru) * 2008-10-02 2013-11-10 Милан Инк. Способ получения многослойного клеящегося ламинированного материала
NZ592616A (en) 2008-11-11 2013-04-26 Boehringer Ingelheim Int Method for treating or preventing thrombosis using dabigatran etexilate or a salt thereof with improved safety profile over conventional warfarin therapy
AU2009316876A1 (en) * 2008-11-20 2011-07-07 Avantor Performance Materials, Inc. Directly compressible high functionality granular dibasic calcium phosphate based co-processed excipient
US10004682B2 (en) 2010-08-24 2018-06-26 Rutgers, The State University Of New Jersey Formulation and manufacture of pharmaceuticals by impregnation onto porous carriers
JP5917964B2 (ja) * 2012-03-19 2016-05-18 富士ゼロックス株式会社 錠剤、錠剤の製造方法、錠剤管理装置、錠剤照合装置及びプログラム
WO2014011830A1 (en) 2012-07-12 2014-01-16 Mallinckrodt Llc Extended release, abuse deterrent pharmaceutical compositions
JP2023526098A (ja) 2020-05-18 2023-06-20 オレクソ・アクチエボラゲット 薬物送達のための新しい医薬組成物
WO2022241159A1 (en) * 2021-05-12 2022-11-17 Spectrix Therapeutics, LLC Compositions and methods
WO2023094826A1 (en) 2021-11-25 2023-06-01 Orexo Ab Pharmaceutical composition comprising adrenaline

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3833392A (en) * 1971-08-09 1974-09-03 Westinghouse Electric Corp Coating composition and method for preparing water-soluble cellulosic polymer coating compositions for coating fluorescent tubes
AU530410B2 (en) * 1978-02-21 1983-07-14 Sintef Preparing aqueous emulsions
EP0028796B1 (de) * 1979-11-13 1983-07-13 Bayer Ag Beschichtete magnetische Metall- und Legierungspigmente, Verfahren zu ihrer Herstellung und ihre Verwendung
US4622057A (en) * 1983-03-02 1986-11-11 Corning Glass Works Process for making thick-walled ceramic bodies from synthetic micas
CA2035325C (en) * 1990-01-26 1997-06-10 Kenneth J. Wise Low density agglomerate utilizing a carbohydrate binder
US5643591A (en) * 1991-01-16 1997-07-01 Fmc Corporation Solid dosage forms
US5397576A (en) * 1992-09-23 1995-03-14 Hoffmann-La Roche Inc. Spray triturated micronutrient compositions
JP2700141B2 (ja) * 1993-09-17 1998-01-19 富士化学工業株式会社 リン酸水素カルシウム及びその製法並びにそれを用いた賦形剤
US5486507A (en) * 1994-01-14 1996-01-23 Fuisz Technologies Ltd. Porous particle aggregate and method therefor
NZ288185A (en) * 1994-06-15 1998-02-26 Dumex Alpharma As Particulate pharmaceutical formulation containing coated cores comprising at least 80% of an inert carrier having a friability of <20%; the inert carrier can be calcium carbonate
US5958458A (en) * 1994-06-15 1999-09-28 Dumex-Alpharma A/S Pharmaceutical multiple unit particulate formulation in the form of coated cores
ATE251896T1 (de) * 1994-12-19 2003-11-15 Daiichi Seiyaku Co Granulat-präparate mit kontinuierlicher freisetzung und verfahren zur herstellung
US6395303B1 (en) * 1996-06-10 2002-05-28 Edward Mendell Co., Inc. Process for preparing a directly compressible solid dosage form containing microcrystalline cellulose
GB9519094D0 (en) * 1995-09-19 1995-11-22 Warwick Int Group Granulated active with controlled release
JP4027535B2 (ja) 1998-05-26 2007-12-26 エーザイ・アール・アンド・ディー・マネジメント株式会社 脂溶性薬物を含有した粉末

Also Published As

Publication number Publication date
US20030211168A1 (en) 2003-11-13
AU3390001A (en) 2001-08-27
DE60113509T2 (de) 2006-06-22
AU784105B2 (en) 2006-02-02
DK1257256T3 (da) 2005-12-19
US20090017125A1 (en) 2009-01-15
ATE304843T1 (de) 2005-10-15
ATE468843T1 (de) 2010-06-15
US7338668B2 (en) 2008-03-04
EP1579852A2 (de) 2005-09-28
CA2396376A1 (en) 2001-08-23
DK1579852T3 (da) 2010-09-27
DE60142259D1 (de) 2010-07-08
EP1579852B1 (de) 2010-05-26
EP1257256A1 (de) 2002-11-20
CA2396376C (en) 2010-04-27
WO2001060338A1 (en) 2001-08-23
GB0003782D0 (en) 2000-04-05
EP1579852A3 (de) 2007-07-25
EP1257256B1 (de) 2005-09-21

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Legal Events

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