BR9808770A - Conjugado medicamentoso, método para suaprodução e seu uso - Google Patents
Conjugado medicamentoso, método para suaprodução e seu usoInfo
- Publication number
- BR9808770A BR9808770A BR9808770-3A BR9808770A BR9808770A BR 9808770 A BR9808770 A BR 9808770A BR 9808770 A BR9808770 A BR 9808770A BR 9808770 A BR9808770 A BR 9808770A
- Authority
- BR
- Brazil
- Prior art keywords
- production
- drug conjugate
- conjugates
- relates
- enantiomer
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
- Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
- Y10S530/815—Carrier is a synthetic polymer
- Y10S530/816—Attached to the carrier via a bridging agent
Abstract
"CONJUGADO MEDICAMENTOSO, MéTODO PARA SUAPRODUçãO E SEU USO". A invenção se relaciona a conjugadoscompreendendo um D-enantiómero de um antagonista de ácidofólico e um portador. A invenção também se relaciona a produçãode tais conjugados e ao uso dos mesmos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP97107657A EP0879604B1 (de) | 1997-05-09 | 1997-05-09 | Konjugat, umfassend einen Folsäureantagonisten und einen Träger |
PCT/EP1998/002701 WO1998051349A1 (de) | 1997-05-09 | 1998-05-08 | Konjugat, umfassend einen folsäureantagonisten und einen träger |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9808770A true BR9808770A (pt) | 2001-10-30 |
Family
ID=8226780
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9808770-3A BR9808770A (pt) | 1997-05-09 | 1998-05-08 | Conjugado medicamentoso, método para suaprodução e seu uso |
Country Status (14)
Country | Link |
---|---|
US (1) | US6720304B1 (pt) |
EP (1) | EP0879604B1 (pt) |
JP (1) | JP2002501512A (pt) |
KR (1) | KR100596940B1 (pt) |
CN (1) | CN1260725A (pt) |
AT (1) | ATE236657T1 (pt) |
AU (1) | AU733885B2 (pt) |
BR (1) | BR9808770A (pt) |
CA (1) | CA2289448A1 (pt) |
DE (1) | DE59709788D1 (pt) |
DK (1) | DK0879604T3 (pt) |
ES (1) | ES2197265T3 (pt) |
RU (1) | RU2205662C2 (pt) |
WO (1) | WO1998051349A1 (pt) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20020002480A (ko) * | 1999-03-17 | 2002-01-09 | 한센 핀 베네드, 안네 제헤르, 웨이콥 마리안느 | 펩티드의 아실화법 및 신규한 아실화제 |
US7273921B2 (en) * | 2002-09-25 | 2007-09-25 | Novo Nordisk A/S | Method for producing acylated peptides |
ATE483476T1 (de) * | 2003-03-20 | 2010-10-15 | Nippon Kayaku Kk | Micellen-zubereitung mit schwer wasserlöslichem anti-krebsmittel und neuem blockcopolymer |
DE102004016355A1 (de) * | 2004-04-02 | 2005-11-03 | Rösner Research GmbH & Co.KG | Herstellung und Verwendung des Konjugats Methotrexat-Albumin als Mittel zur Immunosuppression bei GVHD |
CA2581125C (en) | 2004-09-22 | 2013-04-23 | Nippon Kayaku Kabushiki Kaisha | Modified poly(ethylene oxide-amino acid) copolymer, micelle preparation, and anticancer agent containing the same |
DE102004057196A1 (de) * | 2004-11-26 | 2006-06-01 | Rösner Research GmbH & Co.KG | Verfahren zur Herstellung von Albumin-Konjugaten mit Nicht-steroidalen Antirheumatika (NSAR) |
US8940332B2 (en) * | 2006-05-18 | 2015-01-27 | Nippon Kayaku Kabushiki Kaisha | High-molecular weight conjugate of podophyllotoxins |
JP5548364B2 (ja) * | 2006-10-03 | 2014-07-16 | 日本化薬株式会社 | レゾルシノール誘導体の高分子結合体 |
EP2080779B1 (en) * | 2006-11-06 | 2016-05-18 | Nippon Kayaku Kabushiki Kaisha | Polymeric derivative of nucleic acid metabolic antagonist |
JP5349318B2 (ja) * | 2007-09-28 | 2013-11-20 | 日本化薬株式会社 | ステロイド類の高分子結合体 |
EP2258397B1 (en) * | 2008-03-18 | 2017-10-11 | Nippon Kayaku Kabushiki Kaisha | Polymer conjugate of physiologically active substance |
EP2284209B1 (en) * | 2008-05-08 | 2016-08-31 | Nippon Kayaku Kabushiki Kaisha | Polymer conjugate of folic acid or folic acid derivative |
JP5707338B2 (ja) * | 2009-01-24 | 2015-04-30 | アミノプテリン・リミテッド・ライアビリティ・カンパニーAminopterin LLC | ラセミのアミノプテリンを含む医薬組成物 |
EP2431403B1 (en) | 2009-05-15 | 2016-09-28 | Nipponkayaku Kabushikikaisha | Polymer conjugate of bioactive substance having hydroxy group |
JP2013515004A (ja) * | 2009-12-18 | 2013-05-02 | エクソドス ライフ サイエンシーズ リミテッド パートナーシップ | 安定な液体薬剤のための方法および組成物 |
CN102451301A (zh) * | 2010-10-22 | 2012-05-16 | 王京姝 | 一种治疗牛皮癣的外用膏剂 |
TW201304805A (zh) | 2010-11-17 | 2013-02-01 | Nippon Kayaku Kk | 新穎之胞核苷系代謝拮抗劑之高分子衍生物 |
JP5711378B2 (ja) | 2011-09-11 | 2015-04-30 | 日本化薬株式会社 | ブロック共重合体の製造方法 |
RU2497825C1 (ru) * | 2012-07-03 | 2013-11-10 | Государственное Научное Учреждение "Институт Физики Имени Б.И. Степанова Национальной Академии Наук Беларуси" | Конъюгат фолиевой кислоты и способ его получения |
DE102017204850A1 (de) * | 2017-03-22 | 2018-09-27 | Michael Denck | HSA-Konjugat |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2116979B (en) * | 1982-02-25 | 1985-05-15 | Ward Page Faulk | Conjugates of proteins with anti-tumour agents |
CA1330378C (en) * | 1986-05-08 | 1994-06-21 | Daniel J. Coughlin | Amine derivatives of folic acid analogs |
DE4122210C2 (de) * | 1991-07-04 | 1999-04-01 | Deutsches Krebsforsch | Konjugate aus tumoraktiver Verbindung und Serumalbumin sowie Verfahren zu deren Herstellung und ihre Verwendung |
WO1993015751A1 (en) * | 1992-02-14 | 1993-08-19 | Merck & Co., Inc. | CHIMERIC TOXINS BINDING TO THE GnRH RECEPTOR |
DE4433890C2 (de) * | 1994-09-22 | 1999-02-18 | Deutsches Krebsforsch | Konjugat aus einem Wirkstoff und einem nicht als körperfremd angesehenen, nativen Protein |
-
1997
- 1997-05-09 DK DK97107657T patent/DK0879604T3/da active
- 1997-05-09 EP EP97107657A patent/EP0879604B1/de not_active Expired - Lifetime
- 1997-05-09 ES ES97107657T patent/ES2197265T3/es not_active Expired - Lifetime
- 1997-05-09 AT AT97107657T patent/ATE236657T1/de not_active IP Right Cessation
- 1997-05-09 DE DE59709788T patent/DE59709788D1/de not_active Expired - Fee Related
-
1998
- 1998-05-08 AU AU79109/98A patent/AU733885B2/en not_active Ceased
- 1998-05-08 US US09/423,710 patent/US6720304B1/en not_active Expired - Fee Related
- 1998-05-08 CA CA002289448A patent/CA2289448A1/en not_active Abandoned
- 1998-05-08 KR KR1019997010365A patent/KR100596940B1/ko not_active IP Right Cessation
- 1998-05-08 WO PCT/EP1998/002701 patent/WO1998051349A1/de active IP Right Grant
- 1998-05-08 JP JP54877298A patent/JP2002501512A/ja not_active Withdrawn
- 1998-05-08 BR BR9808770-3A patent/BR9808770A/pt not_active Application Discontinuation
- 1998-05-08 CN CN98806340A patent/CN1260725A/zh active Pending
- 1998-05-08 RU RU99125777/14A patent/RU2205662C2/ru not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
WO1998051349A1 (de) | 1998-11-19 |
KR100596940B1 (ko) | 2006-07-07 |
DE59709788D1 (de) | 2003-05-15 |
AU7910998A (en) | 1998-12-08 |
ATE236657T1 (de) | 2003-04-15 |
EP0879604A1 (de) | 1998-11-25 |
US6720304B1 (en) | 2004-04-13 |
JP2002501512A (ja) | 2002-01-15 |
DK0879604T3 (da) | 2003-08-04 |
KR20010012412A (ko) | 2001-02-15 |
AU733885B2 (en) | 2001-05-31 |
CN1260725A (zh) | 2000-07-19 |
RU2205662C2 (ru) | 2003-06-10 |
EP0879604B1 (de) | 2003-04-09 |
CA2289448A1 (en) | 1998-11-19 |
ES2197265T3 (es) | 2004-01-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR9808770A (pt) | Conjugado medicamentoso, método para suaprodução e seu uso | |
BR9807814B1 (pt) | composto de pirazina, composiÇço farmacÊutica, uso de um composto, e, processo para a preparaÇço de um composto. | |
BR9810802B1 (pt) | composto, composição farmacêutica, e, processo para a preparação de um composto. | |
SE9704545D0 (sv) | Novel compounds | |
BR9909925B1 (pt) | derivados de quinolina, composições farmacêuticas, e, processo para a fabricação de derivados de quinolina. | |
BR0009083B1 (pt) | derivado de amida compreendendo um núcleo de quinazolinona, processo para a preparação de um derivado de amida, composição farmacêutica, e, uso de um derivado de amida. | |
PT1218378E (pt) | Derivados de terc-butil-(7-metil-imidazo-¬1,2-a|-piridin-3-il)-amina | |
UY26495A1 (es) | " derivados de tiazolilamida" | |
DE69808130D1 (de) | Adamantan-derivate | |
BR9909995B1 (pt) | composto, processo para a preparação de um composto, formulação farmacêutica, e, uso de um composto. | |
SE9704546D0 (sv) | Novel compounds | |
BR9912104B1 (pt) | compostos derivados de quinolina, composições farmacêuticas, e, processo para a manufatura de um composto. | |
BR9801533A (pt) | Composição de uréia substituída com éter n,n,n'-trimetil-bis (aminoetila) para a produção de poliuretanos | |
BR0114903A (pt) | 7-azaindóis, sua aplicação como inibidores da fosfodiesterase 4 e processos para a sua preparação | |
TR199801871A3 (tr) | Bifenilsulfonilsiyanamidler üretim yöntemi ve ilaç olarak kullanimlari. | |
BR9805437A (pt) | Derivados de benzocicloalquenos heterocìclicos, processo para fabricação de derivados de benzocicloalquenos heterocìclicos e uso de derivados de benzocicloalquenos heterocìclicos. | |
DE3879985T2 (de) | Anticonvulsive agenzien. | |
ITMI20000293A0 (it) | Derivati del 3,9-diazabiciclo [3.3.1]nonano ad attivita' analgesica | |
PT1157020E (pt) | 1,2,3,4,5,6-hexa-hidro-2,6-metano-3-benzazocin-10-ois substituidos processo para a sua preparacao e sua utilizacao como medicamentos | |
ITMI20001848A0 (it) | Faramaci per l'incontinenza. | |
EA200100317A1 (ru) | Новые производные бензоилгуанидина с эффективными свойствами, способ их получения и их применение при изготовлении лекарственных средств | |
DE60029979D1 (de) | LIPOSOMZUSAMMENSETZUNG VON 6,9-BIS-i(2-AMINOETHYL)-AMINOöBENZOiGöISOQUINOLIN-5,10-DIONE-DIMALEAT | |
SE9902742D0 (sv) | New pharmaceutical formultion | |
BR9903115A (pt) | Derivados de acridina | |
NO971604L (no) | Orale sabeluzolsuspensjoner |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: O DEPOSITANTE DEIXOU DE APRESENTAR MANIFESTACAO SOBRE O PARECER NEGATIVO, ASSIM, DE ACORDO COM O ART. 36 DA LPI (LEI 9279/96) 2O, O PEDIDO VOLTA A EXAME SENDO CONSIDERADO NAO PATENTEAVEL PELAS RAZOES EXPOSTAS NO PARECER TECNICO ANTERIOR. |
|
B15K | Others concerning applications: alteration of classification |
Ipc: A61K 47/64 (2017.01), A61K 47/60 (2017.0 |